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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOXO4

Z-value: 0.62

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Transcription factors associated with FOXO4

Gene Symbol Gene ID Gene Info
FOXO4
ENSG00000184481.12 forkhead box O4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXO4hg19_v2_chrX_+_70316005_70316047-0.671.4e-01Click!

Activity profile of FOXO4 motif

Sorted Z-values of FOXO4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_94577074 0.55 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr1_-_47655686 0.55 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr11_-_104817919 0.43 ENST00000533252.1
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr1_+_81106951 0.41 ENST00000443565.1
RP5-887A10.1
RP5-887A10.1
chr7_+_37723336 0.38 ENST00000450180.1
GPR141
G protein-coupled receptor 141
chr17_+_17876127 0.37 ENST00000582416.1
ENST00000313838.8
ENST00000411504.2
ENST00000581264.1
ENST00000399187.1
ENST00000479684.2
ENST00000584166.1
ENST00000585108.1
ENST00000399182.1
ENST00000579977.1
LRRC48
leucine rich repeat containing 48
chr3_-_71777824 0.35 ENST00000469524.1
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr6_-_32122106 0.34 ENST00000428778.1
PRRT1
proline-rich transmembrane protein 1
chr6_+_62284008 0.31 ENST00000544932.1
MTRNR2L9
MT-RNR2-like 9 (pseudogene)
chr4_-_186696561 0.31 ENST00000445115.1
ENST00000451701.1
ENST00000457247.1
ENST00000435480.1
ENST00000425679.1
ENST00000457934.1
SORBS2
sorbin and SH3 domain containing 2
chr12_-_7596735 0.28 ENST00000416109.2
ENST00000396630.1
ENST00000313599.3
CD163L1
CD163 molecule-like 1
chr6_-_152623231 0.28 ENST00000540663.1
ENST00000537033.1
SYNE1
spectrin repeat containing, nuclear envelope 1
chr9_+_5510558 0.28 ENST00000397747.3
PDCD1LG2
programmed cell death 1 ligand 2
chr1_-_12679171 0.27 ENST00000606790.1
RP11-474O21.5
RP11-474O21.5
chr14_-_57197224 0.27 ENST00000554597.1
ENST00000556696.1
RP11-1085N6.3
Uncharacterized protein
chr10_+_86184676 0.26 ENST00000543283.1
CCSER2
coiled-coil serine-rich protein 2
chr3_-_52869205 0.25 ENST00000446157.2
MUSTN1
musculoskeletal, embryonic nuclear protein 1
chr3_-_139195350 0.24 ENST00000232217.2
RBP2
retinol binding protein 2, cellular
chr11_+_33061336 0.22 ENST00000602733.1
TCP11L1
t-complex 11, testis-specific-like 1
chr17_-_40134339 0.22 ENST00000587727.1
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr7_+_12250943 0.22 ENST00000442107.1
TMEM106B
transmembrane protein 106B
chr11_-_34535332 0.21 ENST00000257832.2
ENST00000429939.2
ELF5
E74-like factor 5 (ets domain transcription factor)
chr1_+_162039558 0.21 ENST00000530878.1
ENST00000361897.5
NOS1AP
nitric oxide synthase 1 (neuronal) adaptor protein
chr16_+_77233294 0.20 ENST00000378644.4
SYCE1L
synaptonemal complex central element protein 1-like
chr16_+_28857957 0.20 ENST00000567536.1
SH2B1
SH2B adaptor protein 1
chr4_-_85771168 0.20 ENST00000514071.1
WDFY3
WD repeat and FYVE domain containing 3
chr10_-_4285835 0.20 ENST00000454470.1
LINC00702
long intergenic non-protein coding RNA 702
chr8_+_31497271 0.20 ENST00000520407.1
NRG1
neuregulin 1
chr1_-_43855479 0.20 ENST00000290663.6
ENST00000372457.4
MED8
mediator complex subunit 8
chr3_+_121289551 0.19 ENST00000334384.3
ARGFX
arginine-fifty homeobox
chr3_-_48956818 0.19 ENST00000408959.2
ARIH2OS
ariadne homolog 2 opposite strand
chr6_-_134638767 0.18 ENST00000524929.1
SGK1
serum/glucocorticoid regulated kinase 1
chr1_-_43855444 0.18 ENST00000372455.4
MED8
mediator complex subunit 8
chr2_+_66918558 0.18 ENST00000435389.1
ENST00000428590.1
ENST00000412944.1
AC007392.3
AC007392.3
chr12_-_31479107 0.18 ENST00000542983.1
FAM60A
family with sequence similarity 60, member A
chr20_+_31823091 0.17 ENST00000601172.1
AL121901.1
Nasopharyngeal carcinoma-related protein YH1; Uncharacterized protein
chr10_-_4285923 0.17 ENST00000418372.1
ENST00000608792.1
LINC00702
long intergenic non-protein coding RNA 702
chr7_-_117512264 0.17 ENST00000454375.1
CTTNBP2
cortactin binding protein 2
chr16_+_4666475 0.16 ENST00000591895.1
MGRN1
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr8_-_116673894 0.16 ENST00000395713.2
TRPS1
trichorhinophalangeal syndrome I
chr21_-_32119551 0.16 ENST00000333892.2
KRTAP21-2
keratin associated protein 21-2
chr9_+_5510492 0.15 ENST00000397745.2
PDCD1LG2
programmed cell death 1 ligand 2
chr12_+_118454500 0.14 ENST00000537315.1
ENST00000229043.3
ENST00000484086.2
ENST00000420967.1
ENST00000454402.2
ENST00000392542.2
ENST00000535092.1
RFC5
replication factor C (activator 1) 5, 36.5kDa
chr3_-_185826718 0.14 ENST00000413301.1
ENST00000421809.1
ETV5
ets variant 5
chr5_-_115872142 0.14 ENST00000510263.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr9_+_27109133 0.14 ENST00000519097.1
ENST00000380036.4
TEK
TEK tyrosine kinase, endothelial
chr6_-_31651817 0.14 ENST00000375863.3
ENST00000375860.2
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr6_+_143447322 0.14 ENST00000458219.1
AIG1
androgen-induced 1
chr19_-_40732594 0.14 ENST00000430325.2
ENST00000433940.1
CNTD2
cyclin N-terminal domain containing 2
chr1_+_43855545 0.14 ENST00000372450.4
ENST00000310739.4
SZT2
seizure threshold 2 homolog (mouse)
chr11_-_62476965 0.13 ENST00000405837.1
ENST00000531524.1
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr4_+_124320665 0.13 ENST00000394339.2
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr10_+_75668916 0.13 ENST00000481390.1
PLAU
plasminogen activator, urokinase
chr22_+_45809560 0.13 ENST00000342894.3
ENST00000538017.1
RIBC2
RIB43A domain with coiled-coils 2
chr20_+_44035200 0.13 ENST00000372717.1
ENST00000360981.4
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr14_+_70918874 0.13 ENST00000603540.1
ADAM21
ADAM metallopeptidase domain 21
chr1_+_200011711 0.13 ENST00000544748.1
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr17_+_7533439 0.13 ENST00000441599.2
ENST00000380450.4
ENST00000416273.3
ENST00000575903.1
ENST00000576830.1
ENST00000571153.1
ENST00000575618.1
ENST00000576152.1
SHBG
sex hormone-binding globulin
chr3_-_112127981 0.13 ENST00000486726.2
RP11-231E6.1
RP11-231E6.1
chr5_+_137203541 0.13 ENST00000421631.2
MYOT
myotilin
chr11_-_62477313 0.12 ENST00000464544.1
ENST00000530009.1
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr17_+_41561317 0.12 ENST00000540306.1
ENST00000262415.3
ENST00000605777.1
DHX8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr9_+_27109392 0.12 ENST00000406359.4
TEK
TEK tyrosine kinase, endothelial
chr19_+_13906250 0.12 ENST00000254323.2
ZSWIM4
zinc finger, SWIM-type containing 4
chr3_-_185826855 0.12 ENST00000306376.5
ETV5
ets variant 5
chr2_+_226265364 0.11 ENST00000272907.6
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr11_-_62477041 0.11 ENST00000433053.1
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr6_+_106535455 0.11 ENST00000424894.1
PRDM1
PR domain containing 1, with ZNF domain
chr14_+_32964258 0.11 ENST00000556638.1
AKAP6
A kinase (PRKA) anchor protein 6
chr4_-_70518941 0.11 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UGT2A1
UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr1_+_172745006 0.11 ENST00000432694.2
RP1-15D23.2
RP1-15D23.2
chr4_+_105828492 0.11 ENST00000506148.1
RP11-556I14.1
RP11-556I14.1
chr8_+_95558771 0.11 ENST00000391679.1
AC023632.1
HCG2009141; PRO2397; Uncharacterized protein
chr2_+_12857043 0.11 ENST00000381465.2
TRIB2
tribbles pseudokinase 2
chr2_+_196522032 0.11 ENST00000418005.1
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr15_+_49462434 0.11 ENST00000558145.1
ENST00000543495.1
ENST00000544523.1
ENST00000560138.1
GALK2
galactokinase 2
chr1_+_154193643 0.10 ENST00000456325.1
UBAP2L
ubiquitin associated protein 2-like
chr16_-_65106110 0.10 ENST00000562882.1
ENST00000567934.1
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr11_-_119247004 0.10 ENST00000531070.1
USP2
ubiquitin specific peptidase 2
chr15_+_63188009 0.10 ENST00000557900.1
RP11-1069G10.2
RP11-1069G10.2
chr1_-_54405773 0.10 ENST00000371376.1
HSPB11
heat shock protein family B (small), member 11
chr2_+_58655461 0.10 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1
long intergenic non-protein coding RNA 1122
chr6_+_13182751 0.10 ENST00000415087.1
PHACTR1
phosphatase and actin regulator 1
chr11_-_85397167 0.10 ENST00000316398.3
CCDC89
coiled-coil domain containing 89
chr8_+_19171196 0.10 ENST00000518040.1
SH2D4A
SH2 domain containing 4A
chr11_+_12115543 0.10 ENST00000537344.1
ENST00000532179.1
ENST00000526065.1
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr8_-_74495065 0.10 ENST00000523533.1
STAU2
staufen double-stranded RNA binding protein 2
chr16_-_28608424 0.10 ENST00000335715.4
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr7_+_37723420 0.10 ENST00000476620.1
EPDR1
ependymin related 1
chr6_-_152489484 0.10 ENST00000354674.4
ENST00000539504.1
SYNE1
spectrin repeat containing, nuclear envelope 1
chr3_-_49066811 0.09 ENST00000442157.1
ENST00000326739.4
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr12_+_96588143 0.09 ENST00000228741.3
ENST00000547249.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr5_+_40841410 0.09 ENST00000381677.3
CARD6
caspase recruitment domain family, member 6
chr16_-_87729753 0.09 ENST00000538868.1
AC010536.1
Uncharacterized protein; cDNA FLJ45526 fis, clone BRTHA2027227
chr14_+_102606181 0.09 ENST00000335263.5
ENST00000322340.5
ENST00000424963.2
ENST00000342702.3
ENST00000556807.1
ENST00000499851.2
ENST00000558567.1
ENST00000299135.6
ENST00000454394.2
ENST00000556511.2
WDR20
WD repeat domain 20
chr18_+_47088401 0.09 ENST00000261292.4
ENST00000427224.2
ENST00000580036.1
LIPG
lipase, endothelial
chr1_+_28844778 0.09 ENST00000411533.1
RCC1
regulator of chromosome condensation 1
chr8_-_133772870 0.09 ENST00000522334.1
ENST00000519016.1
TMEM71
transmembrane protein 71
chr2_+_162165038 0.09 ENST00000437630.1
PSMD14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chr1_+_153940346 0.09 ENST00000405694.3
ENST00000449724.1
ENST00000368607.3
ENST00000271889.4
CREB3L4
cAMP responsive element binding protein 3-like 4
chr2_+_12857015 0.09 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr20_+_9049303 0.09 ENST00000407043.2
ENST00000441846.1
PLCB4
phospholipase C, beta 4
chr18_-_53303123 0.09 ENST00000569357.1
ENST00000565124.1
ENST00000398339.1
TCF4
transcription factor 4
chr4_+_146403912 0.08 ENST00000507367.1
ENST00000394092.2
ENST00000515385.1
SMAD1
SMAD family member 1
chr19_+_2270283 0.08 ENST00000588673.2
OAZ1
ornithine decarboxylase antizyme 1
chr15_+_75940218 0.08 ENST00000308527.5
SNX33
sorting nexin 33
chr1_+_154193325 0.08 ENST00000428931.1
ENST00000441890.1
ENST00000271877.7
ENST00000412596.1
ENST00000368504.1
ENST00000437652.1
UBAP2L
ubiquitin associated protein 2-like
chr5_-_59064458 0.08 ENST00000502575.1
ENST00000507116.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chrX_-_19689106 0.08 ENST00000379716.1
SH3KBP1
SH3-domain kinase binding protein 1
chr3_+_57875711 0.08 ENST00000442599.2
SLMAP
sarcolemma associated protein
chr9_+_27109440 0.08 ENST00000519080.1
TEK
TEK tyrosine kinase, endothelial
chr21_+_39668831 0.08 ENST00000419868.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr4_-_21950356 0.08 ENST00000447367.2
ENST00000382152.2
KCNIP4
Kv channel interacting protein 4
chr6_+_101846664 0.08 ENST00000421544.1
ENST00000413795.1
ENST00000369138.1
ENST00000358361.3
GRIK2
glutamate receptor, ionotropic, kainate 2
chr4_-_147442982 0.08 ENST00000511374.1
ENST00000264986.3
SLC10A7
solute carrier family 10, member 7
chr3_-_71294304 0.08 ENST00000498215.1
FOXP1
forkhead box P1
chr4_-_122148620 0.08 ENST00000509841.1
TNIP3
TNFAIP3 interacting protein 3
chr17_+_8924837 0.08 ENST00000173229.2
NTN1
netrin 1
chr14_-_75518129 0.08 ENST00000556257.1
ENST00000557648.1
ENST00000553263.1
ENST00000355774.2
ENST00000380968.2
ENST00000238662.7
MLH3
mutL homolog 3
