Motif ID: Zic4

Z-value: 0.986


Transcription factors associated with Zic4:

Gene SymbolEntrez IDGene Name
Zic4 ENSMUSG00000036972.8 Zic4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic4mm10_v2_chr9_+_91368811_91368828-0.402.3e-03Click!


Activity profile for motif Zic4.

activity profile for motif Zic4


Sorted Z-values histogram for motif Zic4

Sorted Z-values for motif Zic4



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_180499893 8.422 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr4_+_141368116 6.829 ENSMUST00000006380.4
 Fam131c
family with sequence similarity 131, member C
chr4_+_152338619 6.290 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr4_+_152338887 6.241 ENSMUST00000005175.4
 Chd5
chromodomain helicase DNA binding protein 5
chr9_-_29412204 6.194 ENSMUST00000115237.1
 Ntm
neurotrimin
chr5_-_139325616 4.826 ENSMUST00000110865.1
 Adap1
ArfGAP with dual PH domains 1
chr19_+_4099998 4.764 ENSMUST00000049658.7
 Pitpnm1
phosphatidylinositol transfer protein, membrane-associated 1
chr17_-_29237759 4.760 ENSMUST00000137727.1
ENSMUST00000024805.7
 Cpne5

copine V

chr17_+_46297917 4.654 ENSMUST00000166617.1
ENSMUST00000170271.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr19_+_47178820 4.576 ENSMUST00000111808.3
 Neurl1a
neuralized homolog 1A (Drosophila)
chr7_-_47133684 4.123 ENSMUST00000102626.1
 Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr2_-_152951456 4.085 ENSMUST00000123121.2
 Dusp15
dual specificity phosphatase-like 15
chr7_-_47133395 4.024 ENSMUST00000107617.1
 Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chrX_+_73503074 4.017 ENSMUST00000114479.1
ENSMUST00000088429.1
ENSMUST00000033744.5
 Atp2b3


ATPase, Ca++ transporting, plasma membrane 3


chr4_+_104367549 3.790 ENSMUST00000106830.2
 Dab1
disabled 1
chr11_+_98741871 3.696 ENSMUST00000103139.4
 Thra
thyroid hormone receptor alpha
chr11_+_98741805 3.682 ENSMUST00000064187.5
 Thra
thyroid hormone receptor alpha
chr2_-_152951688 3.529 ENSMUST00000109811.3
 Dusp15
dual specificity phosphatase-like 15
chr2_-_152951547 3.497 ENSMUST00000037715.6
 Dusp15
dual specificity phosphatase-like 15
chr19_+_4855129 3.472 ENSMUST00000119694.1
 Ctsf
cathepsin F

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 12.5 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.2 11.1 GO:0048713 regulation of oligodendrocyte differentiation(GO:0048713)
2.1 8.4 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
1.6 8.1 GO:2001025 positive regulation of response to drug(GO:2001025)
2.5 7.4 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.2 5.3 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.7 4.6 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1 4.3 GO:0015914 phospholipid transport(GO:0015914)
0.8 4.0 GO:1990034 calcium ion export from cell(GO:1990034)
1.3 3.8 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.0 3.8 GO:0045598 regulation of fat cell differentiation(GO:0045598)
0.3 3.6 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.5 3.4 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.3 3.4 GO:0060347 heart trabecula formation(GO:0060347)
0.1 3.4 GO:2000811 negative regulation of anoikis(GO:2000811)
1.1 3.3 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.2 3.3 GO:0008272 sulfate transport(GO:0008272)
0.1 3.2 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.5 2.9 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.4 2.7 GO:0097491 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.7 GO:0031225 anchored component of membrane(GO:0031225)
0.4 10.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
2.1 8.4 GO:0032280 symmetric synapse(GO:0032280)
0.5 8.1 GO:1990635 proximal dendrite(GO:1990635)
0.1 4.6 GO:0097440 apical dendrite(GO:0097440)
0.1 4.4 GO:0005811 lipid particle(GO:0005811)
0.0 3.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.7 3.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 3.4 GO:0031430 M band(GO:0031430)
0.0 3.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.6 2.9 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 2.9 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 2.6 GO:0005903 brush border(GO:0005903)
0.0 2.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 2.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.4 GO:0005871 kinesin complex(GO:0005871)
0.0 2.4 GO:0005643 nuclear pore(GO:0005643)
0.2 2.3 GO:0044327 dendritic spine head(GO:0044327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 12.5 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.3 11.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 8.7 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.4 8.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
2.5 7.4 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.0 6.5 GO:0005096 GTPase activator activity(GO:0005096)
0.4 4.8 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 4.3 GO:0045182 translation regulator activity(GO:0045182)
0.3 4.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 4.2 GO:0008201 heparin binding(GO:0008201)
0.1 3.8 GO:0042169 SH2 domain binding(GO:0042169)
0.0 3.8 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.3 3.6 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 3.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.6 3.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 3.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.6 2.9 GO:0097643 amylin receptor activity(GO:0097643)
0.2 2.7 GO:0038191 neuropilin binding(GO:0038191)
0.1 2.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 2.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 6.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 5.0 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 4.8 PID_ARF6_PATHWAY Arf6 signaling events
0.1 3.7 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.1 2.5 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 2.4 NABA_COLLAGENS Genes encoding collagen proteins
0.1 2.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 2.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.0 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.9 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.6 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 7.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 4.7 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.3 4.0 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 3.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 3.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 3.4 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 3.4 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 3.1 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.2 2.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.4 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 2.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 2.0 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 1.9 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 1.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 1.3 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.0 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 0.9 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions