Motif ID: Zic4
Z-value: 0.986
Transcription factors associated with Zic4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Zic4 | ENSMUSG00000036972.8 | Zic4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zic4 | mm10_v2_chr9_+_91368811_91368828 | -0.40 | 2.3e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 7.4 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 2.1 | 8.4 | GO:0090238 | positive regulation of arachidonic acid secretion(GO:0090238) |
| 1.8 | 12.5 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 1.6 | 8.1 | GO:2001025 | positive regulation of response to drug(GO:2001025) |
| 1.3 | 3.8 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 1.1 | 3.3 | GO:1900738 | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) |
| 0.8 | 4.0 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.8 | 2.4 | GO:0002030 | inhibitory G-protein coupled receptor phosphorylation(GO:0002030) |
| 0.8 | 2.3 | GO:0030827 | negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283) |
| 0.7 | 2.6 | GO:0099527 | postsynapse to nucleus signaling pathway(GO:0099527) |
| 0.7 | 4.6 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.5 | 1.6 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) |
| 0.5 | 1.6 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 0.5 | 2.9 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.5 | 3.4 | GO:0032811 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811) |
| 0.5 | 1.4 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
| 0.4 | 2.7 | GO:0097491 | trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287) |
| 0.4 | 1.4 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.4 | 1.1 | GO:0097274 | urea homeostasis(GO:0097274) |
| 0.3 | 2.4 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.3 | 1.0 | GO:0009838 | abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 0.3 | 3.4 | GO:0060347 | heart trabecula formation(GO:0060347) |
| 0.3 | 2.7 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) vascular wound healing(GO:0061042) |
| 0.3 | 3.6 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.3 | 1.4 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 0.3 | 1.5 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.2 | 1.7 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.2 | 3.3 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.2 | 5.3 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.2 | 1.1 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 0.2 | 11.1 | GO:0048713 | regulation of oligodendrocyte differentiation(GO:0048713) |
| 0.2 | 0.9 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
| 0.2 | 1.7 | GO:0031424 | keratinization(GO:0031424) |
| 0.2 | 1.2 | GO:0015862 | uridine transport(GO:0015862) |
| 0.1 | 1.1 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.1 | 3.4 | GO:2000811 | negative regulation of anoikis(GO:2000811) |
| 0.1 | 0.5 | GO:0045085 | negative regulation of interleukin-2 biosynthetic process(GO:0045085) |
| 0.1 | 0.2 | GO:0061144 | alveolar secondary septum development(GO:0061144) |
| 0.1 | 1.2 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.1 | 1.6 | GO:0048712 | negative regulation of astrocyte differentiation(GO:0048712) |
| 0.1 | 0.8 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.1 | 3.2 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.1 | 0.9 | GO:0048563 | post-embryonic organ morphogenesis(GO:0048563) |
| 0.1 | 0.7 | GO:0045900 | negative regulation of translational elongation(GO:0045900) |
| 0.1 | 1.0 | GO:0048484 | enteric nervous system development(GO:0048484) |
| 0.1 | 0.8 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.1 | 0.3 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.1 | 4.3 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.1 | 0.6 | GO:0070458 | detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458) |
| 0.1 | 1.9 | GO:1900452 | regulation of long term synaptic depression(GO:1900452) |
| 0.1 | 0.5 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.1 | 0.3 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
| 0.1 | 1.4 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 0.9 | GO:0035646 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
| 0.1 | 0.6 | GO:0044336 | canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336) |
| 0.1 | 1.0 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 1.5 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) |
| 0.1 | 0.4 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 0.3 | GO:0035826 | rubidium ion transport(GO:0035826) |
| 0.0 | 0.1 | GO:0035106 | operant conditioning(GO:0035106) |
| 0.0 | 0.2 | GO:1901678 | iron coordination entity transport(GO:1901678) |
| 0.0 | 0.5 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.0 | 0.4 | GO:0070234 | positive regulation of T cell apoptotic process(GO:0070234) |
| 0.0 | 1.9 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
| 0.0 | 0.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
| 0.0 | 0.5 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.0 | 3.8 | GO:0045598 | regulation of fat cell differentiation(GO:0045598) |
| 0.0 | 0.1 | GO:0008582 | regulation of synaptic growth at neuromuscular junction(GO:0008582) regulation of sodium:potassium-exchanging ATPase activity(GO:1903406) |
| 0.0 | 0.8 | GO:0035115 | embryonic forelimb morphogenesis(GO:0035115) |
| 0.0 | 0.2 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.0 | 1.0 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.0 | 1.8 | GO:0006406 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
| 0.0 | 0.5 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.0 | 0.0 | GO:0090647 | modulation of age-related behavioral decline(GO:0090647) |
| 0.0 | 0.6 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 1.6 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.6 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 0.2 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.0 | 1.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.4 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.0 | 1.8 | GO:0008585 | female gonad development(GO:0008585) |
| 0.0 | 0.8 | GO:0048013 | ephrin receptor signaling pathway(GO:0048013) |
| 0.0 | 0.7 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.0 | 2.7 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
| 0.0 | 2.1 | GO:0007568 | aging(GO:0007568) |
| 0.0 | 1.7 | GO:0048814 | regulation of dendrite morphogenesis(GO:0048814) |
| 0.0 | 0.6 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 2.4 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.0 | 1.0 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.0 | 2.1 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 0.1 | GO:0016188 | synaptic vesicle maturation(GO:0016188) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 8.4 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.7 | 3.4 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.6 | 2.9 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.5 | 8.1 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.5 | 1.8 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.4 | 10.8 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.3 | 1.2 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.3 | 1.6 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.3 | 2.0 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.2 | 0.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.2 | 2.3 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.2 | 1.7 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.2 | 0.9 | GO:0002139 | stereocilia coupling link(GO:0002139) |
| 0.1 | 3.4 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 2.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 4.6 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 0.3 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.1 | 1.0 | GO:0090543 | ESCRT III complex(GO:0000815) Flemming body(GO:0090543) |
| 0.1 | 11.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 1.2 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.1 | 1.9 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 0.7 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 4.4 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 3.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.5 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 3.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 1.4 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 2.4 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 0.9 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.2 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.0 | 2.4 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 1.8 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.3 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 1.7 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.2 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 0.2 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 0.5 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 2.6 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 3.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.7 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 3.3 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 0.4 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 2.9 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
| 0.0 | 2.6 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 1.0 | GO:0030426 | growth cone(GO:0030426) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 12.5 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 2.5 | 7.4 | GO:0002153 | steroid receptor RNA activator RNA binding(GO:0002153) |
| 0.8 | 2.3 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.6 | 2.9 | GO:0097643 | amylin receptor activity(GO:0097643) |
| 0.6 | 3.4 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.5 | 1.4 | GO:0005119 | smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) |
| 0.4 | 1.3 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.4 | 4.8 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.4 | 8.4 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.4 | 1.6 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903) |
| 0.4 | 1.6 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.3 | 3.6 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.3 | 1.0 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.3 | 11.9 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.3 | 4.2 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.3 | 1.8 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.2 | 2.4 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.2 | 2.7 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.2 | 8.7 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 1.4 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 0.1 | 1.4 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
| 0.1 | 1.1 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 0.1 | 0.5 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
| 0.1 | 4.3 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.1 | 3.4 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 3.8 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 2.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.6 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.1 | 1.0 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.1 | 1.4 | GO:0016917 | GABA receptor activity(GO:0016917) |
| 0.1 | 0.3 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.1 | 1.9 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 0.3 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.1 | 1.1 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.8 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 3.5 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.5 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 1.6 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 4.2 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 0.5 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.0 | 1.2 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 0.2 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.0 | 1.9 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.1 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.0 | 0.6 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.0 | 3.8 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.0 | 6.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 1.4 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 1.6 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 1.0 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 0.9 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 1.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.1 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.0 | 0.6 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 1.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.6 | GO:0070888 | E-box binding(GO:0070888) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.4 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 5.0 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 6.5 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 4.8 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 1.3 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 2.4 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 3.7 | PID_PI3KCI_AKT_PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.1 | 2.3 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 1.6 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.1 | 1.4 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 2.5 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.1 | 1.7 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.0 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.9 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 2.3 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.8 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.6 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 2.1 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.4 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.8 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.2 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.6 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.4 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 0.5 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.3 | PID_ARF_3PATHWAY | Arf1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.0 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.3 | 3.4 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.2 | 2.0 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.2 | 2.6 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 2.4 | REACTOME_PLATELET_SENSITIZATION_BY_LDL | Genes involved in Platelet sensitization by LDL |
| 0.1 | 10.8 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 0.9 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
| 0.1 | 1.9 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 7.4 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.4 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 3.5 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 0.9 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 1.3 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 2.1 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 4.7 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 1.0 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 3.4 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 3.1 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 3.4 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 1.3 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.6 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.5 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.5 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.6 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.9 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
