Motif ID: Zic3

Z-value: 0.896


Transcription factors associated with Zic3:

Gene SymbolEntrez IDGene Name
Zic3 ENSMUSG00000067860.5 Zic3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic3mm10_v2_chrX_+_58030999_580310180.725.9e-10Click!


Activity profile for motif Zic3.

activity profile for motif Zic3


Sorted Z-values histogram for motif Zic3

Sorted Z-values for motif Zic3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_53159885 4.782 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr7_+_127800604 3.920 ENSMUST00000046863.5
ENSMUST00000106272.1
ENSMUST00000139068.1
 Hsd3b7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr7_+_51879041 3.103 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr8_+_127064107 3.093 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
 Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr1_-_119053339 3.093 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr17_+_86963279 3.045 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr13_-_29984219 3.024 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr13_+_44729535 2.909 ENSMUST00000174068.1
 Jarid2
jumonji, AT rich interactive domain 2
chr4_+_108165449 2.898 ENSMUST00000116309.3
ENSMUST00000116307.1
 Echdc2

enoyl Coenzyme A hydratase domain containing 2

chr5_-_98030727 2.755 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr2_+_172550991 2.720 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chrX_+_56454871 2.715 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr6_-_56362356 2.700 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C



chr7_+_51878967 2.668 ENSMUST00000051912.6
 Gas2
growth arrest specific 2
chr4_+_108165432 2.611 ENSMUST00000052999.6
 Echdc2
enoyl Coenzyme A hydratase domain containing 2
chr9_+_91378636 2.562 ENSMUST00000066384.5
 Zic4
zinc finger protein of the cerebellum 4
chr1_+_135729147 2.474 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr5_+_135725713 2.462 ENSMUST00000127096.1
 Por
P450 (cytochrome) oxidoreductase
chr5_+_137758133 2.455 ENSMUST00000141733.1
ENSMUST00000110985.1
 Tsc22d4

TSC22 domain family, member 4

chr13_-_95891905 2.404 ENSMUST00000068603.6
 Iqgap2
IQ motif containing GTPase activating protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 170 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.0 GO:0003383 apical constriction(GO:0003383)
1.6 6.5 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.4 5.3 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.7 5.0 GO:0035754 B cell chemotaxis(GO:0035754)
0.1 5.0 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 4.5 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.2 4.1 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.3 3.8 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
0.8 3.1 GO:0060032 notochord regression(GO:0060032)
0.1 3.1 GO:1901998 toxin transport(GO:1901998)
0.5 3.0 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.3 3.0 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.1 2.8 GO:0038092 nodal signaling pathway(GO:0038092)
0.9 2.7 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.2 2.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.6 2.5 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.6 2.5 GO:0046210 nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346)
0.3 2.5 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 2.5 GO:0070527 platelet aggregation(GO:0070527)
0.2 2.4 GO:0070493 thrombin receptor signaling pathway(GO:0070493)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.0 GO:0033269 internode region of axon(GO:0033269)
0.3 4.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 4.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 3.7 GO:0005938 cell cortex(GO:0005938)
0.2 3.1 GO:0097542 ciliary tip(GO:0097542)
0.3 3.0 GO:0097165 nuclear stress granule(GO:0097165)
0.0 2.7 GO:0005814 centriole(GO:0005814)
0.0 2.4 GO:0031941 filamentous actin(GO:0031941)
0.2 2.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.3 2.1 GO:0001940 male pronucleus(GO:0001940)
0.0 1.9 GO:0005882 intermediate filament(GO:0005882)
0.0 1.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.9 GO:0045177 apical part of cell(GO:0045177)
0.1 1.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.2 1.7 GO:0000796 condensin complex(GO:0000796)
0.3 1.4 GO:0035189 Rb-E2F complex(GO:0035189)
0.3 1.3 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.2 1.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.3 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 7.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 7.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.4 5.5 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.8 5.0 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
1.6 4.8 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.0 4.5 GO:0001047 core promoter binding(GO:0001047)
0.3 4.1 GO:0005522 profilin binding(GO:0005522)
0.1 3.6 GO:0032452 histone demethylase activity(GO:0032452)
0.0 3.6 GO:0008017 microtubule binding(GO:0008017)
0.1 3.1 GO:0017091 AU-rich element binding(GO:0017091)
0.4 2.7 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.6 2.5 GO:0016708 nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726)
0.2 2.5 GO:0038191 neuropilin binding(GO:0038191)
0.1 2.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 2.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2 2.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.2 2.4 GO:0016805 dipeptidase activity(GO:0016805)
0.5 2.3 GO:0043515 kinetochore binding(GO:0043515)
0.1 2.2 GO:1990226 histone methyltransferase binding(GO:1990226)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 6.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 5.0 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 4.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 3.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 3.4 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 3.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.6 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 2.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 1.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.3 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.3 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.2 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 1.0 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.0 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.0 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 6.1 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6 5.0 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.4 4.8 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 3.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 3.0 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 2.2 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 2.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.4 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.3 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.2 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 1.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.0 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.0 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.0 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 0.8 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.8 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing