Motif ID: Zfhx3

Z-value: 0.861


Transcription factors associated with Zfhx3:

Gene SymbolEntrez IDGene Name
Zfhx3 ENSMUSG00000038872.8 Zfhx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfhx3mm10_v2_chr8_+_108714644_108714644-0.447.1e-04Click!


Activity profile for motif Zfhx3.

activity profile for motif Zfhx3


Sorted Z-values histogram for motif Zfhx3

Sorted Z-values for motif Zfhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfhx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 103 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_101377897 7.770 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr13_-_110280103 6.362 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr10_-_110000219 6.110 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chrX_-_143933089 5.024 ENSMUST00000087313.3
 Dcx
doublecortin
chr9_+_86485407 4.012 ENSMUST00000034987.8
 Dopey1
dopey family member 1
chr2_+_82053222 3.505 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chrX_-_143933204 3.437 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr3_+_28263205 3.266 ENSMUST00000159236.2
 Tnik
TRAF2 and NCK interacting kinase
chr5_+_107497718 3.148 ENSMUST00000112671.2
 A830010M20Rik
RIKEN cDNA A830010M20 gene
chr1_+_179961110 3.144 ENSMUST00000076687.5
ENSMUST00000097450.3
 Cdc42bpa

CDC42 binding protein kinase alpha

chr17_+_35076902 3.052 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr18_+_37518341 2.880 ENSMUST00000097609.1
 Pcdhb22
protocadherin beta 22
chr2_+_120977017 2.685 ENSMUST00000067582.7
 Tmem62
transmembrane protein 62
chr16_-_74411776 2.634 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr14_+_64588112 2.532 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr5_+_107497762 2.382 ENSMUST00000152474.1
ENSMUST00000060553.7
 A830010M20Rik

RIKEN cDNA A830010M20 gene

chr1_-_158814469 2.298 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr9_+_113812547 2.234 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr1_-_24612700 2.051 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr1_-_157256682 2.041 ENSMUST00000134543.1
 Rasal2
RAS protein activator like 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 10.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 7.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 6.4 GO:0019882 antigen processing and presentation(GO:0019882)
0.2 4.6 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.2 4.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 3.5 GO:0051291 protein heterooligomerization(GO:0051291)
0.7 3.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 3.1 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.9 2.6 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 2.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 2.4 GO:0007416 synapse assembly(GO:0007416)
0.3 2.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 2.0 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.3 1.9 GO:0072318 clathrin coat disassembly(GO:0072318)
0.2 1.9 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 1.9 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 1.9 GO:0007605 sensory perception of sound(GO:0007605)
0.6 1.7 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.0 1.7 GO:0060612 adipose tissue development(GO:0060612)
0.3 1.6 GO:0003406 retinal pigment epithelium development(GO:0003406)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.9 GO:0030426 growth cone(GO:0030426)
0.0 7.9 GO:0005635 nuclear envelope(GO:0005635)
0.1 7.8 GO:0031594 neuromuscular junction(GO:0031594)
0.0 6.4 GO:0008021 synaptic vesicle(GO:0008021)
0.0 4.6 GO:0042641 actomyosin(GO:0042641)
0.0 4.3 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.3 GO:0055037 recycling endosome(GO:0055037)
0.0 3.3 GO:0014069 postsynaptic density(GO:0014069)
0.1 2.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 2.6 GO:0030673 axolemma(GO:0030673)
0.6 2.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 2.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 1.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 1.2 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.0 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 1.0 GO:0045275 respiratory chain complex III(GO:0045275)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 7.2 GO:0008017 microtubule binding(GO:0008017)
0.3 6.4 GO:0031489 myosin V binding(GO:0031489)
0.0 4.7 GO:0000287 magnesium ion binding(GO:0000287)
0.2 3.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.2 3.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
1.0 3.1 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.3 2.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 2.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 2.2 GO:0002162 dystroglycan binding(GO:0002162)
0.2 1.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.9 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 1.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 1.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.7 GO:0045499 chemorepellent activity(GO:0045499)
0.1 1.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 1.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 4.6 PID_CDC42_PATHWAY CDC42 signaling events
0.0 3.3 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 2.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.1 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 1.0 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 0.9 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.8 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.5 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.5 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 3.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.6 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 1.9 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.9 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.9 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 1.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 1.0 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.0 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.3 0.8 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.8 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.1 0.5 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 0.5 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors