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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for IRF2_STAT2_IRF8_IRF1
Z-value: 5.02
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Transcription factors associated with IRF2_STAT2_IRF8_IRF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
IRF2
|
ENSG00000168310.6 | interferon regulatory factor 2 |
|
STAT2
|
ENSG00000170581.9 | signal transducer and activator of transcription 2 |
|
IRF8
|
ENSG00000140968.6 | interferon regulatory factor 8 |
|
IRF1
|
ENSG00000125347.9 | interferon regulatory factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT2 | hg19_v2_chr12_-_56753858_56753930 | 0.94 | 5.4e-03 | Click! |
| IRF1 | hg19_v2_chr5_-_131826457_131826514 | 0.59 | 2.1e-01 | Click! |
| IRF2 | hg19_v2_chr4_-_185395672_185395734 | 0.16 | 7.6e-01 | Click! |
Activity profile of IRF2_STAT2_IRF8_IRF1 motif
Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_79086088 | 27.05 |
ENST00000370751.5
ENST00000342282.3 |
IFI44L
|
interferon-induced protein 44-like |
| chr14_+_94577074 | 26.54 |
ENST00000444961.1
ENST00000448882.1 ENST00000557098.1 ENST00000554800.1 ENST00000556544.1 ENST00000298902.5 ENST00000555819.1 ENST00000557634.1 ENST00000555744.1 |
IFI27
|
interferon, alpha-inducible protein 27 |
| chr21_+_42733870 | 15.45 |
ENST00000330714.3
ENST00000436410.1 ENST00000435611.1 |
MX2
|
myxovirus (influenza virus) resistance 2 (mouse) |
| chr21_+_42792442 | 12.87 |
ENST00000398600.2
|
MX1
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
| chr1_-_27998689 | 11.50 |
ENST00000339145.4
ENST00000362020.4 ENST00000361157.6 |
IFI6
|
interferon, alpha-inducible protein 6 |
| chr12_+_113416191 | 10.51 |
ENST00000342315.4
ENST00000392583.2 |
OAS2
|
2'-5'-oligoadenylate synthetase 2, 69/71kDa |
| chr17_+_6659354 | 9.89 |
ENST00000574907.1
|
XAF1
|
XIAP associated factor 1 |
| chr13_-_43566301 | 9.82 |
ENST00000398762.3
ENST00000313640.7 ENST00000313624.7 |
EPSTI1
|
epithelial stromal interaction 1 (breast) |
| chr6_+_32821924 | 9.73 |
ENST00000374859.2
ENST00000453265.2 |
PSMB9
|
proteasome (prosome, macropain) subunit, beta type, 9 |
| chr12_+_113376157 | 9.28 |
ENST00000228928.7
|
OAS3
|
2'-5'-oligoadenylate synthetase 3, 100kDa |
| chr11_-_615942 | 9.07 |
ENST00000397562.3
ENST00000330243.5 ENST00000397570.1 ENST00000397574.2 |
IRF7
|
interferon regulatory factor 7 |
| chr10_+_91152303 | 8.57 |
ENST00000371804.3
|
IFIT1
|
interferon-induced protein with tetratricopeptide repeats 1 |
| chr12_+_113416340 | 8.32 |
ENST00000552756.1
|
OAS2
|
2'-5'-oligoadenylate synthetase 2, 69/71kDa |
| chr12_+_113376249 | 7.74 |
ENST00000551007.1
ENST00000548514.1 |
OAS3
|
2'-5'-oligoadenylate synthetase 3, 100kDa |
| chr19_-_17516449 | 7.49 |
ENST00000252593.6
|
BST2
|
bone marrow stromal cell antigen 2 |
| chr1_+_948803 | 7.47 |
ENST00000379389.4
|
ISG15
|
ISG15 ubiquitin-like modifier |
| chr10_+_91087651 | 7.18 |
ENST00000371818.4
|
IFIT3
|
interferon-induced protein with tetratricopeptide repeats 3 |
| chr10_+_91092241 | 6.30 |
ENST00000371811.4
|
IFIT3
|
interferon-induced protein with tetratricopeptide repeats 3 |
| chr15_-_80263506 | 5.87 |
ENST00000335661.6
|
BCL2A1
|
BCL2-related protein A1 |
| chr21_+_42798094 | 5.80 |
ENST00000398598.3
ENST00000455164.2 ENST00000424365.1 |
MX1
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
| chr17_+_6659153 | 5.76 |
ENST00000441631.1
ENST00000438512.1 ENST00000346752.4 ENST00000361842.3 |
XAF1
|
XIAP associated factor 1 |
| chr12_+_113344811 | 5.24 |
ENST00000551241.1
ENST00000553185.1 ENST00000550689.1 |
OAS1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
| chr11_-_615570 | 5.13 |
ENST00000525445.1
ENST00000348655.6 ENST00000397566.1 |
IRF7
|
interferon regulatory factor 7 |
| chr1_+_79115503 | 4.67 |
ENST00000370747.4
ENST00000438486.1 ENST00000545124.1 |
IFI44
|
interferon-induced protein 44 |
| chr4_-_76944621 | 4.39 |
ENST00000306602.1
|
CXCL10
|
chemokine (C-X-C motif) ligand 10 |
| chr12_+_113344582 | 3.82 |
ENST00000202917.5
ENST00000445409.2 ENST00000452357.2 |
OAS1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
| chr21_+_42798124 | 3.81 |
ENST00000417963.1
|
MX1
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
| chr1_-_114429997 | 3.44 |
ENST00000471267.1
ENST00000393320.3 |
BCL2L15
|
BCL2-like 15 |
| chr12_+_113416265 | 3.41 |
ENST00000449768.2
|
OAS2
|
2'-5'-oligoadenylate synthetase 2, 69/71kDa |
| chr17_-_40264692 | 3.33 |
ENST00000591220.1
ENST00000251642.3 |
DHX58
|
DEXH (Asp-Glu-X-His) box polypeptide 58 |
| chr21_+_42797958 | 3.27 |
ENST00000419044.1
|
MX1
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
| chr21_+_42798158 | 3.24 |
ENST00000441677.1
|
MX1
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
| chr14_+_24630465 | 3.21 |
ENST00000557894.1
ENST00000559284.1 ENST00000560275.1 |
IRF9
|
interferon regulatory factor 9 |
| chr3_-_122283100 | 3.19 |
ENST00000492382.1
ENST00000462315.1 |
PARP9
|
poly (ADP-ribose) polymerase family, member 9 |
| chr17_-_4643114 | 3.18 |
ENST00000293778.6
|
CXCL16
|
chemokine (C-X-C motif) ligand 16 |
| chr8_-_23540402 | 3.12 |
ENST00000523261.1
ENST00000380871.4 |
NKX3-1
|
NK3 homeobox 1 |
| chr17_-_40264321 | 3.08 |
ENST00000430773.1
ENST00000413196.2 |
DHX58
|
DEXH (Asp-Glu-X-His) box polypeptide 58 |
| chr3_-_122283079 | 3.03 |
ENST00000471785.1
ENST00000466126.1 |
PARP9
|
poly (ADP-ribose) polymerase family, member 9 |
| chr9_+_5510558 | 2.91 |
ENST00000397747.3
|
PDCD1LG2
|
programmed cell death 1 ligand 2 |
| chr17_+_25958174 | 2.90 |
ENST00000313648.6
ENST00000577392.1 ENST00000584661.1 ENST00000413914.2 |
LGALS9
|
lectin, galactoside-binding, soluble, 9 |
| chr2_-_163175133 | 2.86 |
ENST00000421365.2
ENST00000263642.2 |
IFIH1
|
interferon induced with helicase C domain 1 |
| chr6_+_116782527 | 2.81 |
ENST00000368606.3
ENST00000368605.1 |
FAM26F
|
family with sequence similarity 26, member F |
| chr4_-_122148620 | 2.78 |
ENST00000509841.1
|
TNIP3
|
TNFAIP3 interacting protein 3 |
| chr2_-_191878874 | 2.76 |
ENST00000392322.3
ENST00000392323.2 ENST00000424722.1 ENST00000361099.3 |
STAT1
|
signal transducer and activator of transcription 1, 91kDa |
| chr3_-_122283424 | 2.76 |
ENST00000477522.2
ENST00000360356.2 |
PARP9
|
poly (ADP-ribose) polymerase family, member 9 |
| chr6_+_126240442 | 2.72 |
ENST00000448104.1
ENST00000438495.1 ENST00000444128.1 |
NCOA7
|
nuclear receptor coactivator 7 |
| chr17_-_4643161 | 2.72 |
ENST00000574412.1
|
CXCL16
|
chemokine (C-X-C motif) ligand 16 |
| chr2_-_191878681 | 2.68 |
ENST00000409465.1
|
STAT1
|
signal transducer and activator of transcription 1, 91kDa |
| chr7_-_92777606 | 2.45 |
ENST00000437805.1
ENST00000446959.1 ENST00000439952.1 ENST00000414791.1 ENST00000446033.1 ENST00000411955.1 ENST00000318238.4 |
SAMD9L
|
sterile alpha motif domain containing 9-like |
| chr5_-_95158375 | 2.43 |
ENST00000512469.2
ENST00000379979.4 ENST00000505427.1 ENST00000508780.1 |
GLRX
|
glutaredoxin (thioltransferase) |
| chr15_+_89182178 | 2.34 |
ENST00000559876.1
|
ISG20
|
interferon stimulated exonuclease gene 20kDa |
| chr9_-_32526299 | 2.24 |
ENST00000379882.1
ENST00000379883.2 |
DDX58
|
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
| chr11_+_313503 | 2.17 |
ENST00000528780.1
ENST00000328221.5 |
IFITM1
|
interferon induced transmembrane protein 1 |
| chr3_+_187086120 | 2.17 |
ENST00000259030.2
|
RTP4
|
receptor (chemosensory) transporter protein 4 |
| chr2_-_7005785 | 2.12 |
ENST00000256722.5
ENST00000404168.1 ENST00000458098.1 |
CMPK2
|
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
| chr9_-_32526184 | 2.11 |
ENST00000545044.1
ENST00000379868.1 |
DDX58
|
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
| chr8_-_79717750 | 2.08 |
ENST00000263851.4
ENST00000379113.2 |
IL7
|
interleukin 7 |
| chr11_-_321050 | 2.07 |
ENST00000399808.4
|
IFITM3
|
interferon induced transmembrane protein 3 |
| chr17_+_41994576 | 2.02 |
ENST00000588043.2
|
FAM215A
|
family with sequence similarity 215, member A (non-protein coding) |
| chr6_+_32811885 | 2.00 |
ENST00000458296.1
ENST00000413039.1 ENST00000429600.1 ENST00000412095.1 ENST00000415067.1 ENST00000395330.1 |
TAPSAR1
PSMB9
|
TAP1 and PSMB8 antisense RNA 1 proteasome (prosome, macropain) subunit, beta type, 9 |
| chr11_-_60719213 | 1.93 |
ENST00000227880.3
|
SLC15A3
|
solute carrier family 15 (oligopeptide transporter), member 3 |
| chr11_-_18258342 | 1.91 |
ENST00000278222.4
|
SAA4
|
serum amyloid A4, constitutive |
| chr17_+_6658878 | 1.90 |
ENST00000574394.1
|
XAF1
|
XIAP associated factor 1 |
| chr17_-_43339474 | 1.89 |
ENST00000331780.4
|
SPATA32
|
spermatogenesis associated 32 |
| chr12_-_49318715 | 1.88 |
ENST00000444214.2
|
FKBP11
|
FK506 binding protein 11, 19 kDa |
| chr9_+_5510492 | 1.88 |
ENST00000397745.2
|
PDCD1LG2
|
programmed cell death 1 ligand 2 |
| chr6_-_32821599 | 1.88 |
ENST00000354258.4
|
TAP1
|
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
| chr7_+_74188309 | 1.85 |
ENST00000289473.4
ENST00000433458.1 |
NCF1
|
neutrophil cytosolic factor 1 |
| chr6_+_27775899 | 1.83 |
ENST00000358739.3
|
HIST1H2AI
|
histone cluster 1, H2ai |
| chr16_+_12059091 | 1.82 |
ENST00000562385.1
|
TNFRSF17
|
tumor necrosis factor receptor superfamily, member 17 |
| chr11_-_57334732 | 1.81 |
ENST00000526659.1
ENST00000527022.1 |
UBE2L6
|
ubiquitin-conjugating enzyme E2L 6 |
| chr15_+_89182156 | 1.79 |
ENST00000379224.5
|
ISG20
|
interferon stimulated exonuclease gene 20kDa |
| chr6_+_3259148 | 1.74 |
ENST00000419065.2
ENST00000473000.2 ENST00000451246.2 ENST00000454610.2 |
PSMG4
|
proteasome (prosome, macropain) assembly chaperone 4 |
| chr15_+_74287035 | 1.71 |
ENST00000395132.2
ENST00000268059.6 ENST00000354026.6 ENST00000268058.3 ENST00000565898.1 ENST00000569477.1 ENST00000569965.1 ENST00000567543.1 ENST00000436891.3 ENST00000435786.2 ENST00000564428.1 ENST00000359928.4 |
PML
|
promyelocytic leukemia |
| chr11_-_102826434 | 1.63 |
ENST00000340273.4
ENST00000260302.3 |
MMP13
|
matrix metallopeptidase 13 (collagenase 3) |
| chr1_+_59486059 | 1.62 |
ENST00000447329.1
|
RP4-794H19.4
|
RP4-794H19.4 |
| chr8_-_145060593 | 1.61 |
ENST00000313059.5
ENST00000524918.1 ENST00000313028.7 ENST00000525773.1 |
PARP10
|
poly (ADP-ribose) polymerase family, member 10 |
| chr3_-_146262637 | 1.60 |
ENST00000472349.1
ENST00000342435.4 |
PLSCR1
|
phospholipid scramblase 1 |
| chr3_-_146262352 | 1.58 |
ENST00000462666.1
|
PLSCR1
|
phospholipid scramblase 1 |
| chr6_-_32811771 | 1.58 |
ENST00000395339.3
ENST00000374882.3 |
PSMB8
|
proteasome (prosome, macropain) subunit, beta type, 8 |
| chr12_+_102271129 | 1.56 |
ENST00000258534.8
|
DRAM1
|
DNA-damage regulated autophagy modulator 1 |
| chr12_-_49319265 | 1.55 |
ENST00000552878.1
ENST00000453172.2 |
FKBP11
|
FK506 binding protein 11, 19 kDa |
| chr22_-_36635225 | 1.54 |
ENST00000529194.1
|
APOL2
|
apolipoprotein L, 2 |
| chr19_+_17516494 | 1.54 |
ENST00000534306.1
|
CTD-2521M24.9
|
CTD-2521M24.9 |
| chr1_+_110453608 | 1.51 |
ENST00000369801.1
|
CSF1
|
colony stimulating factor 1 (macrophage) |
| chr3_+_122283175 | 1.51 |
ENST00000383661.3
|
DTX3L
|
deltex 3-like (Drosophila) |
| chr21_-_16135411 | 1.49 |
ENST00000435315.2
|
AF127936.5
|
AF127936.5 |
| chr19_+_17516531 | 1.48 |
ENST00000528911.1
ENST00000528604.1 ENST00000595892.1 ENST00000500836.2 ENST00000598546.1 ENST00000600369.1 ENST00000598356.1 ENST00000594426.1 |
MVB12A
CTD-2521M24.9
|
multivesicular body subunit 12A CTD-2521M24.9 |
| chr11_-_57335280 | 1.46 |
ENST00000287156.4
|
UBE2L6
|
ubiquitin-conjugating enzyme E2L 6 |
| chr11_-_2160180 | 1.41 |
ENST00000381406.4
|
IGF2
|
insulin-like growth factor 2 (somatomedin A) |
| chr17_+_4643337 | 1.40 |
ENST00000592813.1
|
ZMYND15
|
zinc finger, MYND-type containing 15 |
| chr3_-_49851313 | 1.37 |
ENST00000333486.3
|
UBA7
|
ubiquitin-like modifier activating enzyme 7 |
| chr11_+_72983246 | 1.36 |
ENST00000393590.2
|
P2RY6
|
pyrimidinergic receptor P2Y, G-protein coupled, 6 |
| chr3_-_146262428 | 1.36 |
ENST00000486631.1
|
PLSCR1
|
phospholipid scramblase 1 |
| chr3_+_122283064 | 1.35 |
ENST00000296161.4
|
DTX3L
|
deltex 3-like (Drosophila) |
| chr3_+_122399444 | 1.35 |
ENST00000474629.2
|
PARP14
|
poly (ADP-ribose) polymerase family, member 14 |
| chr17_+_41363854 | 1.34 |
ENST00000588693.1
ENST00000588659.1 ENST00000541594.1 ENST00000536052.1 ENST00000331615.3 |
TMEM106A
|
transmembrane protein 106A |
| chr11_-_62607036 | 1.33 |
ENST00000311713.7
ENST00000278856.4 |
WDR74
|
WD repeat domain 74 |
| chr8_+_72755367 | 1.31 |
ENST00000537896.1
|
RP11-383H13.1
|
Protein LOC100132891; cDNA FLJ53548 |
| chr17_-_43339453 | 1.29 |
ENST00000543122.1
|
SPATA32
|
spermatogenesis associated 32 |
| chr9_-_33402506 | 1.26 |
ENST00000377425.4
ENST00000537089.1 ENST00000297988.1 ENST00000539936.1 ENST00000541274.1 |
AQP7
|
aquaporin 7 |
| chr5_-_159797627 | 1.24 |
ENST00000393975.3
|
C1QTNF2
|
C1q and tumor necrosis factor related protein 2 |
| chr1_-_89531041 | 1.23 |
ENST00000370473.4
|
GBP1
|
guanylate binding protein 1, interferon-inducible |
| chr19_+_36239576 | 1.23 |
ENST00000587751.1
|
LIN37
|
lin-37 homolog (C. elegans) |
| chr11_-_321340 | 1.22 |
ENST00000526811.1
|
IFITM3
|
interferon induced transmembrane protein 3 |
| chr3_-_146262488 | 1.19 |
ENST00000487389.1
|
PLSCR1
|
phospholipid scramblase 1 |
| chr9_+_74764278 | 1.18 |
ENST00000238018.4
ENST00000376989.3 |
GDA
|
guanine deaminase |
| chr6_-_32806483 | 1.18 |
ENST00000374899.4
|
TAP2
|
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
| chr3_-_146262365 | 1.17 |
ENST00000448787.2
|
PLSCR1
|
phospholipid scramblase 1 |
| chr9_-_100881466 | 1.17 |
ENST00000341469.2
ENST00000342043.3 ENST00000375098.3 |
TRIM14
|
tripartite motif containing 14 |
| chr8_+_39770803 | 1.17 |
ENST00000518237.1
|
IDO1
|
indoleamine 2,3-dioxygenase 1 |
| chr6_-_29527702 | 1.14 |
ENST00000377050.4
|
UBD
|
ubiquitin D |
| chr1_-_161039647 | 1.14 |
ENST00000368013.3
|
ARHGAP30
|
Rho GTPase activating protein 30 |
| chr1_+_110453203 | 1.13 |
ENST00000357302.4
ENST00000344188.5 ENST00000329608.6 |
CSF1
|
colony stimulating factor 1 (macrophage) |
| chr19_+_10196781 | 1.12 |
ENST00000253110.11
|
C19orf66
|
chromosome 19 open reading frame 66 |
| chr6_+_3259122 | 1.12 |
ENST00000438998.2
ENST00000380305.4 |
PSMG4
|
proteasome (prosome, macropain) assembly chaperone 4 |
| chr22_-_36635598 | 1.10 |
ENST00000454728.1
|
APOL2
|
apolipoprotein L, 2 |
| chr1_-_161039753 | 1.08 |
ENST00000368015.1
|
ARHGAP30
|
Rho GTPase activating protein 30 |
| chr11_+_5710919 | 1.07 |
ENST00000379965.3
ENST00000425490.1 |
TRIM22
|
tripartite motif containing 22 |
| chr20_-_47894936 | 1.07 |
ENST00000371754.4
|
ZNFX1
|
zinc finger, NFX1-type containing 1 |
| chr20_+_6748311 | 1.06 |
ENST00000378827.4
|
BMP2
|
bone morphogenetic protein 2 |
| chr12_+_102271436 | 1.06 |
ENST00000544152.1
|
DRAM1
|
DNA-damage regulated autophagy modulator 1 |
| chr15_+_74287118 | 1.04 |
ENST00000563500.1
|
PML
|
promyelocytic leukemia |
| chr22_-_50765489 | 1.04 |
ENST00000413817.3
|
DENND6B
|
DENN/MADD domain containing 6B |
| chr17_-_4642429 | 1.04 |
ENST00000573123.1
|
CXCL16
|
chemokine (C-X-C motif) ligand 16 |
| chr16_-_74734672 | 1.03 |
ENST00000306247.7
ENST00000575686.1 |
MLKL
|
mixed lineage kinase domain-like |
| chr9_-_21368075 | 1.02 |
ENST00000449498.1
|
IFNA13
|
interferon, alpha 13 |
| chr14_-_69445968 | 1.00 |
ENST00000438964.2
|
ACTN1
|
actinin, alpha 1 |
| chr16_-_88851618 | 1.00 |
ENST00000301015.9
|
PIEZO1
|
piezo-type mechanosensitive ion channel component 1 |
| chr11_-_47270341 | 0.99 |
ENST00000529444.1
ENST00000530453.1 ENST00000537863.1 ENST00000529788.1 ENST00000444355.2 ENST00000527256.1 ENST00000529663.1 ENST00000256997.3 |
ACP2
|
acid phosphatase 2, lysosomal |
| chr2_+_33701684 | 0.99 |
ENST00000442390.1
|
RASGRP3
|
RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
| chr17_-_54991369 | 0.99 |
ENST00000537230.1
|
TRIM25
|
tripartite motif containing 25 |
| chr17_+_41158742 | 0.96 |
ENST00000415816.2
ENST00000438323.2 |
IFI35
|
interferon-induced protein 35 |
| chr2_-_152118276 | 0.96 |
ENST00000409092.1
|
RBM43
|
RNA binding motif protein 43 |
| chr4_-_169401628 | 0.96 |
ENST00000514748.1
ENST00000512371.1 ENST00000260184.7 ENST00000505890.1 ENST00000511577.1 |
DDX60L
|
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like |
| chr1_+_158901329 | 0.95 |
ENST00000368140.1
ENST00000368138.3 ENST00000392254.2 ENST00000392252.3 ENST00000368135.4 |
PYHIN1
|
pyrin and HIN domain family, member 1 |
| chr13_+_50070491 | 0.94 |
ENST00000496612.1
ENST00000357596.3 ENST00000485919.1 ENST00000442195.1 |
PHF11
|
PHD finger protein 11 |
| chr14_-_69446034 | 0.94 |
ENST00000193403.6
|
ACTN1
|
actinin, alpha 1 |
| chr14_-_21562671 | 0.93 |
ENST00000554923.1
|
ZNF219
|
zinc finger protein 219 |
| chr3_+_121289551 | 0.93 |
ENST00000334384.3
|
ARGFX
|
arginine-fifty homeobox |
| chr7_+_42971799 | 0.93 |
ENST00000223324.2
|
MRPL32
|
mitochondrial ribosomal protein L32 |
| chr5_-_66942617 | 0.92 |
ENST00000507298.1
|
RP11-83M16.5
|
RP11-83M16.5 |
| chr18_+_3466248 | 0.91 |
ENST00000581029.1
ENST00000581442.1 ENST00000579007.1 |
RP11-838N2.4
|
RP11-838N2.4 |
| chr9_+_108424738 | 0.91 |
ENST00000334077.3
|
TAL2
|
T-cell acute lymphocytic leukemia 2 |
| chr20_-_47894569 | 0.91 |
ENST00000371744.1
ENST00000371752.1 ENST00000396105.1 |
ZNFX1
|
zinc finger, NFX1-type containing 1 |
| chr11_-_64647144 | 0.91 |
ENST00000359393.2
ENST00000433803.1 ENST00000411683.1 |
EHD1
|
EH-domain containing 1 |
| chr9_+_26746951 | 0.91 |
ENST00000523363.1
|
RP11-18A15.1
|
RP11-18A15.1 |
| chr3_+_122399697 | 0.91 |
ENST00000494811.1
|
PARP14
|
poly (ADP-ribose) polymerase family, member 14 |
| chr17_-_4167142 | 0.89 |
ENST00000570535.1
ENST00000574367.1 ENST00000341657.4 ENST00000433651.1 |
ANKFY1
|
ankyrin repeat and FYVE domain containing 1 |
| chr22_-_36600727 | 0.88 |
ENST00000397275.2
ENST00000328429.4 |
APOL4
|
apolipoprotein L, 4 |
| chr7_-_77045617 | 0.87 |
ENST00000257626.7
|
GSAP
|
gamma-secretase activating protein |
| chr1_-_161014731 | 0.87 |
ENST00000368020.1
|
USF1
|
upstream transcription factor 1 |
| chr18_+_55712915 | 0.87 |
ENST00000592846.1
|
NEDD4L
|
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase |
| chr6_-_27775694 | 0.87 |
ENST00000377401.2
|
HIST1H2BL
|
histone cluster 1, H2bl |
| chr19_+_49977818 | 0.86 |
ENST00000594009.1
ENST00000595510.1 |
FLT3LG
|
fms-related tyrosine kinase 3 ligand |
| chr22_+_36649170 | 0.85 |
ENST00000438034.1
ENST00000427990.1 ENST00000347595.7 ENST00000397279.4 ENST00000433768.1 ENST00000440669.2 |
APOL1
|
apolipoprotein L, 1 |
| chr11_+_34663913 | 0.84 |
ENST00000532302.1
|
EHF
|
ets homologous factor |
| chr12_-_24737089 | 0.84 |
ENST00000483544.1
|
LINC00477
|
long intergenic non-protein coding RNA 477 |
| chr7_-_47621229 | 0.83 |
ENST00000434451.1
|
TNS3
|
tensin 3 |
| chr16_-_67970990 | 0.83 |
ENST00000358514.4
|
PSMB10
|
proteasome (prosome, macropain) subunit, beta type, 10 |
| chr7_+_18535321 | 0.82 |
ENST00000413380.1
ENST00000430454.1 |
HDAC9
|
histone deacetylase 9 |
| chr8_+_143808605 | 0.82 |
ENST00000336138.3
|
THEM6
|
thioesterase superfamily member 6 |
| chr22_-_30234218 | 0.81 |
ENST00000307790.3
ENST00000542393.1 ENST00000397771.2 |
ASCC2
|
activating signal cointegrator 1 complex subunit 2 |
| chr2_+_201981119 | 0.81 |
ENST00000395148.2
|
CFLAR
|
CASP8 and FADD-like apoptosis regulator |
| chr11_+_59705928 | 0.81 |
ENST00000398992.1
|
OOSP1
|
oocyte secreted protein 1 |
| chr10_-_135187193 | 0.79 |
ENST00000368547.3
|
ECHS1
|
enoyl CoA hydratase, short chain, 1, mitochondrial |
| chr6_-_32806506 | 0.79 |
ENST00000374897.2
ENST00000452392.2 |
TAP2
TAP2
|
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Uncharacterized protein |
| chr17_+_46918925 | 0.79 |
ENST00000502761.1
|
CALCOCO2
|
calcium binding and coiled-coil domain 2 |
| chr6_+_26273144 | 0.78 |
ENST00000377733.2
|
HIST1H2BI
|
histone cluster 1, H2bi |
| chr7_+_18535893 | 0.78 |
ENST00000432645.2
ENST00000441542.2 |
HDAC9
|
histone deacetylase 9 |
| chr5_-_95158644 | 0.78 |
ENST00000237858.6
|
GLRX
|
glutaredoxin (thioltransferase) |
| chr1_-_154580616 | 0.78 |
ENST00000368474.4
|
ADAR
|
adenosine deaminase, RNA-specific |
| chr10_-_128077024 | 0.77 |
ENST00000368679.4
ENST00000368676.4 ENST00000448723.1 |
ADAM12
|
ADAM metallopeptidase domain 12 |
| chr11_-_4414880 | 0.75 |
ENST00000254436.7
ENST00000543625.1 |
TRIM21
|
tripartite motif containing 21 |
| chr17_-_74489215 | 0.75 |
ENST00000585701.1
ENST00000591192.1 ENST00000589526.1 |
RHBDF2
|
rhomboid 5 homolog 2 (Drosophila) |
| chr7_-_76955563 | 0.75 |
ENST00000441833.2
|
GSAP
|
gamma-secretase activating protein |
| chr19_+_17516909 | 0.74 |
ENST00000601007.1
ENST00000594913.1 ENST00000599975.1 ENST00000600514.1 |
CTD-2521M24.9
MVB12A
|
CTD-2521M24.9 multivesicular body subunit 12A |
| chr2_-_220252530 | 0.74 |
ENST00000521459.1
|
DNPEP
|
aspartyl aminopeptidase |
| chr14_+_24605361 | 0.74 |
ENST00000206451.6
ENST00000559123.1 |
PSME1
|
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) |
| chr21_+_43933946 | 0.73 |
ENST00000352133.2
|
SLC37A1
|
solute carrier family 37 (glucose-6-phosphate transporter), member 1 |
| chr11_+_5711010 | 0.73 |
ENST00000454828.1
|
TRIM22
|
tripartite motif containing 22 |
| chr7_-_112635675 | 0.73 |
ENST00000447785.1
ENST00000451962.1 |
AC018464.3
|
AC018464.3 |
| chr11_+_308143 | 0.73 |
ENST00000399817.4
|
IFITM2
|
interferon induced transmembrane protein 2 |
| chr22_-_36635563 | 0.72 |
ENST00000451256.2
|
APOL2
|
apolipoprotein L, 2 |
| chr7_+_150382781 | 0.72 |
ENST00000223293.5
ENST00000474605.1 |
GIMAP2
|
GTPase, IMAP family member 2 |
| chr1_-_206306107 | 0.72 |
ENST00000436158.1
ENST00000455672.1 |
RP11-38J22.6
|
RP11-38J22.6 |
| chr11_-_18343669 | 0.72 |
ENST00000396253.3
ENST00000349215.3 ENST00000438420.2 |
HPS5
|
Hermansky-Pudlak syndrome 5 |
| chr8_-_27941380 | 0.72 |
ENST00000413272.2
ENST00000341513.6 |
NUGGC
|
nuclear GTPase, germinal center associated |
| chr6_+_62284008 | 0.71 |
ENST00000544932.1
|
MTRNR2L9
|
MT-RNR2-like 9 (pseudogene) |
| chr3_-_146262293 | 0.70 |
ENST00000448205.1
|
PLSCR1
|
phospholipid scramblase 1 |
| chr4_+_154622652 | 0.70 |
ENST00000260010.6
|
TLR2
|
toll-like receptor 2 |
| chr4_+_156587853 | 0.69 |
ENST00000506455.1
ENST00000511108.1 |
GUCY1A3
|
guanylate cyclase 1, soluble, alpha 3 |
| chr12_+_48876275 | 0.69 |
ENST00000314014.2
|
C12orf54
|
chromosome 12 open reading frame 54 |
| chr11_+_308217 | 0.68 |
ENST00000602569.1
|
IFITM2
|
interferon induced transmembrane protein 2 |
| chr6_-_11232891 | 0.68 |
ENST00000379433.5
ENST00000379446.5 |
NEDD9
|
neural precursor cell expressed, developmentally down-regulated 9 |
| chr14_-_24615805 | 0.68 |
ENST00000560410.1
|
PSME2
|
proteasome (prosome, macropain) activator subunit 2 (PA28 beta) |
| chr1_+_158149737 | 0.67 |
ENST00000368171.3
|
CD1D
|
CD1d molecule |
| chr1_-_198906528 | 0.67 |
ENST00000432296.1
|
MIR181A1HG
|
MIR181A1 host gene (non-protein coding) |
| chr21_-_37451680 | 0.67 |
ENST00000399201.1
|
SETD4
|
SET domain containing 4 |
| chr10_-_99161033 | 0.67 |
ENST00000315563.6
ENST00000370992.4 ENST00000414986.1 |
RRP12
|
ribosomal RNA processing 12 homolog (S. cerevisiae) |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF2_STAT2_IRF8_IRF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 14.2 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 2.5 | 7.5 | GO:0002731 | negative regulation of dendritic cell cytokine production(GO:0002731) |
| 2.1 | 8.6 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 2.1 | 44.4 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 2.0 | 22.2 | GO:0018377 | protein myristoylation(GO:0018377) |
| 1.4 | 7.2 | GO:0035549 | positive regulation of interferon-beta secretion(GO:0035549) |
| 1.4 | 16.8 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 1.4 | 5.4 | GO:0072308 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 1.2 | 6.2 | GO:0039534 | negative regulation of MDA-5 signaling pathway(GO:0039534) |
| 1.1 | 12.0 | GO:1904180 | negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180) |
| 1.0 | 12.0 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 1.0 | 2.9 | GO:0002361 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) natural killer cell tolerance induction(GO:0002519) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 1.0 | 3.8 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.9 | 4.6 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.8 | 10.1 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.8 | 3.9 | GO:0060611 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141) |
| 0.8 | 11.5 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.8 | 7.6 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 0.7 | 11.2 | GO:0010818 | T cell chemotaxis(GO:0010818) |
| 0.6 | 62.2 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.6 | 1.7 | GO:0006147 | guanine catabolic process(GO:0006147) |
| 0.5 | 2.1 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 0.5 | 3.1 | GO:2000836 | androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836) |
| 0.5 | 0.5 | GO:1903660 | negative regulation of complement-dependent cytotoxicity(GO:1903660) |
| 0.5 | 1.0 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 0.4 | 3.4 | GO:0030578 | PML body organization(GO:0030578) |
| 0.4 | 2.3 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.4 | 1.1 | GO:0060129 | negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) regulation of calcium-independent cell-cell adhesion(GO:0051040) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) |
| 0.3 | 1.3 | GO:0030885 | regulation of myeloid dendritic cell activation(GO:0030885) |
| 0.3 | 2.2 | GO:0019075 | virus maturation(GO:0019075) |
| 0.3 | 0.9 | GO:0050823 | peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823) |
| 0.3 | 1.2 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.3 | 0.8 | GO:0006624 | vacuolar protein processing(GO:0006624) |
| 0.3 | 4.7 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.3 | 1.1 | GO:0009224 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 0.3 | 0.3 | GO:1904933 | regulation of cell proliferation in midbrain(GO:1904933) |
| 0.3 | 3.8 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.2 | 1.0 | GO:0042495 | detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340) |
| 0.2 | 0.7 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.2 | 0.6 | GO:0061536 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 0.2 | 1.2 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 0.2 | 0.8 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
| 0.2 | 2.3 | GO:1903944 | negative regulation of myoblast fusion(GO:1901740) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.2 | 5.9 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.2 | 0.9 | GO:0002906 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
| 0.2 | 0.5 | GO:0033685 | negative regulation of luteinizing hormone secretion(GO:0033685) operant conditioning(GO:0035106) |
| 0.2 | 0.3 | GO:1903216 | regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217) |
| 0.2 | 0.2 | GO:0001302 | replicative cell aging(GO:0001302) |
| 0.2 | 0.5 | GO:1990654 | sebum secreting cell proliferation(GO:1990654) |
| 0.2 | 1.3 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.2 | 0.8 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.2 | 2.8 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.2 | 0.3 | GO:0060809 | mesodermal to mesenchymal transition involved in gastrulation(GO:0060809) |
| 0.1 | 0.4 | GO:1901842 | negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.1 | 0.9 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.1 | 2.4 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.1 | 0.3 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) |
| 0.1 | 0.4 | GO:0048007 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007) |
| 0.1 | 0.8 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.1 | 0.4 | GO:0036451 | cap mRNA methylation(GO:0036451) |
| 0.1 | 0.4 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) |
| 0.1 | 0.7 | GO:0021623 | optic cup structural organization(GO:0003409) oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623) |
| 0.1 | 1.1 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.1 | 12.6 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.1 | 0.4 | GO:0006481 | C-terminal protein methylation(GO:0006481) |
| 0.1 | 0.7 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.1 | 1.4 | GO:2000467 | positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 0.1 | 1.1 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.1 | 0.9 | GO:0000432 | regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) |
| 0.1 | 0.4 | GO:0005986 | sucrose biosynthetic process(GO:0005986) |
| 0.1 | 3.2 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
| 0.1 | 0.7 | GO:0010693 | negative regulation of alkaline phosphatase activity(GO:0010693) |
| 0.1 | 2.6 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.1 | 0.2 | GO:1903862 | positive regulation of oxidative phosphorylation(GO:1903862) |
| 0.1 | 0.6 | GO:0052199 | negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) |
| 0.1 | 0.5 | GO:0009257 | 10-formyltetrahydrofolate biosynthetic process(GO:0009257) |
| 0.1 | 0.3 | GO:0006425 | glutaminyl-tRNA aminoacylation(GO:0006425) |
| 0.1 | 0.2 | GO:0003051 | brain renin-angiotensin system(GO:0002035) angiotensin-mediated drinking behavior(GO:0003051) |
| 0.1 | 0.4 | GO:1900110 | negative regulation of histone H3-K9 dimethylation(GO:1900110) |
| 0.1 | 0.3 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
| 0.1 | 1.4 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.1 | 1.6 | GO:1902004 | positive regulation of beta-amyloid formation(GO:1902004) |
| 0.1 | 0.6 | GO:0007320 | insemination(GO:0007320) |
| 0.1 | 0.2 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.1 | 1.3 | GO:0045725 | positive regulation of glycogen biosynthetic process(GO:0045725) |
| 0.1 | 2.0 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.1 | 0.5 | GO:0006287 | base-excision repair, gap-filling(GO:0006287) |
| 0.1 | 0.2 | GO:0006533 | aspartate catabolic process(GO:0006533) |
| 0.1 | 0.3 | GO:1904116 | response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117) |
| 0.1 | 0.2 | GO:0006059 | hexitol metabolic process(GO:0006059) |
| 0.1 | 0.4 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.1 | 0.3 | GO:0071348 | cellular response to interleukin-11(GO:0071348) |
| 0.1 | 0.4 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.1 | 0.2 | GO:1900019 | regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020) |
| 0.1 | 0.6 | GO:0010990 | regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.1 | 0.3 | GO:1990927 | calcium ion regulated lysosome exocytosis(GO:1990927) |
| 0.1 | 0.1 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 0.1 | 1.9 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 0.3 | GO:0070092 | regulation of glucagon secretion(GO:0070092) |
| 0.1 | 0.6 | GO:0043473 | pigmentation(GO:0043473) |
| 0.1 | 0.2 | GO:0045113 | regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726) |
| 0.1 | 0.3 | GO:1905244 | regulation of modification of synaptic structure(GO:1905244) |
| 0.1 | 0.3 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 0.1 | 0.5 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
| 0.1 | 0.5 | GO:0045348 | positive regulation of MHC class II biosynthetic process(GO:0045348) |
| 0.1 | 0.5 | GO:0003138 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.1 | 0.4 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.1 | 0.3 | GO:1903336 | negative regulation of vacuolar transport(GO:1903336) |
| 0.1 | 0.3 | GO:1902728 | mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728) |
| 0.1 | 1.1 | GO:0021794 | thalamus development(GO:0021794) |
| 0.1 | 1.9 | GO:0002360 | T cell lineage commitment(GO:0002360) |
| 0.1 | 0.3 | GO:0070431 | nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431) |
| 0.1 | 0.2 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.1 | 0.4 | GO:0070164 | negative regulation of adiponectin secretion(GO:0070164) |
| 0.1 | 0.2 | GO:0061373 | mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.1 | 1.2 | GO:0051798 | positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798) |
| 0.1 | 0.5 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
| 0.1 | 0.2 | GO:0034154 | toll-like receptor 7 signaling pathway(GO:0034154) |
| 0.1 | 0.2 | GO:0043012 | regulation of fusion of sperm to egg plasma membrane(GO:0043012) |
| 0.1 | 0.4 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.1 | 0.4 | GO:0033590 | response to cobalamin(GO:0033590) response to erythropoietin(GO:0036017) cellular response to erythropoietin(GO:0036018) |
| 0.1 | 0.4 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 0.1 | 0.4 | GO:0050955 | thermoception(GO:0050955) |
| 0.1 | 1.4 | GO:1900745 | positive regulation of p38MAPK cascade(GO:1900745) |
| 0.1 | 0.2 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.1 | 0.9 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.1 | 0.3 | GO:1901526 | negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925) |
| 0.1 | 0.2 | GO:0045208 | MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209) |
| 0.1 | 2.0 | GO:0034142 | toll-like receptor 4 signaling pathway(GO:0034142) |
| 0.0 | 1.2 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 3.0 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.2 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.0 | 0.1 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin(GO:0033632) |
| 0.0 | 0.7 | GO:0050709 | negative regulation of protein secretion(GO:0050709) |
| 0.0 | 13.0 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.0 | 0.3 | GO:0060754 | positive regulation of mast cell chemotaxis(GO:0060754) |
| 0.0 | 0.7 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
| 0.0 | 0.7 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.0 | 1.4 | GO:0007567 | parturition(GO:0007567) |
| 0.0 | 3.7 | GO:0060135 | maternal process involved in female pregnancy(GO:0060135) |
| 0.0 | 0.1 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
| 0.0 | 0.2 | GO:0001507 | acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581) |
| 0.0 | 0.1 | GO:1990737 | regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) response to manganese-induced endoplasmic reticulum stress(GO:1990737) |
| 0.0 | 0.2 | GO:1904751 | positive regulation of protein localization to nucleolus(GO:1904751) |
| 0.0 | 0.2 | GO:0021678 | third ventricle development(GO:0021678) |
| 0.0 | 0.8 | GO:0021930 | cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930) |
| 0.0 | 0.1 | GO:0009443 | pyridoxal 5'-phosphate salvage(GO:0009443) |
| 0.0 | 0.3 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.0 | 0.3 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.0 | 0.2 | GO:0048690 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 0.0 | 0.2 | GO:0044111 | development involved in symbiotic interaction(GO:0044111) |
| 0.0 | 0.0 | GO:0002838 | negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859) |
| 0.0 | 0.6 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
| 0.0 | 1.5 | GO:0010390 | histone monoubiquitination(GO:0010390) |
| 0.0 | 0.1 | GO:0033037 | polysaccharide localization(GO:0033037) |
| 0.0 | 0.2 | GO:0060290 | transdifferentiation(GO:0060290) |
| 0.0 | 1.2 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.0 | 0.3 | GO:0098912 | membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.0 | 0.1 | GO:0031548 | regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548) |
| 0.0 | 0.0 | GO:0019442 | tryptophan catabolic process to acetyl-CoA(GO:0019442) |
| 0.0 | 0.1 | GO:0052331 | hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331) |
| 0.0 | 0.3 | GO:0009134 | nucleoside diphosphate catabolic process(GO:0009134) |
| 0.0 | 0.8 | GO:0050798 | activated T cell proliferation(GO:0050798) |
| 0.0 | 0.7 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.0 | 0.2 | GO:0098886 | modification of dendritic spine(GO:0098886) |
| 0.0 | 0.6 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 0.6 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.0 | 0.1 | GO:0038098 | sequestering of BMP from receptor via BMP binding(GO:0038098) |
| 0.0 | 0.1 | GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway(GO:0035791) |
| 0.0 | 0.3 | GO:1902410 | mitotic cytokinetic process(GO:1902410) |
| 0.0 | 0.2 | GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway(GO:0040036) |
| 0.0 | 1.9 | GO:0050918 | positive chemotaxis(GO:0050918) |
| 0.0 | 0.1 | GO:0002501 | peptide antigen assembly with MHC protein complex(GO:0002501) |
| 0.0 | 0.2 | GO:1902952 | positive regulation of dendritic spine maintenance(GO:1902952) |
| 0.0 | 0.7 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.0 | 0.4 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.0 | 0.3 | GO:0034214 | protein hexamerization(GO:0034214) |
| 0.0 | 0.1 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 0.0 | 0.5 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.0 | 0.2 | GO:2000769 | regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814) |
| 0.0 | 0.3 | GO:0090385 | phagosome-lysosome fusion(GO:0090385) |
| 0.0 | 0.1 | GO:0000350 | generation of catalytic spliceosome for second transesterification step(GO:0000350) |
| 0.0 | 0.5 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.0 | 0.2 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.0 | 0.1 | GO:1902080 | negative regulation of calcium-transporting ATPase activity(GO:1901895) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081) |
| 0.0 | 0.4 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.0 | 0.2 | GO:0090234 | regulation of kinetochore assembly(GO:0090234) |
| 0.0 | 0.4 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.0 | 0.3 | GO:0035973 | aggrephagy(GO:0035973) |
| 0.0 | 0.2 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.0 | 0.1 | GO:0021569 | rhombomere 3 development(GO:0021569) |
| 0.0 | 0.3 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.0 | 0.1 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 0.0 | 0.2 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
| 0.0 | 0.5 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.0 | 0.2 | GO:1902416 | regulation of mRNA binding(GO:1902415) positive regulation of mRNA binding(GO:1902416) |
| 0.0 | 0.2 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.0 | 0.3 | GO:0014029 | neural crest formation(GO:0014029) |
| 0.0 | 0.2 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 0.0 | 0.1 | GO:1904222 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.0 | 0.2 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.0 | 0.3 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 0.0 | 0.2 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 0.0 | 0.1 | GO:0019858 | diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966) cytosine metabolic process(GO:0019858) |
| 0.0 | 0.8 | GO:0034728 | nucleosome organization(GO:0034728) |
| 0.0 | 0.1 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.0 | 0.6 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.3 | GO:0031069 | hair follicle morphogenesis(GO:0031069) |
| 0.0 | 0.1 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.0 | 0.5 | GO:0031640 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) |
| 0.0 | 0.1 | GO:0097152 | mesenchymal cell apoptotic process(GO:0097152) |
| 0.0 | 0.1 | GO:0051106 | positive regulation of DNA ligation(GO:0051106) |
| 0.0 | 0.7 | GO:0030207 | chondroitin sulfate catabolic process(GO:0030207) |
| 0.0 | 0.2 | GO:0015760 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.0 | 0.1 | GO:0070904 | L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904) |
| 0.0 | 0.1 | GO:0006987 | activation of signaling protein activity involved in unfolded protein response(GO:0006987) |
| 0.0 | 0.2 | GO:0097062 | dendritic spine maintenance(GO:0097062) |
| 0.0 | 0.1 | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) |
| 0.0 | 0.2 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.0 | 0.2 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.0 | 0.1 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.0 | 0.2 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.0 | 0.1 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.0 | 0.2 | GO:0090154 | positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 0.0 | 0.1 | GO:0035989 | tendon development(GO:0035989) |
| 0.0 | 0.2 | GO:0003416 | endochondral bone growth(GO:0003416) |
| 0.0 | 0.1 | GO:0060167 | regulation of adenosine receptor signaling pathway(GO:0060167) |
| 0.0 | 0.4 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.0 | 0.2 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.0 | 0.1 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 0.0 | 0.1 | GO:1904764 | vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741) negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764) |
| 0.0 | 0.3 | GO:0098719 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.1 | GO:0042335 | cuticle development(GO:0042335) |
| 0.0 | 0.1 | GO:0060529 | ectoderm and mesoderm interaction(GO:0007499) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529) |
| 0.0 | 1.3 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.0 | 0.2 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.0 | 0.2 | GO:0006105 | succinate metabolic process(GO:0006105) |
| 0.0 | 0.1 | GO:0000270 | peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253) |
| 0.0 | 0.7 | GO:0048286 | lung alveolus development(GO:0048286) |
| 0.0 | 0.1 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.0 | 0.2 | GO:0060022 | hard palate development(GO:0060022) |
| 0.0 | 0.2 | GO:0002689 | negative regulation of leukocyte chemotaxis(GO:0002689) |
| 0.0 | 0.3 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.0 | 0.2 | GO:0006559 | L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222) |
| 0.0 | 0.1 | GO:0072343 | pancreatic stellate cell proliferation(GO:0072343) regulation of pancreatic stellate cell proliferation(GO:2000229) negative regulation of pancreatic stellate cell proliferation(GO:2000230) |
| 0.0 | 0.2 | GO:0006777 | Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) |
| 0.0 | 0.7 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.0 | 0.1 | GO:0048839 | inner ear development(GO:0048839) |
| 0.0 | 0.3 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.1 | GO:2000134 | negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.0 | 0.3 | GO:0070525 | tRNA threonylcarbamoyladenosine metabolic process(GO:0070525) |
| 0.0 | 0.3 | GO:0000183 | chromatin silencing at rDNA(GO:0000183) |
| 0.0 | 0.1 | GO:0006772 | thiamine metabolic process(GO:0006772) thiamine diphosphate metabolic process(GO:0042357) |
| 0.0 | 0.1 | GO:0009988 | cell-cell recognition(GO:0009988) |
| 0.0 | 0.1 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.0 | 0.1 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.0 | 0.3 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 0.0 | 0.2 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.0 | 0.1 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.0 | 0.3 | GO:0016048 | detection of temperature stimulus(GO:0016048) |
| 0.0 | 0.2 | GO:0001514 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.0 | 0.6 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
| 0.0 | 0.5 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
| 0.0 | 0.1 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.0 | 0.1 | GO:0048239 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.0 | 0.5 | GO:0072348 | sulfur compound transport(GO:0072348) |
| 0.0 | 0.3 | GO:0032211 | negative regulation of telomere maintenance via telomerase(GO:0032211) |
| 0.0 | 0.0 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.0 | 0.5 | GO:0061001 | regulation of dendritic spine morphogenesis(GO:0061001) |
| 0.0 | 0.3 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.0 | 0.0 | GO:0035655 | interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351) |
| 0.0 | 0.6 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 0.1 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.0 | 0.5 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 14.1 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.7 | 4.8 | GO:0042825 | TAP complex(GO:0042825) |
| 0.6 | 3.9 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.5 | 3.4 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.4 | 2.2 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.2 | 1.0 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
| 0.2 | 24.1 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.2 | 0.6 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 0.2 | 1.9 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.2 | 7.8 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 0.2 | 1.2 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.2 | 0.6 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.2 | 0.9 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.1 | 0.8 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.1 | 2.2 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 9.0 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 0.3 | GO:1990723 | cytoplasmic periphery of the nuclear pore complex(GO:1990723) |
| 0.1 | 15.2 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 2.5 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 1.1 | GO:0016589 | NURF complex(GO:0016589) |
| 0.1 | 0.5 | GO:0071547 | piP-body(GO:0071547) |
| 0.1 | 0.3 | GO:0098837 | postsynaptic recycling endosome(GO:0098837) |
| 0.1 | 1.2 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 0.3 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.1 | 0.9 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.1 | 0.3 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.1 | 0.3 | GO:0097635 | extrinsic component of autophagosome membrane(GO:0097635) |
| 0.1 | 0.5 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 6.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 1.4 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 0.4 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.1 | 2.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 29.1 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 0.4 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.1 | 0.8 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.1 | 0.9 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 0.7 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.1 | 0.2 | GO:0097444 | spine apparatus(GO:0097444) |
| 0.1 | 0.2 | GO:0045273 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.1 | 0.3 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.1 | 0.8 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.1 | 1.5 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 0.1 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.1 | 0.2 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 0.1 | 0.3 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.1 | 0.2 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 1.9 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 0.2 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.0 | 1.3 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 1.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.2 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 1.4 | GO:0071556 | integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
| 0.0 | 0.4 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.4 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 0.9 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.0 | 0.6 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.0 | 0.1 | GO:0071020 | post-spliceosomal complex(GO:0071020) |
| 0.0 | 0.3 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
| 0.0 | 1.3 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 0.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.4 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 0.1 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.0 | 0.3 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 0.2 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 0.6 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 69.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 0.1 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.0 | 0.3 | GO:0032059 | bleb(GO:0032059) |
| 0.0 | 0.1 | GO:0000333 | telomerase catalytic core complex(GO:0000333) |
| 0.0 | 0.3 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.0 | 0.3 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 0.1 | GO:0042022 | interleukin-12 receptor complex(GO:0042022) |
| 0.0 | 0.8 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 0.2 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.0 | 1.3 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.0 | 1.1 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.4 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 2.2 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.0 | 0.7 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.0 | 3.1 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 2.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 0.2 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.0 | 0.4 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.1 | GO:0032798 | Swi5-Sfr1 complex(GO:0032798) |
| 0.0 | 0.4 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 1.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.3 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 0.1 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.0 | 0.2 | GO:0032009 | early phagosome(GO:0032009) |
| 0.0 | 0.4 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 0.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 0.1 | GO:0097165 | nuclear stress granule(GO:0097165) |
| 0.0 | 0.4 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 0.1 | GO:0043196 | varicosity(GO:0043196) |
| 0.0 | 0.3 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 0.9 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 4.9 | GO:0045121 | membrane raft(GO:0045121) |
| 0.0 | 0.4 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.1 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.0 | 0.1 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.0 | 6.5 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.0 | 0.3 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 0.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.2 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.5 | GO:0030666 | endocytic vesicle membrane(GO:0030666) |
| 0.0 | 0.1 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 48.0 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 1.5 | 4.6 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 1.1 | 4.4 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.7 | 26.9 | GO:0005521 | lamin binding(GO:0005521) |
| 0.6 | 5.5 | GO:0046977 | TAP binding(GO:0046977) TAP1 binding(GO:0046978) |
| 0.6 | 7.5 | GO:0031386 | protein tag(GO:0031386) |
| 0.6 | 1.7 | GO:0008892 | guanine deaminase activity(GO:0008892) |
| 0.6 | 3.9 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.5 | 2.2 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.5 | 2.1 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.5 | 3.1 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.4 | 12.0 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.4 | 2.9 | GO:0005534 | galactose binding(GO:0005534) |
| 0.4 | 1.2 | GO:0004833 | tryptophan 2,3-dioxygenase activity(GO:0004833) |
| 0.4 | 7.6 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.3 | 3.2 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.3 | 1.7 | GO:0015333 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 0.3 | 8.5 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.3 | 5.9 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.3 | 1.3 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.3 | 7.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 6.9 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.2 | 2.2 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.2 | 3.2 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.2 | 1.1 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
| 0.2 | 1.7 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.2 | 0.8 | GO:1902379 | receptor tyrosine kinase-like orphan receptor binding(GO:0005115) chemoattractant activity involved in axon guidance(GO:1902379) |
| 0.2 | 1.7 | GO:0071723 | lipopeptide binding(GO:0071723) |
| 0.2 | 1.4 | GO:0045029 | UDP-activated nucleotide receptor activity(GO:0045029) |
| 0.2 | 0.5 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 0.2 | 3.8 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.2 | 0.5 | GO:0004995 | tachykinin receptor activity(GO:0004995) |
| 0.2 | 0.6 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
| 0.2 | 1.1 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.1 | 0.4 | GO:0004483 | mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483) |
| 0.1 | 1.4 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.1 | 0.4 | GO:0003880 | protein C-terminal carboxyl O-methyltransferase activity(GO:0003880) |
| 0.1 | 0.8 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.1 | 16.6 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 1.1 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.1 | 0.4 | GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132) |
| 0.1 | 67.3 | GO:0005525 | GTP binding(GO:0005525) |
| 0.1 | 1.9 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.1 | 12.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.1 | 0.5 | GO:0034584 | piRNA binding(GO:0034584) |
| 0.1 | 3.1 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 0.6 | GO:0045569 | TRAIL binding(GO:0045569) |
| 0.1 | 0.5 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.1 | 0.8 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 0.1 | 3.1 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 1.0 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.1 | 0.3 | GO:0004819 | glutamine-tRNA ligase activity(GO:0004819) |
| 0.1 | 0.3 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.1 | 1.3 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 0.1 | 0.3 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.1 | 0.3 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.1 | 0.5 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.1 | 0.3 | GO:0004967 | glucagon receptor activity(GO:0004967) |
| 0.1 | 0.4 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.1 | 0.2 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538) |
| 0.1 | 0.3 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 0.4 | GO:0015086 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.1 | 1.2 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.1 | 1.0 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.1 | 2.4 | GO:0031078 | NAD-dependent histone deacetylase activity(GO:0017136) histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) NAD-dependent protein deacetylase activity(GO:0034979) |
| 0.1 | 1.0 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.1 | 0.4 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
| 0.1 | 0.7 | GO:0015288 | porin activity(GO:0015288) |
| 0.1 | 0.2 | GO:0016435 | rRNA (guanine) methyltransferase activity(GO:0016435) |
| 0.1 | 0.2 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
| 0.1 | 1.9 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 1.3 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.1 | 0.7 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.1 | 2.3 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.1 | 0.3 | GO:0055077 | gap junction hemi-channel activity(GO:0055077) |
| 0.1 | 0.8 | GO:0004300 | enoyl-CoA hydratase activity(GO:0004300) |
| 0.1 | 0.8 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.1 | 0.6 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.1 | 1.5 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.1 | 0.2 | GO:0008441 | 3'(2'),5'-bisphosphate nucleotidase activity(GO:0008441) |
| 0.1 | 0.4 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.0 | 0.3 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.0 | 0.3 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
| 0.0 | 1.0 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 0.5 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
| 0.0 | 0.2 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.0 | 3.0 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 0.5 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 0.0 | 0.2 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.0 | 0.2 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
| 0.0 | 0.1 | GO:0000384 | first spliceosomal transesterification activity(GO:0000384) |
| 0.0 | 1.0 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.0 | 0.3 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.0 | 0.8 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.3 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.0 | 0.5 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.0 | 0.1 | GO:0016503 | pheromone receptor activity(GO:0016503) |
| 0.0 | 0.9 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 1.1 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 0.1 | GO:0008478 | pyridoxal kinase activity(GO:0008478) |
| 0.0 | 0.2 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.0 | 0.1 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.0 | 0.1 | GO:0034602 | oxoglutarate dehydrogenase (NAD+) activity(GO:0034602) |
| 0.0 | 0.2 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
| 0.0 | 0.3 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 2.6 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 0.2 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.0 | 0.3 | GO:0004340 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.0 | 0.8 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 0.3 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.0 | 0.2 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.0 | 0.1 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 0.0 | 0.2 | GO:0015252 | hydrogen ion channel activity(GO:0015252) |
| 0.0 | 0.1 | GO:0033149 | FFAT motif binding(GO:0033149) |
| 0.0 | 4.2 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.0 | 1.4 | GO:0030546 | receptor activator activity(GO:0030546) |
| 0.0 | 0.2 | GO:0030151 | molybdenum ion binding(GO:0030151) |
| 0.0 | 0.2 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.0 | 0.6 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.0 | 0.6 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 0.2 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.0 | 0.2 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 0.0 | 0.6 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.0 | 0.1 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.0 | 0.2 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
| 0.0 | 0.2 | GO:0015315 | hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513) |
| 0.0 | 0.6 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.2 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.0 | 2.1 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 0.2 | GO:1904929 | coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929) |
| 0.0 | 0.2 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.0 | 1.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.3 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 0.1 | GO:0016402 | pristanoyl-CoA oxidase activity(GO:0016402) |
| 0.0 | 0.7 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.3 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.0 | 0.1 | GO:0016517 | interleukin-12 receptor activity(GO:0016517) |
| 0.0 | 0.1 | GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 0.0 | 0.3 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 0.1 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.0 | 0.1 | GO:0015229 | L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
| 0.0 | 0.1 | GO:0042007 | interleukin-18 binding(GO:0042007) |
| 0.0 | 0.6 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.3 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 0.3 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 0.0 | 0.2 | GO:0035325 | Toll-like receptor binding(GO:0035325) |
| 0.0 | 0.4 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.0 | 0.2 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 0.0 | 0.2 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 0.3 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 0.3 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.0 | 0.2 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.0 | 0.4 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.0 | 0.1 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.0 | 0.5 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 0.2 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.0 | 0.2 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.0 | 1.1 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 0.1 | GO:0036122 | BMP binding(GO:0036122) |
| 0.0 | 0.4 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 1.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.8 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 2.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.4 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 0.8 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 0.1 | GO:0016657 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 0.0 | 0.1 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.0 | 0.1 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
| 0.0 | 0.6 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.2 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 0.1 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.0 | 0.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 0.4 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 1.0 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 1.2 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 0.1 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.0 | 0.0 | GO:0019864 | IgG binding(GO:0019864) |
| 0.0 | 0.1 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.0 | 0.1 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.1 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.0 | 1.0 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 0.5 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 0.5 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
| 0.0 | 0.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 8.0 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 19.6 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 2.8 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 2.1 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 6.0 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 12.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 4.0 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 0.3 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.1 | 0.5 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 3.6 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 2.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 3.3 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.3 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 1.6 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 1.1 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 1.5 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.2 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.1 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 2.0 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.3 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.4 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.3 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 1.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.0 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.3 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 0.2 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.2 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.0 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.9 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.1 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 0.3 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 211.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.6 | 9.1 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.2 | 11.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 12.9 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.2 | 4.7 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.1 | 2.4 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 6.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 10.5 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.1 | 1.2 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 2.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 1.0 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.1 | 2.0 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 1.7 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 3.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 0.5 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.1 | 0.8 | REACTOME SIGNALING BY EGFR IN CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.1 | 1.3 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 1.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 1.0 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 1.3 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 1.9 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.8 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.9 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.0 | 0.8 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 0.6 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 2.3 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 1.1 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 0.7 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 1.4 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 1.1 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.8 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.5 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.3 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.1 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 0.2 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.0 | 1.3 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 0.3 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.1 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 0.3 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.0 | 0.3 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.2 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.4 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 1.2 | REACTOME INTERFERON SIGNALING | Genes involved in Interferon Signaling |
| 0.0 | 0.2 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.2 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.3 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |