Motif ID: Zkscan3

Z-value: 0.397


Transcription factors associated with Zkscan3:

Gene SymbolEntrez IDGene Name
Zkscan3 ENSMUSG00000021327.12 Zkscan3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zkscan3mm10_v2_chr13_-_21402688_21402755-0.162.4e-01Click!


Activity profile for motif Zkscan3.

activity profile for motif Zkscan3


Sorted Z-values histogram for motif Zkscan3

Sorted Z-values for motif Zkscan3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zkscan3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_75422586 1.389 ENSMUST00000138661.1
ENSMUST00000000769.7
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr5_+_24985840 1.290 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr4_+_156026120 1.218 ENSMUST00000103173.3
 Tnfrsf18
tumor necrosis factor receptor superfamily, member 18
chr1_-_40790642 1.093 ENSMUST00000039672.5
 Mfsd9
major facilitator superfamily domain containing 9
chr6_-_97459279 1.025 ENSMUST00000113359.1
 Frmd4b
FERM domain containing 4B
chr13_+_42709482 1.007 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr12_+_112588753 0.993 ENSMUST00000101029.2
 Inf2
inverted formin, FH2 and WH2 domain containing
chr6_+_125552948 0.913 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr4_+_156026304 0.899 ENSMUST00000040274.7
ENSMUST00000122001.1
 Tnfrsf18

tumor necrosis factor receptor superfamily, member 18

chr11_-_75422524 0.878 ENSMUST00000125982.1
ENSMUST00000137103.1
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr1_-_173333503 0.818 ENSMUST00000038227.4
 Darc
Duffy blood group, chemokine receptor
chr2_-_66634952 0.801 ENSMUST00000100064.2
ENSMUST00000100063.2
 Scn9a

sodium channel, voltage-gated, type IX, alpha

chr5_-_73338580 0.674 ENSMUST00000087195.5
 Ociad2
OCIA domain containing 2
chr2_+_104095796 0.609 ENSMUST00000040423.5
ENSMUST00000168176.1
 Cd59a

CD59a antigen

chr14_+_51893610 0.602 ENSMUST00000047726.5
ENSMUST00000161888.1
 Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr1_+_132298606 0.569 ENSMUST00000046071.4
 Klhdc8a
kelch domain containing 8A
chr2_+_156613664 0.508 ENSMUST00000169464.2
ENSMUST00000109567.3
 Dlgap4

discs, large homolog-associated protein 4 (Drosophila)

chr12_+_76533540 0.503 ENSMUST00000075249.4
 Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr8_-_70760889 0.495 ENSMUST00000038626.8
 Mpv17l2
MPV17 mitochondrial membrane protein-like 2
chr6_+_127453705 0.475 ENSMUST00000039680.5
 Parp11
poly (ADP-ribose) polymerase family, member 11
chr13_-_19395728 0.475 ENSMUST00000039694.7
 Stard3nl
STARD3 N-terminal like
chr6_-_113719880 0.468 ENSMUST00000064993.5
 Ghrl
ghrelin
chr13_+_104109737 0.453 ENSMUST00000044385.7
 Sgtb
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr7_-_98178254 0.451 ENSMUST00000040971.7
 Capn5
calpain 5
chr18_+_61105844 0.440 ENSMUST00000115268.3
 Csf1r
colony stimulating factor 1 receptor
chr2_+_155775333 0.423 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr2_+_32646586 0.409 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr8_+_70616816 0.378 ENSMUST00000052437.3
 Lrrc25
leucine rich repeat containing 25
chr2_-_30194112 0.375 ENSMUST00000113659.1
ENSMUST00000113660.1
 Ccbl1

cysteine conjugate-beta lyase 1

chr13_-_38658991 0.369 ENSMUST00000001757.7
 Eef1e1
eukaryotic translation elongation factor 1 epsilon 1
chr3_-_63929376 0.350 ENSMUST00000061706.6
 E130311K13Rik
RIKEN cDNA E130311K13 gene
chr6_+_127453667 0.329 ENSMUST00000112193.1
 Parp11
poly (ADP-ribose) polymerase family, member 11
chr8_+_94810446 0.326 ENSMUST00000034232.1
 Ccl17
chemokine (C-C motif) ligand 17
chr16_-_16359016 0.319 ENSMUST00000023477.7
ENSMUST00000096229.3
ENSMUST00000115749.1
 Dnm1l


dynamin 1-like


chr8_-_116978908 0.317 ENSMUST00000070577.5
 1700030J22Rik
RIKEN cDNA 1700030J22 gene
chr6_-_43666158 0.316 ENSMUST00000114644.2
ENSMUST00000150599.1
ENSMUST00000067888.7
 Tpk1


thiamine pyrophosphokinase


chr19_-_10869757 0.293 ENSMUST00000120524.1
ENSMUST00000025645.7
 Tmem132a

transmembrane protein 132A

chr15_-_3979432 0.283 ENSMUST00000022791.8
 Fbxo4
F-box protein 4
chr11_+_116918844 0.280 ENSMUST00000103027.3
 Mgat5b
mannoside acetylglucosaminyltransferase 5, isoenzyme B
chr6_-_122856151 0.275 ENSMUST00000042081.8
 C3ar1
complement component 3a receptor 1
chr5_-_88675190 0.269 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr8_-_105758570 0.261 ENSMUST00000155038.2
ENSMUST00000013294.9
 Gfod2

glucose-fructose oxidoreductase domain containing 2

chr8_+_31091593 0.257 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr5_+_117976761 0.255 ENSMUST00000035579.6
 Fbxo21
F-box protein 21
chr13_+_104109752 0.252 ENSMUST00000160322.1
ENSMUST00000159574.1
 Sgtb

small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta

chr11_-_102218923 0.252 ENSMUST00000131254.1
 Hdac5
histone deacetylase 5
chr14_+_57424054 0.248 ENSMUST00000122063.1
 Ift88
intraflagellar transport 88
chr9_+_114688782 0.246 ENSMUST00000047404.6
 Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr19_+_6276725 0.228 ENSMUST00000025684.3
 Ehd1
EH-domain containing 1
chr8_-_124897685 0.200 ENSMUST00000098312.2
 Exoc8
exocyst complex component 8
chr12_+_69724939 0.193 ENSMUST00000021372.5
 Atp5s
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s
chr2_+_121171155 0.191 ENSMUST00000110658.1
 Tubgcp4
tubulin, gamma complex associated protein 4
chr11_-_88851462 0.184 ENSMUST00000107903.1
 Akap1
A kinase (PRKA) anchor protein 1
chr13_-_32851176 0.182 ENSMUST00000091668.5
ENSMUST00000076352.6
 Serpinb1a

serine (or cysteine) peptidase inhibitor, clade B, member 1a

chr4_+_63544747 0.181 ENSMUST00000035301.6
 Atp6v1g1
ATPase, H+ transporting, lysosomal V1 subunit G1
chr17_+_46110982 0.178 ENSMUST00000024763.3
ENSMUST00000123646.1
 Mrps18a

mitochondrial ribosomal protein S18A

chr13_+_44730726 0.147 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
 Jarid2


jumonji, AT rich interactive domain 2


chr10_+_89744988 0.143 ENSMUST00000020112.5
 Uhrf1bp1l
UHRF1 (ICBP90) binding protein 1-like
chr17_-_24150910 0.128 ENSMUST00000052462.6
 Pdpk1
3-phosphoinositide dependent protein kinase 1
chr13_+_73467197 0.112 ENSMUST00000022099.8
 Lpcat1
lysophosphatidylcholine acyltransferase 1
chrX_-_17571563 0.105 ENSMUST00000177213.1
 Fundc1
FUN14 domain containing 1
chrX_-_17572241 0.092 ENSMUST00000176638.1
ENSMUST00000026016.6
 Fundc1

FUN14 domain containing 1

chr10_-_33951190 0.081 ENSMUST00000048222.4
 Zufsp
zinc finger with UFM1-specific peptidase domain
chr7_-_27228605 0.064 ENSMUST00000003850.7
 Itpkc
inositol 1,4,5-trisphosphate 3-kinase C
chr5_+_24586721 0.064 ENSMUST00000121863.1
ENSMUST00000088295.4
 Chpf2

chondroitin polymerizing factor 2

chr4_-_155863362 0.052 ENSMUST00000030949.3
 Tas1r3
taste receptor, type 1, member 3
chr13_-_104109576 0.049 ENSMUST00000109315.3
 Nln
neurolysin (metallopeptidase M3 family)
chr11_-_102365111 0.046 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr7_+_126759601 0.044 ENSMUST00000050201.4
ENSMUST00000057669.9
 Mapk3

mitogen-activated protein kinase 3

chr2_+_121171204 0.038 ENSMUST00000039541.5
ENSMUST00000110657.1
 Tubgcp4

tubulin, gamma complex associated protein 4

chr8_+_33732237 0.019 ENSMUST00000171010.1
 Gtf2e2
general transcription factor II E, polypeptide 2 (beta subunit)
chr11_-_100650693 0.013 ENSMUST00000103119.3
 Zfp385c
zinc finger protein 385C
chr11_+_35769462 0.006 ENSMUST00000018990.7
 Pank3
pantothenate kinase 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.2 0.5 GO:0035482 intestine smooth muscle contraction(GO:0014827) gastric motility(GO:0035482) gastric emptying(GO:0035483) regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) positive regulation of cortisol secretion(GO:0051464) regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) regulation of small intestine smooth muscle contraction(GO:1904347) small intestine smooth muscle contraction(GO:1990770)
0.1 0.4 GO:1905072 detection of oxygen(GO:0003032) positive regulation of vascular smooth muscle cell differentiation(GO:1905065) cardiac jelly development(GO:1905072)
0.1 0.4 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.1 0.3 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.1 0.6 GO:0090272 negative regulation of fibroblast growth factor production(GO:0090272)
0.1 0.3 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.3 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.2 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.1 0.5 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.1 0.4 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.1 0.2 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.1 2.1 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 0.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.4 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.0 1.0 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.2 GO:0001927 exocyst assembly(GO:0001927)
0.0 0.2 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.8 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.1 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0 0.2 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0 0.3 GO:0006968 cellular defense response(GO:0006968)
0.0 1.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.3 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.6 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.0 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.0 0.3 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.0 0.1 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.8 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.0 GO:0000189 MAPK import into nucleus(GO:0000189)
0.0 0.1 GO:0050912 detection of chemical stimulus involved in sensory perception(GO:0050907) detection of chemical stimulus involved in sensory perception of taste(GO:0050912)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 2.3 GO:0043203 axon hillock(GO:0043203)
0.1 0.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.2 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.2 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.0 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.5 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.2 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.2 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.3 GO:0004875 complement receptor activity(GO:0004875)
0.1 0.9 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 0.3 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.4 GO:0005534 galactose binding(GO:0005534)
0.1 0.3 GO:0016778 diphosphotransferase activity(GO:0016778)
0.1 0.3 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 2.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.5 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.3 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 1.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0008527 taste receptor activity(GO:0008527)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.0 0.2 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.0 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.3 GO:0048020 CCR chemokine receptor binding(GO:0048020)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 2.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.4 PID_ALK1_PATHWAY ALK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.4 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.1 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG