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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for EN2_GBX2_LBX2

Z-value: 0.20

Motif logo

Transcription factors associated with EN2_GBX2_LBX2

Gene Symbol Gene ID Gene Info
ENSG00000164778.4 engrailed homeobox 2
ENSG00000168505.6 gastrulation brain homeobox 2
ENSG00000179528.11 ladybird homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LBX2hg19_v2_chr2_-_74730430_74730451-0.443.8e-01Click!
EN2hg19_v2_chr7_+_155250824_155250824-0.266.2e-01Click!
GBX2hg19_v2_chr2_-_237076992_237077012-0.167.6e-01Click!

Activity profile of EN2_GBX2_LBX2 motif

Sorted Z-values of EN2_GBX2_LBX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_77427676 0.27 ENST00000257663.3
transmembrane protein 60
chr16_+_53133070 0.14 ENST00000565832.1
chromodomain helicase DNA binding protein 9
chr6_-_31107127 0.13 ENST00000259845.4
psoriasis susceptibility 1 candidate 2
chr4_-_36245561 0.13 ENST00000506189.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_+_77428066 0.10 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
putative homeodomain transcription factor 2
chr1_+_84767289 0.10 ENST00000394834.3
ENST00000370669.1
sterile alpha motif domain containing 13
chr18_+_32173276 0.09 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
dystrobrevin, alpha
chr19_-_14064114 0.09 ENST00000585607.1
ENST00000538517.2
ENST00000587458.1
ENST00000538371.2
podocan-like 1
chr7_+_77428149 0.08 ENST00000415251.2
ENST00000275575.7
putative homeodomain transcription factor 2
chr14_-_51027838 0.08 ENST00000555216.1
mitogen-activated protein kinase kinase kinase kinase 5
chr1_-_234667504 0.08 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
chr18_-_33709268 0.08 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
solute carrier family 39 (zinc transporter), member 6
chr5_-_95297534 0.08 ENST00000513343.1
ENST00000431061.2
elongation factor, RNA polymerase II, 2
chr12_+_28410128 0.08 ENST00000381259.1
ENST00000381256.1
coiled-coil domain containing 91
chr1_+_62901968 0.07 ENST00000452143.1
ENST00000442679.1
ENST00000371146.1
ubiquitin specific peptidase 1
chr12_-_89746173 0.07 ENST00000308385.6
dual specificity phosphatase 6
chr19_-_59084647 0.07 ENST00000594234.1
ENST00000596039.1
myeloid zinc finger 1
chr5_-_115890554 0.06 ENST00000509665.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr2_-_73460334 0.06 ENST00000258083.2
protease-associated domain containing 1
chr2_-_61697862 0.06 ENST00000398571.2
ubiquitin specific peptidase 34
chr1_-_151762943 0.06 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
tudor and KH domain containing
chr15_-_55562451 0.06 ENST00000568803.1
RAB27A, member RAS oncogene family
chr17_-_71223839 0.05 ENST00000579872.1
ENST00000580032.1
family with sequence similarity 104, member A
chr11_-_118023594 0.05 ENST00000529878.1
sodium channel, voltage-gated, type IV, beta subunit
chrX_-_46187069 0.05 ENST00000446884.1
RP1-30G7.2
chr2_+_17997763 0.05 ENST00000281047.3
mesogenin 1
chr15_+_96904487 0.04 ENST00000600790.1
Uncharacterized protein
chr14_-_73360796 0.04 ENST00000556509.1
ENST00000541685.1
ENST00000546183.1
D4, zinc and double PHD fingers, family 3
chrX_+_95939638 0.04 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
diaphanous-related formin 2
chr4_+_169013666 0.04 ENST00000359299.3
annexin A10
chrX_+_154444643 0.04 ENST00000286428.5
von Hippel-Lindau binding protein 1
chr15_+_58430368 0.04 ENST00000558772.1
ENST00000219919.4
aquaporin 9
chr11_-_31531121 0.04 ENST00000532287.1
ENST00000526776.1
ENST00000534812.1
ENST00000529749.1
ENST00000278200.1
ENST00000530023.1
ENST00000533642.1
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr15_-_37393406 0.04 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
Meis homeobox 2
chr3_+_172468749 0.04 ENST00000366254.2
ENST00000415665.1
ENST00000438041.1
epithelial cell transforming sequence 2 oncogene
chr8_+_92261516 0.04 ENST00000276609.3
ENST00000309536.2
solute carrier family 26 (anion exchanger), member 7
chr17_-_74163159 0.04 ENST00000591615.1
ring finger protein 157
chr3_+_130569429 0.03 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATPase, Ca++ transporting, type 2C, member 1
chr3_+_172468505 0.03 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
epithelial cell transforming sequence 2 oncogene
chr5_+_125758865 0.03 ENST00000542322.1
ENST00000544396.1
GRAM domain containing 3
chrX_+_47077680 0.03 ENST00000522883.1
cyclin-dependent kinase 16
chr1_-_151762900 0.03 ENST00000440583.2
tudor and KH domain containing
chr12_+_52695617 0.03 ENST00000293525.5
keratin 86
chr3_+_111718173 0.03 ENST00000494932.1
transgelin 3
chrX_+_100353153 0.03 ENST00000423383.1
ENST00000218507.5
ENST00000403304.2
ENST00000435570.1
centromere protein I
chr1_-_149785236 0.03 ENST00000331491.1
histone cluster 2, H3d
chr11_-_33913708 0.03 ENST00000257818.2
LIM domain only 2 (rhombotin-like 1)
chr2_+_149402989 0.03 ENST00000397424.2
enhancer of polycomb homolog 2 (Drosophila)
chr7_-_111424506 0.03 ENST00000450156.1
ENST00000494651.2
dedicator of cytokinesis 4
chr14_+_32798547 0.02 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chr6_-_111927449 0.02 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3 interacting protein 2
chrX_+_95939711 0.02 ENST00000373049.4
ENST00000324765.8
diaphanous-related formin 2
chr12_-_52828147 0.02 ENST00000252245.5
keratin 75
chr7_-_27169801 0.02 ENST00000511914.1
homeobox A4
chr1_-_152131703 0.02 ENST00000316073.3
repetin
chr12_+_64798826 0.02 ENST00000540203.1
exportin, tRNA
chr6_-_18264406 0.02 ENST00000515742.1
DEK oncogene
chr17_+_47448102 0.02 ENST00000576461.1
Uncharacterized protein
chr7_+_74072288 0.02 ENST00000443166.1
general transcription factor IIi
chr6_-_32157947 0.02 ENST00000375050.4
pre-B-cell leukemia homeobox 2
chr4_-_74486109 0.02 ENST00000395777.2
Ras association (RalGDS/AF-6) domain family member 6
chr3_+_167453493 0.02 ENST00000295777.5
ENST00000472747.2
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr1_-_118472171 0.02 ENST00000369442.3
ganglioside induced differentiation associated protein 2
chr15_+_80351910 0.02 ENST00000261749.6
ENST00000561060.1
zinc finger, AN1-type domain 6
chrX_+_129473916 0.02 ENST00000545805.1
ENST00000543953.1
ENST00000218197.5
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr3_-_178984759 0.02 ENST00000349697.2
ENST00000497599.1
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr18_-_53019208 0.02 ENST00000562607.1
transcription factor 4
chr3_+_133292759 0.02 ENST00000431519.2
CDV3 homolog (mouse)
chr14_-_82000140 0.02 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
sel-1 suppressor of lin-12-like (C. elegans)
chr6_-_111927062 0.02 ENST00000359831.4
TRAF3 interacting protein 2
chr3_+_119814070 0.02 ENST00000469070.1
RP11-18H7.1
chr11_+_75526212 0.02 ENST00000356136.3
UV radiation resistance associated
chr1_-_68698197 0.02 ENST00000370973.2
ENST00000370971.1
wntless Wnt ligand secretion mediator
chr22_+_41777927 0.02 ENST00000266304.4
thyrotrophic embryonic factor
chr12_-_57328187 0.02 ENST00000293502.1
short chain dehydrogenase/reductase family 9C, member 7
chrX_+_134654540 0.02 ENST00000370752.4
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr4_+_183065793 0.02 ENST00000512480.1
teneurin transmembrane protein 3
chr15_-_55563072 0.02 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A, member RAS oncogene family
chr3_+_172468472 0.02 ENST00000232458.5
ENST00000392692.3
epithelial cell transforming sequence 2 oncogene
chr1_-_2461684 0.02 ENST00000378453.3
hes family bHLH transcription factor 5
chr12_+_53662073 0.02 ENST00000553219.1
ENST00000257934.4
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr14_+_32798462 0.02 ENST00000280979.4
A kinase (PRKA) anchor protein 6
chr16_+_53164833 0.02 ENST00000564845.1
chromodomain helicase DNA binding protein 9
chr15_-_64673665 0.02 ENST00000300035.4
KIAA0101
chr7_-_92777606 0.02 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
sterile alpha motif domain containing 9-like
chr3_+_111717511 0.02 ENST00000478951.1
ENST00000393917.2
transgelin 3
chr5_+_125758813 0.02 ENST00000285689.3
ENST00000515200.1
GRAM domain containing 3
chr16_+_53164956 0.01 ENST00000563410.1
chromodomain helicase DNA binding protein 9
chr9_+_80912059 0.01 ENST00000347159.2
ENST00000376588.3
phosphoserine aminotransferase 1
chr11_+_57435441 0.01 ENST00000528177.1
zinc finger, DHHC-type containing 5
chr5_+_31193847 0.01 ENST00000514738.1
ENST00000265071.2
cadherin 6, type 2, K-cadherin (fetal kidney)
chr9_+_2159850 0.01 ENST00000416751.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr6_-_31088214 0.01 ENST00000376288.2
corneodesmosin
chr1_-_232651312 0.01 ENST00000262861.4
signal-induced proliferation-associated 1 like 2
chr4_-_89205879 0.01 ENST00000608933.1
ENST00000315194.4
ENST00000514204.1
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr12_-_56694142 0.01 ENST00000550655.1
ENST00000548567.1
ENST00000551430.2
ENST00000351328.3
citrate synthase
chr9_+_12693336 0.01 ENST00000381137.2
ENST00000388918.5
tyrosinase-related protein 1
chr1_+_153190053 0.01 ENST00000368744.3
proline rich 9
chr20_-_18447667 0.01 ENST00000262547.5
ENST00000329494.5
ENST00000357236.4
double zinc ribbon and ankyrin repeat domains 1
chr4_-_74486347 0.01 ENST00000342081.3
Ras association (RalGDS/AF-6) domain family member 6
chr6_+_135502501 0.01 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
v-myb avian myeloblastosis viral oncogene homolog
chr15_+_89631381 0.01 ENST00000352732.5
abhydrolase domain containing 2
chr2_+_171034646 0.01 ENST00000409044.3
ENST00000408978.4
myosin IIIB
chr2_-_157189180 0.01 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
nuclear receptor subfamily 4, group A, member 2
chr1_+_210501589 0.01 ENST00000413764.2
ENST00000541565.1
hedgehog acyltransferase
chr12_+_7014126 0.01 ENST00000415834.1
ENST00000436789.1
leucine rich repeat containing 23
chr1_-_23670817 0.01 ENST00000478691.1
heterogeneous nuclear ribonucleoprotein R
chrX_+_123097014 0.01 ENST00000394478.1
stromal antigen 2
chr19_-_10121144 0.01 ENST00000264828.3
collagen, type V, alpha 3
chr1_+_62439037 0.01 ENST00000545929.1
InaD-like (Drosophila)
chr1_-_23670813 0.01 ENST00000374612.1
heterogeneous nuclear ribonucleoprotein R
chrX_-_53461288 0.01 ENST00000375298.4
ENST00000375304.5
hydroxysteroid (17-beta) dehydrogenase 10
chr1_-_23670752 0.01 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
heterogeneous nuclear ribonucleoprotein R
chr3_+_152879985 0.01 ENST00000323534.2
RAP2B, member of RAS oncogene family
chr8_-_128231299 0.01 ENST00000500112.1
colon cancer associated transcript 1 (non-protein coding)
chr3_+_111718036 0.01 ENST00000455401.2
transgelin 3
chr17_-_47045949 0.01 ENST00000357424.2
gastric inhibitory polypeptide
chr2_+_242089833 0.01 ENST00000404405.3
ENST00000439916.1
ENST00000406106.3
ENST00000401987.1
protein phosphatase 1, regulatory subunit 7
chr14_+_104182105 0.01 ENST00000311141.2
zinc finger, FYVE domain containing 21
chr14_-_78083112 0.01 ENST00000216484.2
serine palmitoyltransferase, long chain base subunit 2
chr2_+_47630108 0.01 ENST00000233146.2
ENST00000454849.1
ENST00000543555.1
mutS homolog 2
chr18_+_32402321 0.01 ENST00000587723.1
dystrobrevin, alpha
chr15_-_31393910 0.01 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
transient receptor potential cation channel, subfamily M, member 1
chr7_-_83278322 0.01 ENST00000307792.3
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr18_-_31803169 0.01 ENST00000590712.1
nucleolar protein 4
chr19_+_48949087 0.01 ENST00000598711.1
glutamate-rich WD repeat containing 1
chr4_+_71587669 0.01 ENST00000381006.3
ENST00000226328.4
RUN and FYVE domain containing 3
chr2_+_86668464 0.01 ENST00000409064.1
lysine (K)-specific demethylase 3A
chr2_+_105654441 0.01 ENST00000258455.3
mitochondrial ribosomal protein S9
chr8_+_9413410 0.01 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr4_-_74486217 0.01 ENST00000335049.5
ENST00000307439.5
Ras association (RalGDS/AF-6) domain family member 6
chr2_+_47630255 0.01 ENST00000406134.1
mutS homolog 2
chr6_-_139613269 0.01 ENST00000358430.3
taxilin beta
chr12_-_16760021 0.01 ENST00000540445.1
LIM domain only 3 (rhombotin-like 2)
chr1_-_68698222 0.01 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
wntless Wnt ligand secretion mediator
chr3_+_111717600 0.01 ENST00000273368.4
transgelin 3
chr4_-_69111401 0.01 ENST00000332644.5
transmembrane protease, serine 11B
chr4_-_89205705 0.01 ENST00000295908.7
ENST00000510548.2
ENST00000508256.1
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr3_+_115342349 0.01 ENST00000393780.3
growth associated protein 43
chr14_-_74551172 0.01 ENST00000553458.1
aldehyde dehydrogenase 6 family, member A1
chr17_+_7792101 0.01 ENST00000358181.4
ENST00000330494.7
chromodomain helicase DNA binding protein 3
chr20_-_50722183 0.01 ENST00000371523.4
ZFP64 zinc finger protein
chr19_-_40931891 0.00 ENST00000357949.4
SERTA domain containing 1
chr6_+_39760129 0.00 ENST00000274867.4
dishevelled associated activator of morphogenesis 2
chr1_-_157746909 0.00 ENST00000392274.3
ENST00000361516.3
ENST00000368181.4
Fc receptor-like 2
chr19_+_34287751 0.00 ENST00000590771.1
ENST00000589786.1
ENST00000284006.6
ENST00000588881.1
potassium channel tetramerization domain containing 15
chr16_+_53412368 0.00 ENST00000565189.1
RP11-44F14.2
chr3_-_112360116 0.00 ENST00000206423.3
ENST00000439685.2
coiled-coil domain containing 80
chr12_+_53662110 0.00 ENST00000552462.1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr3_+_156799587 0.00 ENST00000469196.1
RP11-6F2.5
chr10_-_99447024 0.00 ENST00000370626.3
arginine vasopressin-induced 1
chr4_-_57547870 0.00 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOP homeobox
chr15_+_58430567 0.00 ENST00000536493.1
aquaporin 9
chr5_+_145826867 0.00 ENST00000296702.5
ENST00000394421.2
transcription elongation regulator 1
chr1_+_152943122 0.00 ENST00000328051.2
small proline-rich protein 4
chr4_-_174255536 0.00 ENST00000446922.2
high mobility group box 2
chr7_-_107642348 0.00 ENST00000393561.1
laminin, beta 1
chr18_+_55888767 0.00 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr9_-_133769225 0.00 ENST00000343079.1
pyroglutamylated RFamide peptide
chr21_-_43816052 0.00 ENST00000398405.1
transmembrane protease, serine 3
chr15_-_64673630 0.00 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
chr2_+_158114051 0.00 ENST00000259056.4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chrX_-_53461305 0.00 ENST00000168216.6
hydroxysteroid (17-beta) dehydrogenase 10
chr4_-_143226979 0.00 ENST00000514525.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr4_-_143227088 0.00 ENST00000511838.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr17_-_39203519 0.00 ENST00000542137.1
ENST00000391419.3
keratin associated protein 2-1
chr4_-_174255400 0.00 ENST00000506267.1
high mobility group box 2
chr9_+_116225999 0.00 ENST00000317613.6
regulator of G-protein signaling 3
chr2_+_65216462 0.00 ENST00000234256.3
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr5_+_141303373 0.00 ENST00000432126.2
ENST00000194118.4
KIAA0141
chr17_-_48785216 0.00 ENST00000285243.6
ankyrin repeat domain 40
chr1_+_110881945 0.00 ENST00000602849.1
ENST00000487146.2
RNA binding motif protein 15
chr17_-_10017864 0.00 ENST00000323816.4
growth arrest-specific 7
chr2_-_224467093 0.00 ENST00000305409.2
secretogranin II
chr6_-_116833500 0.00 ENST00000356128.4
trafficking protein particle complex 3-like
chr7_-_137028534 0.00 ENST00000348225.2
pleiotrophin
chr10_+_99205959 0.00 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
zinc finger, DHHC-type containing 16
chr4_-_174256276 0.00 ENST00000296503.5
high mobility group box 2
chr3_-_157217328 0.00 ENST00000392832.2
ENST00000543418.1
ventricular zone expressed PH domain-containing 1
chr14_+_104182061 0.00 ENST00000216602.6
zinc finger, FYVE domain containing 21
chr6_-_72130472 0.00 ENST00000426635.2
long intergenic non-protein coding RNA 472
chr4_-_39979576 0.00 ENST00000303538.8
ENST00000503396.1
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr3_-_27764190 0.00 ENST00000537516.1
eomesodermin
chr10_-_56561022 0.00 ENST00000373965.2
ENST00000414778.1
ENST00000395438.1
ENST00000409834.1
ENST00000395445.1
ENST00000395446.1
ENST00000395442.1
ENST00000395440.1
ENST00000395432.2
ENST00000361849.3
ENST00000395433.1
ENST00000320301.6
ENST00000395430.1
ENST00000437009.1
protocadherin-related 15
chr19_+_51728316 0.00 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33 molecule
chr11_-_71823715 0.00 ENST00000545944.1
ENST00000502597.2
anaphase promoting complex subunit 15

Network of associatons between targets according to the STRING database.

First level regulatory network of EN2_GBX2_LBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 0.1 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.0 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)