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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for LEF1

Z-value: 0.67

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Transcription factors associated with LEF1

Gene Symbol Gene ID Gene Info
LEF1
ENSG00000138795.5 lymphoid enhancer binding factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LEF1hg19_v2_chr4_-_109087906_1090879530.483.4e-01Click!

Activity profile of LEF1 motif

Sorted Z-values of LEF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_94965667 0.96 ENST00000542176.1
ENST00000278499.2
SESN3
sestrin 3
chr15_+_96869165 0.69 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr6_+_144606817 0.49 ENST00000433557.1
UTRN
utrophin
chr3_-_169381166 0.48 ENST00000486748.1
MECOM
MDS1 and EVI1 complex locus
chr2_-_178129551 0.44 ENST00000430047.1
NFE2L2
nuclear factor, erythroid 2-like 2
chrX_-_45629661 0.42 ENST00000602507.1
ENST00000602461.1
RP6-99M1.2
RP6-99M1.2
chr1_-_116383738 0.41 ENST00000320238.3
NHLH2
nescient helix loop helix 2
chr1_+_6845578 0.38 ENST00000467404.2
ENST00000439411.2
CAMTA1
calmodulin binding transcription activator 1
chr4_-_23891693 0.37 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chrX_-_80457385 0.35 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
HMGN5
high mobility group nucleosome binding domain 5
chr5_+_112074029 0.31 ENST00000512211.2
APC
adenomatous polyposis coli
chr14_-_54418598 0.31 ENST00000609748.1
ENST00000558961.1
BMP4
bone morphogenetic protein 4
chr15_-_52944231 0.29 ENST00000546305.2
FAM214A
family with sequence similarity 214, member A
chr21_+_17791648 0.28 ENST00000602892.1
ENST00000418813.2
ENST00000435697.1
LINC00478
long intergenic non-protein coding RNA 478
chr8_+_42873548 0.28 ENST00000533338.1
ENST00000534420.1
HOOK3
RP11-598P20.5
hook microtubule-tethering protein 3
Uncharacterized protein
chr4_+_113152978 0.27 ENST00000309703.6
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr14_+_38065052 0.26 ENST00000556845.1
TTC6
tetratricopeptide repeat domain 6
chr17_-_8263538 0.26 ENST00000535173.1
AC135178.1
HCG1985372; Uncharacterized protein; cDNA FLJ37541 fis, clone BRCAN2026340
chr1_+_6845497 0.26 ENST00000473578.1
ENST00000557126.1
CAMTA1
calmodulin binding transcription activator 1
chr14_-_71107921 0.26 ENST00000553982.1
ENST00000500016.1
CTD-2540L5.5
CTD-2540L5.6
CTD-2540L5.5
CTD-2540L5.6
chr12_+_80838126 0.25 ENST00000266688.5
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr3_+_107244229 0.25 ENST00000456419.1
ENST00000402163.2
BBX
bobby sox homolog (Drosophila)
chr7_+_74379083 0.24 ENST00000361825.7
GATSL1
GATS protein-like 1
chr11_-_85430204 0.24 ENST00000389958.3
ENST00000527794.1
SYTL2
synaptotagmin-like 2
chr13_+_97928395 0.23 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr11_-_85430088 0.23 ENST00000533057.1
ENST00000533892.1
SYTL2
synaptotagmin-like 2
chr4_+_95972822 0.23 ENST00000509540.1
ENST00000440890.2
BMPR1B
bone morphogenetic protein receptor, type IB
chr1_+_100111479 0.23 ENST00000263174.4
PALMD
palmdelphin
chrX_+_106045891 0.22 ENST00000357242.5
ENST00000310452.2
ENST00000481617.2
ENST00000276175.3
TBC1D8B
TBC1 domain family, member 8B (with GRAM domain)
chr4_-_36245561 0.22 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_108231101 0.22 ENST00000544443.1
ENST00000415432.2
VAV3
vav 3 guanine nucleotide exchange factor
chr1_-_116383322 0.22 ENST00000429731.1
NHLH2
nescient helix loop helix 2
chr7_-_84122033 0.22 ENST00000424555.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr6_+_64282447 0.22 ENST00000370650.2
ENST00000578299.1
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr4_+_30721968 0.22 ENST00000361762.2
PCDH7
protocadherin 7
chr8_-_124665190 0.22 ENST00000325995.7
KLHL38
kelch-like family member 38