chr1_+_43855560 0.08 ENST00000562955.1
SZT2
seizure threshold 2 homolog (mouse)
chr11_-_46141338 0.08 ENST00000529782.1
ENST00000532010.1
ENST00000525438.1
ENST00000533757.1
ENST00000527782.1
PHF21A
PHD finger protein 21A
chr2_+_33661382 0.08 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr14_-_103987679 0.08 ENST00000553610.1
CKB
creatine kinase, brain
chr10_+_111985837 0.08 ENST00000393134.1
MXI1
MAX interactor 1, dimerization protein
chr19_-_29704448 0.08 ENST00000304863.4
UQCRFS1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr8_-_141931287 0.08 ENST00000517887.1
PTK2
protein tyrosine kinase 2
chr2_+_157292933 0.08 ENST00000540309.1
GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr17_+_79213039 0.08 ENST00000431388.2
C17orf89
chromosome 17 open reading frame 89
chr12_-_92539614 0.08 ENST00000256015.3
BTG1
B-cell translocation gene 1, anti-proliferative
chr7_+_5229819 0.08 ENST00000288828.4
ENST00000401525.3
ENST00000404704.3
WIPI2
WD repeat domain, phosphoinositide interacting 2
chr15_-_40600026 0.08 ENST00000456256.2
ENST00000557821.1
PLCB2
phospholipase C, beta 2
chr2_-_214013353 0.08 ENST00000451136.2
ENST00000421754.2
ENST00000374327.4
ENST00000413091.3
IKZF2
IKAROS family zinc finger 2 (Helios)
chr1_-_168106536 0.08 ENST00000537209.1
ENST00000361697.2
ENST00000546300.1
ENST00000367835.1
GPR161
G protein-coupled receptor 161
chr20_+_44035847 0.07 ENST00000372712.2
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chrX_+_12156582 0.07 ENST00000380682.1
FRMPD4
FERM and PDZ domain containing 4
chr5_-_125930877 0.07 ENST00000510111.2
ENST00000509270.1
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr3_+_108015382 0.07 ENST00000463019.3
ENST00000491820.1
ENST00000467562.1
ENST00000482430.1
ENST00000462629.1
HHLA2
HERV-H LTR-associating 2
chr3_-_57530051 0.07 ENST00000311202.6
ENST00000351747.2
ENST00000495027.1
ENST00000389536.4
DNAH12
dynein, axonemal, heavy chain 12
chr19_-_7293942 0.07 ENST00000341500.5
ENST00000302850.5
INSR
insulin receptor
chr16_+_84801852 0.07 ENST00000569925.1
ENST00000567526.1
USP10
ubiquitin specific peptidase 10
chrX_-_110655391 0.07 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr8_-_6420565 0.07 ENST00000338312.6
ANGPT2
angiopoietin 2
chr2_+_157292859 0.07 ENST00000438166.2
GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr17_-_15554940 0.07 ENST00000455584.2
RP11-385D13.1
Uncharacterized protein
chr19_-_50380536 0.07 ENST00000391832.3
ENST00000391834.2
ENST00000344175.5
AKT1S1
AKT1 substrate 1 (proline-rich)
chr2_-_100721178 0.07 ENST00000409236.2
AFF3
AF4/FMR2 family, member 3
chr11_-_89224299 0.07 ENST00000343727.5
ENST00000531342.1
ENST00000375979.3
NOX4
NADPH oxidase 4
chr6_+_21666633 0.07 ENST00000606851.1
CASC15
cancer susceptibility candidate 15 (non-protein coding)
chr12_+_96588279 0.07 ENST00000552142.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr2_-_86422523 0.07 ENST00000442664.2
ENST00000409051.2
ENST00000449247.2
IMMT
inner membrane protein, mitochondrial
chr7_+_76101379 0.07 ENST00000429179.1
DTX2
deltex homolog 2 (Drosophila)
chr2_+_182850743 0.07 ENST00000409702.1
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr12_-_58240470 0.07 ENST00000548823.1
ENST00000398073.2
CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr20_-_1309809 0.07 ENST00000360779.3
SDCBP2
syndecan binding protein (syntenin) 2
chr5_-_133706695 0.07 ENST00000521755.1
ENST00000523054.1
ENST00000435240.2
ENST00000609654.1
ENST00000536186.1
ENST00000609383.1
CDKL3
cyclin-dependent kinase-like 3
chr5_+_60933634 0.07 ENST00000505642.1
C5orf64
chromosome 5 open reading frame 64
chr11_+_77532155 0.07 ENST00000532481.1
ENST00000526415.1
ENST00000393427.2
ENST00000527134.1
ENST00000304716.8
AAMDC
adipogenesis associated, Mth938 domain containing
chr11_+_57365150 0.07 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr3_-_141868357 0.07 ENST00000489671.1
ENST00000475734.1
ENST00000467072.1
ENST00000499676.2
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr17_+_2240916 0.07 ENST00000574563.1
SGSM2
small G protein signaling modulator 2
chr1_-_8075693 0.07 ENST00000467067.1
ERRFI1
ERBB receptor feedback inhibitor 1
chr5_+_137203557 0.06 ENST00000515645.1
MYOT
myotilin
chr7_+_12250886 0.06 ENST00000444443.1
ENST00000396667.3
TMEM106B
transmembrane protein 106B
chr2_-_128615681 0.06 ENST00000409955.1
ENST00000272645.4
POLR2D
polymerase (RNA) II (DNA directed) polypeptide D
chr3_-_98235962 0.06 ENST00000513873.1
CLDND1
claudin domain containing 1
chr16_-_28857677 0.06 ENST00000313511.3
TUFM
Tu translation elongation factor, mitochondrial
chr7_-_14028488 0.06 ENST00000405358.4
ETV1
ets variant 1
chr5_-_133510456 0.06 ENST00000520417.1
SKP1
S-phase kinase-associated protein 1
chr2_-_183731882 0.06 ENST00000295113.4
FRZB
frizzled-related protein
chr16_+_1730338 0.06 ENST00000566691.1
ENST00000382710.4
HN1L
hematological and neurological expressed 1-like
chr19_+_17378278 0.06 ENST00000596335.1
ENST00000601436.1
ENST00000595632.1
BABAM1
BRISC and BRCA1 A complex member 1
chr17_-_17875688 0.06 ENST00000379504.3
ENST00000318094.10
ENST00000540946.1
ENST00000542206.1
ENST00000395739.4
ENST00000581396.1
ENST00000535933.1
ENST00000579586.1
TOM1L2
target of myb1-like 2 (chicken)
chr11_-_82745238 0.06 ENST00000531021.1
RAB30
RAB30, member RAS oncogene family
chr12_-_109219937 0.06 ENST00000546697.1
SSH1
slingshot protein phosphatase 1
chr6_+_8652370 0.06 ENST00000503668.1
HULC
hepatocellular carcinoma up-regulated long non-coding RNA
chr1_+_41448820 0.06 ENST00000372616.1
CTPS1
CTP synthase 1
chr9_-_88896977 0.06 ENST00000311534.6
ISCA1
iron-sulfur cluster assembly 1
chr7_+_106505912 0.06 ENST00000359195.3
PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr16_-_79804394 0.06 ENST00000567993.1
RP11-345M22.2
RP11-345M22.2
chr6_+_32121789 0.06 ENST00000437001.2
ENST00000375137.2
PPT2
palmitoyl-protein thioesterase 2
chr1_+_15668240 0.06 ENST00000444385.1
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr5_-_58571935 0.06 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_82726817 0.06 ENST00000420549.1
RP11-147G16.1
RP11-147G16.1
chr2_+_173955327 0.06 ENST00000422149.1
MLTK
Mitogen-activated protein kinase kinase kinase MLT
chr4_-_186696515 0.06 ENST00000456596.1
ENST00000414724.1
SORBS2
sorbin and SH3 domain containing 2
chr2_-_197458323 0.06 ENST00000452031.1
HECW2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr9_+_134000948 0.06 ENST00000359428.5
ENST00000411637.2
ENST00000451030.1
NUP214
nucleoporin 214kDa
chr7_+_134832808 0.06 ENST00000275767.3
TMEM140
transmembrane protein 140
chr1_+_24018269 0.06 ENST00000374550.3
RPL11
ribosomal protein L11
chrX_-_110655306 0.06 ENST00000371993.2
DCX
doublecortin
chr15_-_40600111 0.06 ENST00000543785.2
ENST00000260402.3
PLCB2
phospholipase C, beta 2
chr5_+_176853702 0.05 ENST00000507633.1
ENST00000393576.3
ENST00000355958.5
ENST00000528793.1
ENST00000512684.1
GRK6
G protein-coupled receptor kinase 6
chr2_+_74229812 0.05 ENST00000305799.7
TET3
tet methylcytosine dioxygenase 3
chr9_+_706842 0.05 ENST00000382293.3
KANK1
KN motif and ankyrin repeat domains 1
chr10_-_73848086 0.05 ENST00000536168.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr11_-_62476694 0.05 ENST00000524862.1
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr10_-_1246300 0.05 ENST00000381310.3
ADARB2
adenosine deaminase, RNA-specific, B2 (non-functional)
chr13_+_32838801 0.05 ENST00000542859.1
FRY
furry homolog (Drosophila)
chr13_+_73629107 0.05 ENST00000539231.1
KLF5
Kruppel-like factor 5 (intestinal)
chr3_-_157221128 0.05 ENST00000392833.2
ENST00000362010.2
VEPH1
ventricular zone expressed PH domain-containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXO4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1903762 positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903762) positive regulation of ventricular cardiac muscle cell action potential(GO:1903947) positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential(GO:1905026) positive regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905033)
0.1 0.2 GO:0045081 negative regulation of interleukin-10 biosynthetic process(GO:0045081)
0.0 0.4 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.1 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.4 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.1 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.0 0.1 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.2 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.0 0.1 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.0 0.1 GO:0010983 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.0 0.1 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
0.0 0.2 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.3 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.1 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.0 0.1 GO:1903615 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.1 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.1 GO:1990535 neuron projection maintenance(GO:1990535)
0.0 0.2 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.4 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.2 GO:0038129 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.0 0.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.1 GO:1904717 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.0 0.1 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.1 GO:0044727 DNA demethylation of male pronucleus(GO:0044727)
0.0 0.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 0.1 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.0 0.1 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.0 0.1 GO:0002276 basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575)
0.0 0.1 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.2 GO:0035973 aggrephagy(GO:0035973)
0.0 0.1 GO:0061739 protein lipidation involved in autophagosome assembly(GO:0061739)
0.0 0.5 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.1 GO:0051945 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.1 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.0 GO:0002305 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.0 0.0 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.0 0.0 GO:0002740 negative regulation of cytokine secretion involved in immune response(GO:0002740)
0.0 0.0 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.0 0.1 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.1 GO:0060029 convergent extension involved in organogenesis(GO:0060029)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 0.2 GO:0097635 extrinsic component of autophagosome membrane(GO:0097635)
0.0 0.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.1 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.1 GO:0005712 chiasma(GO:0005712)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.4 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0035838 growing cell tip(GO:0035838)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0052590 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.0 0.1 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.9 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.4 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.2 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.3 GO:0016918 retinal binding(GO:0016918)
0.0 0.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.1 GO:0005497 androgen binding(GO:0005497)
0.0 0.1 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.0 0.1 GO:0003883 CTP synthase activity(GO:0003883)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.0 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.0 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME OPSINS Genes involved in Opsins
0.0 0.1 REACTOME SHC RELATED EVENTS Genes involved in SHC-related events
0.0 0.4 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling