Motif ID: Zfp524

Z-value: 0.690


Transcription factors associated with Zfp524:

Gene SymbolEntrez IDGene Name
Zfp524 ENSMUSG00000051184.6 Zfp524

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp524mm10_v2_chr7_+_5015466_5015509-0.358.9e-03Click!


Activity profile for motif Zfp524.

activity profile for motif Zfp524


Sorted Z-values histogram for motif Zfp524

Sorted Z-values for motif Zfp524



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp524

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_54045182 6.394 ENSMUST00000036700.5
 Adra2a
adrenergic receptor, alpha 2a
chr4_-_136898803 5.038 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr18_-_61911783 4.526 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr7_+_3303643 4.381 ENSMUST00000172109.1
 Prkcg
protein kinase C, gamma
chr13_-_92131494 4.275 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr11_-_6065737 3.967 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr19_+_26623419 3.519 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr15_+_76660564 3.416 ENSMUST00000004294.10
 Kifc2
kinesin family member C2
chr5_+_30711564 3.396 ENSMUST00000114729.1
 Dpysl5
dihydropyrimidinase-like 5
chr2_-_24763047 3.387 ENSMUST00000100348.3
ENSMUST00000041342.5
ENSMUST00000114447.1
ENSMUST00000102939.2
ENSMUST00000070864.7
 Cacna1b




calcium channel, voltage-dependent, N type, alpha 1B subunit




chr5_+_30711849 3.283 ENSMUST00000088081.4
ENSMUST00000101442.3
 Dpysl5

dihydropyrimidinase-like 5

chr7_-_112159034 3.222 ENSMUST00000033036.5
 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chr12_+_40446050 3.178 ENSMUST00000037488.6
 Dock4
dedicator of cytokinesis 4
chr4_+_149586555 3.038 ENSMUST00000039144.6
 Clstn1
calsyntenin 1
chr4_-_120747248 2.992 ENSMUST00000030376.7
 Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr9_+_95559817 2.850 ENSMUST00000079597.5
 Paqr9
progestin and adipoQ receptor family member IX
chr9_-_75611308 2.835 ENSMUST00000064433.3
 Tmod2
tropomodulin 2
chr2_-_5676046 2.743 ENSMUST00000114987.3
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr19_-_57118981 2.704 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr8_+_65618009 2.693 ENSMUST00000110258.1
ENSMUST00000110256.1
ENSMUST00000110255.1
 March1


membrane-associated ring finger (C3HC4) 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 216 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.3 8.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
1.6 6.4 GO:0035624 receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) thermoception(GO:0050955)
0.3 6.1 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.2 5.8 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.2 5.7 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1 5.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.7 5.2 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
0.6 5.0 GO:0033602 negative regulation of dopamine secretion(GO:0033602)
0.2 5.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 4.6 GO:0015807 L-amino acid transport(GO:0015807)
0.9 4.4 GO:0032423 regulation of mismatch repair(GO:0032423)
0.1 4.2 GO:0033344 cholesterol efflux(GO:0033344)
0.3 4.0 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.4 3.5 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 3.4 GO:0033574 response to testosterone(GO:0033574)
0.0 3.3 GO:0007411 axon guidance(GO:0007411)
0.8 3.2 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 3.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.7 3.0 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.1 GO:0060076 excitatory synapse(GO:0060076)
0.0 9.3 GO:0045202 synapse(GO:0045202)
0.1 8.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 7.0 GO:0031901 early endosome membrane(GO:0031901)
0.2 5.9 GO:0051233 spindle midzone(GO:0051233)
0.2 5.8 GO:0071565 nBAF complex(GO:0071565)
0.0 5.7 GO:0030425 dendrite(GO:0030425)
0.1 5.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 5.1 GO:0005768 endosome(GO:0005768)
0.1 5.0 GO:0005581 collagen trimer(GO:0005581)
0.0 4.4 GO:0001726 ruffle(GO:0001726)
0.0 3.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 3.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 3.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.7 3.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 3.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 3.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 2.9 GO:0032420 stereocilium(GO:0032420)
0.4 2.8 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 2.8 GO:0005865 striated muscle thin filament(GO:0005865)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.3 GO:0003779 actin binding(GO:0003779)
0.2 9.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.3 8.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 7.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
2.1 6.4 GO:0004936 alpha-adrenergic receptor activity(GO:0004936) epinephrine binding(GO:0051379)
0.1 6.3 GO:0005496 steroid binding(GO:0005496)
0.0 6.3 GO:0005525 GTP binding(GO:0005525)
0.3 5.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 4.6 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
1.5 4.4 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
1.0 4.2 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.1 3.8 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 3.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 3.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.6 3.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 3.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 3.4 GO:0071617 lysophospholipid acyltransferase activity(GO:0071617)
0.1 3.3 GO:0042287 MHC protein binding(GO:0042287)
0.1 3.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 2.8 GO:0005523 tropomyosin binding(GO:0005523)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 5.2 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.2 5.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 5.0 PID_ARF6_PATHWAY Arf6 signaling events
0.2 4.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 3.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 3.5 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 3.4 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 3.1 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 3.1 PID_ATM_PATHWAY ATM pathway
0.1 3.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 2.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.9 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 1.6 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 1.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 1.4 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 1.2 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 1.1 PID_GMCSF_PATHWAY GMCSF-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 7.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 7.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 6.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.5 6.4 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 5.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.8 5.0 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 4.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 4.2 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 4.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.6 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.3 3.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 3.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.1 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 2.5 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.2 2.4 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 2.2 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 2.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.0 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways