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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NFKB1

Z-value: 2.01

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Transcription factors associated with NFKB1

Gene Symbol Gene ID Gene Info
NFKB1
ENSG00000109320.7 nuclear factor kappa B subunit 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFKB1hg19_v2_chr4_+_103422471_1034224950.954.1e-03Click!

Activity profile of NFKB1 motif

Sorted Z-values of NFKB1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_74904398 6.19 ENST00000296026.4
CXCL3
chemokine (C-X-C motif) ligand 3
chr2_+_228678550 5.15 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr4_-_74964904 3.97 ENST00000508487.2
CXCL2
chemokine (C-X-C motif) ligand 2
chr2_+_113735575 3.67 ENST00000376489.2
ENST00000259205.4
IL36G
interleukin 36, gamma
chr4_-_74864386 3.46 ENST00000296027.4
CXCL5
chemokine (C-X-C motif) ligand 5
chr4_+_74735102 3.32 ENST00000395761.3
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr6_+_138188551 3.09 ENST00000237289.4
ENST00000433680.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr5_-_150467221 3.08 ENST00000522226.1
TNIP1
TNFAIP3 interacting protein 1
chr5_+_159895275 3.01 ENST00000517927.1
MIR146A
microRNA 146a
chr6_+_138188351 2.91 ENST00000421450.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr6_+_138188378 2.80 ENST00000420009.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr10_+_104154229 2.79 ENST00000428099.1
ENST00000369966.3
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr1_+_37940153 2.63 ENST00000373087.6
ZC3H12A
zinc finger CCCH-type containing 12A
chr12_-_49259643 2.63 ENST00000309739.5
RND1
Rho family GTPase 1
chr11_+_102188272 2.50 ENST00000532808.1
BIRC3
baculoviral IAP repeat containing 3
chr5_-_150466692 2.44 ENST00000315050.7
ENST00000523338.1
ENST00000522100.1
TNIP1
TNFAIP3 interacting protein 1
chr11_+_102188224 2.37 ENST00000263464.3
BIRC3
baculoviral IAP repeat containing 3
chr5_-_150460914 2.27 ENST00000389378.2
TNIP1
TNFAIP3 interacting protein 1
chr19_+_45504688 1.99 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr6_-_31550192 1.92 ENST00000429299.2
ENST00000446745.2
LTB
lymphotoxin beta (TNF superfamily, member 3)
chr5_-_150460539 1.89 ENST00000520931.1
ENST00000520695.1
ENST00000521591.1
ENST00000518977.1
TNIP1
TNFAIP3 interacting protein 1
chr17_+_40440481 1.89 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
STAT5A
signal transducer and activator of transcription 5A
chr14_-_35873856 1.87 ENST00000553342.1
ENST00000216797.5
ENST00000557140.1
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr2_+_74212073 1.60 ENST00000441217.1
AC073046.25
AC073046.25
chr3_+_101546827 1.38 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr6_+_32821924 1.37 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr10_+_30723045 1.19 ENST00000542547.1
ENST00000415139.1
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr14_+_75988851 1.15 ENST00000555504.1
BATF
basic leucine zipper transcription factor, ATF-like
chr4_-_76944621 1.09 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr10_+_30722866 1.04 ENST00000263056.1
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr10_+_30723105 1.04 ENST00000375322.2
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr20_+_6748311 1.03 ENST00000378827.4
BMP2
bone morphogenetic protein 2
chr12_+_56732658 1.03 ENST00000228534.4
IL23A
interleukin 23, alpha subunit p19
chr18_-_72920372 1.02 ENST00000581620.1
ENST00000582437.1
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr4_+_103422471 0.97 ENST00000226574.4
ENST00000394820.4
NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr3_-_4793274 0.93 ENST00000414938.1
EGOT
eosinophil granule ontogeny transcript (non-protein coding)
chr6_+_29691198 0.88 ENST00000440587.2
ENST00000434407.2
HLA-F
major histocompatibility complex, class I, F
chr6_+_14117872 0.86 ENST00000379153.3
CD83
CD83 molecule
chr19_+_45251804 0.86 ENST00000164227.5
BCL3
B-cell CLL/lymphoma 3
chr8_+_72755367 0.84 ENST00000537896.1
RP11-383H13.1
Protein LOC100132891; cDNA FLJ53548
chr17_+_40440094 0.79 ENST00000546010.2
STAT5A
signal transducer and activator of transcription 5A
chr2_-_242447732 0.78 ENST00000439101.1
ENST00000424537.1
ENST00000401869.1
ENST00000436402.1
STK25
serine/threonine kinase 25
chr5_-_149792295 0.76 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr1_-_186649543 0.74 ENST00000367468.5
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr6_+_106534192 0.73 ENST00000369091.2
ENST00000369096.4
PRDM1
PR domain containing 1, with ZNF domain
chr6_+_33378517 0.73 ENST00000428274.1
PHF1
PHD finger protein 1
chr6_-_29527702 0.71 ENST00000377050.4
UBD
ubiquitin D
chr4_+_103422499 0.71 ENST00000511926.1
ENST00000507079.1
NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr19_-_46145696 0.65 ENST00000588172.1
EML2
echinoderm microtubule associated protein like 2
chr10_+_12391685 0.63 ENST00000378845.1
CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr4_-_122085469 0.62 ENST00000057513.3
TNIP3
TNFAIP3 interacting protein 3
chr2_+_64681641 0.61 ENST00000409537.2
LGALSL
lectin, galactoside-binding-like
chr20_+_35090150 0.60 ENST00000340491.4
DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr9_-_136344197 0.60 ENST00000414172.1
ENST00000371897.4
SLC2A6
solute carrier family 2 (facilitated glucose transporter), member 6
chr16_+_50730910 0.59 ENST00000300589.2
NOD2
nucleotide-binding oligomerization domain containing 2
chr6_+_29691056 0.59 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
HLA-F
major histocompatibility complex, class I, F
chr4_-_122148620 0.59 ENST00000509841.1
TNIP3
TNFAIP3 interacting protein 3
chr1_+_110453203 0.58 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
CSF1
colony stimulating factor 1 (macrophage)
chr12_-_62997214 0.57 ENST00000408887.2
C12orf61
chromosome 12 open reading frame 61
chr16_-_66959429 0.57 ENST00000420652.1
ENST00000299759.6
RRAD
Ras-related associated with diabetes
chr10_+_99609996 0.55 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr2_-_163175133 0.53 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr17_-_4852332 0.53 ENST00000572383.1
PFN1
profilin 1
chr5_-_141338377 0.52 ENST00000510041.1
PCDH12
protocadherin 12
chr6_+_30297306 0.50 ENST00000420746.1
ENST00000513556.1
TRIM39
TRIM39-RPP21
tripartite motif containing 39
TRIM39-RPP21 readthrough
chr5_+_35852797 0.50 ENST00000508941.1
IL7R
interleukin 7 receptor
chr14_+_103243813 0.50 ENST00000560371.1
ENST00000347662.4
ENST00000392745.2
ENST00000539721.1
ENST00000560463.1
TRAF3
TNF receptor-associated factor 3
chr12_-_54813229 0.49 ENST00000293379.4
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr2_-_191885686 0.48 ENST00000432058.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr11_+_73000449 0.47 ENST00000535931.1
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr3_+_52279737 0.44 ENST00000457351.2
PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr1_+_67632083 0.43 ENST00000347310.5
ENST00000371002.1
IL23R
interleukin 23 receptor
chr1_-_155939437 0.43 ENST00000609707.1
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr6_-_44233361 0.43 ENST00000275015.5
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr17_-_7197881 0.41 ENST00000007699.5
YBX2
Y box binding protein 2
chr22_+_31488433 0.40 ENST00000455608.1
SMTN
smoothelin
chr12_-_57081940 0.40 ENST00000436399.2
PTGES3
prostaglandin E synthase 3 (cytosolic)
chr6_-_31613280 0.40 ENST00000453833.1
BAG6
BCL2-associated athanogene 6
chr16_+_50775948 0.40 ENST00000569681.1
ENST00000569418.1
ENST00000540145.1
CYLD
cylindromatosis (turban tumor syndrome)
chr9_-_125240235 0.40 ENST00000259357.2
OR1J1
olfactory receptor, family 1, subfamily J, member 1
chr14_-_24616426 0.40 ENST00000216802.5
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr17_-_61776522 0.40 ENST00000582055.1
LIMD2
LIM domain containing 2
chr1_-_204436344 0.39 ENST00000367184.2
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr2_+_97202480 0.39 ENST00000357485.3
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr6_-_32821599 0.39 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_+_72525353 0.39 ENST00000321297.5
ENST00000534905.1
ENST00000540567.1
ATG16L2
autophagy related 16-like 2 (S. cerevisiae)
chr19_-_4182530 0.38 ENST00000601571.1
ENST00000601488.1
ENST00000305232.6
ENST00000381935.3
ENST00000337491.2
SIRT6
sirtuin 6
chr7_-_6570817 0.37 ENST00000435185.1
GRID2IP
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein
chr1_+_11539204 0.37 ENST00000294484.6
ENST00000389575.3
PTCHD2
patched domain containing 2
chr1_+_6845384 0.37 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr1_+_169077133 0.36 ENST00000494797.1
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr14_-_24615805 0.36 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr12_-_48499826 0.36 ENST00000551798.1
SENP1
SUMO1/sentrin specific peptidase 1
chr2_-_206950996 0.36 ENST00000414320.1
INO80D
INO80 complex subunit D
chr10_+_75668916 0.36 ENST00000481390.1
PLAU
plasminogen activator, urokinase
chr1_-_156051789 0.35 ENST00000532414.2
MEX3A
mex-3 RNA binding family member A
chr16_+_50775971 0.35 ENST00000311559.9
ENST00000564326.1
ENST00000566206.1
CYLD
cylindromatosis (turban tumor syndrome)
chr10_+_89124746 0.34 ENST00000465545.1
NUTM2D
NUT family member 2D
chr17_+_4854375 0.34 ENST00000521811.1
ENST00000519602.1
ENST00000323997.6
ENST00000522249.1
ENST00000519584.1
ENO3
enolase 3 (beta, muscle)
chr12_-_28124903 0.33 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr14_-_64970494 0.33 ENST00000608382.1
ZBTB25
zinc finger and BTB domain containing 25
chr12_+_57623907 0.33 ENST00000553529.1
ENST00000554310.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr1_-_16302565 0.33 ENST00000537142.1
ENST00000448462.2
ZBTB17
zinc finger and BTB domain containing 17
chr7_-_93520259 0.33 ENST00000222543.5
TFPI2
tissue factor pathway inhibitor 2
chr1_-_16302608 0.32 ENST00000375743.4
ENST00000375733.2
ZBTB17
zinc finger and BTB domain containing 17
chr19_-_4338838 0.32 ENST00000594605.1
STAP2
signal transducing adaptor family member 2
chr1_+_10093188 0.32 ENST00000377153.1
UBE4B
ubiquitination factor E4B
chr1_-_155658085 0.31 ENST00000311573.5
ENST00000438245.2
YY1AP1
YY1 associated protein 1
chr7_+_18548924 0.31 ENST00000524023.1
HDAC9
histone deacetylase 9
chr12_+_7053172 0.31 ENST00000229281.5
C12orf57
chromosome 12 open reading frame 57
chr11_-_58345569 0.30 ENST00000528954.1
ENST00000528489.1
LPXN
leupaxin
chr19_-_4338783 0.30 ENST00000601482.1
ENST00000600324.1
STAP2
signal transducing adaptor family member 2
chr14_-_69446034 0.30 ENST00000193403.6
ACTN1
actinin, alpha 1
chr3_+_9774164 0.29 ENST00000426583.1
BRPF1
bromodomain and PHD finger containing, 1
chr16_+_50776021 0.29 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD
cylindromatosis (turban tumor syndrome)
chr1_-_173886491 0.29 ENST00000367698.3
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr1_+_110453462 0.29 ENST00000488198.1
CSF1
colony stimulating factor 1 (macrophage)
chr14_-_75078725 0.28 ENST00000556690.1
LTBP2
latent transforming growth factor beta binding protein 2
chr3_+_10857885 0.28 ENST00000254488.2
ENST00000454147.1
SLC6A11
solute carrier family 6 (neurotransmitter transporter), member 11
chr20_+_44746885 0.28 ENST00000372285.3
CD40
CD40 molecule, TNF receptor superfamily member 5
chr12_+_57624059 0.28 ENST00000557427.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr6_+_292253 0.28 ENST00000603453.1
ENST00000605315.1
ENST00000603881.1
DUSP22
dual specificity phosphatase 22
chr19_-_4831701 0.27 ENST00000248244.5
TICAM1
toll-like receptor adaptor molecule 1
chr3_-_156878482 0.27 ENST00000295925.4
CCNL1
cyclin L1
chr17_+_21191341 0.26 ENST00000526076.2
ENST00000361818.5
ENST00000316920.6
MAP2K3
mitogen-activated protein kinase kinase 3
chr2_-_240230890 0.26 ENST00000446876.1
HDAC4
histone deacetylase 4
chr7_-_100881109 0.26 ENST00000308344.5
CLDN15
claudin 15
chr20_+_44746939 0.25 ENST00000372276.3
CD40
CD40 molecule, TNF receptor superfamily member 5
chr11_+_128562372 0.25 ENST00000344954.6
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr1_+_169077172 0.25 ENST00000499679.3
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr2_+_97203082 0.25 ENST00000454558.2
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr1_-_205904950 0.25 ENST00000340781.4
SLC26A9
solute carrier family 26 (anion exchanger), member 9
chr17_-_1389228 0.25 ENST00000438665.2
MYO1C
myosin IC
chr1_+_155657737 0.25 ENST00000471642.2
ENST00000471214.1
DAP3
death associated protein 3
chr5_-_54468974 0.25 ENST00000381375.2
ENST00000296733.1
ENST00000322374.6
ENST00000334206.5
ENST00000331730.3
CDC20B
cell division cycle 20B
chr3_+_157154578 0.24 ENST00000295927.3
PTX3
pentraxin 3, long
chr12_+_7053228 0.24 ENST00000540506.2
C12orf57
chromosome 12 open reading frame 57
chrX_+_109246285 0.24 ENST00000372073.1
ENST00000372068.2
ENST00000288381.4
TMEM164
transmembrane protein 164
chr4_-_185395191 0.24 ENST00000510814.1
ENST00000507523.1
ENST00000506230.1
IRF2
interferon regulatory factor 2
chr7_-_93520191 0.24 ENST00000545378.1
TFPI2
tissue factor pathway inhibitor 2
chr16_+_67571351 0.24 ENST00000428437.2
ENST00000569253.1
FAM65A
family with sequence similarity 65, member A
chr9_-_140115775 0.24 ENST00000391553.1
ENST00000392827.1
RNF208
ring finger protein 208
chr21_+_34775698 0.24 ENST00000381995.1
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr14_-_69262916 0.23 ENST00000553375.1
ZFP36L1
ZFP36 ring finger protein-like 1
chr6_-_31612808 0.23 ENST00000438149.1
BAG6
BCL2-associated athanogene 6
chr19_+_48898132 0.23 ENST00000263269.3
GRIN2D
glutamate receptor, ionotropic, N-methyl D-aspartate 2D
chr17_+_40719073 0.23 ENST00000435881.2
ENST00000246912.4
ENST00000346833.4
ENST00000591024.1
MLX
MLX, MAX dimerization protein
chrX_+_109245863 0.23 ENST00000372072.3
TMEM164
transmembrane protein 164
chr12_+_57623869 0.23 ENST00000414700.3
ENST00000557703.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr3_+_63638372 0.23 ENST00000496807.1
SNTN
sentan, cilia apical structure protein
chr19_+_35485682 0.22 ENST00000599564.1
GRAMD1A
GRAM domain containing 1A
chr19_+_39574945 0.22 ENST00000331256.5
PAPL
Iron/zinc purple acid phosphatase-like protein
chr5_-_150521192 0.22 ENST00000523714.1
ENST00000521749.1
ANXA6
annexin A6
chr6_-_35464727 0.22 ENST00000402886.3
TEAD3
TEA domain family member 3
chr17_-_1389419 0.22 ENST00000575158.1
MYO1C
myosin IC
chr8_-_139926236 0.22 ENST00000303045.6
ENST00000435777.1
COL22A1
collagen, type XXII, alpha 1
chr19_-_46272106 0.21 ENST00000560168.1
SIX5
SIX homeobox 5
chrX_-_100129128 0.21 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NOX1
NADPH oxidase 1
chr6_+_144471643 0.21 ENST00000367568.4
STX11
syntaxin 11
chr9_-_117568365 0.21 ENST00000374045.4
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr19_-_47734448 0.21 ENST00000439096.2
BBC3
BCL2 binding component 3
chr17_-_61777090 0.21 ENST00000578061.1
LIMD2
LIM domain containing 2
chr2_-_61108449 0.20 ENST00000439412.1
ENST00000452343.1
AC010733.4
AC010733.4
chr11_+_94706804 0.20 ENST00000335080.5
KDM4D
lysine (K)-specific demethylase 4D
chr11_-_66313699 0.20 ENST00000526986.1
ENST00000310442.3
ZDHHC24
zinc finger, DHHC-type containing 24
chr1_-_38100539 0.20 ENST00000401069.1
RSPO1
R-spondin 1
chr7_+_18548878 0.20 ENST00000456174.2
HDAC9
histone deacetylase 9
chr3_+_9439400 0.20 ENST00000450326.1
ENST00000402198.1
ENST00000402466.1
SETD5
SET domain containing 5
chr17_-_61819121 0.19 ENST00000245865.5
ENST00000375840.4
ENST00000582137.1
ENST00000579549.1
ENST00000582030.1
ENST00000584110.1
ENST00000580288.1
ENST00000336174.6
ENST00000579340.1
ENST00000580338.1
STRADA
STE20-related kinase adaptor alpha
chr5_-_43313269 0.19 ENST00000511774.1
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr5_-_137090028 0.19 ENST00000314940.4
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr8_-_11058847 0.19 ENST00000297303.4
ENST00000416569.2
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr15_-_89438742 0.19 ENST00000562281.1
ENST00000562889.1
ENST00000359595.3
HAPLN3
hyaluronan and proteoglycan link protein 3
chr12_+_52445191 0.19 ENST00000243050.1
ENST00000394825.1
ENST00000550763.1
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr6_-_31138439 0.19 ENST00000259915.8
POU5F1
POU class 5 homeobox 1
chr1_-_155959853 0.18 ENST00000462460.2
ENST00000368316.1
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr10_-_51371321 0.18 ENST00000602930.1
AGAP8
ArfGAP with GTPase domain, ankyrin repeat and PH domain 8
chr7_+_44663908 0.18 ENST00000543843.1
OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr14_-_21852119 0.18 ENST00000555943.1
SUPT16H
suppressor of Ty 16 homolog (S. cerevisiae)
chr12_+_57624119 0.18 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr1_-_113249678 0.18 ENST00000369633.2
ENST00000425265.2
ENST00000369632.2
ENST00000436685.2
RHOC
ras homolog family member C
chr16_+_29823552 0.18 ENST00000300797.6
PRRT2
proline-rich transmembrane protein 2
chr21_+_34775772 0.18 ENST00000405436.1
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr2_-_157189180 0.18 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr1_+_26872324 0.18 ENST00000531382.1
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr7_+_143013198 0.17 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr17_-_39968406 0.17 ENST00000393928.1
LEPREL4
leprecan-like 4
chr17_-_7123021 0.17 ENST00000399510.2
DLG4
discs, large homolog 4 (Drosophila)
chr12_+_50690489 0.17 ENST00000598429.1
AC140061.12
Uncharacterized protein
chr7_+_120629653 0.17 ENST00000450913.2
ENST00000340646.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr12_+_48499883 0.17 ENST00000546755.1
ENST00000549366.1
ENST00000552792.1
PFKM
phosphofructokinase, muscle
chr8_-_145582118 0.17 ENST00000455319.2
ENST00000331890.5
FBXL6
F-box and leucine-rich repeat protein 6
chrX_-_80065146 0.17 ENST00000373275.4
BRWD3
bromodomain and WD repeat domain containing 3
chr19_-_39735646 0.17 ENST00000413851.2
IFNL3
interferon, lambda 3
chr19_-_39390212 0.17 ENST00000437828.1
SIRT2
sirtuin 2
chr9_-_123691047 0.17 ENST00000373887.3
TRAF1
TNF receptor-associated factor 1
chr19_+_1067144 0.17 ENST00000313093.2
HMHA1
histocompatibility (minor) HA-1
chr19_+_1067492 0.17 ENST00000586866.1
HMHA1
histocompatibility (minor) HA-1
chr16_+_53738053 0.17 ENST00000394647.3
FTO
fat mass and obesity associated
chr16_+_58537737 0.17 ENST00000561738.1
NDRG4
NDRG family member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.8 GO:0034147 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of CD40 signaling pathway(GO:2000349)
1.9 9.7 GO:0085032 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
1.7 5.1 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.9 3.6 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.9 2.6 GO:2000625 regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.7 19.1 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.6 1.9 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.6 1.7 GO:0045083 negative regulation of interleukin-12 biosynthetic process(GO:0045083)
0.5 2.7 GO:0000255 allantoin metabolic process(GO:0000255)
0.4 4.9 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.3 1.0 GO:1990108 protein linear deubiquitination(GO:1990108)
0.3 1.0 GO:0060129 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) regulation of calcium-independent cell-cell adhesion(GO:0051040) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.3 1.9 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.3 0.6 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.2 0.7 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.2 0.7 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.2 1.0 GO:0060611 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141)
0.2 0.6 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.4 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) histone H3-K9 deacetylation(GO:1990619)
0.1 1.3 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.1 0.5 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1 2.6 GO:0016322 neuron remodeling(GO:0016322)
0.1 1.3 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 1.3 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 0.5 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.1 0.8 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.6 GO:0036343 psychomotor behavior(GO:0036343)
0.1 0.5 GO:0033590 response to cobalamin(GO:0033590)
0.1 0.4 GO:0009386 translational attenuation(GO:0009386)
0.1 0.4 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 3.1 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 0.4 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.6 GO:1903288 protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288)
0.1 0.4 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.1 0.2 GO:0001878 response to yeast(GO:0001878)
0.1 0.9 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.1 0.5 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.6 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 0.5 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 0.9 GO:0036481 intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036481)
0.1 0.4 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.1 0.6 GO:1904379 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.1 0.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 0.6 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1 0.2 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.2 GO:0045726 regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726)
0.1 0.2 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 0.4 GO:0006939 smooth muscle contraction(GO:0006939)
0.1 0.2 GO:0042245 RNA repair(GO:0042245)
0.1 0.3 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 0.7 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.3 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.0 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.0 0.1 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.0 0.6 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.3 GO:0045359 positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0 0.1 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.0 0.3 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.0 0.5 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.3 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.4 GO:0042940 D-amino acid transport(GO:0042940)
0.0 3.3 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.5 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.3 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.2 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.0 0.2 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.3 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.2 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0 0.1 GO:0035065 regulation of histone acetylation(GO:0035065)
0.0 0.3 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.8 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.5 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.1 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.4 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 1.2 GO:0034142 toll-like receptor 4 signaling pathway(GO:0034142)
0.0 0.3 GO:0035897 proteolysis in other organism(GO:0035897)
0.0 0.5 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0 0.7 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.2 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.1 GO:0042441 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0 0.1 GO:0007296 vitellogenesis(GO:0007296)
0.0 2.0 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.3 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.0 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.0 0.6 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.7 GO:0007398 ectoderm development(GO:0007398)
0.0 0.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.2 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.0 GO:0060168 regulation of axon diameter(GO:0031133) regulation of adenosine receptor signaling pathway(GO:0060167) positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.0 0.1 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.0 0.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.0 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116) hindlimb morphogenesis(GO:0035137)
0.0 0.0 GO:1903093 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.0 0.1 GO:0051106 positive regulation of DNA ligation(GO:0051106)
0.0 0.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.6 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.0 0.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 0.3 GO:0051931 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.0 0.2 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.2 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.4 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.5 GO:0006692 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 0.1 GO:0006600 creatine metabolic process(GO:0006600)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.5 5.0 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.4 2.6 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 1.4 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 0.5 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1 1.0 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 1.3 GO:0070552 BRISC complex(GO:0070552)
0.1 0.8 GO:0008537 proteasome activator complex(GO:0008537)
0.1 1.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.5 GO:0045160 myosin I complex(GO:0045160)
0.1 0.5 GO:0043196 varicosity(GO:0043196)
0.1 0.4 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 0.8 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.4 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.1 0.2 GO:0035101 FACT complex(GO:0035101)
0.1 0.4 GO:0042825 TAP complex(GO:0042825)
0.1 0.6 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.1 GO:0044308 axonal spine(GO:0044308)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 3.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.3 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.5 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)
0.0 0.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0016938 kinesin I complex(GO:0016938)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.2 GO:0005683 U7 snRNP(GO:0005683)
0.0 1.0 GO:0097542 ciliary tip(GO:0097542)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 21.9 GO:0005615 extracellular space(GO:0005615)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
1.3 18.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.5 9.8 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.3 1.9 GO:0046979 TAP2 binding(GO:0046979)
0.2 0.4 GO:0046969 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.2 0.5 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.2 3.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 9.7 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 0.7 GO:0050473 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
0.1 1.0 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 1.3 GO:0004793 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 0.9 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 2.6 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 0.8 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.8 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.6 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.1 0.4 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.1 0.4 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 1.0 GO:0019211 phosphatase activator activity(GO:0019211) BMP receptor binding(GO:0070700)
0.1 3.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.4 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.1 0.5 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.1 3.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.3 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 0.2 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.0 1.9 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.1 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.2 GO:0035514 DNA demethylase activity(GO:0035514)
0.0 0.7 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.5 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.2 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.6 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 1.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0072544 L-DOPA receptor activity(GO:0035643) L-DOPA binding(GO:0072544)
0.0 0.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.6 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.3 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.6 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.1 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.0 0.2 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.0 0.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.3 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.8 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.1 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.0 0.2 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.5 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.3 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 0.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 1.1 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.2 GO:0035198 miRNA binding(GO:0035198)
0.0 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 20.4 PID CD40 PATHWAY CD40/CD40L signaling
0.1 3.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 5.3 PID IL23 PATHWAY IL23-mediated signaling events
0.1 2.6 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 2.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 19.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.7 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.7 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.1 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.7 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID MYC PATHWAY C-MYC pathway
0.0 0.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 23.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 15.4 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.2 4.1 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1 1.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 2.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.6 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 3.3 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 0.5 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.1 0.2 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 0.3 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 1.0 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.5 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.3 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.5 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 2.3 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 1.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.6 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions