Motif ID: Zbtb7b

Z-value: 0.864


Transcription factors associated with Zbtb7b:

Gene SymbolEntrez IDGene Name
Zbtb7b ENSMUSG00000028042.9 Zbtb7b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb7bmm10_v2_chr3_-_89393294_893933780.366.4e-03Click!


Activity profile for motif Zbtb7b.

activity profile for motif Zbtb7b


Sorted Z-values histogram for motif Zbtb7b

Sorted Z-values for motif Zbtb7b



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb7b

PNG image of the network

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Top targets:


Showing 1 to 20 of 196 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_32244632 7.723 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19
chr8_-_105471481 6.990 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr1_-_119053339 6.821 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr3_+_34649987 6.635 ENSMUST00000099151.2
 Sox2
SRY-box containing gene 2
chr7_+_51879041 6.615 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr7_+_51878967 6.458 ENSMUST00000051912.6
 Gas2
growth arrest specific 2
chr10_+_84756055 5.836 ENSMUST00000060397.6
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr9_-_91365778 5.521 ENSMUST00000065360.3
 Zic1
zinc finger protein of the cerebellum 1
chr5_+_139543889 5.076 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr17_+_85620816 4.939 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr2_-_117342949 4.748 ENSMUST00000102534.4
 Rasgrp1
RAS guanyl releasing protein 1
chr7_-_4752972 4.601 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr2_-_117342709 4.292 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr7_-_101837776 4.200 ENSMUST00000165052.1
 Inppl1
inositol polyphosphate phosphatase-like 1
chr19_+_55742242 4.179 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
 Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr2_-_117342831 4.177 ENSMUST00000178884.1
 Rasgrp1
RAS guanyl releasing protein 1
chr14_-_62456286 4.132 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr19_-_36736653 3.910 ENSMUST00000087321.2
 Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr17_-_28350747 3.626 ENSMUST00000080572.7
ENSMUST00000156862.1
 Tead3

TEA domain family member 3

chr5_+_137350371 3.619 ENSMUST00000166239.1
ENSMUST00000111054.1
 Ephb4

Eph receptor B4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 13.2 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.1 13.1 GO:0008360 regulation of cell shape(GO:0008360)
0.1 7.0 GO:0046785 microtubule polymerization(GO:0046785)
1.7 6.8 GO:0060032 notochord regression(GO:0060032)
0.5 6.8 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.9 6.6 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
1.2 5.8 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1 5.5 GO:0007628 adult walking behavior(GO:0007628)
1.3 5.4 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.7 5.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.6 4.9 GO:0097402 neuroblast migration(GO:0097402)
0.3 4.4 GO:0051451 myoblast migration(GO:0051451)
0.6 4.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.5 4.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.4 4.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 4.0 GO:0051592 response to calcium ion(GO:0051592)
0.2 3.9 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 3.7 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.9 3.6 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.4 3.4 GO:0015074 DNA integration(GO:0015074)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.8 GO:0005667 transcription factor complex(GO:0005667)
0.8 7.0 GO:0097427 microtubule bundle(GO:0097427)
0.5 6.8 GO:0097542 ciliary tip(GO:0097542)
0.0 6.6 GO:0044798 nuclear transcription factor complex(GO:0044798)
1.1 5.4 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 4.9 GO:0005871 kinesin complex(GO:0005871)
0.3 4.6 GO:0030061 mitochondrial crista(GO:0030061)
0.6 4.4 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.5 4.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 4.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 3.9 GO:0042587 glycogen granule(GO:0042587)
0.2 3.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 3.3 GO:0030027 lamellipodium(GO:0030027)
0.2 2.9 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 2.8 GO:0051233 spindle midzone(GO:0051233)
0.1 2.5 GO:0016235 aggresome(GO:0016235)
0.4 2.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 2.2 GO:0005923 bicellular tight junction(GO:0005923)
0.1 2.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.9 GO:0030673 axolemma(GO:0030673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.8 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.2 13.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 11.0 GO:0008017 microtubule binding(GO:0008017)
0.0 8.5 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 6.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 6.6 GO:0035198 miRNA binding(GO:0035198)
0.0 6.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 4.9 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 4.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 4.9 GO:0001047 core promoter binding(GO:0001047)
0.7 4.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 4.2 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.2 4.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 4.2 GO:0015631 tubulin binding(GO:0015631)
0.2 3.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 3.6 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 3.5 GO:0019208 phosphatase regulator activity(GO:0019208)
0.5 3.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 3.3 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 3.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 13.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 6.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 5.9 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 5.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.4 5.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 4.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 4.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 4.7 PID_E2F_PATHWAY E2F transcription factor network
0.2 4.2 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 3.9 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 3.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 3.0 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 2.9 PID_FGF_PATHWAY FGF signaling pathway
0.0 2.3 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 2.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.5 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.8 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.4 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 13.1 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4 12.0 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.7 8.1 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 6.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 4.9 REACTOME_KINESINS Genes involved in Kinesins
0.1 4.2 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 4.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 3.9 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 3.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.4 3.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.4 2.9 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 2.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 2.4 REACTOME_TRANSLATION Genes involved in Translation
0.2 2.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 2.0 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 1.9 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP