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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CEBPB
Z-value: 1.05
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Transcription factors associated with CEBPB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPB | hg19_v2_chr20_+_48807351_48807384 | 0.39 | 4.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_80263506 Show fit | 1.69 |
ENST00000335661.6
|
BCL2-related protein A1 |
|
| chr5_-_150473127 Show fit | 1.66 |
ENST00000521001.1
|
TNFAIP3 interacting protein 1 |
|
| chr6_+_31895467 Show fit | 1.10 |
ENST00000556679.1
ENST00000456570.1 |
complement factor B Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B |
|
| chr6_+_31895480 Show fit | 1.02 |
ENST00000418949.2
ENST00000383177.3 ENST00000477310.1 |
complement component 2 Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B |
|
| chr1_+_212782012 Show fit | 0.81 |
ENST00000341491.4
ENST00000366985.1 |
activating transcription factor 3 |
|
| chr2_-_214017151 Show fit | 0.78 |
ENST00000452786.1
|
IKAROS family zinc finger 2 (Helios) |
|
| chr22_-_39640756 Show fit | 0.71 |
ENST00000331163.6
|
platelet-derived growth factor beta polypeptide |
|
| chrX_-_133792480 Show fit | 0.71 |
ENST00000359237.4
|
placenta-specific 1 |
|
| chr11_+_93754513 Show fit | 0.69 |
ENST00000315765.9
|
hephaestin-like 1 |
|
| chr22_-_30901637 Show fit | 0.66 |
ENST00000381982.3
ENST00000255858.7 ENST00000540456.1 ENST00000392772.2 |
SEC14-like 4 (S. cerevisiae) |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.3 | 1.7 | GO:0052250 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.0 | 1.7 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.3 | 0.8 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
| 0.2 | 0.7 | GO:1905176 | metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936) |
| 0.2 | 0.7 | GO:0090214 | spongiotrophoblast layer developmental growth(GO:0090214) |
| 0.0 | 0.7 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.1 | 0.6 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 0.1 | 0.6 | GO:0046878 | positive regulation of saliva secretion(GO:0046878) |
| 0.1 | 0.6 | GO:0001554 | luteolysis(GO:0001554) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 0.7 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.1 | 0.6 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 0.5 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.4 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.1 | 0.3 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
| 0.0 | 0.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.3 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.2 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.0 | 0.2 | GO:0071953 | elastic fiber(GO:0071953) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 1.7 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 1.4 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 0.7 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 0.7 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.2 | 0.6 | GO:0005146 | leukemia inhibitory factor receptor binding(GO:0005146) |
| 0.0 | 0.6 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 0.5 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.1 | 0.5 | GO:0008732 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.0 | 0.5 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.4 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 1.2 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.7 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.4 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 1.0 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.8 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.5 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.5 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.4 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.0 | 0.3 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.0 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |