Motif ID: Zbtb7a

Z-value: 0.919


Transcription factors associated with Zbtb7a:

Gene SymbolEntrez IDGene Name
Zbtb7a ENSMUSG00000035011.9 Zbtb7a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb7amm10_v2_chr10_+_81136534_811366080.133.6e-01Click!


Activity profile for motif Zbtb7a.

activity profile for motif Zbtb7a


Sorted Z-values histogram for motif Zbtb7a

Sorted Z-values for motif Zbtb7a



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb7a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_32938955 5.125 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr6_+_51432663 4.932 ENSMUST00000005103.5
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr16_+_11984581 4.773 ENSMUST00000170672.2
ENSMUST00000023138.7
 Shisa9

shisa homolog 9 (Xenopus laevis)

chr11_+_24076529 4.160 ENSMUST00000148087.1
 Gm12063
predicted gene 12063
chr1_-_154725920 4.020 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr7_+_49246812 3.935 ENSMUST00000184945.1
 Nav2
neuron navigator 2
chr2_+_180499893 3.923 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr1_-_21961581 3.730 ENSMUST00000029667.6
ENSMUST00000173058.1
ENSMUST00000173404.1
 Kcnq5


potassium voltage-gated channel, subfamily Q, member 5


chr7_+_96210107 3.727 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4
chr13_-_59556845 3.654 ENSMUST00000170378.1
ENSMUST00000169434.1
 Agtpbp1

ATP/GTP binding protein 1

chr5_+_37028329 3.631 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr8_-_34965631 3.501 ENSMUST00000033929.4
 Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr11_+_75531690 3.480 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
 Slc43a2



solute carrier family 43, member 2



chrX_+_159697308 3.349 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr7_+_131966446 3.308 ENSMUST00000045840.4
 Gpr26
G protein-coupled receptor 26
chr9_-_44234014 3.303 ENSMUST00000037644.6
 Cbl
Casitas B-lineage lymphoma
chr4_-_123664725 3.272 ENSMUST00000147030.1
 Macf1
microtubule-actin crosslinking factor 1
chr1_-_155417394 3.244 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr11_+_75532127 3.143 ENSMUST00000127226.1
 Slc43a2
solute carrier family 43, member 2
chr15_-_98567630 3.127 ENSMUST00000012104.6
 Ccnt1
cyclin T1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.8 GO:0015807 L-amino acid transport(GO:0015807)
0.3 7.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 6.6 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
1.1 6.5 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.4 6.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.4 5.8 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.2 5.7 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
1.4 5.4 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
1.7 5.2 GO:0050975 sensory perception of touch(GO:0050975)
0.9 5.1 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.4 5.1 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.3 4.8 GO:0014041 regulation of neuron maturation(GO:0014041)
0.0 4.8 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
1.2 4.7 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.8 4.2 GO:1990034 calcium ion export from cell(GO:1990034)
0.8 4.1 GO:0034436 glycoprotein transport(GO:0034436)
0.8 4.0 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.6 4.0 GO:1901525 negative regulation of macromitophagy(GO:1901525)
1.0 3.9 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
1.3 3.8 GO:0070650 actin filament bundle distribution(GO:0070650)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 8.8 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 7.1 GO:0070382 exocytic vesicle(GO:0070382)
0.6 6.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 6.2 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 5.9 GO:0005903 brush border(GO:0005903)
0.3 4.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 4.8 GO:0031941 filamentous actin(GO:0031941)
0.1 4.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 4.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 4.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 4.2 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.2 4.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 4.1 GO:0001650 fibrillar center(GO:0001650)
1.0 3.9 GO:0032280 symmetric synapse(GO:0032280)
1.0 3.8 GO:0044307 dendritic branch(GO:0044307)
0.6 3.8 GO:0097513 myosin II filament(GO:0097513)
0.2 3.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 3.7 GO:0030118 clathrin coat(GO:0030118)
0.2 3.5 GO:0097431 mitotic spindle pole(GO:0097431)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 172 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.4 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.4 7.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 7.2 GO:0008017 microtubule binding(GO:0008017)
0.2 7.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 6.8 GO:0070064 proline-rich region binding(GO:0070064)
0.3 6.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 5.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.7 5.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.4 5.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.4 5.0 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.1 4.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 4.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
1.4 4.1 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.3 4.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 3.9 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.6 3.8 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 3.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 3.6 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.8 3.4 GO:0001602 pancreatic polypeptide receptor activity(GO:0001602)
0.8 3.3 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 15.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 8.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 5.5 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 3.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 3.6 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.1 3.3 PID_ARF_3PATHWAY Arf1 pathway
0.1 2.7 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 2.6 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.2 2.2 PID_ALK2_PATHWAY ALK2 signaling events
0.1 2.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.9 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 1.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.7 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 1.6 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 1.6 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.1 1.4 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 1.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.2 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.3 9.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 8.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 7.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 7.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 5.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 3.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 3.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.2 3.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 3.3 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.2 3.2 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 3.2 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 3.0 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 2.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.4 2.8 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 2.8 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 2.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 2.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.9 2.6 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.3 2.6 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors