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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for EGR3_EGR2

Z-value: 0.38

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Transcription factors associated with EGR3_EGR2

Gene Symbol Gene ID Gene Info
ENSG00000179388.8 early growth response 3
ENSG00000122877.9 early growth response 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
EGR2hg19_v2_chr10_-_64576105_64576133-0.962.1e-03Click!
EGR3hg19_v2_chr8_-_22549856_225499270.384.6e-01Click!

Activity profile of EGR3_EGR2 motif

Sorted Z-values of EGR3_EGR2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_49622348 0.52 ENST00000408991.2
chromosome 19 open reading frame 73
chr15_-_80263506 0.38 ENST00000335661.6
BCL2-related protein A1
chr5_-_176924562 0.38 ENST00000359895.2
ENST00000355572.2
ENST00000355841.2
ENST00000393551.1
ENST00000505074.1
ENST00000356618.4
ENST00000393546.4
PDZ and LIM domain 7 (enigma)
chr19_+_49617581 0.33 ENST00000391864.3
lin-7 homolog B (C. elegans)
chr6_+_31543334 0.28 ENST00000449264.2
tumor necrosis factor
chr6_+_43739697 0.24 ENST00000230480.6
vascular endothelial growth factor A
chr14_-_69445793 0.24 ENST00000538545.2
ENST00000394419.4
actinin, alpha 1
chr14_-_69445968 0.23 ENST00000438964.2
actinin, alpha 1
chr6_+_138188551 0.23 ENST00000237289.4
ENST00000433680.1
tumor necrosis factor, alpha-induced protein 3
chr1_+_43148059 0.22 ENST00000321358.7
ENST00000332220.6
Y box binding protein 1
chr6_+_138188351 0.22 ENST00000421450.1
tumor necrosis factor, alpha-induced protein 3
chr19_-_14201776 0.19 ENST00000269724.5
sterile alpha motif domain containing 1
chr6_+_138188378 0.19 ENST00000420009.1
tumor necrosis factor, alpha-induced protein 3
chr2_-_27718052 0.18 ENST00000264703.3
fibronectin type III domain containing 4
chr8_+_32406137 0.18 ENST00000521670.1
neuregulin 1
chr1_+_43148625 0.18 ENST00000436427.1
Y box binding protein 1
chr22_-_30722912 0.18 ENST00000215790.7
TBC1 domain family, member 10A
chr1_-_16302608 0.18 ENST00000375743.4
ENST00000375733.2
zinc finger and BTB domain containing 17
chr3_+_101546827 0.17 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr15_-_75743991 0.17 ENST00000567289.1
SIN3 transcription regulator family member A
chr22_+_37956453 0.17 ENST00000249014.4
CDC42 effector protein (Rho GTPase binding) 1
chrX_-_19905577 0.16 ENST00000379697.3
SH3-domain kinase binding protein 1
chr16_-_30134441 0.16 ENST00000395200.1
mitogen-activated protein kinase 3
chr19_+_50180409 0.16 ENST00000391851.4
protein arginine methyltransferase 1
chr16_+_30194916 0.16 ENST00000570045.1
ENST00000565497.1
ENST00000570244.1
coronin, actin binding protein, 1A
chrX_-_48814810 0.15 ENST00000376488.3
ENST00000396743.3
ENST00000156084.4
OTU domain containing 5
chr16_-_30134524 0.15 ENST00000395202.1
ENST00000395199.3
ENST00000263025.4
ENST00000322266.5
ENST00000403394.1
mitogen-activated protein kinase 3
chr1_-_16302565 0.15 ENST00000537142.1
ENST00000448462.2
zinc finger and BTB domain containing 17
chr6_+_30689350 0.15 ENST00000330914.3
tubulin, beta class I
chr15_+_91446961 0.15 ENST00000559965.1
mannosidase, alpha, class 2A, member 2
chr19_+_13906250 0.14 ENST00000254323.2
zinc finger, SWIM-type containing 4
chr1_-_9189144 0.14 ENST00000414642.2
G protein-coupled receptor 157
chr6_+_30689401 0.14 ENST00000396389.1
ENST00000396384.1
tubulin, beta class I
chr20_+_44035200 0.13 ENST00000372717.1
ENST00000360981.4
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr16_-_402639 0.13 ENST00000262320.3
axin 1
chr9_+_34989638 0.13 ENST00000453597.3
ENST00000335998.3
ENST00000312316.5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr14_-_69446034 0.13 ENST00000193403.6
actinin, alpha 1
chr19_+_50180507 0.12 ENST00000454376.2
ENST00000524771.1
protein arginine methyltransferase 1
chr3_+_10206545 0.12 ENST00000256458.4
interleukin-1 receptor-associated kinase 2
chr11_-_507184 0.12 ENST00000533410.1
ENST00000354420.2
ENST00000397604.3
ENST00000531149.1
ENST00000356187.5
ribonuclease/angiogenin inhibitor 1
chr14_+_64971438 0.12 ENST00000555321.1
zinc finger and BTB domain containing 1
chr19_+_10400615 0.12 ENST00000221980.4
intercellular adhesion molecule 5, telencephalin
chr11_-_125365435 0.12 ENST00000524435.1
fasciculation and elongation protein zeta 1 (zygin I)
chr12_-_1703331 0.12 ENST00000339235.3
F-box and leucine-rich repeat protein 14
chr17_-_4890919 0.12 ENST00000572543.1
ENST00000381311.5
ENST00000348066.3
ENST00000358183.4
calmodulin binding transcription activator 2
chr1_+_155051379 0.12 ENST00000418360.2
ephrin-A3
chr1_-_94312706 0.12 ENST00000370244.1
breast cancer anti-estrogen resistance 3
chr6_-_30712313 0.11 ENST00000376377.2
ENST00000259874.5
immediate early response 3
chr22_+_37956479 0.11 ENST00000430687.1
CDC42 effector protein (Rho GTPase binding) 1
chr19_+_47778119 0.11 ENST00000552360.2
proline rich 24
chr20_+_35202909 0.11 ENST00000558530.1
ENST00000558028.1
ENST00000560025.1
TGIF2-C20orf24 readthrough
TGFB-induced factor homeobox 2
chr19_-_10530784 0.11 ENST00000593124.1
cell division cycle 37
chr19_+_41882466 0.11 ENST00000436170.2
transmembrane protein 91
chr19_+_45504688 0.11 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr4_+_8201091 0.11 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
SH3 domain and tetratricopeptide repeats 1
chr11_-_64545941 0.11 ENST00000377387.1
splicing factor 1
chr20_+_34894247 0.11 ENST00000373913.3
discs, large (Drosophila) homolog-associated protein 4
chr15_+_39873268 0.10 ENST00000397591.2
ENST00000260356.5
thrombospondin 1
chr10_-_102790852 0.10 ENST00000470414.1
ENST00000370215.3
PDZ domain containing 7
chr8_-_33424636 0.10 ENST00000256257.1
ring finger protein 122
chr11_-_64546202 0.10 ENST00000377390.3
ENST00000227503.9
ENST00000377394.3
ENST00000422298.2
ENST00000334944.5
splicing factor 1
chr11_+_64009072 0.10 ENST00000535135.1
ENST00000394540.3
FK506 binding protein 2, 13kDa
chr19_+_50180317 0.10 ENST00000534465.1
protein arginine methyltransferase 1
chr11_-_125366089 0.10 ENST00000366139.3
ENST00000278919.3
fasciculation and elongation protein zeta 1 (zygin I)
chr6_-_31697255 0.10 ENST00000436437.1
dimethylarginine dimethylaminohydrolase 2
chr19_-_663171 0.10 ENST00000606896.1
ENST00000589762.2
ring finger protein 126
chr15_-_93199069 0.10 ENST00000327355.5
family with sequence similarity 174, member B
chr16_-_55866997 0.10 ENST00000360526.3
ENST00000361503.4
carboxylesterase 1
chr15_+_75494214 0.10 ENST00000394987.4
chromosome 15 open reading frame 39
chr4_+_103422471 0.10 ENST00000226574.4
ENST00000394820.4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr22_-_30722866 0.10 ENST00000403477.3
TBC1 domain family, member 10A
chr15_-_71146480 0.10 ENST00000299213.8
La ribonucleoprotein domain family, member 6
chr18_-_43684186 0.10 ENST00000590406.1
ENST00000282050.2
ENST00000590324.1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr2_+_30454390 0.10 ENST00000395323.3
ENST00000406087.1
ENST00000404397.1
limb bud and heart development
chr11_-_125366018 0.09 ENST00000527534.1
fasciculation and elongation protein zeta 1 (zygin I)
chr6_+_12012536 0.09 ENST00000379388.2
human immunodeficiency virus type I enhancer binding protein 1
chrX_-_19905703 0.09 ENST00000397821.3
SH3-domain kinase binding protein 1
chr9_-_35115836 0.09 ENST00000378566.1
ENST00000378554.2
ENST00000322813.5
family with sequence similarity 214, member B
chr13_-_111214015 0.09 ENST00000267328.3
RAB20, member RAS oncogene family
chr6_-_26108355 0.09 ENST00000338379.4
histone cluster 1, H1t
chr6_-_31697563 0.09 ENST00000375789.2
ENST00000416410.1
dimethylarginine dimethylaminohydrolase 2
chr19_+_797392 0.09 ENST00000350092.4
ENST00000349038.4
ENST00000586481.1
ENST00000585535.1
polypyrimidine tract binding protein 1
chr2_-_61108449 0.09 ENST00000439412.1
ENST00000452343.1
AC010733.4
chr3_-_88108212 0.09 ENST00000482016.1
CGG triplet repeat binding protein 1
chr2_+_191513789 0.09 ENST00000409581.1
NGFI-A binding protein 1 (EGR1 binding protein 1)
chr17_-_72772462 0.09 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
N-acetyltransferase 9 (GCN5-related, putative)
chr19_-_16682987 0.09 ENST00000431408.1
ENST00000436553.2
ENST00000595753.1
solute carrier family 35, member E1
chr3_-_52273098 0.09 ENST00000499914.2
ENST00000305533.5
ENST00000597542.1
twinfilin actin-binding protein 2
toll-like receptor 9
chr11_-_65640071 0.09 ENST00000526624.1
EGF containing fibulin-like extracellular matrix protein 2
chr19_+_8455200 0.09 ENST00000601897.1
ENST00000594216.1
RAB11B, member RAS oncogene family
chr1_-_33647267 0.08 ENST00000291416.5
tripartite motif containing 62
chr9_+_131709966 0.08 ENST00000372577.2
nucleoporin 188kDa
chr3_-_169487617 0.08 ENST00000330368.2
actin-related protein T3
chr17_-_4890649 0.08 ENST00000361571.5
calmodulin binding transcription activator 2
chr7_+_142985467 0.08 ENST00000392925.2
caspase 2, apoptosis-related cysteine peptidase
chr1_+_178994939 0.08 ENST00000440702.1
family with sequence similarity 20, member B
chr11_-_44972299 0.08 ENST00000528473.1
tumor protein p53 inducible protein 11
chr1_+_156698743 0.08 ENST00000524343.1
ribosomal RNA adenine dimethylase domain containing 1
chr15_-_34502197 0.08 ENST00000557877.1
katanin p80 subunit B-like 1
chr1_-_6321035 0.08 ENST00000377893.2
G protein-coupled receptor 153
chr5_-_141030943 0.08 ENST00000522783.1
ENST00000519800.1
ENST00000435817.2
FCH and double SH3 domains 1
chr11_+_66624527 0.08 ENST00000393952.3
leucine rich repeat and fibronectin type III domain containing 4
chr15_+_31619013 0.08 ENST00000307145.3
Kruppel-like factor 13
chr19_-_10946871 0.08 ENST00000589638.1
transmembrane emp24 protein transport domain containing 1
chr16_+_29818857 0.08 ENST00000567444.1
MYC-associated zinc finger protein (purine-binding transcription factor)
chr16_+_2285817 0.08 ENST00000564065.1
deoxyribonuclease I-like 2
chr4_-_82393009 0.08 ENST00000436139.2
RasGEF domain family, member 1B
chr16_+_69139467 0.08 ENST00000569188.1
hyaluronan synthase 3
chr19_+_40871734 0.08 ENST00000359274.5
phospholipase D family, member 3
chr11_+_64685026 0.08 ENST00000526559.1
protein phosphatase 2, regulatory subunit B', beta
chr5_-_176037105 0.08 ENST00000303991.4
G protein regulated inducer of neurite outgrowth 1
chr19_-_51568324 0.08 ENST00000595547.1
ENST00000335422.3
ENST00000595793.1
ENST00000596955.1
kallikrein-related peptidase 13
chr6_-_110501200 0.08 ENST00000392586.1
ENST00000419252.1
ENST00000392589.1
ENST00000392588.1
ENST00000359451.2
WAS protein family, member 1
chr14_-_24610779 0.08 ENST00000560403.1
ENST00000419198.2
ENST00000216799.4
ER membrane protein complex subunit 9
chr18_+_77794446 0.08 ENST00000262197.7
ribosome binding factor A (putative)
chr11_-_506739 0.08 ENST00000529306.1
ENST00000438658.2
ENST00000527485.1
ENST00000397615.2
ENST00000397614.1
ribonuclease/angiogenin inhibitor 1
chr4_-_109087872 0.07 ENST00000510624.1
lymphoid enhancer-binding factor 1
chr5_+_172068232 0.07 ENST00000520919.1
ENST00000522853.1
ENST00000369800.5
neuralized E3 ubiquitin protein ligase 1B
chr20_+_60878005 0.07 ENST00000253003.2
adhesion regulating molecule 1
chr4_+_103422499 0.07 ENST00000511926.1
ENST00000507079.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr2_-_152118276 0.07 ENST00000409092.1
RNA binding motif protein 43
chr20_-_3996165 0.07 ENST00000545616.2
ENST00000358395.6
ring finger protein 24
chr6_+_35310312 0.07 ENST00000448077.2
ENST00000360694.3
ENST00000418635.2
ENST00000444397.1
peroxisome proliferator-activated receptor delta
chr4_+_83351791 0.07 ENST00000509635.1
enolase-phosphatase 1
chr1_-_161147275 0.07 ENST00000319769.5
ENST00000367998.1
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
chr8_+_32405728 0.07 ENST00000523079.1
ENST00000338921.4
ENST00000356819.4
ENST00000287845.5
ENST00000341377.5
neuregulin 1
chr16_-_28621353 0.07 ENST00000567512.1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr17_-_4710288 0.07 ENST00000571067.1
RP11-81A22.5
chr8_-_57123815 0.07 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
pleiomorphic adenoma gene 1
chr17_-_72772425 0.07 ENST00000578822.1
N-acetyltransferase 9 (GCN5-related, putative)
chr19_-_663277 0.07 ENST00000292363.5
ring finger protein 126
chr16_-_2185899 0.07 ENST00000262304.4
ENST00000423118.1
polycystic kidney disease 1 (autosomal dominant)
chr7_-_108096765 0.07 ENST00000379024.4
ENST00000351718.4
neuronal cell adhesion molecule
chr19_+_11457232 0.07 ENST00000587531.1
coiled-coil domain containing 159
chrX_-_47479246 0.07 ENST00000295987.7
ENST00000340666.4
synapsin I
chr18_+_3449695 0.07 ENST00000343820.5
TGFB-induced factor homeobox 1
chr15_-_40213080 0.07 ENST00000561100.1
G protein-coupled receptor 176
chr19_+_19303720 0.07 ENST00000392324.4
regulatory factor X-associated ankyrin-containing protein
chr3_+_88108381 0.07 ENST00000473136.1
Uncharacterized protein
chr1_+_41157361 0.07 ENST00000427410.2
ENST00000447388.3
ENST00000425457.2
ENST00000453631.1
ENST00000456393.2
nuclear transcription factor Y, gamma
chr19_-_344786 0.07 ENST00000264819.4
mesoderm induction early response 1, family member 2
chrX_+_133930798 0.07 ENST00000414371.2
family with sequence similarity 122C
chr16_-_30134266 0.07 ENST00000484663.1
ENST00000478356.1
mitogen-activated protein kinase 3
chr19_+_11071685 0.07 ENST00000541122.2
ENST00000589677.1
ENST00000444061.3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr14_-_64971288 0.07 ENST00000394715.1
zinc finger and BTB domain containing 25
chr17_-_41623691 0.07 ENST00000545954.1
ets variant 4
chr14_+_100842735 0.07 ENST00000554998.1
ENST00000402312.3
ENST00000335290.6
ENST00000554175.1
WD repeat domain 25
chr17_-_1083078 0.07 ENST00000574266.1
ENST00000302538.5
active BCR-related
chr19_-_14201507 0.07 ENST00000533683.2
sterile alpha motif domain containing 1
chr1_-_160068645 0.07 ENST00000448417.1
immunoglobulin superfamily, member 8
chr20_+_44034676 0.07 ENST00000372723.3
ENST00000372722.3
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr15_+_90792760 0.07 ENST00000339615.5
ENST00000438251.1
tubulin tyrosine ligase-like family, member 13
chr3_-_138048653 0.07 ENST00000460099.1
NME/NM23 family member 9
chr1_+_155051305 0.07 ENST00000368408.3
ephrin-A3
chr11_-_47447970 0.07 ENST00000298852.3
ENST00000530912.1
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr10_-_101380121 0.07 ENST00000370495.4
solute carrier family 25 (mitochondrial iron transporter), member 28
chr19_-_48673552 0.06 ENST00000536218.1
ENST00000596549.1
ligase I, DNA, ATP-dependent
chr11_-_65640198 0.06 ENST00000528176.1
EGF containing fibulin-like extracellular matrix protein 2
chr1_+_114522049 0.06 ENST00000369551.1
ENST00000320334.4
olfactomedin-like 3
chr1_-_155947951 0.06 ENST00000313695.7
ENST00000497907.1
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr6_+_144471643 0.06 ENST00000367568.4
syntaxin 11
chr12_-_125473600 0.06 ENST00000308736.2
DEAH (Asp-Glu-Ala-His) box polypeptide 37
chr11_+_111473108 0.06 ENST00000304987.3
salt-inducible kinase 2
chr16_-_838329 0.06 ENST00000563560.1
ENST00000569601.1
ENST00000565809.1
ENST00000565377.1
ENST00000007264.2
ENST00000567114.1
RNA pseudouridylate synthase domain containing 1
chr17_-_41623716 0.06 ENST00000319349.5
ets variant 4
chr1_-_38471156 0.06 ENST00000373016.3
four and a half LIM domains 3
chr16_+_75182376 0.06 ENST00000570010.1
ENST00000568079.1
ENST00000464850.1
ENST00000332307.4
ENST00000393430.2
ZFP1 zinc finger protein
chr19_-_13617247 0.06 ENST00000573710.2
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr19_-_55770311 0.06 ENST00000412770.2
protein phosphatase 6, regulatory subunit 1
chr19_-_13068012 0.06 ENST00000316939.1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr12_+_49658855 0.06 ENST00000549183.1
tubulin, alpha 1c
chr20_-_61569227 0.06 ENST00000266070.4
ENST00000395335.2
ENST00000266071.5
death inducer-obliterator 1
chr18_+_55102917 0.06 ENST00000491143.2
one cut homeobox 2
chr5_-_38845812 0.06 ENST00000513480.1
ENST00000512519.1
CTD-2127H9.1
chr9_-_131709858 0.06 ENST00000372586.3
dolichol kinase
chr19_+_797443 0.06 ENST00000394601.4
ENST00000589575.1
polypyrimidine tract binding protein 1
chr18_-_43684230 0.06 ENST00000592989.1
ENST00000589869.1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr7_-_108096822 0.06 ENST00000379028.3
ENST00000413765.2
ENST00000379022.4
neuronal cell adhesion molecule
chr1_+_156698708 0.06 ENST00000519086.1
ribosomal RNA adenine dimethylase domain containing 1
chr19_+_7985880 0.06 ENST00000597584.1
small nuclear RNA activating complex, polypeptide 2, 45kDa
chr22_+_31090793 0.06 ENST00000332585.6
ENST00000382310.3
ENST00000446658.2
oxysterol binding protein 2
chr14_+_65170820 0.06 ENST00000555982.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr5_-_162887054 0.06 ENST00000517501.1
NudC domain containing 2
chr15_-_75744014 0.06 ENST00000394947.3
ENST00000565264.1
SIN3 transcription regulator family member A
chr16_+_3070313 0.06 ENST00000326577.4
tumor necrosis factor receptor superfamily, member 12A
chr1_-_38273840 0.06 ENST00000373044.2
yrdC N(6)-threonylcarbamoyltransferase domain containing
chr20_-_17662705 0.06 ENST00000455029.2
ribosome binding protein 1
chr22_+_29138013 0.06 ENST00000216027.3
ENST00000398941.2
HscB mitochondrial iron-sulfur cluster co-chaperone
chr19_+_7968728 0.06 ENST00000397981.3
ENST00000545011.1
ENST00000397983.3
ENST00000397979.3
mitogen-activated protein kinase kinase 7
chr14_+_75230011 0.06 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLP motif containing 1
chr16_-_74808710 0.06 ENST00000219368.3
ENST00000544337.1
fatty acid 2-hydroxylase
chr6_-_85474219 0.06 ENST00000369663.5
T-box 18
chr1_-_155948218 0.06 ENST00000313667.4
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr6_-_31864977 0.06 ENST00000395728.3
ENST00000375528.4
euchromatic histone-lysine N-methyltransferase 2
chr1_-_160068465 0.06 ENST00000314485.7
ENST00000368086.1
immunoglobulin superfamily, member 8
chr19_+_40854559 0.06 ENST00000598962.1
ENST00000409419.1
ENST00000409587.1
ENST00000602131.1
ENST00000409735.4
ENST00000600948.1
ENST00000356508.5
ENST00000596682.1
ENST00000594908.1
phospholipase D family, member 3
chr6_-_112575758 0.06 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
laminin, alpha 4
chr1_+_215256467 0.06 ENST00000391894.2
ENST00000444842.2
potassium channel, subfamily K, member 2
chr19_-_37096139 0.06 ENST00000585983.1
ENST00000585960.1
ENST00000586115.1
zinc finger protein 529
chr6_+_35310391 0.06 ENST00000337400.2
ENST00000311565.4
ENST00000540939.1
peroxisome proliferator-activated receptor delta

Network of associatons between targets according to the STRING database.

First level regulatory network of EGR3_EGR2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0034148 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of CD40 signaling pathway(GO:2000349)
0.1 0.4 GO:2000657 regulation of apolipoprotein binding(GO:2000656) negative regulation of apolipoprotein binding(GO:2000657)
0.1 0.3 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) positive regulation of translational initiation by iron(GO:0045994)
0.1 0.2 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.1 0.2 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.1 0.2 GO:0045083 negative regulation of interleukin-12 biosynthetic process(GO:0045083)
0.1 0.4 GO:0046985 negative regulation of megakaryocyte differentiation(GO:0045653) positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.1 0.3 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.2 GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823)
0.0 0.4 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.3 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.2 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0 0.3 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.0 0.1 GO:0002605 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605) negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.1 GO:1902824 cleavage furrow ingression(GO:0036090) positive regulation of late endosome to lysosome transport(GO:1902824)
0.0 0.1 GO:1990108 protein linear deubiquitination(GO:1990108)
0.0 0.2 GO:0007068 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.0 0.2 GO:0032796 uropod organization(GO:0032796)
0.0 0.1 GO:0017198 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 0.1 GO:0060381 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.0 0.1 GO:0045081 negative regulation of interleukin-10 biosynthetic process(GO:0045081)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.1 GO:0016334 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.0 0.1 GO:0071733 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.0 0.1 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.0 0.1 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.0 0.1 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.0 0.1 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.0 0.1 GO:0006172 ADP biosynthetic process(GO:0006172)
0.0 0.6 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.0 0.3 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 0.1 GO:0035674 tricarboxylic acid transmembrane transport(GO:0035674)
0.0 0.0 GO:0043311 regulation of eosinophil degranulation(GO:0043309) positive regulation of eosinophil degranulation(GO:0043311) regulation of eosinophil activation(GO:1902566) positive regulation of eosinophil activation(GO:1902568)
0.0 0.1 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.0 0.2 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.0 0.3 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:0060721 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.0 0.1 GO:0072287 metanephric distal tubule morphogenesis(GO:0072287)
0.0 0.2 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.0 GO:0072554 blood vessel lumenization(GO:0072554)
0.0 0.1 GO:0090135 actin filament branching(GO:0090135)
0.0 0.1 GO:1904674 positive regulation of somatic stem cell population maintenance(GO:1904674)
0.0 0.1 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.0 0.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.1 GO:0071926 endocannabinoid signaling pathway(GO:0071926)
0.0 0.1 GO:0015862 uridine transport(GO:0015862)
0.0 0.1 GO:1904048 regulation of spontaneous neurotransmitter secretion(GO:1904048)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.0 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.1 GO:0071899 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.0 0.1 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 0.0 GO:0042137 sequestering of neurotransmitter(GO:0042137)
0.0 0.0 GO:0090340 positive regulation of high-density lipoprotein particle assembly(GO:0090108) positive regulation of pancreatic juice secretion(GO:0090187) positive regulation of secretion of lysosomal enzymes(GO:0090340)
0.0 0.0 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.0 0.0 GO:0061145 bronchus cartilage development(GO:0060532) lung smooth muscle development(GO:0061145)
0.0 0.1 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.2 GO:0060019 radial glial cell differentiation(GO:0060019)
0.0 0.1 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.0 0.0 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.0 0.1 GO:0097473 cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.0 0.1 GO:0015692 lead ion transport(GO:0015692)
0.0 0.0 GO:0043449 cellular alkene metabolic process(GO:0043449)
0.0 0.1 GO:0046836 glycolipid transport(GO:0046836)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.1 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.0 GO:0060129 forebrain dorsal/ventral pattern formation(GO:0021798) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.0 GO:0061054 dermatome development(GO:0061054) regulation of dermatome development(GO:0061183)
0.0 0.0 GO:0036517 cardiac right atrium morphogenesis(GO:0003213) chemoattraction of serotonergic neuron axon(GO:0036517) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) chemoattraction of axon(GO:0061642) negative regulation of cell proliferation in midbrain(GO:1904934) planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation(GO:1904955)
0.0 0.0 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.0 0.0 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.0 GO:0090472 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.0 0.0 GO:0052552 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.0 0.0 GO:0010159 specification of organ position(GO:0010159)
0.0 0.2 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.1 GO:1902564 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of neutrophil activation(GO:1902564)
0.0 0.0 GO:1902339 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.1 GO:0030807 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.0 0.0 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0 0.1 GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0 0.0 GO:1900368 regulation of RNA interference(GO:1900368)
0.0 0.1 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.4 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:1990535 neuron projection maintenance(GO:1990535)
0.0 0.1 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 0.1 GO:0090650 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0036117 hyaluranon cable(GO:0036117)
0.0 0.4 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.1 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.6 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.1 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.4 GO:0034709 methylosome(GO:0034709)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.2 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.0 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.0 GO:0000806 Y chromosome(GO:0000806)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.0 GO:0000791 euchromatin(GO:0000791)
0.0 0.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.0 GO:0075341 host cell PML body(GO:0075341)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.4 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.2 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.2 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)
0.0 0.2 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.1 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.1 GO:0047291 neolactotetraosylceramide alpha-2,3-sialyltransferase activity(GO:0004513) lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.0 0.3 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.3 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.2 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.0 0.1 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.4 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.1 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.1 GO:0097108 hedgehog family protein binding(GO:0097108)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.1 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.0 0.1 GO:0003978 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.5 GO:0017166 vinculin binding(GO:0017166)
0.0 0.2 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.0 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.0 0.0 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0015087 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.0 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.2 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.0 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0035500 MH2 domain binding(GO:0035500)
0.0 0.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0016874 ligase activity(GO:0016874)
0.0 0.1 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.0 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.1 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.1 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.9 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.1 REACTOME SHC RELATED EVENTS Genes involved in SHC-related events