chr5_+_67584174 0.21 ENST00000320694.8
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_-_139163491 0.20 ENST00000280612.5
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr1_+_100111580 0.20 ENST00000605497.1
PALMD
palmdelphin
chr14_+_75746664 0.20 ENST00000557139.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr6_+_114178512 0.20 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr8_-_17579726 0.20 ENST00000381861.3
MTUS1
microtubule associated tumor suppressor 1
chr1_-_211752073 0.20 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr2_+_14772810 0.20 ENST00000295092.2
ENST00000331243.4
FAM84A
family with sequence similarity 84, member A
chr3_-_125655882 0.20 ENST00000340333.3
ALG1L
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like
chr18_-_53019208 0.20 ENST00000562607.1
TCF4
transcription factor 4
chr11_-_111794446 0.19 ENST00000527950.1
CRYAB
crystallin, alpha B
chr10_+_54074033 0.19 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr12_+_53491220 0.19 ENST00000548547.1
ENST00000301464.3
IGFBP6
insulin-like growth factor binding protein 6
chr5_+_138210919 0.19 ENST00000522013.1
ENST00000520260.1
ENST00000523298.1
ENST00000520865.1
ENST00000519634.1
ENST00000517533.1
ENST00000523685.1
ENST00000519768.1
ENST00000517656.1
ENST00000521683.1
ENST00000521640.1
ENST00000519116.1
CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr14_-_36990061 0.19 ENST00000546983.1
NKX2-1
NK2 homeobox 1
chr14_-_23624511 0.19 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr1_+_164528866 0.18 ENST00000420696.2
PBX1
pre-B-cell leukemia homeobox 1
chr11_-_85430163 0.18 ENST00000529581.1
ENST00000533577.1
SYTL2
synaptotagmin-like 2
chr1_+_100435535 0.18 ENST00000427993.2
SLC35A3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr6_+_35704855 0.18 ENST00000288065.2
ENST00000373866.3
ARMC12
armadillo repeat containing 12
chr17_+_38337491 0.17 ENST00000538981.1
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr11_+_113930955 0.17 ENST00000535700.1
ZBTB16
zinc finger and BTB domain containing 16
chr11_-_102323489 0.17 ENST00000361236.3
TMEM123
transmembrane protein 123
chr6_+_134274354 0.17 ENST00000367869.1
TBPL1
TBP-like 1
chr18_+_9136758 0.17 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ANKRD12
ankyrin repeat domain 12
chr7_+_116451100 0.17 ENST00000464223.1
ENST00000484325.1
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr7_-_84121858 0.17 ENST00000448879.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr1_+_78383813 0.17 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chr12_+_21654714 0.17 ENST00000542038.1
ENST00000540141.1
ENST00000229314.5
GOLT1B
golgi transport 1B
chr2_-_165697717 0.17 ENST00000439313.1
COBLL1
cordon-bleu WH2 repeat protein-like 1
chr11_-_111649074 0.17 ENST00000534218.1
RP11-108O10.2
RP11-108O10.2
chr3_+_149535022 0.17 ENST00000466795.1
RNF13
ring finger protein 13
chr2_-_211341411 0.16 ENST00000233714.4
ENST00000443314.1
ENST00000441020.3
ENST00000450366.2
ENST00000431941.2
LANCL1
LanC lantibiotic synthetase component C-like 1 (bacterial)
chr9_+_97766469 0.16 ENST00000433691.2
C9orf3
chromosome 9 open reading frame 3
chr8_-_21988558 0.16 ENST00000312841.8
HR
hair growth associated
chr17_-_56065540 0.16 ENST00000583932.1
VEZF1
vascular endothelial zinc finger 1
chr9_-_27005686 0.16 ENST00000380055.5
LRRC19
leucine rich repeat containing 19
chrX_-_109683446 0.16 ENST00000372057.1
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr1_+_93645314 0.16 ENST00000343253.7
CCDC18
coiled-coil domain containing 18
chr1_+_100435315 0.16 ENST00000370155.3
ENST00000465289.1
SLC35A3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr1_-_244006528 0.16 ENST00000336199.5
ENST00000263826.5
AKT3
v-akt murine thymoma viral oncogene homolog 3
chr15_-_35280426 0.16 ENST00000559564.1
ENST00000356321.4
ZNF770
zinc finger protein 770
chr12_-_76817036 0.16 ENST00000546946.1
OSBPL8
oxysterol binding protein-like 8
chr20_+_36531499 0.16 ENST00000373458.3
ENST00000373461.4
ENST00000373459.4
VSTM2L
V-set and transmembrane domain containing 2 like
chr11_-_18062335 0.15 ENST00000341556.2
TPH1
tryptophan hydroxylase 1
chr2_-_170681375 0.15 ENST00000410097.1
ENST00000308099.3
ENST00000409837.1
ENST00000538491.1
ENST00000260953.5
ENST00000409965.1
ENST00000392640.2
METTL5
methyltransferase like 5
chr18_+_29027696 0.15 ENST00000257189.4
DSG3
desmoglein 3
chr1_+_27668505 0.15 ENST00000318074.5
SYTL1
synaptotagmin-like 1
chr15_-_52043722 0.15 ENST00000454181.2
LYSMD2
LysM, putative peptidoglycan-binding, domain containing 2
chrX_-_138724677 0.15 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2
MCF.2 cell line derived transforming sequence
chr5_+_65222438 0.15 ENST00000380938.2
ERBB2IP
erbb2 interacting protein
chr12_+_94071129 0.15 ENST00000552983.1
ENST00000332896.3
ENST00000552033.1
ENST00000548483.1
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr17_+_67410832 0.15 ENST00000590474.1
MAP2K6
mitogen-activated protein kinase kinase 6
chr2_-_170681324 0.15 ENST00000409340.1
METTL5
methyltransferase like 5
chr1_+_84630053 0.15 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr4_+_90033968 0.15 ENST00000317005.2
TIGD2
tigger transposable element derived 2
chr1_+_100818009 0.14 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
CDC14A
cell division cycle 14A
chr8_-_124553437 0.14 ENST00000517956.1
ENST00000443022.2
FBXO32
F-box protein 32
chr16_+_67143828 0.14 ENST00000563853.2
ENST00000569914.1
ENST00000569600.1
C16orf70
chromosome 16 open reading frame 70
chr1_-_219615984 0.14 ENST00000420762.1
RP11-95P13.1
RP11-95P13.1
chr2_-_152146385 0.14 ENST00000414946.1
ENST00000243346.5
NMI
N-myc (and STAT) interactor
chr9_-_94186131 0.14 ENST00000297689.3
NFIL3
nuclear factor, interleukin 3 regulated
chr2_+_220309379 0.14 ENST00000451076.1
SPEG
SPEG complex locus
chr4_+_95129061 0.14 ENST00000354268.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr5_+_95066823 0.14 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr11_-_46141338 0.14 ENST00000529782.1
ENST00000532010.1
ENST00000525438.1
ENST00000533757.1
ENST00000527782.1
PHF21A
PHD finger protein 21A
chr5_+_110073853 0.14 ENST00000513807.1
ENST00000509442.2
SLC25A46
solute carrier family 25, member 46
chr2_+_17997763 0.14 ENST00000281047.3
MSGN1
mesogenin 1
chr18_-_53089723 0.14 ENST00000561992.1
ENST00000562512.2
TCF4
transcription factor 4
chr10_+_18948311 0.14 ENST00000377275.3
ARL5B
ADP-ribosylation factor-like 5B
chr14_+_23025534 0.14 ENST00000557595.1
AE000662.92
Uncharacterized protein
chr3_+_29323043 0.13 ENST00000452462.1
ENST00000456853.1
RBMS3
RNA binding motif, single stranded interacting protein 3
chr4_-_76649546 0.13 ENST00000508510.1
ENST00000509561.1
ENST00000499709.2
ENST00000511868.1
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr13_-_39611956 0.13 ENST00000418503.1
PROSER1
proline and serine rich 1
chrX_+_95939638 0.13 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
DIAPH2
diaphanous-related formin 2
chr16_+_57673348 0.13 ENST00000567915.1
ENST00000564103.1
ENST00000562467.1
GPR56
G protein-coupled receptor 56
chr18_-_25616519 0.13 ENST00000399380.3
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr19_+_13135439 0.13 ENST00000586873.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr14_-_35182994 0.13 ENST00000341223.3
CFL2
cofilin 2 (muscle)
chr9_-_74525847 0.13 ENST00000377041.2
ABHD17B
abhydrolase domain containing 17B
chr4_+_95128996 0.13 ENST00000457823.2
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr19_-_3029011 0.13 ENST00000590536.1
ENST00000587137.1
ENST00000455444.2
ENST00000262953.6
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr15_+_96873921 0.13 ENST00000394166.3
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr6_-_153304148 0.13 ENST00000229758.3
FBXO5
F-box protein 5
chr11_-_102323740 0.13 ENST00000398136.2
TMEM123
transmembrane protein 123
chr11_+_130184888 0.13 ENST00000602376.1
ENST00000532116.3
ENST00000602310.1
RP11-121M22.1
RP11-121M22.1
chr4_+_86699834 0.13 ENST00000395183.2
ARHGAP24
Rho GTPase activating protein 24
chr1_-_93645818 0.13 ENST00000370280.1
ENST00000479918.1
TMED5
transmembrane emp24 protein transport domain containing 5
chr6_-_134639042 0.13 ENST00000461976.2
SGK1
serum/glucocorticoid regulated kinase 1
chr6_+_83777374 0.13 ENST00000349129.2
ENST00000237163.5
ENST00000536812.1
DOPEY1
dopey family member 1
chr14_-_61124977 0.13 ENST00000554986.1
SIX1
SIX homeobox 1
chrX_+_119737806 0.13 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr6_-_153304697 0.12 ENST00000367241.3
FBXO5
F-box protein 5
chr4_+_95174445 0.12 ENST00000509418.1
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr2_-_25194476 0.12 ENST00000534855.1
DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr11_-_34535297 0.12 ENST00000532417.1
ELF5
E74-like factor 5 (ets domain transcription factor)
chr14_-_92041383 0.12 ENST00000596306.1
AL133373.1
Uncharacterized protein
chr3_-_18466026 0.12 ENST00000417717.2
SATB1
SATB homeobox 1
chr10_+_123970670 0.12 ENST00000496913.2
TACC2
transforming, acidic coiled-coil containing protein 2
chr3_+_69985734 0.12 ENST00000314557.6
ENST00000394351.3
MITF
microphthalmia-associated transcription factor
chr3_-_66024213 0.12 ENST00000483466.1
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr9_+_128510454 0.12 ENST00000491787.3
ENST00000447726.2
PBX3
pre-B-cell leukemia homeobox 3
chr17_+_48611853 0.12 ENST00000507709.1
ENST00000515126.1
ENST00000507467.1
EPN3
epsin 3
chr3_-_148804275 0.12 ENST00000392912.2
ENST00000465259.1
ENST00000310053.5
ENST00000494055.1
HLTF
helicase-like transcription factor
chr18_-_74728998 0.12 ENST00000359645.3
ENST00000397875.3
ENST00000397869.3
ENST00000578193.1
ENST00000578873.1
ENST00000397866.4
ENST00000528160.1
ENST00000527041.1
ENST00000526111.1
ENST00000397865.5
ENST00000382582.3
MBP
myelin basic protein
chr7_-_96654133 0.12 ENST00000486603.2
ENST00000222598.4
DLX5
distal-less homeobox 5
chr4_+_95128748 0.12 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr12_-_109797249 0.12 ENST00000538041.1
RP11-256L11.1
RP11-256L11.1
chr5_-_146833803 0.12 ENST00000512722.1
DPYSL3
dihydropyrimidinase-like 3
chr4_-_157892055 0.12 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr3_-_149375783 0.12 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WWTR1
WW domain containing transcription regulator 1
chr11_+_27076764 0.12 ENST00000525090.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr3_+_183353356 0.11 ENST00000242810.6
ENST00000493074.1
ENST00000437402.1
ENST00000454495.2
ENST00000473045.1
ENST00000468101.1
ENST00000427201.2
ENST00000482138.1
ENST00000454652.2
KLHL24
kelch-like family member 24
chr5_+_170846640 0.11 ENST00000274625.5
FGF18
fibroblast growth factor 18
chr2_+_181845843 0.11 ENST00000602710.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr3_+_152017924 0.11 ENST00000465907.2
ENST00000492948.1
ENST00000485509.1
ENST00000464596.1
MBNL1
muscleblind-like splicing regulator 1
chr9_-_117150303 0.11 ENST00000312033.3
AKNA
AT-hook transcription factor
chrX_-_119694538 0.11 ENST00000371322.5
CUL4B
cullin 4B
chr10_-_116444371 0.11 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr7_+_23146271 0.11 ENST00000545771.1
KLHL7
kelch-like family member 7
chr3_+_177159744 0.11 ENST00000439009.1
LINC00578
long intergenic non-protein coding RNA 578
chr3_-_112320749 0.11 ENST00000610103.1
RP11-572C15.6
RP11-572C15.6
chr9_+_97766409 0.11 ENST00000425634.2
C9orf3
chromosome 9 open reading frame 3
chr4_-_157892498 0.11 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr1_+_12538594 0.11 ENST00000543710.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr10_-_21806759 0.11 ENST00000444772.3
SKIDA1
SKI/DACH domain containing 1
chr16_-_3350614 0.11 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr7_+_151791095 0.11 ENST00000422997.2
GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr14_+_54863682 0.11 ENST00000543789.2
ENST00000442975.2
ENST00000458126.2
ENST00000556102.2
CDKN3
cyclin-dependent kinase inhibitor 3
chr21_+_30672433 0.11 ENST00000451655.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr4_+_160203650 0.11 ENST00000514565.1
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr17_-_37382105 0.11 ENST00000333461.5
STAC2
SH3 and cysteine rich domain 2
chr5_+_137673200 0.10 ENST00000434981.2
FAM53C
family with sequence similarity 53, member C
chr1_+_100818156 0.10 ENST00000336454.3
CDC14A
cell division cycle 14A
chr11_-_85430356 0.10 ENST00000526999.1
SYTL2
synaptotagmin-like 2
chr7_-_27142290 0.10 ENST00000222718.5
HOXA2
homeobox A2
chr5_+_67586465 0.10 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_61548225 0.10 ENST00000371187.3
NFIA
nuclear factor I/A
chr13_+_50589390 0.10 ENST00000360473.4
ENST00000312942.1
KCNRG
potassium channel regulator
chr1_+_196621156 0.10 ENST00000359637.2
CFH
complement factor H
chrX_+_38420783 0.10 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7
tetraspanin 7
chr18_-_53089538 0.10 ENST00000566777.1
TCF4
transcription factor 4
chrX_+_100353153 0.10 ENST00000423383.1
ENST00000218507.5
ENST00000403304.2
ENST00000435570.1
CENPI
centromere protein I
chr14_-_23451467 0.10 ENST00000555074.1
ENST00000361265.4
RP11-298I3.5
AJUBA
RP11-298I3.5
ajuba LIM protein
chr14_-_31676674 0.10 ENST00000399332.1
ENST00000556224.1
HECTD1
HECT domain containing E3 ubiquitin protein ligase 1
chr4_-_111120334 0.10 ENST00000503885.1
ELOVL6
ELOVL fatty acid elongase 6
chr15_-_41120896 0.10 ENST00000299174.5
ENST00000427255.2
PPP1R14D
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr9_+_36036430 0.10 ENST00000377966.3
RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chrX_+_12993336 0.10 ENST00000380635.1
TMSB4X
thymosin beta 4, X-linked
chrX_-_63425561 0.10 ENST00000374869.3
ENST00000330258.3
AMER1
APC membrane recruitment protein 1
chr17_-_39526052 0.10 ENST00000251646.3
KRT33B
keratin 33B
chr2_+_172864490 0.10 ENST00000315796.4
METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chr7_+_7811992 0.10 ENST00000406829.1
RPA3-AS1
RPA3 antisense RNA 1
chr9_-_98268883 0.10 ENST00000551630.1
ENST00000548420.1
PTCH1
patched 1
chr11_-_46848393 0.10 ENST00000526496.1
CKAP5
cytoskeleton associated protein 5
chr12_-_112443767 0.10 ENST00000550233.1
ENST00000546962.1
ENST00000550800.2
TMEM116
transmembrane protein 116
chr3_-_169381183 0.10 ENST00000494292.1
MECOM
MDS1 and EVI1 complex locus
chr2_-_178129853 0.09 ENST00000397062.3
NFE2L2
nuclear factor, erythroid 2-like 2
chr6_-_56707943 0.09 ENST00000370769.4
ENST00000421834.2
ENST00000312431.6
ENST00000361203.3
ENST00000523817.1
DST
dystonin
chr2_+_201170999 0.09 ENST00000439395.1
ENST00000444012.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr14_+_57857262 0.09 ENST00000555166.1
ENST00000556492.1
ENST00000554703.1
NAA30
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr11_-_118047376 0.09 ENST00000278947.5
SCN2B
sodium channel, voltage-gated, type II, beta subunit
chr4_-_184243561 0.09 ENST00000514470.1
ENST00000541814.1
CLDN24
claudin 24
chr1_+_87794150 0.09 ENST00000370544.5
LMO4
LIM domain only 4

Network of associatons between targets according to the STRING database.

First level regulatory network of LEF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0009956 radial pattern formation(GO:0009956)
0.1 0.4 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.1 0.3 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of mitochondrial DNA metabolic process(GO:1901860) response to methionine(GO:1904640)
0.1 0.4 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.1 0.3 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.1 0.5 GO:1903788 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.1 0.3 GO:1990569 UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569)
0.1 0.2 GO:0100012 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of mesodermal cell fate specification(GO:0042662) regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012) regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.1 0.3 GO:0048392 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 0.2 GO:0021569 rhombomere 3 development(GO:0021569)
0.1 0.4 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.2 GO:0051300 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1 1.0 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.5 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.1 0.8 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.1 GO:0090191 mesenchymal cell proliferation involved in ureter development(GO:0072198) regulation of mesenchymal cell proliferation involved in ureter development(GO:0072199) negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:0007388 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.0 0.1 GO:0060166 olfactory pit development(GO:0060166)
0.0 0.1 GO:0071895 odontoblast differentiation(GO:0071895)
0.0 0.2 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.6 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.1 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.0 0.3 GO:0097338 response to clozapine(GO:0097338)
0.0 0.3 GO:0006235 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.0 0.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.0 0.2 GO:0097501 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 0.1 GO:0045354 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0 0.5 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.2 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.1 GO:0010157 response to chlorate(GO:0010157)
0.0 0.6 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.1 GO:0046684 response to pyrethroid(GO:0046684)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.1 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.2 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.6 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 0.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.1 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.1 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 0.1 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0 0.1 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 0.1 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.0 0.2 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.1 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.0 0.1 GO:0070444 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.1 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.1 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.6 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0 0.0 GO:0021523 somatic motor neuron differentiation(GO:0021523)
0.0 0.1 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.1 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.6 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.0 GO:0072095 regulation of branch elongation involved in ureteric bud branching(GO:0072095)
0.0 0.1 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.0 0.1 GO:0050893 sensory processing(GO:0050893)
0.0 0.1 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.4 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.0 GO:0009996 negative regulation of cell fate specification(GO:0009996)
0.0 0.2 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.0 0.0 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.1 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.0 0.3 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.0 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 1.0 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.2 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.3 GO:0070695 FHF complex(GO:0070695)
0.0 0.6 GO:0016342 catenin complex(GO:0016342)
0.0 0.3 GO:0035976 AP1 complex(GO:0035976)
0.0 0.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.5 GO:0070938 contractile ring(GO:0070938)
0.0 0.2 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 0.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0075341 host cell PML body(GO:0075341)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0031673 H zone(GO:0031673)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.1 GO:0097422 tubular endosome(GO:0097422)
0.0 0.0 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:0044294 dendritic growth cone(GO:0044294)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 0.3 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.0 0.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.2 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0019150 D-ribulokinase activity(GO:0019150)
0.0 0.1 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.0 0.2 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.0 0.1 GO:1990175 EH domain binding(GO:1990175)
0.0 0.5 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.3 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.5 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.5 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0005119 smoothened binding(GO:0005119)
0.0 0.7 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0070491 RNA polymerase II repressing transcription factor binding(GO:0001103) repressing transcription factor binding(GO:0070491)
0.0 0.1 GO:0030350 iron-responsive element binding(GO:0030350)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 1.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.7 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.2 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.1 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.0 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0070513 death domain binding(GO:0070513)
0.0 0.0 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) chondroitin sulfotransferase activity(GO:0034481)
0.0 0.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.3 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.9 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors