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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ESRRA_ESR2
Z-value: 3.16
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Transcription factors associated with ESRRA_ESR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESRRA | hg19_v2_chr11_+_64073699_64073918 | 0.58 | 2.2e-01 | Click! |
| ESR2 | hg19_v2_chr14_-_64804814_64804842 | 0.26 | 6.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_113735575 Show fit | 5.15 |
ENST00000376489.2
ENST00000259205.4 |
interleukin 36, gamma |
|
| chr2_+_228678550 Show fit | 4.53 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr1_-_47655686 Show fit | 4.26 |
ENST00000294338.2
|
PDZK1 interacting protein 1 |
|
| chr5_+_131409476 Show fit | 3.16 |
ENST00000296871.2
|
colony stimulating factor 2 (granulocyte-macrophage) |
|
| chr11_+_18154059 Show fit | 2.99 |
ENST00000531264.1
|
MAS-related GPR, member X3 |
|
| chr11_-_45928830 Show fit | 2.56 |
ENST00000449465.1
|
chromosome 11 open reading frame 94 |
|
| chr6_+_31916733 Show fit | 2.51 |
ENST00000483004.1
|
complement factor B |
|
| chr17_+_7533439 Show fit | 2.22 |
ENST00000441599.2
ENST00000380450.4 ENST00000416273.3 ENST00000575903.1 ENST00000576830.1 ENST00000571153.1 ENST00000575618.1 ENST00000576152.1 |
sex hormone-binding globulin |
|
| chr15_+_31658349 Show fit | 2.22 |
ENST00000558844.1
|
Kruppel-like factor 13 |
|
| chr5_-_150473127 Show fit | 2.01 |
ENST00000521001.1
|
TNFAIP3 interacting protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRA_ESR2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.2 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.1 | 5.6 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 5.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 5.2 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 0.0 | 4.8 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 1.5 | 4.5 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.1 | 4.3 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.1 | 4.2 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.8 | 3.9 | GO:0052250 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.1 | 3.8 | GO:0071624 | positive regulation of granulocyte chemotaxis(GO:0071624) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 9.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 7.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 5.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 4.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 4.9 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 4.6 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 4.1 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 3.9 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.9 | 3.5 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 8.6 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 8.1 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 8.0 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 6.2 | GO:0035591 | signaling adaptor activity(GO:0035591) |
| 0.0 | 6.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 6.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 6.0 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.5 | 5.9 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 5.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 8.0 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 5.5 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 5.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 5.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.9 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 4.3 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 4.2 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 4.1 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 4.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 22.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 8.3 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 7.7 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 7.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 6.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.3 | 5.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 4.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 4.6 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.1 | 4.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 4.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |