Motif ID: Zfx_Zfp711

Z-value: 2.593

Transcription factors associated with Zfx_Zfp711:

Gene SymbolEntrez IDGene Name
Zfp711 ENSMUSG00000025529.8 Zfp711
Zfx ENSMUSG00000079509.4 Zfx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfxmm10_v2_chrX_-_94123087_941231590.392.9e-03Click!
Zfp711mm10_v2_chrX_+_112604274_112604274-0.172.2e-01Click!


Activity profile for motif Zfx_Zfp711.

activity profile for motif Zfx_Zfp711


Sorted Z-values histogram for motif Zfx_Zfp711

Sorted Z-values for motif Zfx_Zfp711



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfx_Zfp711

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_180225812 14.576 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr4_+_109978004 13.053 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr2_-_34372004 12.026 ENSMUST00000113132.2
ENSMUST00000040638.8
 Pbx3

pre B cell leukemia homeobox 3

chr5_-_115119277 11.111 ENSMUST00000031524.7
 Acads
acyl-Coenzyme A dehydrogenase, short chain
chr11_-_12037391 10.834 ENSMUST00000093321.5
 Grb10
growth factor receptor bound protein 10
chr19_-_30175414 10.505 ENSMUST00000025778.7
 Gldc
glycine decarboxylase
chr2_+_105675478 10.431 ENSMUST00000167211.2
ENSMUST00000111083.3
 Pax6

paired box gene 6

chr2_+_172549581 10.059 ENSMUST00000030391.2
 Tfap2c
transcription factor AP-2, gamma
chr17_-_28350747 9.778 ENSMUST00000080572.7
ENSMUST00000156862.1
 Tead3

TEA domain family member 3

chr8_+_127064107 9.713 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
 Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr2_+_37776229 9.348 ENSMUST00000050372.7
 Crb2
crumbs homolog 2 (Drosophila)
chr15_-_75747922 9.148 ENSMUST00000062002.4
 Mafa
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
chr6_-_38876163 8.939 ENSMUST00000161779.1
 Hipk2
homeodomain interacting protein kinase 2
chr17_-_28350600 8.630 ENSMUST00000114799.1
 Tead3
TEA domain family member 3
chr5_+_30666886 8.477 ENSMUST00000144742.1
 Cenpa
centromere protein A
chr4_+_137468767 8.211 ENSMUST00000030547.8
ENSMUST00000171332.1
 Hspg2

perlecan (heparan sulfate proteoglycan 2)

chr2_+_130295148 8.086 ENSMUST00000110288.2
 Ebf4
early B cell factor 4
chr9_-_72111827 7.936 ENSMUST00000183404.1
ENSMUST00000184783.1
 Tcf12

transcription factor 12

chr3_-_8667033 7.837 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr7_-_38107490 7.831 ENSMUST00000108023.3
 Ccne1
cyclin E1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,120 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 55.7 GO:0035329 hippo signaling(GO:0035329)
4.6 23.1 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
2.4 21.7 GO:0003190 atrioventricular valve formation(GO:0003190)
1.9 20.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
1.8 19.4 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
1.3 18.4 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.7 17.2 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
2.8 17.1 GO:0003383 apical constriction(GO:0003383)
4.3 17.0 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
1.7 17.0 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.5 16.9 GO:0006270 DNA replication initiation(GO:0006270)
0.4 16.5 GO:0001738 morphogenesis of a polarized epithelium(GO:0001738)
0.9 15.0 GO:0021516 dorsal spinal cord development(GO:0021516)
1.8 14.5 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
1.4 14.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.9 14.2 GO:0006337 nucleosome disassembly(GO:0006337)
0.5 14.0 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
4.6 13.8 GO:0021998 neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) positive regulation of cardiac ventricle development(GO:1904414)
2.0 13.7 GO:1902965 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.9 13.7 GO:0010715 regulation of extracellular matrix disassembly(GO:0010715)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 339 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 215.7 GO:0005634 nucleus(GO:0005634)
0.1 87.4 GO:0005654 nucleoplasm(GO:0005654)
0.3 82.8 GO:0005667 transcription factor complex(GO:0005667)
0.5 62.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 48.3 GO:0016604 nuclear body(GO:0016604)
0.4 29.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.4 28.3 GO:0005643 nuclear pore(GO:0005643)
0.5 27.0 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.5 24.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 21.7 GO:0000790 nuclear chromatin(GO:0000790)
0.2 19.6 GO:0000776 kinetochore(GO:0000776)
0.2 18.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
4.4 17.6 GO:0043259 laminin-10 complex(GO:0043259)
0.3 17.5 GO:0005657 replication fork(GO:0005657)
2.0 16.0 GO:0033269 internode region of axon(GO:0033269)
0.1 16.0 GO:0005694 chromosome(GO:0005694)
0.5 15.9 GO:0016592 mediator complex(GO:0016592)
0.4 15.1 GO:0000791 euchromatin(GO:0000791)
2.9 14.7 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 13.9 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 602 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 81.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 34.3 GO:0003677 DNA binding(GO:0003677)
2.1 34.2 GO:0003680 AT DNA binding(GO:0003680)
0.2 32.9 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.3 30.2 GO:0001047 core promoter binding(GO:0001047)
0.5 29.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.3 29.5 GO:0003714 transcription corepressor activity(GO:0003714)
1.1 29.1 GO:0071837 HMG box domain binding(GO:0071837)
0.8 29.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.2 27.5 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 25.6 GO:0042393 histone binding(GO:0042393)
0.1 25.6 GO:0003682 chromatin binding(GO:0003682)
0.3 24.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.5 21.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.0 21.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 21.0 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 21.0 GO:0045296 cadherin binding(GO:0045296)
0.6 20.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 20.3 GO:0004386 helicase activity(GO:0004386)
1.0 18.5 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 60.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
1.3 38.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.5 36.2 PID_E2F_PATHWAY E2F transcription factor network
0.5 31.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.5 29.9 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.5 28.4 PID_PLK1_PATHWAY PLK1 signaling events
0.4 25.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.4 24.0 PID_CDC42_PATHWAY CDC42 signaling events
0.6 23.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.6 22.4 PID_BARD1_PATHWAY BARD1 signaling events
2.8 22.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
1.6 22.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4 21.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.4 20.7 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.5 18.7 PID_BMP_PATHWAY BMP receptor signaling
0.7 18.4 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.4 17.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.6 16.9 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.2 14.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.6 14.0 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 48.3 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
1.5 47.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
2.0 39.1 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.5 38.5 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
1.0 30.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.5 29.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.8 27.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.4 27.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.9 26.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.9 26.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
1.1 18.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.6 18.0 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 17.9 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.7 17.1 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
1.0 16.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.3 15.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.7 15.2 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.5 14.9 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.3 13.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.8 12.9 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10