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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NHLH1

Z-value: 0.89

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Transcription factors associated with NHLH1

Gene Symbol Gene ID Gene Info
NHLH1
ENSG00000171786.5 nescient helix-loop-helix 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NHLH1hg19_v2_chr1_+_160336851_1603368680.207.1e-01Click!

Activity profile of NHLH1 motif

Sorted Z-values of NHLH1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_39258461 1.13 ENST00000440582.1
KRTAP4-16P
keratin associated protein 4-16, pseudogene
chr17_+_38171614 0.70 ENST00000583218.1
ENST00000394149.3
CSF3
colony stimulating factor 3 (granulocyte)
chr20_+_44637526 0.64 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr6_-_160148356 0.63 ENST00000401980.3
ENST00000545162.1
SOD2
superoxide dismutase 2, mitochondrial
chr6_+_31895467 0.54 ENST00000556679.1
ENST00000456570.1
CFB
CFB
complement factor B
Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr6_+_31895480 0.49 ENST00000418949.2
ENST00000383177.3
ENST00000477310.1
C2
CFB
complement component 2
Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr1_-_38273840 0.43 ENST00000373044.2
YRDC
yrdC N(6)-threonylcarbamoyltransferase domain containing
chrX_+_70521584 0.40 ENST00000373829.3
ENST00000538820.1
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr12_-_58145889 0.39 ENST00000547853.1
CDK4
cyclin-dependent kinase 4
chr10_+_12391685 0.38 ENST00000378845.1
CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr11_+_71238313 0.34 ENST00000398536.4
KRTAP5-7
keratin associated protein 5-7
chr16_-_2770216 0.32 ENST00000302641.3
PRSS27
protease, serine 27
chr4_-_2758015 0.32 ENST00000510267.1
ENST00000503235.1
ENST00000315423.7
TNIP2
TNFAIP3 interacting protein 2
chr4_-_80994210 0.32 ENST00000403729.2
ANTXR2
anthrax toxin receptor 2
chr12_-_86650077 0.30 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr1_-_2461684 0.30 ENST00000378453.3
HES5
hes family bHLH transcription factor 5
chr6_-_30712313 0.30 ENST00000376377.2
ENST00000259874.5
IER3
immediate early response 3
chr11_-_1619524 0.30 ENST00000412090.1
KRTAP5-2
keratin associated protein 5-2
chr19_+_39989535 0.29 ENST00000356433.5
DLL3
delta-like 3 (Drosophila)
chr11_+_61276214 0.29 ENST00000378075.2
LRRC10B
leucine rich repeat containing 10B
chr12_-_113658892 0.29 ENST00000299732.2
ENST00000416617.2
IQCD
IQ motif containing D
chr16_+_23847339 0.29 ENST00000303531.7
PRKCB
protein kinase C, beta
chr4_+_89299994 0.29 ENST00000264346.7
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr6_-_38607628 0.28 ENST00000498633.1
BTBD9
BTB (POZ) domain containing 9
chr6_+_126112001 0.28 ENST00000392477.2
NCOA7
nuclear receptor coactivator 7
chr1_-_119682812 0.28 ENST00000537870.1
WARS2
tryptophanyl tRNA synthetase 2, mitochondrial
chr2_+_58655461 0.28 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1
long intergenic non-protein coding RNA 1122
chr2_-_230135937 0.28 ENST00000392054.3
ENST00000409462.1
ENST00000392055.3
PID1
phosphotyrosine interaction domain containing 1
chr5_-_138739739 0.27 ENST00000514983.1
ENST00000507779.2
ENST00000451821.2
ENST00000450845.2
ENST00000509959.1
ENST00000302091.5
SPATA24
spermatogenesis associated 24
chr4_+_89299885 0.27 ENST00000380265.5
ENST00000273960.3
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr7_-_131241361 0.27 ENST00000378555.3
ENST00000322985.9
ENST00000541194.1
ENST00000537928.1
PODXL
podocalyxin-like
chr7_-_6388389 0.26 ENST00000578372.1
FAM220A
family with sequence similarity 220, member A
chrX_-_19905577 0.26 ENST00000379697.3
SH3KBP1
SH3-domain kinase binding protein 1
chr9_-_112970436 0.25 ENST00000400613.4
C9orf152
chromosome 9 open reading frame 152
chr9_-_117880477 0.25 ENST00000534839.1
ENST00000340094.3
ENST00000535648.1
ENST00000346706.3
ENST00000345230.3
ENST00000350763.4
TNC
tenascin C
chr12_-_54813229 0.24 ENST00000293379.4
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr2_-_96811170 0.24 ENST00000288943.4
DUSP2
dual specificity phosphatase 2
chr6_+_126112074 0.23 ENST00000453302.1
ENST00000417494.1
ENST00000229634.9
NCOA7
nuclear receptor coactivator 7
chr6_-_75915757 0.23 ENST00000322507.8
COL12A1
collagen, type XII, alpha 1
chr22_-_24989014 0.23 ENST00000318753.8
FAM211B
family with sequence similarity 211, member B
chrX_-_43832711 0.23 ENST00000378062.5
NDP
Norrie disease (pseudoglioma)
chr7_-_127671674 0.22 ENST00000478726.1
LRRC4
leucine rich repeat containing 4
chr10_-_101380121 0.22 ENST00000370495.4
SLC25A28
solute carrier family 25 (mitochondrial iron transporter), member 28
chr16_+_23847267 0.22 ENST00000321728.7
PRKCB
protein kinase C, beta
chr14_+_64971438 0.21 ENST00000555321.1
ZBTB1
zinc finger and BTB domain containing 1
chr8_-_125740514 0.21 ENST00000325064.5
ENST00000518547.1
MTSS1
metastasis suppressor 1
chr7_-_77045617 0.21 ENST00000257626.7
GSAP
gamma-secretase activating protein
chr16_-_88772670 0.21 ENST00000562544.1
RNF166
ring finger protein 166
chr1_+_20915409 0.21 ENST00000375071.3
CDA
cytidine deaminase
chr1_+_13910479 0.21 ENST00000509009.1
PDPN
podoplanin
chr20_+_44036620 0.20 ENST00000372710.3
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr14_-_24732403 0.20 ENST00000206765.6
TGM1
transglutaminase 1
chr1_+_226411319 0.20 ENST00000542034.1
ENST00000366810.5
MIXL1
Mix paired-like homeobox
chr3_+_167453026 0.20 ENST00000472941.1
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr2_+_196522032 0.20 ENST00000418005.1
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chrX_+_150151752 0.20 ENST00000325307.7
HMGB3
high mobility group box 3
chr16_-_90085824 0.20 ENST00000002501.6
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr7_-_766879 0.20 ENST00000537384.1
ENST00000417852.1
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr15_+_91427726 0.19 ENST00000452243.1
FES
feline sarcoma oncogene
chr1_+_13910194 0.19 ENST00000376057.4
ENST00000510906.1
PDPN
podoplanin
chr12_+_90102729 0.19 ENST00000605386.1
LINC00936
long intergenic non-protein coding RNA 936
chr22_+_32340481 0.19 ENST00000397492.1
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr22_+_32340447 0.19 ENST00000248975.5
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr5_+_52776228 0.18 ENST00000256759.3
FST
follistatin
chr15_-_102264619 0.18 ENST00000335968.3
TARSL2
threonyl-tRNA synthetase-like 2
chr20_-_56100155 0.18 ENST00000423479.3
ENST00000502686.2
ENST00000433949.3
ENST00000539382.1
ENST00000608903.1
CTCFL
CCCTC-binding factor (zinc finger protein)-like
chr6_-_43543702 0.18 ENST00000265351.7
XPO5
exportin 5
chr4_-_80994619 0.18 ENST00000404191.1
ANTXR2
anthrax toxin receptor 2
chrX_-_19905703 0.17 ENST00000397821.3
SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_32538520 0.17 ENST00000438825.1
ENST00000456834.2
ENST00000373634.4
ENST00000427288.1
TMEM39B
transmembrane protein 39B
chr5_-_178772424 0.17 ENST00000251582.7
ENST00000274609.5
ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr11_+_110001723 0.17 ENST00000528673.1
ZC3H12C
zinc finger CCCH-type containing 12C
chr1_-_8075693 0.17 ENST00000467067.1
ERRFI1
ERBB receptor feedback inhibitor 1
chr15_-_60884706 0.17 ENST00000449337.2
RORA
RAR-related orphan receptor A
chr14_-_24732368 0.17 ENST00000544573.1
TGM1
transglutaminase 1
chr3_+_49711777 0.17 ENST00000442186.1
ENST00000438011.1
ENST00000457042.1
APEH
acylaminoacyl-peptide hydrolase
chr1_+_32538492 0.17 ENST00000336294.5
TMEM39B
transmembrane protein 39B
chr4_+_87856191 0.17 ENST00000503477.1
AFF1
AF4/FMR2 family, member 1
chrX_-_68385354 0.17 ENST00000361478.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr3_+_49711391 0.16 ENST00000296456.5
ENST00000449966.1
APEH
acylaminoacyl-peptide hydrolase
chr10_+_103348031 0.16 ENST00000370151.4
ENST00000370147.1
ENST00000370148.2
DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
chrX_+_49126294 0.16 ENST00000466508.1
ENST00000438316.1
ENST00000055335.6
ENST00000495799.1
PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr1_-_22469459 0.16 ENST00000290167.6
WNT4
wingless-type MMTV integration site family, member 4
chr5_-_16936340 0.16 ENST00000507288.1
ENST00000513610.1
MYO10
myosin X
chr14_-_64971288 0.16 ENST00000394715.1
ZBTB25
zinc finger and BTB domain containing 25
chr1_+_14075903 0.16 ENST00000343137.4
ENST00000503842.1
ENST00000407521.3
ENST00000505823.1
PRDM2
PR domain containing 2, with ZNF domain
chr2_+_137523086 0.16 ENST00000409968.1
THSD7B
thrombospondin, type I, domain containing 7B
chr6_+_30848829 0.16 ENST00000508317.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr17_-_1012305 0.16 ENST00000291107.2
ABR
active BCR-related
chr17_-_54991369 0.16 ENST00000537230.1
TRIM25
tripartite motif containing 25
chr12_+_27932803 0.15 ENST00000381271.2
KLHL42
kelch-like family member 42
chr2_+_48541776 0.15 ENST00000413569.1
ENST00000340553.3
FOXN2
forkhead box N2
chr11_+_62556596 0.15 ENST00000526546.1
TMEM179B
transmembrane protein 179B
chr6_+_30848740 0.15 ENST00000505534.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr13_-_28194541 0.15 ENST00000316334.3
LNX2
ligand of numb-protein X 2
chr17_-_79792909 0.15 ENST00000330261.4
ENST00000570394.1
PPP1R27
protein phosphatase 1, regulatory subunit 27
chr6_+_30848557 0.15 ENST00000460944.2
ENST00000324771.8
DDR1
discoidin domain receptor tyrosine kinase 1
chr6_-_131211534 0.15 ENST00000456097.2
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr15_-_80215984 0.15 ENST00000485386.1
ENST00000479961.1
ST20
ST20-MTHFS
suppressor of tumorigenicity 20
ST20-MTHFS readthrough
chr19_-_47104118 0.15 ENST00000593888.1
ENST00000602017.1
AC011551.3
PPP5D1
Uncharacterized protein
PPP5 tetratricopeptide repeat domain containing 1
chr2_+_191513789 0.15 ENST00000409581.1
NAB1
NGFI-A binding protein 1 (EGR1 binding protein 1)
chrX_-_68385274 0.15 ENST00000374584.3
ENST00000590146.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr20_+_35234137 0.14 ENST00000344795.3
ENST00000373852.5
C20orf24
chromosome 20 open reading frame 24
chr2_+_65663812 0.14 ENST00000606978.1
ENST00000377977.3
ENST00000536804.1
AC074391.1
AC074391.1
chr20_+_44036900 0.14 ENST00000443296.1
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr2_-_70475586 0.14 ENST00000416149.2
TIA1
TIA1 cytotoxic granule-associated RNA binding protein
chr1_-_38218577 0.14 ENST00000540011.1
EPHA10
EPH receptor A10
chr6_-_43596899 0.14 ENST00000307126.5
ENST00000452781.1
GTPBP2
GTP binding protein 2
chr11_-_71293921 0.14 ENST00000398530.1
KRTAP5-11
keratin associated protein 5-11
chr3_+_99833755 0.14 ENST00000489081.1
CMSS1
cms1 ribosomal small subunit homolog (yeast)
chr15_+_91427642 0.14 ENST00000328850.3
ENST00000414248.2
FES
feline sarcoma oncogene
chr19_+_36024310 0.14 ENST00000222286.4
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr3_-_45187843 0.14 ENST00000296129.1
ENST00000425231.2
CDCP1
CUB domain containing protein 1
chr7_-_767249 0.14 ENST00000403562.1
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr1_-_229694406 0.14 ENST00000344517.4
ABCB10
ATP-binding cassette, sub-family B (MDR/TAP), member 10
chr19_+_16187085 0.14 ENST00000300933.4
TPM4
tropomyosin 4
chr21_+_35445811 0.14 ENST00000399312.2
MRPS6
mitochondrial ribosomal protein S6
chr12_+_113659234 0.14 ENST00000551096.1
ENST00000551099.1
ENST00000335509.6
ENST00000552897.1
ENST00000550785.1
ENST00000549279.1
TPCN1
two pore segment channel 1
chr3_-_62860704 0.14 ENST00000490353.2
CADPS
Ca++-dependent secretion activator
chr17_-_15554940 0.13 ENST00000455584.2
RP11-385D13.1
Uncharacterized protein
chr10_+_1102303 0.13 ENST00000381329.1
WDR37
WD repeat domain 37
chr2_+_10442993 0.13 ENST00000423674.1
ENST00000307845.3
HPCAL1
hippocalcin-like 1
chr11_+_62554860 0.13 ENST00000533861.1
ENST00000333449.4
TMEM179B
transmembrane protein 179B
chr1_-_207096529 0.13 ENST00000525793.1
ENST00000529560.1
FAIM3
Fas apoptotic inhibitory molecule 3
chr12_-_110318130 0.13 ENST00000540772.1
GLTP
glycolipid transfer protein
chr11_-_74022658 0.13 ENST00000427714.2
ENST00000331597.4
P4HA3
prolyl 4-hydroxylase, alpha polypeptide III
chr20_-_43438912 0.13 ENST00000541604.2
ENST00000372851.3
RIMS4
regulating synaptic membrane exocytosis 4
chr10_+_112257596 0.13 ENST00000369583.3
DUSP5
dual specificity phosphatase 5
chr14_+_73525265 0.13 ENST00000525161.1
RBM25
RNA binding motif protein 25
chr14_+_31343747 0.13 ENST00000216361.4
ENST00000396618.3
ENST00000475087.1
COCH
cochlin
chr3_-_73673991 0.13 ENST00000308537.4
ENST00000263666.4
PDZRN3
PDZ domain containing ring finger 3
chr12_-_113658826 0.12 ENST00000546692.1
IQCD
IQ motif containing D
chr5_+_49962772 0.12 ENST00000281631.5
ENST00000513738.1
ENST00000503665.1
ENST00000514067.2
ENST00000503046.1
PARP8
poly (ADP-ribose) polymerase family, member 8
chr20_-_48770244 0.12 ENST00000371650.5
ENST00000371652.4
ENST00000557021.1
TMEM189
transmembrane protein 189
chr6_+_30848771 0.12 ENST00000503180.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr10_-_103347883 0.12 ENST00000339310.3
ENST00000370158.3
ENST00000299206.4
ENST00000456836.2
ENST00000413344.1
ENST00000429502.1
ENST00000430045.1
ENST00000370172.1
ENST00000436284.2
ENST00000370162.3
POLL
polymerase (DNA directed), lambda
chr6_+_4776580 0.12 ENST00000397588.3
CDYL
chromodomain protein, Y-like
chr1_-_119683251 0.12 ENST00000369426.5
ENST00000235521.4
WARS2
tryptophanyl tRNA synthetase 2, mitochondrial
chr19_+_10217364 0.12 ENST00000430370.1
PPAN
peter pan homolog (Drosophila)
chr17_-_73266616 0.12 ENST00000579194.1
ENST00000581777.1
MIF4GD
MIF4G domain containing
chr3_+_5020801 0.12 ENST00000256495.3
BHLHE40
basic helix-loop-helix family, member e40
chr12_+_57984965 0.12 ENST00000540759.2
ENST00000551772.1
ENST00000550465.1
ENST00000354947.5
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr2_+_69001913 0.12 ENST00000409030.3
ENST00000409220.1
ARHGAP25
Rho GTPase activating protein 25
chr6_-_43337180 0.12 ENST00000318149.3
ENST00000361428.2
ZNF318
zinc finger protein 318
chr5_+_52776449 0.12 ENST00000396947.3
FST
follistatin
chr1_-_19536744 0.12 ENST00000375267.2
ENST00000375217.2
ENST00000375226.2
ENST00000375254.3
UBR4
ubiquitin protein ligase E3 component n-recognin 4
chr15_+_91427691 0.12 ENST00000559355.1
ENST00000394302.1
FES
feline sarcoma oncogene
chr8_+_128747757 0.12 ENST00000517291.1
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr12_+_652294 0.11 ENST00000322843.3
B4GALNT3
beta-1,4-N-acetyl-galactosaminyl transferase 3
chr8_+_86376081 0.11 ENST00000285379.5
CA2
carbonic anhydrase II
chr16_+_67562702 0.11 ENST00000379312.3
ENST00000042381.4
ENST00000540839.3
FAM65A
family with sequence similarity 65, member A
chr17_-_8301132 0.11 ENST00000399398.2
RNF222
ring finger protein 222
chr6_-_44095183 0.11 ENST00000372014.3
MRPL14
mitochondrial ribosomal protein L14
chr12_-_110318226 0.11 ENST00000544393.1
GLTP
glycolipid transfer protein
chr14_+_90863327 0.11 ENST00000356978.4
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr1_-_92351666 0.11 ENST00000465892.2
ENST00000417833.2
TGFBR3
transforming growth factor, beta receptor III
chr19_+_47104553 0.11 ENST00000598871.1
ENST00000594523.1
CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr8_+_128748308 0.11 ENST00000377970.2
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr19_-_59070239 0.11 ENST00000595957.1
ENST00000253023.3
UBE2M
ubiquitin-conjugating enzyme E2M
chr11_+_17756279 0.11 ENST00000265969.6
KCNC1
potassium voltage-gated channel, Shaw-related subfamily, member 1
chr7_-_105925558 0.11 ENST00000222553.3
NAMPT
nicotinamide phosphoribosyltransferase
chr12_-_118406777 0.11 ENST00000339824.5
KSR2
kinase suppressor of ras 2
chr8_+_24772455 0.11 ENST00000433454.2
NEFM
neurofilament, medium polypeptide
chr7_+_20370300 0.11 ENST00000537992.1
ITGB8
integrin, beta 8
chr20_+_32399093 0.11 ENST00000217402.2
CHMP4B
charged multivesicular body protein 4B
chr4_+_75311019 0.11 ENST00000502307.1
AREG
amphiregulin
chr6_-_3157760 0.11 ENST00000333628.3
TUBB2A
tubulin, beta 2A class IIa
chr6_+_31730773 0.11 ENST00000415669.2
ENST00000425424.1
SAPCD1
suppressor APC domain containing 1
chr12_-_2944184 0.10 ENST00000337508.4
NRIP2
nuclear receptor interacting protein 2
chrX_+_84498989 0.10 ENST00000395402.1
ZNF711
zinc finger protein 711
chr16_+_69373471 0.10 ENST00000569637.2
NIP7
NIP7, nucleolar pre-rRNA processing protein
chr16_+_330581 0.10 ENST00000219409.3
ARHGDIG
Rho GDP dissociation inhibitor (GDI) gamma
chr9_-_104357277 0.10 ENST00000374806.1
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr9_+_2017420 0.10 ENST00000439732.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr16_+_69373323 0.10 ENST00000254940.5
NIP7
NIP7, nucleolar pre-rRNA processing protein
chr17_-_27278304 0.10 ENST00000577226.1
PHF12
PHD finger protein 12
chr11_-_75141206 0.10 ENST00000376292.4
KLHL35
kelch-like family member 35
chr19_-_55953704 0.10 ENST00000416792.1
SHISA7
shisa family member 7
chr20_+_35234223 0.10 ENST00000342422.3
C20orf24
chromosome 20 open reading frame 24
chr1_+_15272271 0.10 ENST00000400797.3
KAZN
kazrin, periplakin interacting protein
chr14_+_70346125 0.10 ENST00000361956.3
ENST00000381280.4
SMOC1
SPARC related modular calcium binding 1
chr14_-_89021077 0.10 ENST00000556564.1
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr14_+_24584056 0.10 ENST00000561001.1
DCAF11
DDB1 and CUL4 associated factor 11
chr14_-_101053739 0.10 ENST00000554140.1
BEGAIN
brain-enriched guanylate kinase-associated
chr6_-_154831779 0.10 ENST00000607772.1
CNKSR3
CNKSR family member 3
chr19_+_35521572 0.10 ENST00000262631.5
SCN1B
sodium channel, voltage-gated, type I, beta subunit
chr6_+_129204337 0.10 ENST00000421865.2
LAMA2
laminin, alpha 2
chr16_-_67694129 0.10 ENST00000602320.1
ACD
adrenocortical dysplasia homolog (mouse)
chr20_-_48770174 0.09 ENST00000341698.2
TMEM189-UBE2V1
TMEM189-UBE2V1 readthrough
chr19_+_16186903 0.09 ENST00000588507.1
TPM4
tropomyosin 4
chr1_+_157963063 0.09 ENST00000360089.4
ENST00000368173.3
ENST00000392272.2
KIRREL
kin of IRRE like (Drosophila)
chr18_-_5544241 0.09 ENST00000341928.2
ENST00000540638.2
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr2_+_103236004 0.09 ENST00000233969.2
SLC9A2
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
chr1_+_32687971 0.09 ENST00000373586.1
EIF3I
eukaryotic translation initiation factor 3, subunit I
chr2_+_54683419 0.09 ENST00000356805.4
SPTBN1
spectrin, beta, non-erythrocytic 1
chr3_+_167453493 0.09 ENST00000295777.5
ENST00000472747.2
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr16_-_89883015 0.09 ENST00000563673.1
ENST00000389301.3
ENST00000568369.1
ENST00000534992.1
ENST00000389302.3
ENST00000543736.1
FANCA
Fanconi anemia, complementation group A
chr6_+_30851840 0.09 ENST00000511510.1
ENST00000376569.3
ENST00000376575.3
ENST00000376570.4
ENST00000446312.1
ENST00000504927.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr13_+_49794474 0.09 ENST00000218721.1
ENST00000398307.1
MLNR
motilin receptor
chr18_+_3449821 0.09 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1
TGFB-induced factor homeobox 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NHLH1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.1 0.4 GO:1990764 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.1 0.6 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.1 0.4 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 0.3 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.1 0.3 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.2 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.1 0.1 GO:0001798 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.1 0.2 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.1 0.6 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.1 0.2 GO:0019858 cytosine metabolic process(GO:0019858)
0.1 0.4 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.2 GO:0035281 pre-miRNA export from nucleus(GO:0035281)
0.1 0.2 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.1 0.2 GO:0060381 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.1 0.3 GO:2001170 positive regulation of fat cell proliferation(GO:0070346) negative regulation of ATP biosynthetic process(GO:2001170)
0.1 0.2 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.1 0.7 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 0.2 GO:0061183 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) renal vesicle induction(GO:0072034) regulation of testosterone biosynthetic process(GO:2000224)
0.1 0.4 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.1 1.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0 0.2 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.2 GO:0090096 regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.0 0.4 GO:1904636 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.0 0.3 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.2 GO:1903613 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.0 0.4 GO:0023035 CD40 signaling pathway(GO:0023035)
0.0 0.2 GO:0007468 regulation of rhodopsin gene expression(GO:0007468) positive regulation of rhodopsin gene expression(GO:0045872)
0.0 0.1 GO:0042938 positive regulation of cellular pH reduction(GO:0032849) dipeptide transport(GO:0042938)
0.0 0.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.7 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.0 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0 0.1 GO:2000176 regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.0 0.1 GO:0099525 presynaptic dense core granule exocytosis(GO:0099525)
0.0 0.3 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.1 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.0 0.2 GO:0030035 microspike assembly(GO:0030035)
0.0 0.1 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.0 0.3 GO:0010616 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.0 0.3 GO:1900242 regulation of synaptic vesicle endocytosis(GO:1900242)
0.0 0.2 GO:0046836 glycolipid transport(GO:0046836)
0.0 0.1 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.0 0.0 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0 0.1 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.1 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.0 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.0 0.1 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408)
0.0 0.5 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.1 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.0 0.2 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.2 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.1 GO:0098972 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.0 0.3 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.1 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0 0.1 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
0.0 0.1 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.1 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181) vasculogenesis involved in coronary vascular morphogenesis(GO:0060979)
0.0 0.1 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.1 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.0 0.2 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.2 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.0 GO:0072186 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094)
0.0 0.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 0.2 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.0 GO:0009996 negative regulation of cell fate specification(GO:0009996) positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.4 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.2 GO:0021678 third ventricle development(GO:0021678)
0.0 0.3 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785)
0.0 0.1 GO:0015853 adenine transport(GO:0015853)
0.0 0.3 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.0 0.0 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.0 0.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.1 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.1 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.0 0.1 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.1 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.2 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.0 0.1 GO:0039533 regulation of MDA-5 signaling pathway(GO:0039533)
0.0 0.0 GO:0035696 egg activation(GO:0007343) monocyte extravasation(GO:0035696) regulation of fertilization(GO:0080154) activation of meiosis(GO:0090427) regulation of monocyte extravasation(GO:2000437)
0.0 0.2 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.1 GO:0032661 release of cytoplasmic sequestered NF-kappaB(GO:0008588) regulation of interleukin-18 production(GO:0032661) negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.0 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.0 0.2 GO:0008340 determination of adult lifespan(GO:0008340)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1 0.2 GO:0005595 collagen type XII trimer(GO:0005595)
0.1 0.2 GO:0042565 nuclear RNA export factor complex(GO:0042272) RNA nuclear export complex(GO:0042565)
0.0 0.4 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.2 GO:0032044 DSIF complex(GO:0032044)
0.0 0.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.0 0.2 GO:0097165 nuclear stress granule(GO:0097165)
0.0 0.3 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.1 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.0 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.1 GO:0000801 central element(GO:0000801)
0.0 0.2 GO:0070187 telosome(GO:0070187)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.1 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 0.6 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.4 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.2 GO:0090631 pre-miRNA transporter activity(GO:0090631)
0.1 0.2 GO:0047280 nicotinamide phosphoribosyltransferase activity(GO:0047280)
0.1 0.3 GO:0097677 STAT family protein binding(GO:0097677)
0.0 0.1 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.0 0.2 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.2 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.2 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 0.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.1 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.1 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.1 GO:0070123 transforming growth factor beta receptor activity, type III(GO:0070123)
0.0 0.5 GO:0015250 water channel activity(GO:0015250)
0.0 1.1 GO:0001848 complement binding(GO:0001848)
0.0 0.1 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0 0.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.1 GO:0005365 myo-inositol transmembrane transporter activity(GO:0005365)
0.0 0.1 GO:0044594 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
0.0 0.1 GO:0019863 IgE binding(GO:0019863)
0.0 0.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.2 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.3 GO:0048185 activin binding(GO:0048185)
0.0 0.2 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.4 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.1 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0042731 PH domain binding(GO:0042731)
0.0 0.3 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.1 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.0 0.2 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)
0.0 0.1 GO:0098519 phosphoserine phosphatase activity(GO:0004647) nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.6 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.2 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.5 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.9 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.4 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation