Motif ID: Zkscan1

Z-value: 0.536


Transcription factors associated with Zkscan1:

Gene SymbolEntrez IDGene Name
Zkscan1 ENSMUSG00000029729.6 Zkscan1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zkscan1mm10_v2_chr5_+_138085083_138085147-0.248.1e-02Click!


Activity profile for motif Zkscan1.

activity profile for motif Zkscan1


Sorted Z-values histogram for motif Zkscan1

Sorted Z-values for motif Zkscan1



Network of associatons between targets according to the STRING database.



First level regulatory network of Zkscan1

PNG image of the network

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Top targets:


Showing 1 to 20 of 113 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56969864 3.668 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr15_+_83779999 3.268 ENSMUST00000046168.5
 Mpped1
metallophosphoesterase domain containing 1
chr19_-_61228396 3.093 ENSMUST00000076046.6
 Csf2ra
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr15_-_79164477 2.924 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr1_-_56969827 2.859 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr12_+_73997749 2.502 ENSMUST00000110451.2
 Syt16
synaptotagmin XVI
chr4_+_129960760 2.438 ENSMUST00000139884.1
 1700003M07Rik
RIKEN cDNA 1700003M07 gene
chr15_-_75048837 2.230 ENSMUST00000179762.1
ENSMUST00000065408.9
 Ly6c1

lymphocyte antigen 6 complex, locus C1

chr7_+_112225856 2.227 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr4_+_103619580 1.513 ENSMUST00000106827.1
 Dab1
disabled 1
chr14_-_30353468 1.502 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chrX_+_20870166 1.389 ENSMUST00000115342.3
ENSMUST00000009530.4
 Timp1

tissue inhibitor of metalloproteinase 1

chr17_+_28575718 1.279 ENSMUST00000080780.6
 Lhfpl5
lipoma HMGIC fusion partner-like 5
chr1_+_50927511 1.177 ENSMUST00000081851.3
 Tmeff2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr10_-_83337845 1.111 ENSMUST00000039956.5
 Slc41a2
solute carrier family 41, member 2
chr3_+_62338344 1.107 ENSMUST00000079300.6
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr11_-_61453992 1.041 ENSMUST00000060255.7
ENSMUST00000054927.7
ENSMUST00000102661.3
 Rnf112


ring finger protein 112


chr11_+_19924354 0.982 ENSMUST00000093299.6
 Spred2
sprouty-related, EVH1 domain containing 2
chr15_-_74997634 0.975 ENSMUST00000023248.6
 Ly6a
lymphocyte antigen 6 complex, locus A
chr1_+_171840607 0.972 ENSMUST00000136479.1
ENSMUST00000042302.6
 Cd84

CD84 antigen


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 3.1 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.6 2.9 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.0 2.5 GO:0006906 vesicle fusion(GO:0006906)
0.4 2.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.2 2.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 1.7 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.5 1.5 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.4 1.5 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.2 1.4 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.0 1.4 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
0.1 1.3 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.3 1.2 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.0 1.2 GO:0021904 dorsal/ventral neural tube patterning(GO:0021904)
0.1 1.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 1.1 GO:0032418 lysosome localization(GO:0032418)
0.3 1.0 GO:2001180 negative regulation of interleukin-18 production(GO:0032701) negative regulation of interleukin-10 secretion(GO:2001180)
0.0 0.9 GO:0046033 AMP metabolic process(GO:0046033)
0.0 0.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.9 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 3.6 GO:0031225 anchored component of membrane(GO:0031225)
0.4 2.9 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 2.0 GO:0005903 brush border(GO:0005903)
0.2 1.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.2 GO:0005604 basement membrane(GO:0005604)
0.1 1.1 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.9 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.7 GO:0005581 collagen trimer(GO:0005581)
0.0 0.6 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.1 0.5 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.5 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.5 GO:0030008 TRAPP complex(GO:0030008)
0.1 0.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.4 GO:0034464 BBSome(GO:0034464)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.2 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 2.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 2.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 2.2 GO:0071949 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) FAD binding(GO:0071949)
0.0 2.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.3 1.7 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 1.5 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 1.5 GO:0042169 SH2 domain binding(GO:0042169)
0.1 1.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 0.9 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 0.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 0.8 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 0.8 GO:0019841 retinol binding(GO:0019841)
0.2 0.7 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.7 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.7 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.4 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.2 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.7 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.7 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.5 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.4 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 0.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 1.4 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.1 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 0.7 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.7 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.7 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.6 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.6 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.2 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins