Motif ID: Zfp219_Zfp740

Z-value: 1.142

Transcription factors associated with Zfp219_Zfp740:

Gene SymbolEntrez IDGene Name
Zfp219 ENSMUSG00000049295.10 Zfp219
Zfp740 ENSMUSG00000046897.10 Zfp740

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp740mm10_v2_chr15_+_102203639_1022037090.402.7e-03Click!
Zfp219mm10_v2_chr14_-_52020698_520207370.284.2e-02Click!


Activity profile for motif Zfp219_Zfp740.

activity profile for motif Zfp219_Zfp740


Sorted Z-values histogram for motif Zfp219_Zfp740

Sorted Z-values for motif Zfp219_Zfp740



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp219_Zfp740

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_127341583 5.928 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr15_+_57694651 5.858 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr5_-_134747241 5.851 ENSMUST00000015138.9
 Eln
elastin
chr7_-_78577771 5.577 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr7_-_78578308 5.187 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr10_-_127620922 4.614 ENSMUST00000118455.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr16_+_43503607 4.316 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
 Zbtb20


zinc finger and BTB domain containing 20


chr19_-_59170978 4.267 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr2_-_36105271 4.266 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr1_-_56972437 4.108 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr2_-_180225812 4.061 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr7_+_127777095 4.033 ENSMUST00000144406.1
 Setd1a
SET domain containing 1A
chr16_+_44173271 4.009 ENSMUST00000088356.4
ENSMUST00000169582.1
 Gm608

predicted gene 608

chr7_+_127511976 3.977 ENSMUST00000098025.4
 Srcap
Snf2-related CREBBP activator protein
chr12_-_27342696 3.858 ENSMUST00000079063.5
 Sox11
SRY-box containing gene 11
chr10_-_127620960 3.853 ENSMUST00000121829.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr2_+_48949495 3.753 ENSMUST00000112745.1
 Mbd5
methyl-CpG binding domain protein 5
chr2_-_116065798 3.689 ENSMUST00000110907.1
ENSMUST00000110908.2
 Meis2

Meis homeobox 2

chr11_-_69369377 3.660 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr17_+_75005523 3.317 ENSMUST00000001927.5
 Ltbp1
latent transforming growth factor beta binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 232 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 10.8 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
2.3 9.2 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.5 6.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.5 5.9 GO:0060032 notochord regression(GO:0060032)
0.1 5.7 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.3 5.2 GO:1990403 embryonic brain development(GO:1990403)
0.6 5.0 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.5 5.0 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 4.8 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
1.5 4.6 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.5 4.6 GO:0042118 endothelial cell activation(GO:0042118)
0.4 4.6 GO:0042572 retinol metabolic process(GO:0042572)
1.1 4.4 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.7 4.3 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 4.3 GO:0030325 adrenal gland development(GO:0030325)
0.2 4.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
1.3 3.9 GO:0060023 soft palate development(GO:0060023)
1.3 3.8 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0 3.8 GO:0006333 chromatin assembly or disassembly(GO:0006333)
0.4 3.7 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 8.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 7.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
2.0 5.9 GO:0071953 elastic fiber(GO:0071953)
0.5 5.9 GO:0097542 ciliary tip(GO:0097542)
0.0 5.8 GO:0032993 protein-DNA complex(GO:0032993)
0.0 5.6 GO:0016607 nuclear speck(GO:0016607)
0.1 5.2 GO:0035869 ciliary transition zone(GO:0035869)
0.3 5.0 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 4.8 GO:0016604 nuclear body(GO:0016604)
0.1 4.7 GO:0005844 polysome(GO:0005844)
0.9 4.6 GO:1990761 growth cone lamellipodium(GO:1990761)
0.1 4.5 GO:0017053 transcriptional repressor complex(GO:0017053)
1.0 4.1 GO:0043259 laminin-10 complex(GO:0043259)
0.2 4.1 GO:0010369 chromocenter(GO:0010369)
0.1 4.1 GO:0009925 basal plasma membrane(GO:0009925)
0.0 3.9 GO:0055037 recycling endosome(GO:0055037)
0.7 3.6 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 3.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
1.1 3.3 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 148 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 13.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 12.8 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
2.2 10.8 GO:0005030 neurotrophin receptor activity(GO:0005030)
3.1 9.2 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.1 7.4 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.1 7.1 GO:0008013 beta-catenin binding(GO:0008013)
0.2 5.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 5.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
1.0 5.0 GO:1990188 euchromatin binding(GO:1990188)
1.1 4.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.7 4.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 4.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 4.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.3 4.4 GO:0005003 ephrin receptor activity(GO:0005003)
0.5 4.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.6 3.8 GO:0045322 unmethylated CpG binding(GO:0045322)
0.3 3.7 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.2 3.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.8 3.3 GO:0050436 microfibril binding(GO:0050436)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.1 PID_SHP2_PATHWAY SHP2 signaling
0.1 9.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.3 9.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 8.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 6.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.1 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 4.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 4.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.6 4.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 4.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 3.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.2 3.0 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 2.8 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.7 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.2 2.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 2.1 PID_EPO_PATHWAY EPO signaling pathway
0.1 2.0 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 2.0 PID_PLK1_PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.5 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 5.1 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 4.5 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 4.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 3.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.7 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 2.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 2.5 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 2.5 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.1 2.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 2.2 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.2 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 2.1 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.5 1.9 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.9 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 1.8 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.6 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.1 1.5 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling