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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for BACH1_NFE2_NFE2L2

Z-value: 1.13

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Transcription factors associated with BACH1_NFE2_NFE2L2

Gene Symbol Gene ID Gene Info
BACH1
ENSG00000156273.11 BTB domain and CNC homolog 1
NFE2
ENSG00000123405.9 nuclear factor, erythroid 2
NFE2L2
ENSG00000116044.11 nuclear factor, erythroid 2 like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFE2L2hg19_v2_chr2_-_178129551_178129572-0.843.6e-02Click!
BACH1hg19_v2_chr21_+_30672433_30672464-0.562.5e-01Click!
NFE2hg19_v2_chr12_-_54691668_54691725-0.424.1e-01Click!

Activity profile of BACH1_NFE2_NFE2L2 motif

Sorted Z-values of BACH1_NFE2_NFE2L2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_22766766 4.49 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
IL6
interleukin 6 (interferon, beta 2)
chr20_+_44637526 1.48 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr21_+_42742429 1.32 ENST00000418103.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr12_-_122238464 0.87 ENST00000546227.1
RHOF
ras homolog family member F (in filopodia)
chr7_-_127671674 0.78 ENST00000478726.1
LRRC4
leucine rich repeat containing 4
chr16_+_89988259 0.78 ENST00000554444.1
ENST00000556565.1
TUBB3
Tubulin beta-3 chain
chr16_+_47496023 0.60 ENST00000567200.1
PHKB
phosphorylase kinase, beta
chr10_-_6019552 0.57 ENST00000379977.3
ENST00000397251.3
ENST00000397248.2
IL15RA
interleukin 15 receptor, alpha
chr16_+_30077055 0.55 ENST00000564595.2
ENST00000569798.1
ALDOA
aldolase A, fructose-bisphosphate
chr2_+_113763031 0.54 ENST00000259211.6
IL36A
interleukin 36, alpha
chr16_-_1429010 0.52 ENST00000513783.1
UNKL
unkempt family zinc finger-like
chr1_-_109968973 0.52 ENST00000271308.4
ENST00000538610.1
PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr11_-_2924970 0.52 ENST00000533594.1
SLC22A18AS
solute carrier family 22 (organic cation transporter), member 18 antisense
chr8_+_125283924 0.47 ENST00000517482.1
RP11-383J24.1
RP11-383J24.1
chr17_-_38859996 0.47 ENST00000264651.2
KRT24
keratin 24
chr22_-_19466454 0.44 ENST00000494054.1
UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr3_+_14474178 0.43 ENST00000452775.1
SLC6A6
solute carrier family 6 (neurotransmitter transporter), member 6
chr1_-_200992827 0.42 ENST00000332129.2
ENST00000422435.2
KIF21B
kinesin family member 21B
chr14_+_103589789 0.40 ENST00000558056.1
ENST00000560869.1
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr14_+_35761540 0.39 ENST00000261479.4
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr4_+_22999152 0.38 ENST00000511453.1
RP11-412P11.1
RP11-412P11.1
chr16_+_30077098 0.37 ENST00000395240.3
ENST00000566846.1
ALDOA
aldolase A, fructose-bisphosphate
chr22_-_19466643 0.36 ENST00000474226.1
UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr2_-_220117867 0.35 ENST00000456818.1
ENST00000447205.1
TUBA4A
tubulin, alpha 4a
chr6_-_3157760 0.35 ENST00000333628.3
TUBB2A
tubulin, beta 2A class IIa
chr14_-_57197224 0.33 ENST00000554597.1
ENST00000556696.1
RP11-1085N6.3
Uncharacterized protein
chr1_+_96208646 0.33 ENST00000603401.1
RP11-286B14.2
RP11-286B14.2
chr14_+_35761580 0.33 ENST00000553809.1
ENST00000555764.1
ENST00000556506.1
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr14_-_24732403 0.33 ENST00000206765.6
TGM1
transglutaminase 1
chr10_-_6019984 0.33 ENST00000525219.2
IL15RA
interleukin 15 receptor, alpha
chr22_-_19466683 0.32 ENST00000399523.1
ENST00000421968.2
ENST00000447868.1
UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr11_-_102668879 0.32 ENST00000315274.6
MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr3_+_46204959 0.31 ENST00000357422.2
CCR3
chemokine (C-C motif) receptor 3
chr12_+_64846129 0.30 ENST00000540417.1
ENST00000539810.1
TBK1
TANK-binding kinase 1
chr8_-_82395461 0.29 ENST00000256104.4
FABP4
fatty acid binding protein 4, adipocyte
chr11_+_72983246 0.29 ENST00000393590.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr11_-_102826434 0.28 ENST00000340273.4
ENST00000260302.3
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr16_-_1429627 0.27 ENST00000248104.7
UNKL
unkempt family zinc finger-like
chr22_-_39636914 0.27 ENST00000381551.4
PDGFB
platelet-derived growth factor beta polypeptide
chr14_-_24732368 0.27 ENST00000544573.1
TGM1
transglutaminase 1
chr1_+_165796753 0.27 ENST00000367879.4
UCK2
uridine-cytidine kinase 2
chr8_-_95220775 0.27 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr22_-_19466732 0.26 ENST00000263202.10
ENST00000360834.4
UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr12_+_64845864 0.26 ENST00000538890.1
TBK1
TANK-binding kinase 1
chr19_-_6670128 0.25 ENST00000245912.3
TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr1_+_218683438 0.25 ENST00000443836.1
C1orf143
chromosome 1 open reading frame 143
chr17_-_39769005 0.24 ENST00000301653.4
ENST00000593067.1
KRT16
keratin 16
chr12_+_56075330 0.24 ENST00000394252.3
METTL7B
methyltransferase like 7B
chr16_+_74330673 0.23 ENST00000219313.4
ENST00000540379.1
ENST00000567958.1
ENST00000568615.2
PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr4_-_101111615 0.23 ENST00000273990.2
DDIT4L
DNA-damage-inducible transcript 4-like
chr6_+_44214824 0.23 ENST00000371646.5
ENST00000353801.3
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr4_+_79567057 0.22 ENST00000503259.1
ENST00000507802.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chr9_+_140083099 0.22 ENST00000322310.5
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr14_-_24732738 0.22 ENST00000558074.1
ENST00000560226.1
TGM1
transglutaminase 1
chr3_+_184016986 0.21 ENST00000417952.1
PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr18_+_68002675 0.21 ENST00000584919.1
RP11-41O4.1
Uncharacterized protein
chr11_+_10477733 0.20 ENST00000528723.1
AMPD3
adenosine monophosphate deaminase 3
chr10_+_91087651 0.20 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr21_+_33671264 0.20 ENST00000339944.4
MRAP
melanocortin 2 receptor accessory protein
chr5_+_35852797 0.19 ENST00000508941.1
IL7R
interleukin 7 receptor
chr12_+_10365404 0.19 ENST00000266458.5
ENST00000421801.2
ENST00000544284.1
ENST00000545047.1
ENST00000543602.1
ENST00000545887.1
GABARAPL1
GABA(A) receptor-associated protein like 1
chr4_-_76944621 0.19 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr5_-_90610200 0.19 ENST00000511918.1
ENST00000513626.1
ENST00000607854.1
LUCAT1
RP11-213H15.4
lung cancer associated transcript 1 (non-protein coding)
RP11-213H15.4
chr10_-_71892555 0.19 ENST00000307864.1
AIFM2
apoptosis-inducing factor, mitochondrion-associated, 2
chr19_+_56652643 0.18 ENST00000586123.1
ZNF444
zinc finger protein 444
chr14_-_23504087 0.18 ENST00000493471.2
ENST00000460922.2
PSMB5
proteasome (prosome, macropain) subunit, beta type, 5
chr10_+_69865866 0.18 ENST00000354393.2
MYPN
myopalladin
chr11_-_67141640 0.18 ENST00000533438.1
CLCF1
cardiotrophin-like cytokine factor 1
chr7_+_139528952 0.17 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr7_+_42971799 0.17 ENST00000223324.2
MRPL32
mitochondrial ribosomal protein L32
chr2_+_90248739 0.17 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr7_+_1084206 0.17 ENST00000444847.1
GPR146
G protein-coupled receptor 146
chr19_+_50706866 0.17 ENST00000440075.2
ENST00000376970.2
ENST00000425460.1
ENST00000599920.1
ENST00000601313.1
MYH14
myosin, heavy chain 14, non-muscle
chr6_+_44215603 0.17 ENST00000371554.1
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr22_+_19466980 0.17 ENST00000407835.1
ENST00000438587.1
CDC45
cell division cycle 45
chr2_+_201987200 0.17 ENST00000425030.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr5_-_93954227 0.17 ENST00000513200.3
ENST00000329378.7
ENST00000312498.7
KIAA0825
KIAA0825
chr22_+_39353527 0.17 ENST00000249116.2
APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr12_+_10366223 0.17 ENST00000545290.1
GABARAPL1
GABA(A) receptor-associated protein like 1
chr12_+_10365082 0.17 ENST00000545859.1
GABARAPL1
GABA(A) receptor-associated protein like 1
chr11_-_47447970 0.17 ENST00000298852.3
ENST00000530912.1
PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr11_-_4599050 0.16 ENST00000307616.1
C11orf40
chromosome 11 open reading frame 40
chr1_+_214163033 0.16 ENST00000607425.1
PROX1
prospero homeobox 1
chr12_-_10826612 0.16 ENST00000535345.1
ENST00000542562.1
STYK1
serine/threonine/tyrosine kinase 1
chr6_+_33378517 0.16 ENST00000428274.1
PHF1
PHD finger protein 1
chr12_-_49523896 0.16 ENST00000549870.1
TUBA1B
tubulin, alpha 1b
chr14_-_74462922 0.16 ENST00000553284.1
ENTPD5
ectonucleoside triphosphate diphosphohydrolase 5
chr16_+_22308717 0.16 ENST00000299853.5
ENST00000564209.1
ENST00000565358.1
ENST00000418581.2
ENST00000564883.1
ENST00000359210.4
ENST00000563024.1
POLR3E
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
chr1_-_158656488 0.15 ENST00000368147.4
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr4_-_87374330 0.15 ENST00000511328.1
ENST00000503911.1
MAPK10
mitogen-activated protein kinase 10
chr20_-_1306391 0.15 ENST00000339987.3
SDCBP2
syndecan binding protein (syntenin) 2
chr14_-_65769392 0.15 ENST00000555736.1
CTD-2509G16.5
CTD-2509G16.5
chr11_-_2924720 0.15 ENST00000455942.2
SLC22A18AS
solute carrier family 22 (organic cation transporter), member 18 antisense
chr1_+_14075903 0.15 ENST00000343137.4
ENST00000503842.1
ENST00000407521.3
ENST00000505823.1
PRDM2
PR domain containing 2, with ZNF domain
chr17_+_16284399 0.15 ENST00000535788.1
UBB
ubiquitin B
chr3_+_183903811 0.14 ENST00000429586.2
ENST00000292808.5
ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr3_-_186262166 0.14 ENST00000307944.5
CRYGS
crystallin, gamma S
chr11_+_123396307 0.14 ENST00000456860.2
GRAMD1B
GRAM domain containing 1B
chr19_-_54604083 0.14 ENST00000391761.1
ENST00000356532.3
ENST00000359649.4
ENST00000358375.4
ENST00000391760.1
ENST00000351806.4
OSCAR
osteoclast associated, immunoglobulin-like receptor
chr11_+_123325106 0.14 ENST00000525757.1
LINC01059
long intergenic non-protein coding RNA 1059
chr2_-_191885686 0.14 ENST00000432058.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr22_-_39637135 0.14 ENST00000440375.1
PDGFB
platelet-derived growth factor beta polypeptide
chr21_+_33031935 0.14 ENST00000270142.6
ENST00000389995.4
SOD1
superoxide dismutase 1, soluble
chr3_+_184038234 0.14 ENST00000427607.1
ENST00000457456.1
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr20_+_42839600 0.13 ENST00000439943.1
ENST00000437730.1
OSER1-AS1
OSER1 antisense RNA 1 (head to head)
chr18_+_61637159 0.13 ENST00000397985.2
ENST00000353706.2
ENST00000542677.1
ENST00000397988.3
ENST00000448851.1
SERPINB8
serpin peptidase inhibitor, clade B (ovalbumin), member 8
chr2_+_54342533 0.13 ENST00000406041.1
ACYP2
acylphosphatase 2, muscle type
chr2_-_11606275 0.13 ENST00000381525.3
ENST00000362009.4
E2F6
E2F transcription factor 6
chr7_+_139529040 0.13 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr6_-_11232891 0.13 ENST00000379433.5
ENST00000379446.5
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr17_+_18625336 0.13 ENST00000395671.4
ENST00000571542.1
ENST00000395672.2
ENST00000414850.2
ENST00000424146.2
TRIM16L
tripartite motif containing 16-like
chr11_-_128894053 0.13 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr3_+_184038073 0.13 ENST00000428387.1
ENST00000434061.2
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr3_+_184037466 0.13 ENST00000441154.1
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr15_-_34502197 0.12 ENST00000557877.1
KATNBL1
katanin p80 subunit B-like 1
chr19_-_10613421 0.12 ENST00000393623.2
KEAP1
kelch-like ECH-associated protein 1
chr22_+_21987005 0.12 ENST00000607942.1
ENST00000425975.1
ENST00000292779.3
CCDC116
coiled-coil domain containing 116
chr17_+_30771279 0.12 ENST00000261712.3
ENST00000578213.1
ENST00000457654.2
ENST00000579451.1
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr18_-_55253830 0.12 ENST00000591215.1
FECH
ferrochelatase
chrX_-_24665353 0.12 ENST00000379144.2
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr12_-_57081940 0.12 ENST00000436399.2
PTGES3
prostaglandin E synthase 3 (cytosolic)
chr2_-_220119280 0.12 ENST00000392088.2
TUBA4A
tubulin, alpha 4a
chr16_-_1429674 0.12 ENST00000403703.1
ENST00000397464.1
ENST00000402641.2
UNKL
unkempt family zinc finger-like
chr16_-_30125177 0.12 ENST00000406256.3
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr7_+_141463897 0.12 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr22_+_20008678 0.12 ENST00000434168.1
TANGO2
transport and golgi organization 2 homolog (Drosophila)
chr4_-_44450814 0.12 ENST00000360029.3
KCTD8
potassium channel tetramerization domain containing 8
chr15_-_43212836 0.12 ENST00000566931.1
ENST00000564431.1
ENST00000567274.1
TTBK2
tau tubulin kinase 2
chr22_+_39916558 0.12 ENST00000337304.2
ENST00000396680.1
ATF4
activating transcription factor 4
chr6_-_35888905 0.12 ENST00000510290.1
ENST00000423325.2
ENST00000373822.1
SRPK1
SRSF protein kinase 1
chr17_-_79604075 0.12 ENST00000374747.5
ENST00000539314.1
ENST00000331134.6
NPLOC4
nuclear protein localization 4 homolog (S. cerevisiae)
chr1_+_36554470 0.12 ENST00000373178.4
ADPRHL2
ADP-ribosylhydrolase like 2
chr19_+_38865398 0.12 ENST00000585598.1
ENST00000602911.1
ENST00000592561.1
PSMD8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr16_-_28222797 0.11 ENST00000569951.1
ENST00000565698.1
XPO6
exportin 6
chr12_+_6644443 0.11 ENST00000396858.1
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr12_-_125399573 0.11 ENST00000339647.5
UBC
ubiquitin C
chr12_-_51611477 0.11 ENST00000389243.4
POU6F1
POU class 6 homeobox 1
chr14_+_71165292 0.11 ENST00000553682.1
RP6-65G23.1
RP6-65G23.1
chr17_-_8301132 0.11 ENST00000399398.2
RNF222
ring finger protein 222
chr17_-_42276574 0.11 ENST00000589805.1
ATXN7L3
ataxin 7-like 3
chr4_+_123747834 0.11 ENST00000264498.3
FGF2
fibroblast growth factor 2 (basic)
chr21_+_19273574 0.11 ENST00000400128.1
CHODL
chondrolectin
chr18_-_72920372 0.11 ENST00000581620.1
ENST00000582437.1
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr17_+_16284104 0.11 ENST00000577958.1
ENST00000302182.3
ENST00000577640.1
UBB
ubiquitin B
chr5_+_179247759 0.11 ENST00000389805.4
ENST00000504627.1
ENST00000402874.3
ENST00000510187.1
SQSTM1
sequestosome 1
chr19_-_44324750 0.11 ENST00000594049.1
ENST00000414615.2
LYPD5
LY6/PLAUR domain containing 5
chr20_+_10199468 0.11 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr3_+_100053542 0.11 ENST00000394140.4
NIT2
nitrilase family, member 2
chr17_-_73150629 0.11 ENST00000356033.4
ENST00000405458.3
ENST00000409753.3
HN1
hematological and neurological expressed 1
chr20_-_1306351 0.10 ENST00000381812.1
SDCBP2
syndecan binding protein (syntenin) 2
chr20_-_1309809 0.10 ENST00000360779.3
SDCBP2
syndecan binding protein (syntenin) 2
chr15_-_43212996 0.10 ENST00000567840.1
TTBK2
tau tubulin kinase 2
chr18_+_21594384 0.10 ENST00000584250.1
TTC39C
tetratricopeptide repeat domain 39C
chr20_-_634000 0.10 ENST00000381962.3
SRXN1
sulfiredoxin 1
chr9_+_26746951 0.10 ENST00000523363.1
RP11-18A15.1
RP11-18A15.1
chrX_-_24665208 0.10 ENST00000356768.4
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr11_-_47447767 0.10 ENST00000530651.1
ENST00000524447.2
ENST00000531051.2
ENST00000526993.1
ENST00000602866.1
PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr19_+_38865176 0.10 ENST00000215071.4
PSMD8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr2_+_173955327 0.10 ENST00000422149.1
MLTK
Mitogen-activated protein kinase kinase kinase MLT
chr14_-_95942173 0.09 ENST00000334258.5
ENST00000557275.1
ENST00000553340.1
SYNE3
spectrin repeat containing, nuclear envelope family member 3
chr17_-_7518145 0.09 ENST00000250113.7
ENST00000571597.1
FXR2
fragile X mental retardation, autosomal homolog 2
chr2_-_233641265 0.09 ENST00000438786.1
ENST00000409779.1
ENST00000233826.3
KCNJ13
potassium inwardly-rectifying channel, subfamily J, member 13
chr17_-_28619059 0.09 ENST00000580709.1
BLMH
bleomycin hydrolase
chr13_+_78109804 0.09 ENST00000535157.1
SCEL
sciellin
chr19_-_46142680 0.09 ENST00000245925.3
EML2
echinoderm microtubule associated protein like 2
chr19_-_46142637 0.09 ENST00000590043.1
ENST00000589876.1
EML2
echinoderm microtubule associated protein like 2
chr9_+_116917807 0.09 ENST00000356083.3
COL27A1
collagen, type XXVII, alpha 1
chr17_-_79818354 0.09 ENST00000576541.1
ENST00000576380.1
ENST00000571617.1
ENST00000576052.1
ENST00000576390.1
ENST00000573778.2
ENST00000439918.2
ENST00000574914.1
ENST00000331483.4
P4HB
prolyl 4-hydroxylase, beta polypeptide
chr20_+_2796948 0.09 ENST00000361033.1
ENST00000380585.1
TMEM239
transmembrane protein 239
chr19_-_14992264 0.09 ENST00000327462.2
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr9_-_35112376 0.09 ENST00000488109.2
FAM214B
family with sequence similarity 214, member B
chr19_-_51568324 0.09 ENST00000595547.1
ENST00000335422.3
ENST00000595793.1
ENST00000596955.1
KLK13
kallikrein-related peptidase 13
chr13_+_114567131 0.08 ENST00000608651.1
GAS6-AS2
GAS6 antisense RNA 2 (head to head)
chrX_+_30671476 0.08 ENST00000378946.3
ENST00000378943.3
ENST00000378945.3
ENST00000427190.1
ENST00000378941.3
GK
glycerol kinase
chr9_-_140082983 0.08 ENST00000323927.2
ANAPC2
anaphase promoting complex subunit 2
chr3_+_126423045 0.08 ENST00000290913.3
ENST00000508789.1
CHCHD6
coiled-coil-helix-coiled-coil-helix domain containing 6
chr2_-_11605966 0.08 ENST00000307236.4
ENST00000542100.1
ENST00000546212.1
E2F6
E2F transcription factor 6
chr3_+_120315149 0.08 ENST00000184266.2
NDUFB4
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
chr7_-_75988321 0.08 ENST00000307630.3
YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
chrX_+_99899180 0.08 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr18_+_55712915 0.08 ENST00000592846.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr7_+_139529085 0.08 ENST00000539806.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr17_-_1395954 0.08 ENST00000359786.5
MYO1C
myosin IC
chr6_-_24799117 0.08 ENST00000565469.1
RP3-369A17.5
chromosome 6 open reading frame 229
chr9_-_34458531 0.08 ENST00000379089.1
ENST00000379087.1
ENST00000379084.1
ENST00000379081.1
ENST00000379080.1
ENST00000422409.1
ENST00000379078.1
ENST00000445726.1
ENST00000297620.4
FAM219A
family with sequence similarity 219, member A
chr10_+_122216316 0.08 ENST00000398250.1
ENST00000439221.1
ENST00000398248.1
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr8_+_39972170 0.08 ENST00000521257.1
RP11-359E19.2
RP11-359E19.2
chr22_-_32058416 0.08 ENST00000439502.2
PISD
phosphatidylserine decarboxylase
chr1_+_26605618 0.08 ENST00000270792.5
SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr9_-_26947220 0.08 ENST00000520884.1
PLAA
phospholipase A2-activating protein
chr4_-_987217 0.08 ENST00000361661.2
ENST00000398516.2
SLC26A1
solute carrier family 26 (anion exchanger), member 1
chr5_+_179125368 0.08 ENST00000502296.1
ENST00000504734.1
ENST00000415618.2
CANX
calnexin
chr16_+_57844549 0.08 ENST00000564282.1
CTD-2600O9.1
uncharacterized protein LOC388282
chr17_-_61905005 0.07 ENST00000584574.1
ENST00000585145.1
ENST00000427159.2
FTSJ3
FtsJ homolog 3 (E. coli)
chr2_-_10588630 0.07 ENST00000234111.4
ODC1
ornithine decarboxylase 1
chr20_+_42839722 0.07 ENST00000442383.1
ENST00000435163.1
OSER1-AS1
OSER1 antisense RNA 1 (head to head)
chr10_+_127661942 0.07 ENST00000417114.1
ENST00000445510.1
ENST00000368691.1
FANK1
fibronectin type III and ankyrin repeat domains 1
chr6_+_53948328 0.07 ENST00000370876.2
MLIP
muscular LMNA-interacting protein
chr16_+_56642489 0.07 ENST00000561491.1
MT2A
metallothionein 2A
chr6_-_31745085 0.07 ENST00000375686.3
ENST00000447450.1
VWA7
von Willebrand factor A domain containing 7

Network of associatons between targets according to the STRING database.

First level regulatory network of BACH1_NFE2_NFE2L2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0002384 hepatic immune response(GO:0002384) response to prolactin(GO:1990637)
0.2 1.5 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.1 0.4 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.1 0.8 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.1 0.4 GO:1900241 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.1 0.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.3 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.1 1.3 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.1 0.5 GO:0044565 dendritic cell proliferation(GO:0044565)
0.1 0.2 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.2 GO:0061114 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) negative regulation of bile acid biosynthetic process(GO:0070858) acinar cell differentiation(GO:0090425) negative regulation of bile acid metabolic process(GO:1904252) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.3 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.2 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0 0.1 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0 0.1 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 0.1 GO:0042660 positive regulation of cell fate specification(GO:0042660)
0.0 0.1 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.0 0.1 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.0 0.1 GO:0006117 acetaldehyde metabolic process(GO:0006117)
0.0 0.7 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.0 0.3 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.2 GO:0006196 AMP catabolic process(GO:0006196)
0.0 0.1 GO:1990169 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.0 0.4 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.0 0.2 GO:0051546 keratinocyte migration(GO:0051546)
0.0 0.4 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 0.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.2 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0 0.1 GO:0070541 response to platinum ion(GO:0070541)
0.0 0.2 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.4 GO:0051601 exocyst localization(GO:0051601)
0.0 0.1 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.4 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.1 GO:0015728 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.0 0.1 GO:1902534 single-organism membrane invagination(GO:1902534)
0.0 0.3 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.1 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.4 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.0 GO:0060168 regulation of adenosine receptor signaling pathway(GO:0060167) positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.0 1.3 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.1 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.1 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
0.0 0.6 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.2 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.0 GO:0050894 determination of affect(GO:0050894)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.0 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.0 0.3 GO:0071625 vocalization behavior(GO:0071625)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.5 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.2 GO:0034515 proteasome storage granule(GO:0034515)
0.1 0.6 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751) sperm plasma membrane(GO:0097524)
0.1 0.2 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.2 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 0.1 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
0.0 0.1 GO:0097444 spine apparatus(GO:0097444)
0.0 0.2 GO:0097513 myosin II filament(GO:0097513)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.5 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 0.1 GO:0044753 amphisome(GO:0044753)
0.0 2.5 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.1 GO:0045160 myosin I complex(GO:0045160)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.2 GO:0032437 cuticular plate(GO:0032437)
0.0 0.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0097452 GAIT complex(GO:0097452)
0.0 0.9 GO:0001533 cornified envelope(GO:0001533)
0.0 0.1 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.5 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.4 GO:0002134 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
0.1 0.4 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.1 0.3 GO:0015322 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.1 0.3 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 0.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.2 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.1 0.2 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 0.6 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.3 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.1 GO:0004325 ferrochelatase activity(GO:0004325)
0.0 0.2 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 0.2 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.0 0.3 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.1 GO:0019828 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) aspartic-type endopeptidase inhibitor activity(GO:0019828) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.3 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.0 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.0 0.1 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.1 GO:0016005 phospholipase A2 activator activity(GO:0016005)
0.0 0.4 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.1 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.0 0.1 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947)
0.0 0.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:0016672 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.0 0.1 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 1.7 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.0 0.1 GO:0070026 nitric oxide binding(GO:0070026)
0.0 0.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.0 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.0 GO:0052642 lysophosphatidic acid phosphatase activity(GO:0052642)
0.0 0.1 GO:0046870 cadmium ion binding(GO:0046870)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 ST STAT3 PATHWAY STAT3 Pathway
0.0 1.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.4 PID S1P S1P1 PATHWAY S1P1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 2.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.7 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.5 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.1 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.2 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage