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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX1-2_RAX

Z-value: 0.40

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Transcription factors associated with NKX1-2_RAX

Gene Symbol Gene ID Gene Info
ENSG00000229544.6 NK1 homeobox 2
ENSG00000134438.9 retina and anterior neural fold homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX1-2hg19_v2_chr10_-_126138550_126138612-0.901.5e-02Click!

Activity profile of NKX1-2_RAX motif

Sorted Z-values of NKX1-2_RAX motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_4285923 0.28 ENST00000418372.1
ENST00000608792.1
long intergenic non-protein coding RNA 702
chr11_-_62521614 0.26 ENST00000527994.1
ENST00000394807.3
zinc finger and BTB domain containing 3
chr12_+_90674665 0.21 ENST00000549313.1
RP11-753N8.1
chr5_-_20575959 0.20 ENST00000507958.1
cadherin 18, type 2
chr6_+_130339710 0.20 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr16_-_28608424 0.19 ENST00000335715.4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr14_-_88200641 0.17 ENST00000556168.1
RP11-1152H15.1
chr19_+_36239576 0.16 ENST00000587751.1
lin-37 homolog (C. elegans)
chr4_+_26324474 0.15 ENST00000514675.1
recombination signal binding protein for immunoglobulin kappa J region
chr12_-_25348007 0.14 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
cancer susceptibility candidate 1
chr8_+_105235572 0.12 ENST00000523362.1
regulating synaptic membrane exocytosis 2
chr2_+_13677795 0.12 ENST00000434509.1
AC092635.1
chr9_-_3469181 0.11 ENST00000366116.2
Uncharacterized protein
chr3_+_158519654 0.11 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
major facilitator superfamily domain containing 1
chr13_-_36050819 0.11 ENST00000379919.4
mab-21-like 1 (C. elegans)
chr4_-_89442940 0.10 ENST00000527353.1
phosphatidylinositol glycan anchor biosynthesis, class Y
chr19_+_8740061 0.10 ENST00000593792.1
CTD-2586B10.1
chr2_-_74618907 0.10 ENST00000421392.1
ENST00000437375.1
dynactin 1
chr13_+_111748183 0.09 ENST00000422994.1
long intergenic non-protein coding RNA 368
chr3_-_105587879 0.09 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr11_-_124981475 0.09 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
transmembrane protein 218
chr12_+_64798826 0.08 ENST00000540203.1
exportin, tRNA
chr16_-_28608364 0.08 ENST00000533150.1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr17_+_57233087 0.08 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
proline rich 11
chr3_-_180397256 0.08 ENST00000442201.2
coiled-coil domain containing 39
chr3_-_55539287 0.08 ENST00000472238.1
RP11-875H7.5
chr13_+_36050881 0.08 ENST00000537702.1
neurobeachin
chr14_+_67831576 0.08 ENST00000555876.1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr2_+_210518057 0.07 ENST00000452717.1
microtubule-associated protein 2
chr1_-_92952433 0.07 ENST00000294702.5
growth factor independent 1 transcription repressor
chr11_+_33061543 0.07 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
t-complex 11, testis-specific-like 1
chr6_+_52442083 0.06 ENST00000606714.1
TRAM2 antisense RNA 1 (head to head)
chr14_+_32798547 0.06 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chrX_+_77166172 0.06 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATPase, Cu++ transporting, alpha polypeptide
chr17_-_71258491 0.06 ENST00000397671.1
cleavage and polyadenylation specific factor 4-like
chr3_-_120400960 0.06 ENST00000476082.2
homogentisate 1,2-dioxygenase
chr10_+_99205894 0.06 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
zinc finger, DHHC-type containing 16
chr17_-_57232525 0.06 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
spindle and kinetochore associated complex subunit 2
chr14_-_81425828 0.06 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
centrosomal protein 128kDa
chr10_+_99205959 0.06 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
zinc finger, DHHC-type containing 16
chr2_-_169887827 0.06 ENST00000263817.6
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr8_-_101571964 0.06 ENST00000520552.1
ENST00000521345.1
ENST00000523000.1
ENST00000335659.3
ENST00000358990.3
ENST00000519597.1
ankyrin repeat domain 46
chr3_+_183853052 0.05 ENST00000273783.3
ENST00000432569.1
ENST00000444495.1
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
chr17_+_1666108 0.05 ENST00000570731.1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr2_+_166095898 0.05 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
sodium channel, voltage-gated, type II, alpha subunit
chr5_+_150226085 0.05 ENST00000522154.1
immunity-related GTPase family, M
chrX_+_77154935 0.05 ENST00000481445.1
cytochrome c oxidase subunit VIIb
chr2_+_187371440 0.05 ENST00000445547.1
zinc finger CCCH-type containing 15
chr12_+_7014064 0.05 ENST00000443597.2
leucine rich repeat containing 23
chr5_-_102898465 0.05 ENST00000507423.1
ENST00000230792.2
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr11_-_59383617 0.05 ENST00000263847.1
oxysterol binding protein
chr3_-_105588231 0.05 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr1_+_186265399 0.05 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
proteoglycan 4
chr8_+_29605860 0.05 ENST00000517491.1
AC145110.1
chr12_-_112279694 0.04 ENST00000443596.1
ENST00000442119.1
MAPKAPK5 antisense RNA 1
chr3_-_151034734 0.04 ENST00000260843.4
G protein-coupled receptor 87
chr12_+_7013897 0.04 ENST00000007969.8
ENST00000323702.5
leucine rich repeat containing 23
chr12_+_16500571 0.04 ENST00000543076.1
ENST00000396210.3
microsomal glutathione S-transferase 1
chr11_-_111741994 0.04 ENST00000398006.2
ALG9, alpha-1,2-mannosyltransferase
chr15_+_93447675 0.04 ENST00000536619.1
chromodomain helicase DNA binding protein 2
chr14_+_103851712 0.04 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
MAP/microtubule affinity-regulating kinase 3
chr17_+_57232690 0.04 ENST00000262293.4
proline rich 11
chr12_-_22063787 0.04 ENST00000544039.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr4_-_19458597 0.04 ENST00000505347.1
RP11-3J1.1
chr7_+_99717230 0.04 ENST00000262932.3
canopy FGF signaling regulator 4
chr1_+_160370344 0.04 ENST00000368061.2
VANGL planar cell polarity protein 2
chr3_+_28390637 0.04 ENST00000420223.1
ENST00000383768.2
zinc finger, CW type with PWWP domain 2
chr9_+_135937365 0.04 ENST00000372080.4
ENST00000351304.7
carboxyl ester lipase
chr8_-_102803163 0.04 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
neurocalcin delta
chr2_+_210517895 0.04 ENST00000447185.1
microtubule-associated protein 2
chr15_+_93443419 0.04 ENST00000557381.1
ENST00000420239.2
chromodomain helicase DNA binding protein 2
chr9_+_34646651 0.04 ENST00000378842.3
galactose-1-phosphate uridylyltransferase
chr4_-_74486217 0.04 ENST00000335049.5
ENST00000307439.5
Ras association (RalGDS/AF-6) domain family member 6
chr1_+_201979645 0.03 ENST00000367284.5
ENST00000367283.3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr17_-_57232596 0.03 ENST00000581068.1
ENST00000330137.7
spindle and kinetochore associated complex subunit 2
chr1_-_17766198 0.03 ENST00000375436.4
regulator of chromosome condensation 2
chr11_+_47293795 0.03 ENST00000422579.1
MAP-kinase activating death domain
chr17_-_4938712 0.03 ENST00000254853.5
ENST00000424747.1
solute carrier family 52 (riboflavin transporter), member 1
chr3_+_195447738 0.03 ENST00000447234.2
ENST00000320736.6
ENST00000436408.1
mucin 20, cell surface associated
chr6_+_160542870 0.03 ENST00000324965.4
ENST00000457470.2
solute carrier family 22 (organic cation transporter), member 1
chr15_-_43882140 0.03 ENST00000429176.1
diphosphoinositol pentakisphosphate kinase 1
chr9_+_34646624 0.03 ENST00000450095.2
ENST00000556278.1
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr17_+_59489112 0.03 ENST00000335108.2
chromosome 17 open reading frame 82
chr12_+_16500599 0.03 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
microsomal glutathione S-transferase 1
chr11_+_112047087 0.03 ENST00000526088.1
ENST00000532593.1
ENST00000531169.1
beta-carotene oxygenase 2
chr1_-_201140673 0.03 ENST00000367333.2
transmembrane protein 9
chr4_-_103749179 0.03 ENST00000502690.1
ubiquitin-conjugating enzyme E2D 3
chr2_-_74618964 0.03 ENST00000417090.1
ENST00000409868.1
dynactin 1
chr2_+_27008865 0.03 ENST00000335756.4
ENST00000233505.8
centromere protein A
chrX_+_19362011 0.03 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
pyruvate dehydrogenase (lipoamide) alpha 1
chr18_+_63273310 0.03 ENST00000579862.1
RP11-775G23.1
chr4_-_25865159 0.03 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr19_-_36001113 0.03 ENST00000434389.1
dermokine
chr6_-_167040693 0.02 ENST00000366863.2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_-_224624730 0.02 ENST00000445239.1
WD repeat domain 26
chr15_+_64680003 0.02 ENST00000261884.3
thyroid hormone receptor interactor 4
chr19_-_36822551 0.02 ENST00000591372.1
long intergenic non-protein coding RNA 665
chr2_-_86422095 0.02 ENST00000254636.5
inner membrane protein, mitochondrial
chr3_+_186353756 0.02 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
fetuin B
chr4_-_74486109 0.02 ENST00000395777.2
Ras association (RalGDS/AF-6) domain family member 6
chr11_+_73498898 0.02 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
mitochondrial ribosomal protein L48
chr4_-_141348789 0.02 ENST00000414773.1
calmegin
chr6_+_26402517 0.02 ENST00000414912.2
butyrophilin, subfamily 3, member A1
chr2_+_112939365 0.02 ENST00000272559.4
fibulin 7
chr11_-_65625678 0.02 ENST00000308162.5
cofilin 1 (non-muscle)
chr6_+_26365443 0.02 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
butyrophilin, subfamily 3, member A2
chr12_+_8309630 0.02 ENST00000396570.3
zinc finger protein 705A
chr10_-_92681033 0.02 ENST00000371697.3
ankyrin repeat domain 1 (cardiac muscle)
chr7_+_100770328 0.02 ENST00000223095.4
ENST00000445463.2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr18_+_22040593 0.02 ENST00000256906.4
histamine receptor H4
chr16_-_48281305 0.02 ENST00000356608.2
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr10_+_114206956 0.02 ENST00000432306.1
ENST00000393077.2
vesicle transport through interaction with t-SNAREs 1A
chr11_+_29181503 0.02 ENST00000530960.1
RP11-466I1.1
chrX_-_6453159 0.02 ENST00000381089.3
ENST00000398729.1
variable charge, X-linked 3A
chr5_-_159546396 0.01 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP domain containing 2A
chr1_-_28969517 0.01 ENST00000263974.4
ENST00000373824.4
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
chr3_+_186560476 0.01 ENST00000320741.2
ENST00000444204.2
adiponectin, C1Q and collagen domain containing
chr1_+_62439037 0.01 ENST00000545929.1
InaD-like (Drosophila)
chr13_+_78315348 0.01 ENST00000441784.1
SLAIN motif family, member 1
chr17_-_40337470 0.01 ENST00000293330.1
hypocretin (orexin) neuropeptide precursor
chr10_+_124913930 0.01 ENST00000368858.5
BUB3 mitotic checkpoint protein
chr17_-_38821373 0.01 ENST00000394052.3
keratin 222
chr6_-_111927062 0.01 ENST00000359831.4
TRAF3 interacting protein 2
chr10_+_124914285 0.01 ENST00000407911.2
BUB3 mitotic checkpoint protein
chrM_+_9207 0.01 ENST00000362079.2
mitochondrially encoded cytochrome c oxidase III
chr8_-_135522425 0.01 ENST00000521673.1
zinc finger and AT hook domain containing
chr19_+_37808831 0.01 ENST00000589801.1
HKR1, GLI-Kruppel zinc finger family member
chr17_-_41466555 0.01 ENST00000586231.1
long intergenic non-protein coding RNA 910
chr2_+_24714729 0.01 ENST00000406961.1
ENST00000405141.1
nuclear receptor coactivator 1
chr7_+_120628731 0.01 ENST00000310396.5
cadherin-like and PC-esterase domain containing 1
chr8_+_29605841 0.01 ENST00000523123.1
AC145110.1
chr16_+_29832634 0.01 ENST00000565164.1
ENST00000570234.1
major vault protein
chr3_+_186560462 0.01 ENST00000412955.2
adiponectin, C1Q and collagen domain containing
chr11_+_22689648 0.01 ENST00000278187.3
growth arrest-specific 2
chr8_+_9413410 0.01 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr12_-_74686314 0.01 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
chr12_+_32832203 0.01 ENST00000553257.1
ENST00000549701.1
ENST00000358214.5
ENST00000266481.6
ENST00000551476.1
ENST00000550154.1
ENST00000547312.1
ENST00000414834.2
ENST00000381000.4
ENST00000548750.1
dynamin 1-like
chr8_+_29605825 0.01 ENST00000522158.1
AC145110.1
chr1_-_151804314 0.01 ENST00000318247.6
RAR-related orphan receptor C
chr12_-_50790267 0.01 ENST00000327337.5
ENST00000543111.1
family with sequence similarity 186, member A
chrX_-_13835147 0.01 ENST00000493677.1
ENST00000355135.2
glycoprotein M6B
chr6_+_26501449 0.01 ENST00000244513.6
butyrophilin, subfamily 1, member A1
chr4_-_66536057 0.01 ENST00000273854.3
EPH receptor A5
chr8_-_37351424 0.01 ENST00000522718.1
RP11-150O12.1
chr4_-_66536196 0.01 ENST00000511294.1
EPH receptor A5
chr4_-_10686475 0.01 ENST00000226951.6
cytokine-dependent hematopoietic cell linker
chrX_-_77225135 0.01 ENST00000458128.1
phosphoglycerate mutase family member 4
chrX_+_43515467 0.01 ENST00000338702.3
ENST00000542639.1
monoamine oxidase A
chr10_+_6779326 0.01 ENST00000417112.1
RP11-554I8.2
chr16_-_48281444 0.01 ENST00000537808.1
ENST00000569991.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr10_-_4285835 0.01 ENST00000454470.1
long intergenic non-protein coding RNA 702
chr6_-_111927449 0.00 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3 interacting protein 2
chr11_+_5710919 0.00 ENST00000379965.3
ENST00000425490.1
tripartite motif containing 22
chr10_+_24755416 0.00 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
chr19_+_107471 0.00 ENST00000585993.1
olfactory receptor, family 4, subfamily F, member 17
chr3_+_45986511 0.00 ENST00000458629.1
ENST00000457814.1
chemokine (C-X-C motif) receptor 6
chr2_-_220264703 0.00 ENST00000519905.1
ENST00000523282.1
ENST00000434339.1
ENST00000457935.1
aspartyl aminopeptidase
chr4_-_74486347 0.00 ENST00000342081.3
Ras association (RalGDS/AF-6) domain family member 6
chrX_+_135730373 0.00 ENST00000370628.2
CD40 ligand
chr19_-_14785622 0.00 ENST00000443157.2
egf-like module containing, mucin-like, hormone receptor-like 3
chr19_-_14785674 0.00 ENST00000253673.5
egf-like module containing, mucin-like, hormone receptor-like 3
chr7_-_87342564 0.00 ENST00000265724.3
ENST00000416177.1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr21_-_37914898 0.00 ENST00000399136.1
claudin 14
chr19_-_14785698 0.00 ENST00000344373.4
ENST00000595472.1
egf-like module containing, mucin-like, hormone receptor-like 3
chr15_+_94899183 0.00 ENST00000557742.1
multiple C2 domains, transmembrane 2
chr4_-_103748880 0.00 ENST00000453744.2
ENST00000349311.8
ubiquitin-conjugating enzyme E2D 3
chr10_+_35894338 0.00 ENST00000321660.1
gap junction protein, delta 4, 40.1kDa
chr8_-_30670384 0.00 ENST00000221138.4
ENST00000518243.1
protein phosphatase 2, catalytic subunit, beta isozyme
chr8_+_107738240 0.00 ENST00000449762.2
ENST00000297447.6
oxidation resistance 1
chr10_-_105845536 0.00 ENST00000393211.3
collagen, type XVII, alpha 1
chr7_-_37488547 0.00 ENST00000453399.1
engulfment and cell motility 1
chr8_-_29605625 0.00 ENST00000506121.3
long intergenic non-protein coding RNA 589

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-2_RAX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.0 0.1 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.1 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.0 0.1 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.1 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.1 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.0 0.1 GO:0019364 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.0 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.0 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.1 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.0 0.1 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993)
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.1 GO:0015432 bile acid-exporting ATPase activity(GO:0015432)
0.0 0.1 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532) copper-dependent protein binding(GO:0032767)
0.0 0.0 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.0 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.0 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)