Motif ID: Zfp652

Z-value: 0.907


Transcription factors associated with Zfp652:

Gene SymbolEntrez IDGene Name
Zfp652 ENSMUSG00000075595.3 Zfp652

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp652mm10_v2_chr11_+_95712673_95712673-0.133.3e-01Click!


Activity profile for motif Zfp652.

activity profile for motif Zfp652


Sorted Z-values histogram for motif Zfp652

Sorted Z-values for motif Zfp652



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp652

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_53707532 15.654 ENSMUST00000031093.3
Cckar
cholecystokinin A receptor
chr4_-_63403330 10.571 ENSMUST00000035724.4
Akna
AT-hook transcription factor
chr10_-_92165159 9.751 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr10_+_26229707 9.336 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr16_+_30065333 9.082 ENSMUST00000023171.7
Hes1
hairy and enhancer of split 1 (Drosophila)
chr5_+_115908644 8.806 ENSMUST00000141101.1
Cit
citron
chr1_-_138847579 7.729 ENSMUST00000093486.3
ENSMUST00000046870.6
Lhx9

LIM homeobox protein 9

chr6_+_83137089 7.373 ENSMUST00000121093.1
ENSMUST00000087938.4
Rtkn

rhotekin

chr14_+_73237891 7.155 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr7_-_25788635 6.985 ENSMUST00000002677.4
ENSMUST00000085948.4
Axl

AXL receptor tyrosine kinase

chr1_+_184034381 6.844 ENSMUST00000048655.7
Dusp10
dual specificity phosphatase 10
chr3_+_87971071 6.662 ENSMUST00000090973.5
Nes
nestin
chr3_+_87971129 6.661 ENSMUST00000160694.1
Nes
nestin
chr1_-_118982551 5.990 ENSMUST00000159678.1
Gli2
GLI-Kruppel family member GLI2
chr1_+_153665274 5.973 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr3_-_116129615 5.894 ENSMUST00000029574.8
Vcam1
vascular cell adhesion molecule 1
chr6_+_137754529 5.638 ENSMUST00000087675.6
Dera
2-deoxyribose-5-phosphate aldolase homolog (C. elegans)
chr1_+_153665666 5.618 ENSMUST00000111814.1
ENSMUST00000111810.1
Rgs8

regulator of G-protein signaling 8

chr6_+_124808885 5.279 ENSMUST00000143040.1
ENSMUST00000052727.4
ENSMUST00000130160.1
Spsb2


splA/ryanodine receptor domain and SOCS box containing 2


chr14_+_55853997 4.921 ENSMUST00000100529.3
Nynrin
NYN domain and retroviral integrase containing
chr11_-_94242701 4.494 ENSMUST00000061469.3
Wfikkn2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr6_-_54593139 4.343 ENSMUST00000046520.6
Fkbp14
FK506 binding protein 14
chr1_+_153665587 4.319 ENSMUST00000147700.1
Rgs8
regulator of G-protein signaling 8
chr1_+_153665627 4.165 ENSMUST00000147482.1
Rgs8
regulator of G-protein signaling 8
chr2_-_180225812 4.059 ENSMUST00000015791.5
Lama5
laminin, alpha 5
chr11_+_98960412 3.875 ENSMUST00000107473.2
Rara
retinoic acid receptor, alpha
chr11_+_117266216 3.398 ENSMUST00000019038.8
Sept9
septin 9
chr10_-_6980376 3.308 ENSMUST00000105617.1
Ipcef1
interaction protein for cytohesin exchange factors 1
chr5_-_124354671 3.253 ENSMUST00000031341.4
Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr4_+_128654686 3.115 ENSMUST00000030588.6
ENSMUST00000136377.1
Phc2

polyhomeotic-like 2 (Drosophila)

chr9_-_72111827 3.104 ENSMUST00000183404.1
ENSMUST00000184783.1
Tcf12

transcription factor 12

chr2_-_79456750 3.066 ENSMUST00000041099.4
Neurod1
neurogenic differentiation 1
chr9_-_72111651 2.999 ENSMUST00000185117.1
Tcf12
transcription factor 12
chr2_+_167777467 2.851 ENSMUST00000139927.1
ENSMUST00000127441.1
Gm14321

predicted gene 14321

chr2_+_4882204 2.744 ENSMUST00000115019.1
Sephs1
selenophosphate synthetase 1
chr9_-_72111755 2.743 ENSMUST00000183492.1
ENSMUST00000184523.1
ENSMUST00000034755.6
Tcf12


transcription factor 12


chr19_-_4928241 2.680 ENSMUST00000025851.3
Dpp3
dipeptidylpeptidase 3
chrX_-_48034842 2.664 ENSMUST00000039026.7
Apln
apelin
chr3_+_127791374 2.655 ENSMUST00000171621.1
Tifa
TRAF-interacting protein with forkhead-associated domain
chr12_-_34528844 2.607 ENSMUST00000110819.2
Hdac9
histone deacetylase 9
chr9_-_108452377 2.586 ENSMUST00000035232.7
Klhdc8b
kelch domain containing 8B
chr11_+_23666479 2.565 ENSMUST00000143117.1
Pus10
pseudouridylate synthase 10
chr2_-_84743655 2.511 ENSMUST00000181711.1
Gm19426
predicted gene, 19426
chr1_-_184033998 2.424 ENSMUST00000050306.5
1700056E22Rik
RIKEN cDNA 1700056E22 gene
chr9_+_75775355 2.420 ENSMUST00000012281.7
Bmp5
bone morphogenetic protein 5
chr19_+_55898553 2.327 ENSMUST00000148666.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr7_-_127615208 2.287 ENSMUST00000122066.1
Zfp629
zinc finger protein 629
chr6_-_39557830 2.257 ENSMUST00000036877.3
ENSMUST00000154149.1
Dennd2a

DENN/MADD domain containing 2A

chr1_-_45503282 2.132 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr7_+_128237357 1.869 ENSMUST00000044660.5
Armc5
armadillo repeat containing 5
chrX_+_110814390 1.849 ENSMUST00000078229.3
Pou3f4
POU domain, class 3, transcription factor 4
chr10_+_19591949 1.837 ENSMUST00000020188.6
Ifngr1
interferon gamma receptor 1
chr17_-_32388885 1.789 ENSMUST00000087703.5
ENSMUST00000170603.1
Wiz

widely-interspaced zinc finger motifs

chr5_+_139423151 1.787 ENSMUST00000066211.4
Gper1
G protein-coupled estrogen receptor 1
chr11_-_102819663 1.759 ENSMUST00000092567.4
Gjc1
gap junction protein, gamma 1
chr11_+_23666007 1.747 ENSMUST00000058163.4
Pus10
pseudouridylate synthase 10
chr11_-_118569910 1.656 ENSMUST00000136551.1
Rbfox3
RNA binding protein, fox-1 homolog (C. elegans) 3
chr18_+_56432116 1.632 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr11_+_108920342 1.468 ENSMUST00000052915.7
Axin2
axin2
chr7_-_128237984 1.431 ENSMUST00000078816.3
9130023H24Rik
RIKEN cDNA 9130023H24 gene
chr19_+_46397009 1.427 ENSMUST00000118440.1
Sufu
suppressor of fused homolog (Drosophila)
chr7_-_127615226 1.356 ENSMUST00000084564.3
Zfp629
zinc finger protein 629
chr3_-_104818539 1.331 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
Mov10



Moloney leukemia virus 10



chr8_-_115707778 1.197 ENSMUST00000109104.1
Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
chr11_+_62820469 1.182 ENSMUST00000108703.1
Trim16
tripartite motif-containing 16
chr11_-_109472611 1.179 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr14_-_54653616 1.096 ENSMUST00000126166.1
ENSMUST00000141453.1
ENSMUST00000150371.1
ENSMUST00000123875.1
ENSMUST00000022794.7
ENSMUST00000148754.3
Acin1





apoptotic chromatin condensation inducer 1





chr19_-_30549516 1.078 ENSMUST00000025803.8
Dkk1
dickkopf homolog 1 (Xenopus laevis)
chr12_+_55598917 1.064 ENSMUST00000051857.3
Insm2
insulinoma-associated 2
chr6_+_50110837 1.048 ENSMUST00000167628.1
Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr19_+_46396885 1.018 ENSMUST00000039922.6
ENSMUST00000111867.2
ENSMUST00000120778.1
Sufu


suppressor of fused homolog (Drosophila)


chr10_+_75589363 0.988 ENSMUST00000072217.2
Ggt5
gamma-glutamyltransferase 5
chr1_+_133246092 0.987 ENSMUST00000038295.8
ENSMUST00000105082.2
Plekha6

pleckstrin homology domain containing, family A member 6

chr7_-_4164796 0.961 ENSMUST00000076831.6
Cdc42ep5
CDC42 effector protein (Rho GTPase binding) 5
chr11_-_109473220 0.937 ENSMUST00000070872.6
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr7_-_4164442 0.931 ENSMUST00000140410.1
ENSMUST00000143825.1
Cdc42ep5

CDC42 effector protein (Rho GTPase binding) 5

chr1_-_167285110 0.903 ENSMUST00000027839.8
Uck2
uridine-cytidine kinase 2
chr17_+_69383319 0.776 ENSMUST00000062369.7
Zbtb14
zinc finger and BTB domain containing 14
chr9_+_44334685 0.760 ENSMUST00000052686.2
H2afx
H2A histone family, member X
chr17_+_69383024 0.733 ENSMUST00000112674.1
Zbtb14
zinc finger and BTB domain containing 14
chr10_-_7792795 0.677 ENSMUST00000065124.1
6530403G13Rik
RIKEN cDNA 6530403G13 gene
chr11_-_23665862 0.638 ENSMUST00000020523.3
Pex13
peroxisomal biogenesis factor 13
chr3_+_90072641 0.554 ENSMUST00000121503.1
ENSMUST00000119570.1
ENSMUST00000062193.9
Tpm3


tropomyosin 3, gamma


chr16_+_45094036 0.468 ENSMUST00000061050.5
Ccdc80
coiled-coil domain containing 80
chr1_+_24195187 0.455 ENSMUST00000088349.2
Col9a1
collagen, type IX, alpha 1
chr2_-_125723387 0.429 ENSMUST00000042246.7
Shc4
SHC (Src homology 2 domain containing) family, member 4
chr9_+_108854024 0.327 ENSMUST00000098376.3
Slc26a6
solute carrier family 26, member 6
chr8_-_47289394 0.322 ENSMUST00000079195.5
Stox2
storkhead box 2
chrX_+_159459125 0.315 ENSMUST00000043151.5
ENSMUST00000112470.1
ENSMUST00000156172.1
Map7d2


MAP7 domain containing 2


chr2_+_3118407 0.244 ENSMUST00000091505.4
Fam171a1
family with sequence similarity 171, member A1
chr2_+_3118335 0.226 ENSMUST00000115099.2
Fam171a1
family with sequence similarity 171, member A1
chr11_-_95041335 0.220 ENSMUST00000038431.7
Pdk2
pyruvate dehydrogenase kinase, isoenzyme 2
chr1_-_156718989 0.195 ENSMUST00000122424.1
Fam20b
family with sequence similarity 20, member B
chr15_-_76199835 0.193 ENSMUST00000054449.7
ENSMUST00000169714.1
ENSMUST00000165453.1
Plec


plectin


chr5_+_65131184 0.094 ENSMUST00000031089.5
ENSMUST00000101191.3
Klhl5

kelch-like 5

chr16_+_45093611 0.080 ENSMUST00000099498.2
Ccdc80
coiled-coil domain containing 80

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.7 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
3.0 9.1 GO:0021557 oculomotor nerve development(GO:0021557)
2.3 7.0 GO:0097350 neutrophil clearance(GO:0097350)
1.5 7.7 GO:0035262 gonad morphogenesis(GO:0035262)
1.5 6.0 GO:0060032 notochord regression(GO:0060032)
1.4 20.1 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
1.4 5.6 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
1.4 6.8 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
1.3 3.9 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.9 2.7 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.8 3.1 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.7 2.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.6 4.9 GO:0015074 DNA integration(GO:0015074)
0.6 2.4 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.6 2.4 GO:0021502 neural fold elevation formation(GO:0021502)
0.6 1.8 GO:0010579 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.6 1.8 GO:0086053 AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.5 1.1 GO:1903224 regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.5 5.9 GO:0061032 visceral serous pericardium development(GO:0061032)
0.5 1.5 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.4 4.3 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.4 8.7 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.3 7.2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.3 1.8 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.3 0.9 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.3 2.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.3 2.6 GO:0034983 peptidyl-lysine deacetylation(GO:0034983) regulation of skeletal muscle fiber development(GO:0048742)
0.2 1.0 GO:0006751 glutathione catabolic process(GO:0006751)
0.2 1.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.2 1.8 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.2 1.9 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 4.1 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.1 3.4 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 0.6 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 0.3 GO:0035672 transepithelial chloride transport(GO:0030321) oligopeptide transmembrane transport(GO:0035672)
0.1 1.2 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.1 4.5 GO:0048747 muscle fiber development(GO:0048747)
0.1 3.3 GO:0060325 face morphogenesis(GO:0060325)
0.1 0.2 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 4.3 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 1.3 GO:0006379 mRNA cleavage(GO:0006379)
0.0 7.4 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 1.5 GO:0003170 heart valve development(GO:0003170)
0.0 1.2 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 1.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 2.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.5 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 8.8 GO:0045666 positive regulation of neuron differentiation(GO:0045666)
0.0 3.0 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.0 1.6 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 2.7 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 3.9 GO:0007283 spermatogenesis(GO:0007283)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.1 GO:0043259 laminin-10 complex(GO:0043259)
0.7 2.1 GO:0005588 collagen type V trimer(GO:0005588)
0.5 6.0 GO:0097542 ciliary tip(GO:0097542)
0.3 12.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 7.0 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.3 2.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 1.8 GO:0044327 dendritic spine head(GO:0044327)
0.2 3.4 GO:0031105 septin complex(GO:0031105)
0.2 13.3 GO:0005882 intermediate filament(GO:0005882)
0.2 9.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 3.1 GO:0035102 PRC1 complex(GO:0035102)
0.1 1.8 GO:0005922 connexon complex(GO:0005922)
0.1 1.1 GO:0061574 ASAP complex(GO:0061574)
0.1 15.7 GO:0043195 terminal bouton(GO:0043195)
0.1 0.5 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 3.1 GO:0002102 podosome(GO:0002102)
0.1 11.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 0.2 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 10.6 GO:0001650 fibrillar center(GO:0001650)
0.1 0.8 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 2.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.6 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 1.3 GO:0016235 aggresome(GO:0016235)
0.0 1.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.8 GO:0014069 postsynaptic density(GO:0014069)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.0 1.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 3.3 GO:0000790 nuclear chromatin(GO:0000790)
0.0 3.0 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 13.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
1.5 5.9 GO:0008131 primary amine oxidase activity(GO:0008131)
1.0 7.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.9 7.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.6 7.0 GO:0032036 myosin heavy chain binding(GO:0032036)
0.6 15.9 GO:0008432 JUN kinase binding(GO:0008432)
0.6 1.8 GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.5 20.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 2.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.4 5.6 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.4 1.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.4 4.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.4 1.1 GO:0048019 receptor antagonist activity(GO:0048019)
0.3 6.6 GO:0035497 cAMP response element binding(GO:0035497)
0.3 3.9 GO:0035014 retinoic acid binding(GO:0001972) phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.3 1.8 GO:0030284 estrogen receptor activity(GO:0030284)
0.3 15.7 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.3 4.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.2 2.4 GO:0070700 BMP receptor binding(GO:0070700)
0.2 4.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 2.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 0.9 GO:0004849 uridine kinase activity(GO:0004849)
0.2 6.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.0 GO:0008242 omega peptidase activity(GO:0008242)
0.1 2.3 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.1 2.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.8 GO:0003680 AT DNA binding(GO:0003680)
0.1 3.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 1.9 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.3 GO:0015563 uptake transmembrane transporter activity(GO:0015563)
0.1 0.6 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 2.8 GO:0070888 E-box binding(GO:0070888)
0.1 6.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 2.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 2.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 2.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 3.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 10.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.8 GO:0003684 damaged DNA binding(GO:0003684)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 16.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 5.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 6.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 1.8 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.2 8.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.2 6.8 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 3.3 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 3.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 2.6 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 3.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 2.4 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 3.3 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 0.8 PID_ATM_PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.4 12.1 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.3 5.9 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 8.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 20.1 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 15.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 1.8 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 1.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 4.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 4.1 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.3 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.8 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 2.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.9 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.0 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.3 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 5.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.2 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex