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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRX5

Z-value: 1.23

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Transcription factors associated with IRX5

Gene Symbol Gene ID Gene Info
IRX5
ENSG00000176842.10 iroquois homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX5hg19_v2_chr16_+_54964740_54964789-0.148.0e-01Click!

Activity profile of IRX5 motif

Sorted Z-values of IRX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_141264597 2.83 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr14_+_73563735 1.54 ENST00000532192.1
RBM25
RNA binding motif protein 25
chr6_+_71104588 1.32 ENST00000418403.1
RP11-462G2.1
RP11-462G2.1
chr15_+_66585555 0.98 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr1_-_186365908 0.96 ENST00000598663.1
AL596220.1
Uncharacterized protein
chr13_+_97928395 0.96 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr16_+_48657361 0.89 ENST00000565072.1
RP11-42I10.1
RP11-42I10.1
chr1_+_158969752 0.82 ENST00000566111.1
IFI16
interferon, gamma-inducible protein 16
chr14_+_39944025 0.74 ENST00000554328.1
ENST00000556620.1
ENST00000557197.1
RP11-111A21.1
RP11-111A21.1
chr10_-_115904361 0.69 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr11_+_31531291 0.64 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chr17_+_58018269 0.64 ENST00000591035.1
RP11-178C3.1
Uncharacterized protein
chr1_-_197115818 0.57 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr5_+_136070614 0.57 ENST00000502421.1
CTB-1I21.1
CTB-1I21.1
chr1_+_63989004 0.56 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr12_-_100486668 0.54 ENST00000550544.1
ENST00000551980.1
ENST00000548045.1
ENST00000545232.2
ENST00000551973.1
UHRF1BP1L
UHRF1 binding protein 1-like
chr4_-_104119528 0.54 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr7_+_116451100 0.50 ENST00000464223.1
ENST00000484325.1
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr1_-_115124257 0.49 ENST00000369541.3
BCAS2
breast carcinoma amplified sequence 2
chr7_+_116502527 0.49 ENST00000361183.3
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr4_+_71091786 0.49 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr14_+_56127989 0.48 ENST00000555573.1
KTN1
kinectin 1 (kinesin receptor)
chr8_-_17555164 0.46 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr1_+_53480598 0.46 ENST00000430330.2
ENST00000408941.3
ENST00000478274.2
ENST00000484100.1
ENST00000435345.2
ENST00000488965.1
SCP2
sterol carrier protein 2
chr10_-_18944123 0.46 ENST00000606425.1
RP11-139J15.7
Uncharacterized protein
chr13_-_38172863 0.46 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr8_+_101349823 0.44 ENST00000519566.1
KB-1991G8.1
KB-1991G8.1
chr4_-_75695366 0.43 ENST00000512743.1
BTC
betacellulin
chr1_+_212475148 0.42 ENST00000537030.3
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr12_+_32655048 0.42 ENST00000427716.2
ENST00000266482.3
FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_-_116383738 0.42 ENST00000320238.3
NHLH2
nescient helix loop helix 2
chr12_-_76462713 0.41 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr3_+_180586536 0.41 ENST00000465551.1
FXR1
fragile X mental retardation, autosomal homolog 1
chr10_-_96829246 0.41 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
CYP2C8
cytochrome P450, family 2, subfamily C, polypeptide 8
chr16_+_76668895 0.40 ENST00000512279.1
RP11-96P7.1
RP11-96P7.1
chr4_+_159131630 0.38 ENST00000504569.1
ENST00000509278.1
ENST00000514558.1
ENST00000503200.1
TMEM144
transmembrane protein 144
chr5_+_128300810 0.36 ENST00000262462.4
SLC27A6
solute carrier family 27 (fatty acid transporter), member 6
chr14_+_56127960 0.36 ENST00000553624.1
KTN1
kinectin 1 (kinesin receptor)
chr13_-_34250861 0.35 ENST00000445227.1
ENST00000454681.2
RP11-141M1.3
RP11-141M1.3
chr1_+_87012753 0.35 ENST00000370563.3
CLCA4
chloride channel accessory 4
chr7_+_77469439 0.34 ENST00000450574.1
ENST00000416283.2
ENST00000248550.7
PHTF2
putative homeodomain transcription factor 2
chr4_-_104119488 0.34 ENST00000514974.1
CENPE
centromere protein E, 312kDa
chr3_-_27498235 0.34 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr2_+_160590469 0.34 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr11_+_114310237 0.33 ENST00000539119.1
REXO2
RNA exonuclease 2
chr12_-_58329819 0.33 ENST00000551421.1
RP11-620J15.3
RP11-620J15.3
chr11_-_104905840 0.32 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
CASP1
caspase 1, apoptosis-related cysteine peptidase
chr1_-_244006528 0.32 ENST00000336199.5
ENST00000263826.5
AKT3
v-akt murine thymoma viral oncogene homolog 3
chr10_+_118349920 0.31 ENST00000531984.1
PNLIPRP1
pancreatic lipase-related protein 1
chr6_-_111804905 0.31 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr4_+_144312659 0.31 ENST00000509992.1
GAB1
GRB2-associated binding protein 1
chr6_-_111804393 0.31 ENST00000368802.3
ENST00000368805.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr5_-_93447333 0.30 ENST00000395965.3
ENST00000505869.1
ENST00000509163.1
FAM172A
family with sequence similarity 172, member A
chr16_+_19535133 0.30 ENST00000396212.2
ENST00000381396.5
CCP110
centriolar coiled coil protein 110kDa
chr15_+_65204075 0.29 ENST00000380230.3
ENST00000357698.3
ENST00000395720.1
ENST00000496660.1
ENST00000319580.8
ANKDD1A
ankyrin repeat and death domain containing 1A
chr2_-_206950996 0.29 ENST00000414320.1
INO80D
INO80 complex subunit D
chr17_-_29641104 0.29 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chrX_+_12809463 0.29 ENST00000380663.3
ENST00000380668.5
ENST00000398491.2
ENST00000489404.1
PRPS2
phosphoribosyl pyrophosphate synthetase 2
chr5_+_81601166 0.29 ENST00000439350.1
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr12_+_32655110 0.29 ENST00000546442.1
ENST00000583694.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr10_-_35379524 0.29 ENST00000374751.3
ENST00000374742.1
ENST00000602371.1
CUL2
cullin 2
chr18_-_28622774 0.28 ENST00000434452.1
DSC3
desmocollin 3
chr11_-_35547572 0.28 ENST00000378880.2
PAMR1
peptidase domain containing associated with muscle regeneration 1
chr12_-_10282742 0.28 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr2_+_38177575 0.28 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2
regulator of microtubule dynamics 2
chr3_-_196987309 0.27 ENST00000453607.1
DLG1
discs, large homolog 1 (Drosophila)
chr10_+_90484301 0.27 ENST00000404190.1
LIPK
lipase, family member K
chr12_+_2912363 0.27 ENST00000544366.1
FKBP4
FK506 binding protein 4, 59kDa
chr16_+_19535235 0.27 ENST00000565376.2
ENST00000396208.2
CCP110
centriolar coiled coil protein 110kDa
chr15_+_41057818 0.27 ENST00000558467.1
GCHFR
GTP cyclohydrolase I feedback regulator
chr12_-_123728548 0.26 ENST00000545406.1
MPHOSPH9
M-phase phosphoprotein 9
chr15_+_66585879 0.26 ENST00000319212.4
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chrX_-_138790348 0.26 ENST00000414978.1
ENST00000519895.1
MCF2
MCF.2 cell line derived transforming sequence
chr1_+_196788887 0.26 ENST00000320493.5
ENST00000367424.4
ENST00000367421.3
CFHR1
CFHR2
complement factor H-related 1
complement factor H-related 2
chrX_-_83757399 0.26 ENST00000373177.2
ENST00000297977.5
ENST00000506585.2
ENST00000449553.2
HDX
highly divergent homeobox
chr15_+_81225699 0.25 ENST00000560027.1
KIAA1199
KIAA1199
chr2_-_88125471 0.25 ENST00000398146.3
RGPD2
RANBP2-like and GRIP domain containing 2
chr18_-_32924372 0.25 ENST00000261332.6
ENST00000399061.3
ZNF24
zinc finger protein 24
chr6_+_26217159 0.25 ENST00000303910.2
HIST1H2AE
histone cluster 1, H2ae
chr7_+_13141010 0.24 ENST00000443947.1
AC011288.2
AC011288.2
chr12_-_52867569 0.24 ENST00000252250.6
KRT6C
keratin 6C
chr3_-_9994021 0.24 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr20_+_54933971 0.24 ENST00000371384.3
ENST00000437418.1
FAM210B
family with sequence similarity 210, member B
chr4_+_130017268 0.23 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr18_+_22006580 0.23 ENST00000284202.4
IMPACT
impact RWD domain protein
chr3_-_168865522 0.23 ENST00000464456.1
MECOM
MDS1 and EVI1 complex locus
chr1_+_87012922 0.23 ENST00000263723.5
CLCA4
chloride channel accessory 4
chr14_-_23623577 0.23 ENST00000422941.2
ENST00000453702.1
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr11_-_6790286 0.22 ENST00000338569.2
OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr17_-_29641084 0.22 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr4_+_76995855 0.22 ENST00000355810.4
ENST00000349321.3
ART3
ADP-ribosyltransferase 3
chr9_-_19065082 0.22 ENST00000415524.1
HAUS6
HAUS augmin-like complex, subunit 6
chr3_+_111630451 0.22 ENST00000495180.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr10_+_118187379 0.22 ENST00000369230.3
PNLIPRP3
pancreatic lipase-related protein 3
chr12_-_11036844 0.22 ENST00000428168.2
PRH1
proline-rich protein HaeIII subfamily 1
chr12_-_25102252 0.21 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr22_+_20877924 0.21 ENST00000445189.1
MED15
mediator complex subunit 15
chr1_-_62190793 0.21 ENST00000371177.2
ENST00000606498.1
TM2D1
TM2 domain containing 1
chr15_-_56757329 0.21 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr3_+_160473996 0.20 ENST00000498165.1
PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr6_+_116850174 0.20 ENST00000416171.2
ENST00000368597.2
ENST00000452373.1
ENST00000405399.1
FAM26D
family with sequence similarity 26, member D
chr7_-_55583740 0.19 ENST00000453256.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr6_+_149887377 0.19 ENST00000367419.5
GINM1
glycoprotein integral membrane 1
chr12_+_5541267 0.18 ENST00000423158.3
NTF3
neurotrophin 3
chr10_-_91403625 0.17 ENST00000322191.6
ENST00000342512.3
ENST00000371774.2
PANK1
pantothenate kinase 1
chr9_-_125667618 0.17 ENST00000423239.2
RC3H2
ring finger and CCCH-type domains 2
chr2_+_191792376 0.17 ENST00000409428.1
ENST00000409215.1
GLS
glutaminase
chr17_+_18380051 0.17 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
LGALS9C
lectin, galactoside-binding, soluble, 9C
chr1_-_114355083 0.17 ENST00000261441.5
RSBN1
round spermatid basic protein 1
chr8_-_101724989 0.17 ENST00000517403.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr9_-_3489428 0.17 ENST00000451859.1
RFX3
regulatory factor X, 3 (influences HLA class II expression)
chr5_+_179135246 0.16 ENST00000508787.1
CANX
calnexin
chr12_+_75874460 0.16 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr1_+_220267429 0.16 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr1_+_87458692 0.16 ENST00000370548.2
ENST00000356813.4
RP5-1052I5.2
HS2ST1
Heparan sulfate 2-O-sulfotransferase 1
heparan sulfate 2-O-sulfotransferase 1
chr15_+_92006567 0.16 ENST00000554333.1
RP11-661P17.1
RP11-661P17.1
chr6_+_106988986 0.16 ENST00000457437.1
ENST00000535438.1
AIM1
absent in melanoma 1
chr13_+_50589390 0.16 ENST00000360473.4
ENST00000312942.1
KCNRG
potassium channel regulator
chr19_-_44388116 0.15 ENST00000587539.1
ZNF404
zinc finger protein 404
chr15_-_64665911 0.15 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1
Uncharacterized protein
chr1_+_202317815 0.15 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr18_+_6729725 0.15 ENST00000400091.2
ENST00000583410.1
ENST00000584387.1
ARHGAP28
Rho GTPase activating protein 28
chr2_-_32490801 0.14 ENST00000360906.5
ENST00000342905.6
NLRC4
NLR family, CARD domain containing 4
chr9_+_95909309 0.14 ENST00000366188.2
RP11-370F5.4
RP11-370F5.4
chr3_+_186383741 0.14 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr5_+_54455946 0.14 ENST00000503787.1
ENST00000296734.6
ENST00000515370.1
GPX8
glutathione peroxidase 8 (putative)
chr6_+_53948221 0.14 ENST00000460844.2
MLIP
muscular LMNA-interacting protein
chr3_-_20053741 0.14 ENST00000389050.4
PP2D1
protein phosphatase 2C-like domain containing 1
chr5_+_169011033 0.14 ENST00000513795.1
SPDL1
spindle apparatus coiled-coil protein 1
chr19_-_52531600 0.14 ENST00000356322.6
ENST00000270649.6
ZNF614
zinc finger protein 614
chr18_-_44702668 0.14 ENST00000256433.3
IER3IP1
immediate early response 3 interacting protein 1
chr2_+_173686303 0.13 ENST00000397087.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr19_-_44952635 0.13 ENST00000592308.1
ENST00000588931.1
ENST00000291187.4
ZNF229
zinc finger protein 229
chr8_+_120885949 0.13 ENST00000523492.1
ENST00000286234.5
DEPTOR
DEP domain containing MTOR-interacting protein
chr8_-_116504448 0.13 ENST00000518018.1
TRPS1
trichorhinophalangeal syndrome I
chr3_-_3221358 0.13 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
CRBN
cereblon
chr6_+_12008986 0.13 ENST00000491710.1
HIVEP1
human immunodeficiency virus type I enhancer binding protein 1
chr18_-_69246167 0.13 ENST00000566582.1
RP11-510D19.1
RP11-510D19.1
chr6_-_138833630 0.13 ENST00000533765.1
NHSL1
NHS-like 1
chr21_+_38792602 0.13 ENST00000398960.2
ENST00000398956.2
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr10_+_90660832 0.13 ENST00000371924.1
STAMBPL1
STAM binding protein-like 1
chr13_-_46716969 0.13 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr8_-_101962777 0.12 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr7_-_99573677 0.12 ENST00000292401.4
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr19_-_2740036 0.12 ENST00000586572.1
ENST00000269740.4
AC006538.4
SLC39A3
Uncharacterized protein
solute carrier family 39 (zinc transporter), member 3
chr12_-_120315074 0.12 ENST00000261833.7
ENST00000392521.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr19_-_52227221 0.12 ENST00000222115.1
ENST00000540069.2
HAS1
hyaluronan synthase 1
chr4_+_41361616 0.12 ENST00000513024.1
LIMCH1
LIM and calponin homology domains 1
chr14_-_95624227 0.12 ENST00000526495.1
DICER1
dicer 1, ribonuclease type III
chr1_-_160492994 0.11 ENST00000368055.1
ENST00000368057.3
ENST00000368059.3
SLAMF6
SLAM family member 6
chr4_+_17616253 0.11 ENST00000237380.7
MED28
mediator complex subunit 28
chr7_-_99573640 0.11 ENST00000411734.1
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr1_-_85156417 0.11 ENST00000422026.1
SSX2IP
synovial sarcoma, X breakpoint 2 interacting protein
chr16_+_1578674 0.10 ENST00000253934.5
TMEM204
transmembrane protein 204
chr5_+_169010638 0.10 ENST00000265295.4
ENST00000506574.1
ENST00000515224.1
ENST00000508247.1
ENST00000513941.1
SPDL1
spindle apparatus coiled-coil protein 1
chr4_-_186392898 0.10 ENST00000510617.1
ENST00000307588.3
CCDC110
coiled-coil domain containing 110
chr4_+_26344754 0.09 ENST00000515573.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr3_-_81792780 0.09 ENST00000489715.1
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr11_+_114310102 0.09 ENST00000265881.5
REXO2
RNA exonuclease 2
chr5_+_67576109 0.09 ENST00000522084.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_-_8763278 0.09 ENST00000468247.1
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr13_+_24844857 0.09 ENST00000409126.1
ENST00000343003.6
SPATA13
spermatogenesis associated 13
chr14_-_23624511 0.09 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr13_+_96085847 0.09 ENST00000376873.3
CLDN10
claudin 10
chrX_-_19988382 0.09 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr7_-_111424506 0.08 ENST00000450156.1
ENST00000494651.2
DOCK4
dedicator of cytokinesis 4
chr11_-_22647350 0.08 ENST00000327470.3
FANCF
Fanconi anemia, complementation group F
chrX_-_15353629 0.08 ENST00000333590.4
ENST00000428964.1
ENST00000542278.1
PIGA
phosphatidylinositol glycan anchor biosynthesis, class A
chr2_-_32490859 0.08 ENST00000404025.2
NLRC4
NLR family, CARD domain containing 4
chr18_-_69246186 0.08 ENST00000568095.1
RP11-510D19.1
RP11-510D19.1
chr12_+_58335360 0.08 ENST00000300145.3
XRCC6BP1
XRCC6 binding protein 1
chr8_+_67976593 0.08 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chr4_+_113558612 0.08 ENST00000505034.1
ENST00000324052.6
LARP7
La ribonucleoprotein domain family, member 7
chr7_+_133615169 0.08 ENST00000541309.1
EXOC4
exocyst complex component 4
chr14_+_51706886 0.08 ENST00000457354.2
TMX1
thioredoxin-related transmembrane protein 1
chr1_+_97188188 0.07 ENST00000541987.1
PTBP2
polypyrimidine tract binding protein 2
chr19_-_40596828 0.07 ENST00000414720.2
ENST00000455521.1
ENST00000340963.5
ENST00000595773.1
ZNF780A
zinc finger protein 780A
chr3_+_46283944 0.07 ENST00000452454.1
ENST00000457243.1
CCR3
chemokine (C-C motif) receptor 3
chr17_-_6524159 0.07 ENST00000589033.1
KIAA0753
KIAA0753
chr4_+_80584903 0.07 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr15_+_49170083 0.07 ENST00000530028.2
EID1
EP300 interacting inhibitor of differentiation 1
chr8_+_9009202 0.07 ENST00000518496.1
RP11-10A14.4
Uncharacterized protein
chr7_-_112430427 0.07 ENST00000449743.1
ENST00000441474.1
ENST00000454074.1
ENST00000447395.1
TMEM168
transmembrane protein 168
chr4_-_103998439 0.06 ENST00000503230.1
ENST00000503818.1
SLC9B2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
chr14_+_50291993 0.06 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chrX_+_108779004 0.05 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr8_+_27631903 0.05 ENST00000305188.8
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr12_+_56114189 0.05 ENST00000548082.1
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr19_-_12992274 0.05 ENST00000592506.1
ENST00000222219.3
DNASE2
deoxyribonuclease II, lysosomal
chr2_+_201173667 0.05 ENST00000409755.3
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr16_-_58585513 0.05 ENST00000245138.4
ENST00000567285.1
CNOT1
CCR4-NOT transcription complex, subunit 1
chr8_-_67976509 0.05 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chr17_-_67264947 0.05 ENST00000586811.1
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr4_+_189376725 0.05 ENST00000510832.1
ENST00000510005.1
ENST00000503458.1
LINC01060
long intergenic non-protein coding RNA 1060
chr18_+_33709834 0.04 ENST00000358232.6
ENST00000351393.6
ENST00000442325.2
ENST00000423854.2
ENST00000350494.6
ENST00000542824.1
ELP2
elongator acetyltransferase complex subunit 2
chr19_+_20959098 0.04 ENST00000360204.5
ENST00000594534.1
ZNF66
zinc finger protein 66
chr8_-_108510224 0.04 ENST00000517746.1
ENST00000297450.3
ANGPT1
angiopoietin 1
chr1_-_227505289 0.04 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr12_+_106751436 0.04 ENST00000228347.4
POLR3B
polymerase (RNA) III (DNA directed) polypeptide B
chr17_-_47723943 0.04 ENST00000510476.1
ENST00000503676.1
SPOP
speckle-type POZ protein

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.2 2.8 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 0.6 GO:0032053 ciliary basal body organization(GO:0032053)
0.1 0.9 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 0.5 GO:0032571 response to vitamin K(GO:0032571)
0.1 0.3 GO:0043105 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.1 0.3 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1 0.2 GO:0071262 regulation of eIF2 alpha phosphorylation by amino acid starvation(GO:0060733) regulation of translational initiation in response to starvation(GO:0071262) positive regulation of translational initiation in response to starvation(GO:0071264)
0.1 0.5 GO:0032383 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.1 0.4 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.1 0.3 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.4 GO:0002933 lipid hydroxylation(GO:0002933)
0.1 0.2 GO:0002071 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.1 1.3 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.1 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.2 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.1 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
0.0 0.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.0 0.2 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 2.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.3 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.3 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.2 GO:0070269 pyroptosis(GO:0070269)
0.0 0.2 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 1.0 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.2 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.4 GO:0035810 positive regulation of urine volume(GO:0035810)
0.0 0.6 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.3 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.4 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 0.2 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.3 GO:0002643 regulation of tolerance induction(GO:0002643)
0.0 0.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.1 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.2 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:1905068 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.4 GO:2000637 positive regulation of gene silencing by miRNA(GO:2000637)
0.0 0.9 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.2 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 0.3 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 1.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 0.7 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.6 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.1 1.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.6 GO:0072687 meiotic spindle(GO:0072687)
0.1 1.0 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.3 GO:0030891 VCB complex(GO:0030891)
0.0 0.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.3 GO:0043219 lateral loop(GO:0043219)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0070538 oleic acid binding(GO:0070538)
0.1 1.1 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.3 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.1 0.3 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 0.3 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.1 0.6 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 0.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.2 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.2 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.4 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.3 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 1.7 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 0.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.3 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.3 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.6 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 0.2 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.4 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.1 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.0 0.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.8 GO:0019894 kinesin binding(GO:0019894)
0.0 0.2 GO:0008320 protein transmembrane transporter activity(GO:0008320)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.5 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.4 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.1 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.4 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling