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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX1-1

Z-value: 0.34

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Transcription factors associated with NKX1-1

Gene Symbol Gene ID Gene Info
ENSG00000235608.1 NK1 homeobox 1

Activity profile of NKX1-1 motif

Sorted Z-values of NKX1-1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_16500571 0.21 ENST00000543076.1
ENST00000396210.3
microsomal glutathione S-transferase 1
chr12_+_16500599 0.21 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
microsomal glutathione S-transferase 1
chr4_-_89442940 0.20 ENST00000527353.1
phosphatidylinositol glycan anchor biosynthesis, class Y
chr10_+_120789223 0.19 ENST00000425699.1
nanos homolog 1 (Drosophila)
chr12_+_16500037 0.19 ENST00000536371.1
ENST00000010404.2
microsomal glutathione S-transferase 1
chr4_-_87515202 0.19 ENST00000502302.1
ENST00000513186.1
mitogen-activated protein kinase 10
chr2_+_8822113 0.17 ENST00000396290.1
ENST00000331129.3
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr7_+_12726623 0.16 ENST00000439721.1
ADP-ribosylation factor-like 4A
chr17_+_57233087 0.14 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
proline rich 11
chr1_-_108507631 0.13 ENST00000527011.1
ENST00000370056.4
vav 3 guanine nucleotide exchange factor
chr12_+_64798826 0.12 ENST00000540203.1
exportin, tRNA
chr15_+_96904487 0.11 ENST00000600790.1
Uncharacterized protein
chr13_-_36050819 0.11 ENST00000379919.4
mab-21-like 1 (C. elegans)
chrX_-_47509994 0.10 ENST00000343894.4
ELK1, member of ETS oncogene family
chr14_+_32798547 0.09 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chr1_+_174843548 0.09 ENST00000478442.1
ENST00000465412.1
RAB GTPase activating protein 1-like
chr1_-_221915418 0.09 ENST00000323825.3
ENST00000366899.3
dual specificity phosphatase 10
chr17_-_57232525 0.09 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
spindle and kinetochore associated complex subunit 2
chr2_-_97405775 0.09 ENST00000264963.4
ENST00000537039.1
ENST00000377079.4
ENST00000426463.2
ENST00000534882.1
lectin, mannose-binding 2-like
chr1_-_197115818 0.08 ENST00000367409.4
ENST00000294732.7
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr11_-_105892937 0.07 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr7_+_26331678 0.07 ENST00000446848.2
sorting nexin 10
chr1_+_62439037 0.07 ENST00000545929.1
InaD-like (Drosophila)
chr12_+_102513950 0.07 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARP1 binding protein
chr16_-_66864806 0.07 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NEDD8 activating enzyme E1 subunit 1
chr7_+_12727250 0.07 ENST00000404894.1
ADP-ribosylation factor-like 4A
chr5_-_159546396 0.07 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP domain containing 2A
chr1_-_151762943 0.07 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
tudor and KH domain containing
chr8_+_26371763 0.07 ENST00000521913.1
dihydropyrimidinase-like 2
chr11_-_62521614 0.06 ENST00000527994.1
ENST00000394807.3
zinc finger and BTB domain containing 3
chr7_-_86849883 0.06 ENST00000433078.1
transmembrane protein 243, mitochondrial
chr12_+_102514019 0.06 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARP1 binding protein
chr11_-_4629388 0.06 ENST00000526337.1
ENST00000300747.5
tripartite motif containing 68
chr1_+_100818009 0.06 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
cell division cycle 14A
chr18_-_33709268 0.06 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
solute carrier family 39 (zinc transporter), member 6
chr6_-_80247105 0.06 ENST00000369846.4
Leber congenital amaurosis 5
chr11_-_111741994 0.06 ENST00000398006.2
ALG9, alpha-1,2-mannosyltransferase
chr3_+_158519654 0.06 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
major facilitator superfamily domain containing 1
chr17_-_57232596 0.06 ENST00000581068.1
ENST00000330137.7
spindle and kinetochore associated complex subunit 2
chr8_+_98656693 0.05 ENST00000519934.1
metadherin
chr19_+_36249057 0.05 ENST00000301165.5
ENST00000536950.1
ENST00000537459.1
ENST00000421853.2
chromosome 19 open reading frame 55
chr11_-_118023594 0.05 ENST00000529878.1
sodium channel, voltage-gated, type IV, beta subunit
chr10_+_5238793 0.05 ENST00000263126.1
aldo-keto reductase family 1, member C4
chr12_+_7014126 0.05 ENST00000415834.1
ENST00000436789.1
leucine rich repeat containing 23
chr11_-_124981475 0.05 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
transmembrane protein 218
chr16_-_2318111 0.04 ENST00000301730.8
ENST00000564822.1
RNA binding protein S1, serine-rich domain
chr15_-_78526942 0.04 ENST00000258873.4
acyl-CoA synthetase bubblegum family member 1
chr3_-_105588231 0.04 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr2_+_187371440 0.04 ENST00000445547.1
zinc finger CCCH-type containing 15
chr17_-_44657017 0.04 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
ADP-ribosylation factor-like 17A
chr3_+_57261743 0.04 ENST00000288266.3
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr6_-_82957433 0.04 ENST00000306270.7
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr17_-_44439084 0.04 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
ADP-ribosylation factor-like 17B
chrX_+_72783026 0.04 ENST00000373504.6
ENST00000373502.5
cysteine-rich hydrophobic domain 1
chr4_-_54232144 0.04 ENST00000388940.4
ENST00000503450.1
ENST00000401642.3
sec1 family domain containing 2
chr3_-_59035673 0.04 ENST00000491845.1
ENST00000472469.1
ENST00000471288.1
ENST00000295966.7
chromosome 3 open reading frame 67
chr3_-_105587879 0.04 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr6_-_85473073 0.04 ENST00000606621.1
T-box 18
chr19_-_14228541 0.04 ENST00000590853.1
ENST00000308677.4
protein kinase, cAMP-dependent, catalytic, alpha
chr2_-_239197238 0.03 ENST00000254657.3
period circadian clock 2
chr12_+_7014064 0.03 ENST00000443597.2
leucine rich repeat containing 23
chr13_+_36050881 0.03 ENST00000537702.1
neurobeachin
chr1_+_100818156 0.03 ENST00000336454.3
cell division cycle 14A
chr7_+_99647411 0.03 ENST00000438937.1
zinc finger and SCAN domain containing 21
chr8_+_98656336 0.03 ENST00000336273.3
metadherin
chr4_+_87515454 0.03 ENST00000427191.2
ENST00000436978.1
ENST00000502971.1
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
chr4_-_103682145 0.03 ENST00000226578.4
mannosidase, beta A, lysosomal
chr5_+_150226085 0.03 ENST00000522154.1
immunity-related GTPase family, M
chr17_+_57232690 0.03 ENST00000262293.4
proline rich 11
chr8_+_22132810 0.03 ENST00000356766.6
piwi-like RNA-mediated gene silencing 2
chr7_-_6048702 0.02 ENST00000265849.7
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr7_+_26331541 0.02 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
sorting nexin 10
chr7_+_2559399 0.02 ENST00000222725.5
ENST00000359574.3
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr2_-_47142884 0.02 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
multiple coagulation factor deficiency 2
chr1_+_46972668 0.02 ENST00000371956.4
ENST00000360032.3
diencephalon/mesencephalon homeobox 1
chr7_-_73256838 0.02 ENST00000297873.4
Williams Beuren syndrome chromosome region 27
chr17_-_45266542 0.02 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
cell division cycle 27
chr2_-_239197201 0.02 ENST00000254658.3
period circadian clock 2
chr2_-_167232484 0.02 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
sodium channel, voltage-gated, type IX, alpha subunit
chr10_+_99205959 0.02 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
zinc finger, DHHC-type containing 16
chr1_-_51796226 0.02 ENST00000451380.1
ENST00000371747.3
ENST00000439482.1
tetratricopeptide repeat domain 39A
chr18_+_63273310 0.02 ENST00000579862.1
RP11-775G23.1
chr1_-_151762900 0.01 ENST00000440583.2
tudor and KH domain containing
chr17_+_59489112 0.01 ENST00000335108.2
chromosome 17 open reading frame 82
chr1_-_231004220 0.01 ENST00000366663.5
chromosome 1 open reading frame 198
chr19_+_32896697 0.01 ENST00000586987.1
dpy-19-like 3 (C. elegans)
chr11_-_65625678 0.01 ENST00000308162.5
cofilin 1 (non-muscle)
chr7_-_143991230 0.01 ENST00000543357.1
Rho guanine nucleotide exchange factor (GEF) 35
chrX_-_47509887 0.01 ENST00000247161.3
ENST00000592066.1
ENST00000376983.3
ELK1, member of ETS oncogene family
chr12_-_50790267 0.01 ENST00000327337.5
ENST00000543111.1
family with sequence similarity 186, member A
chr1_-_28969517 0.01 ENST00000263974.4
ENST00000373824.4
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
chr19_+_32897009 0.01 ENST00000342179.5
ENST00000586427.1
dpy-19-like 3 (C. elegans)
chr8_+_94929168 0.01 ENST00000518107.1
ENST00000396200.3
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr19_+_42811093 0.01 ENST00000595750.1
proline rich 19
chr1_-_51796987 0.01 ENST00000262676.5
tetratricopeptide repeat domain 39A
chr9_+_124329336 0.01 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2 interacting protein
chr14_+_32798462 0.01 ENST00000280979.4
A kinase (PRKA) anchor protein 6
chr19_-_8070474 0.01 ENST00000407627.2
ENST00000593807.1
ELAV like RNA binding protein 1
chr11_-_59383617 0.01 ENST00000263847.1
oxysterol binding protein
chr9_+_116225999 0.01 ENST00000317613.6
regulator of G-protein signaling 3
chr4_+_128554081 0.01 ENST00000335251.6
ENST00000296461.5
inturned planar cell polarity protein
chr4_-_66536196 0.01 ENST00000511294.1
EPH receptor A5
chr12_-_102513843 0.01 ENST00000551744.2
ENST00000552283.1
nucleoporin 37kDa
chr7_+_99647389 0.00 ENST00000543588.1
ENST00000292450.4
ENST00000456748.2
zinc finger and SCAN domain containing 21
chr8_+_22132847 0.00 ENST00000521356.1
piwi-like RNA-mediated gene silencing 2
chr11_-_71823715 0.00 ENST00000545944.1
ENST00000502597.2
anaphase promoting complex subunit 15
chr3_+_186560476 0.00 ENST00000320741.2
ENST00000444204.2
adiponectin, C1Q and collagen domain containing
chr10_+_99205894 0.00 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
zinc finger, DHHC-type containing 16
chr7_-_143892748 0.00 ENST00000378115.2
Rho guanine nucleotide exchange factor (GEF) 35
chr12_+_28410128 0.00 ENST00000381259.1
ENST00000381256.1
coiled-coil domain containing 91
chr3_+_186288454 0.00 ENST00000265028.3
DnaJ (Hsp40) homolog, subfamily B, member 11
chr3_+_186560462 0.00 ENST00000412955.2
adiponectin, C1Q and collagen domain containing
chr8_+_94929110 0.00 ENST00000520728.1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr15_+_64386261 0.00 ENST00000560829.1
sorting nexin 1
chr10_+_1095416 0.00 ENST00000358220.1
WD repeat domain 37

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 0.2 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.1 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.1 GO:0060264 respiratory burst involved in inflammatory response(GO:0002536) regulation of respiratory burst involved in inflammatory response(GO:0060264) negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.0 GO:0060829 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0043295 glutathione binding(GO:0043295)
0.0 0.1 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation