Motif ID: Zbtb6

Z-value: 0.812


Transcription factors associated with Zbtb6:

Gene SymbolEntrez IDGene Name
Zbtb6 ENSMUSG00000066798.3 Zbtb6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb6mm10_v2_chr2_-_37430835_374309190.412.1e-03Click!


Activity profile for motif Zbtb6.

activity profile for motif Zbtb6


Sorted Z-values histogram for motif Zbtb6

Sorted Z-values for motif Zbtb6



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_102897123 6.430 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr3_+_54156039 4.377 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr6_+_114131229 4.353 ENSMUST00000032451.7
 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr11_-_102897146 4.089 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr15_+_103503261 2.891 ENSMUST00000023132.3
 Pde1b
phosphodiesterase 1B, Ca2+-calmodulin dependent
chr11_+_101246405 2.830 ENSMUST00000122006.1
ENSMUST00000151830.1
 Ramp2

receptor (calcitonin) activity modifying protein 2

chr4_+_136286061 2.830 ENSMUST00000069195.4
ENSMUST00000130658.1
 Zfp46

zinc finger protein 46

chr11_+_101246960 2.826 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr6_+_124997062 2.804 ENSMUST00000159391.1
 Pianp
PILR alpha associated neural protein
chr11_-_30025915 2.684 ENSMUST00000058902.5
 Eml6
echinoderm microtubule associated protein like 6
chr11_-_42182924 2.678 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr8_+_25518783 2.644 ENSMUST00000084027.5
ENSMUST00000117179.2
 Fgfr1

fibroblast growth factor receptor 1

chr8_+_25518757 2.542 ENSMUST00000178276.1
ENSMUST00000179592.1
 Fgfr1

fibroblast growth factor receptor 1

chr1_+_75549581 2.484 ENSMUST00000154101.1
 Slc4a3
solute carrier family 4 (anion exchanger), member 3
chr16_-_26371828 2.461 ENSMUST00000023154.2
 Cldn1
claudin 1
chr18_+_37504264 2.351 ENSMUST00000052179.6
 Pcdhb20
protocadherin beta 20
chr19_+_46003468 2.328 ENSMUST00000099393.2
 Hps6
Hermansky-Pudlak syndrome 6
chr7_-_4789541 2.136 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238
chr18_+_37513652 2.026 ENSMUST00000061405.4
 Pcdhb21
protocadherin beta 21
chr5_-_18360384 2.006 ENSMUST00000074694.5
 Gnai1
guanine nucleotide binding protein (G protein), alpha inhibiting 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 10.5 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.9 5.7 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 5.7 GO:0007416 synapse assembly(GO:0007416)
0.1 5.6 GO:0051453 regulation of intracellular pH(GO:0051453)
1.7 5.2 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.2 4.4 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.0 4.3 GO:0006836 neurotransmitter transport(GO:0006836)
0.2 3.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.9 3.7 GO:0009414 response to water deprivation(GO:0009414)
1.0 3.1 GO:0006601 creatine biosynthetic process(GO:0006601)
0.5 3.1 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.4 2.9 GO:0036006 response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006)
0.3 2.7 GO:0071420 cellular response to histamine(GO:0071420)
0.8 2.5 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.2 2.3 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 2.3 GO:0030318 melanocyte differentiation(GO:0030318)
0.2 2.2 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 2.2 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)
0.5 2.0 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.6 1.9 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.5 GO:0005887 integral component of plasma membrane(GO:0005887)
2.6 10.5 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 7.1 GO:0043235 receptor complex(GO:0043235)
0.0 6.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 5.9 GO:0016323 basolateral plasma membrane(GO:0016323)
1.1 5.7 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 5.6 GO:0034704 calcium channel complex(GO:0034704)
0.0 3.3 GO:0043209 myelin sheath(GO:0043209)
0.1 3.0 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 2.9 GO:0030141 secretory granule(GO:0030141)
0.2 2.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 2.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 2.5 GO:0005783 endoplasmic reticulum(GO:0005783)
0.2 2.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 2.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.6 2.3 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 2.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.0 GO:0099738 cell cortex region(GO:0099738)
0.5 1.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.8 GO:0045177 apical part of cell(GO:0045177)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 6.0 GO:0005351 sugar:proton symporter activity(GO:0005351)
1.1 5.7 GO:0097643 amylin receptor activity(GO:0097643)
0.3 5.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.6 5.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
1.5 4.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.4 4.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 3.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.4 2.9 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.4 2.7 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 2.5 GO:0001618 virus receptor activity(GO:0001618)
0.3 2.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 2.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 2.3 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.3 2.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 2.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 2.0 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.5 1.9 GO:0038025 reelin receptor activity(GO:0038025)
0.3 1.8 GO:0050544 arachidonic acid binding(GO:0050544)
0.2 1.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.0 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 2.5 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 2.1 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 1.9 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 1.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.6 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.1 1.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.0 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 0.9 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 0.6 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 0.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.5 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 8.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.5 5.2 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 4.5 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.4 4.4 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.4 4.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 3.0 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 2.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 2.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 2.4 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 2.0 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 1.9 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 1.8 REACTOME_AMYLOIDS Genes involved in Amyloids
0.2 1.7 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.4 REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.4 1.3 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.1 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.1 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling