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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NR2C1

Z-value: 0.42

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Transcription factors associated with NR2C1

Gene Symbol Gene ID Gene Info
NR2C1
ENSG00000120798.12 nuclear receptor subfamily 2 group C member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR2C1hg19_v2_chr12_-_95467267_954673500.364.8e-01Click!

Activity profile of NR2C1 motif

Sorted Z-values of NR2C1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_12679171 0.27 ENST00000606790.1
RP11-474O21.5
RP11-474O21.5
chrX_+_38420623 0.24 ENST00000378482.2
TSPAN7
tetraspanin 7
chr13_+_103046954 0.18 ENST00000606448.1
FGF14-AS2
FGF14 antisense RNA 2
chr6_+_33172407 0.18 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr2_-_201936302 0.17 ENST00000453765.1
ENST00000452799.1
ENST00000446678.1
ENST00000418596.3
FAM126B
family with sequence similarity 126, member B
chr1_-_45140227 0.16 ENST00000372237.3
TMEM53
transmembrane protein 53
chr5_-_42811986 0.14 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1
selenoprotein P, plasma, 1
chr12_-_124873357 0.13 ENST00000448614.1
NCOR2
nuclear receptor corepressor 2
chr20_+_44486246 0.12 ENST00000255152.2
ENST00000454862.2
ZSWIM3
zinc finger, SWIM-type containing 3
chr19_+_45116921 0.12 ENST00000402988.1
IGSF23
immunoglobulin superfamily, member 23
chr12_-_42631529 0.12 ENST00000548917.1
YAF2
YY1 associated factor 2
chr2_-_164592497 0.12 ENST00000333129.3
ENST00000409634.1
FIGN
fidgetin
chrX_+_38420783 0.12 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7
tetraspanin 7
chr17_-_1928621 0.12 ENST00000331238.6
RTN4RL1
reticulon 4 receptor-like 1
chr12_-_109797249 0.11 ENST00000538041.1
RP11-256L11.1
RP11-256L11.1
chr17_+_13972807 0.11 ENST00000429152.2
ENST00000261643.3
ENST00000536205.1
ENST00000537334.1
COX10
cytochrome c oxidase assembly homolog 10 (yeast)
chr6_+_149068464 0.11 ENST00000367463.4
UST
uronyl-2-sulfotransferase
chr5_-_42812143 0.10 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr3_-_50605077 0.10 ENST00000426034.1
ENST00000441239.1
C3orf18
chromosome 3 open reading frame 18
chr14_+_105212297 0.10 ENST00000556623.1
ENST00000555674.1
ADSSL1
adenylosuccinate synthase like 1
chr17_+_37821593 0.10 ENST00000578283.1
TCAP
titin-cap
chr19_-_38806560 0.09 ENST00000591755.1
ENST00000337679.8
ENST00000339413.6
YIF1B
Yip1 interacting factor homolog B (S. cerevisiae)
chr8_-_80680078 0.09 ENST00000337919.5
ENST00000354724.3
HEY1
hes-related family bHLH transcription factor with YRPW motif 1
chr8_+_96037255 0.08 ENST00000286687.4
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr9_-_77643189 0.08 ENST00000376837.3
C9orf41
chromosome 9 open reading frame 41
chr10_+_63808970 0.08 ENST00000309334.5
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr19_-_38806390 0.08 ENST00000589247.1
ENST00000329420.8
ENST00000591784.1
YIF1B
Yip1 interacting factor homolog B (S. cerevisiae)
chr17_+_4853442 0.08 ENST00000522301.1
ENO3
enolase 3 (beta, muscle)
chr12_-_48499591 0.07 ENST00000551330.1
ENST00000004980.5
ENST00000339976.6
ENST00000448372.1
SENP1
SUMO1/sentrin specific peptidase 1
chr10_+_26986582 0.07 ENST00000376215.5
ENST00000376203.5
PDSS1
prenyl (decaprenyl) diphosphate synthase, subunit 1
chr3_+_37284824 0.07 ENST00000431105.1
GOLGA4
golgin A4
chr8_+_96037205 0.07 ENST00000396124.4
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr12_+_96252706 0.07 ENST00000266735.5
ENST00000553192.1
ENST00000552085.1
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr22_-_31536480 0.07 ENST00000215885.3
PLA2G3
phospholipase A2, group III
chr19_+_16771936 0.07 ENST00000187762.2
ENST00000599479.1
TMEM38A
transmembrane protein 38A
chr8_+_70404996 0.07 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr14_-_73360796 0.07 ENST00000556509.1
ENST00000541685.1
ENST00000546183.1
DPF3
D4, zinc and double PHD fingers, family 3
chr1_-_45140074 0.07 ENST00000420706.1
ENST00000372235.3
ENST00000372242.3
ENST00000372243.3
ENST00000372244.3
TMEM53
transmembrane protein 53
chr21_-_15918618 0.07 ENST00000400564.1
ENST00000400566.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr15_-_83474806 0.07 ENST00000541889.1
ENST00000334574.8
ENST00000561368.1
FSD2
fibronectin type III and SPRY domain containing 2
chr15_+_45422131 0.07 ENST00000321429.4
DUOX1
dual oxidase 1
chr19_-_38806540 0.07 ENST00000592694.1
YIF1B
Yip1 interacting factor homolog B (S. cerevisiae)
chr9_-_140513231 0.07 ENST00000371417.3
C9orf37
chromosome 9 open reading frame 37
chr11_-_67275542 0.06 ENST00000531506.1
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr16_-_70729496 0.06 ENST00000567648.1
VAC14
Vac14 homolog (S. cerevisiae)
chr11_-_73687997 0.06 ENST00000545212.1
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr3_+_107318157 0.06 ENST00000406780.1
BBX
bobby sox homolog (Drosophila)
chr3_+_14989186 0.06 ENST00000435454.1
ENST00000323373.6
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr17_-_36105009 0.06 ENST00000560016.1
ENST00000427275.2
ENST00000561193.1
HNF1B
HNF1 homeobox B
chr19_+_10196981 0.05 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr1_+_159750720 0.05 ENST00000368109.1
ENST00000368108.3
DUSP23
dual specificity phosphatase 23
chr1_+_45140400 0.05 ENST00000453711.1
C1orf228
chromosome 1 open reading frame 228
chr12_-_48500085 0.05 ENST00000549518.1
SENP1
SUMO1/sentrin specific peptidase 1
chr20_-_57607347 0.05 ENST00000395663.1
ENST00000395659.1
ENST00000243997.3
ATP5E
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
chr1_+_159750776 0.05 ENST00000368107.1
DUSP23
dual specificity phosphatase 23
chr16_-_88752889 0.05 ENST00000332281.5
SNAI3
snail family zinc finger 3
chr10_-_103815874 0.05 ENST00000370033.4
ENST00000311122.5
C10orf76
chromosome 10 open reading frame 76
chr22_+_39745930 0.05 ENST00000318801.4
ENST00000216155.7
ENST00000406293.3
ENST00000328933.5
SYNGR1
synaptogyrin 1
chr2_-_219433014 0.05 ENST00000418019.1
ENST00000454775.1
ENST00000338465.5
ENST00000415516.1
ENST00000258399.3
USP37
ubiquitin specific peptidase 37
chr20_+_327413 0.05 ENST00000609179.1
NRSN2
neurensin 2
chr1_-_166944561 0.04 ENST00000271417.3
ILDR2
immunoglobulin-like domain containing receptor 2
chr1_-_917466 0.04 ENST00000341290.2
C1orf170
chromosome 1 open reading frame 170
chr12_-_95467267 0.04 ENST00000330677.7
NR2C1
nuclear receptor subfamily 2, group C, member 1
chr19_-_18548962 0.04 ENST00000317018.6
ENST00000581800.1
ENST00000583534.1
ENST00000457269.4
ENST00000338128.8
ISYNA1
inositol-3-phosphate synthase 1
chr15_+_45422178 0.04 ENST00000389037.3
ENST00000558322.1
DUOX1
dual oxidase 1
chr11_-_63684316 0.04 ENST00000301459.4
RCOR2
REST corepressor 2
chr1_-_173886491 0.04 ENST00000367698.3
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr15_-_45422056 0.04 ENST00000267803.4
ENST00000559014.1
ENST00000558851.1
ENST00000559988.1
ENST00000558996.1
ENST00000558422.1
ENST00000559226.1
ENST00000558326.1
ENST00000558377.1
ENST00000559644.1
DUOXA1
dual oxidase maturation factor 1
chrX_-_40036520 0.04 ENST00000406200.2
ENST00000378455.4
ENST00000342274.4
BCOR
BCL6 corepressor
chr2_-_202316260 0.04 ENST00000332624.3
TRAK2
trafficking protein, kinesin binding 2
chr19_+_44100727 0.04 ENST00000528387.1
ENST00000529930.1
ENST00000336564.4
ENST00000607544.1
ENST00000526798.1
ZNF576
SRRM5
zinc finger protein 576
serine/arginine repetitive matrix 5
chr10_+_64564469 0.04 ENST00000373783.1
ADO
2-aminoethanethiol (cysteamine) dioxygenase
chr11_+_65383227 0.04 ENST00000355703.3
PCNXL3
pecanex-like 3 (Drosophila)
chr12_-_118810688 0.03 ENST00000542532.1
ENST00000392533.3
TAOK3
TAO kinase 3
chr3_+_154801678 0.03 ENST00000462837.1
MME
membrane metallo-endopeptidase
chr11_-_72414430 0.03 ENST00000452383.2
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr19_+_44100544 0.03 ENST00000391965.2
ENST00000525771.1
ZNF576
zinc finger protein 576
chr19_-_48867291 0.03 ENST00000435956.3
TMEM143
transmembrane protein 143
chr22_+_41777927 0.03 ENST00000266304.4
TEF
thyrotrophic embryonic factor
chr12_-_42632016 0.03 ENST00000442791.3
ENST00000327791.4
ENST00000534854.2
ENST00000380788.3
ENST00000380790.4
YAF2
YY1 associated factor 2
chr2_+_33701707 0.03 ENST00000425210.1
ENST00000444784.1
ENST00000423159.1
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr3_-_50605150 0.03 ENST00000357203.3
C3orf18
chromosome 3 open reading frame 18
chr7_+_121513143 0.03 ENST00000393386.2
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr7_-_229557 0.03 ENST00000514988.1
AC145676.2
Uncharacterized protein
chr12_+_109577202 0.03 ENST00000377848.3
ENST00000377854.5
ACACB
acetyl-CoA carboxylase beta
chr15_+_82555169 0.03 ENST00000565432.1
ENST00000427381.2
FAM154B
family with sequence similarity 154, member B
chr2_+_219135115 0.02 ENST00000248451.3
ENST00000273077.4
PNKD
paroxysmal nonkinesigenic dyskinesia
chr20_+_19870167 0.02 ENST00000440354.2
RIN2
Ras and Rab interactor 2
chr16_+_83932684 0.02 ENST00000262430.4
MLYCD
malonyl-CoA decarboxylase
chr7_-_38948774 0.02 ENST00000395969.2
ENST00000414632.1
ENST00000310301.4
VPS41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr19_+_44100632 0.02 ENST00000533118.1
ZNF576
zinc finger protein 576
chr12_-_22487588 0.02 ENST00000381424.3
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr3_-_33700589 0.02 ENST00000461133.3
ENST00000496954.2
CLASP2
cytoplasmic linker associated protein 2
chr19_-_18548921 0.02 ENST00000545187.1
ENST00000578352.1
ISYNA1
inositol-3-phosphate synthase 1
chr2_-_163100045 0.02 ENST00000188790.4
FAP
fibroblast activation protein, alpha
chr17_+_73997419 0.02 ENST00000425876.2
CDK3
cyclin-dependent kinase 3
chr8_-_80942467 0.02 ENST00000518271.1
ENST00000276585.4
ENST00000521605.1
MRPS28
mitochondrial ribosomal protein S28
chr3_-_116164306 0.02 ENST00000490035.2
LSAMP
limbic system-associated membrane protein
chr10_+_24755416 0.02 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr20_+_37590942 0.02 ENST00000373325.2
ENST00000252011.3
ENST00000373323.4
DHX35
DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr17_-_15903002 0.02 ENST00000399277.1
ZSWIM7
zinc finger, SWIM-type containing 7
chr13_+_21714653 0.02 ENST00000382533.4
SAP18
Sin3A-associated protein, 18kDa
chr14_-_21492251 0.02 ENST00000554398.1
NDRG2
NDRG family member 2
chr6_-_31138439 0.02 ENST00000259915.8
POU5F1
POU class 5 homeobox 1
chr18_+_8609402 0.01 ENST00000329286.6
RAB12
RAB12, member RAS oncogene family
chr8_+_77318769 0.01 ENST00000518732.1
RP11-706J10.1
long intergenic non-protein coding RNA 1111
chr1_-_31381528 0.01 ENST00000339394.6
SDC3
syndecan 3
chr19_-_46142362 0.01 ENST00000586770.1
ENST00000591721.1
EML2
echinoderm microtubule associated protein like 2
chrX_-_128657457 0.01 ENST00000371121.3
ENST00000371123.1
ENST00000371122.4
SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr2_-_163099885 0.01 ENST00000443424.1
FAP
fibroblast activation protein, alpha
chr11_-_45939374 0.01 ENST00000533151.1
ENST00000241041.3
PEX16
peroxisomal biogenesis factor 16
chr3_+_184055240 0.01 ENST00000383847.2
FAM131A
family with sequence similarity 131, member A
chr17_-_39203519 0.01 ENST00000542137.1
ENST00000391419.3
KRTAP2-1
keratin associated protein 2-1
chr6_+_10585979 0.01 ENST00000265012.4
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr7_+_120969045 0.01 ENST00000222462.2
WNT16
wingless-type MMTV integration site family, member 16
chr19_-_41256207 0.01 ENST00000598485.2
ENST00000470681.1
ENST00000339153.3
ENST00000598729.1
C19orf54
chromosome 19 open reading frame 54
chr1_+_212797789 0.01 ENST00000294829.3
FAM71A
family with sequence similarity 71, member A
chr2_+_210636697 0.01 ENST00000439458.1
ENST00000272845.6
UNC80
unc-80 homolog (C. elegans)
chr15_-_65715401 0.01 ENST00000352385.2
IGDCC4
immunoglobulin superfamily, DCC subclass, member 4
chr5_+_179125907 0.01 ENST00000247461.4
ENST00000452673.2
ENST00000502498.1
ENST00000507307.1
ENST00000513246.1
ENST00000502673.1
ENST00000506654.1
ENST00000512607.2
ENST00000510810.1
CANX
calnexin
chr19_+_10197463 0.01 ENST00000590378.1
ENST00000397881.3
C19orf66
chromosome 19 open reading frame 66
chr19_-_48867171 0.01 ENST00000377431.2
ENST00000436660.2
ENST00000541566.1
TMEM143
transmembrane protein 143
chr13_+_21714711 0.01 ENST00000607003.1
ENST00000492245.1
SAP18
Sin3A-associated protein, 18kDa
chr11_-_72414256 0.01 ENST00000427971.2
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr19_-_10679697 0.01 ENST00000335766.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr6_+_133561725 0.01 ENST00000452339.2
EYA4
eyes absent homolog 4 (Drosophila)
chr7_+_100770328 0.01 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr13_+_21714913 0.01 ENST00000450573.1
ENST00000467636.1
SAP18
Sin3A-associated protein, 18kDa
chr2_+_109745655 0.01 ENST00000418513.1
SH3RF3
SH3 domain containing ring finger 3
chr15_+_91449971 0.01 ENST00000557865.1
MAN2A2
mannosidase, alpha, class 2A, member 2
chr12_+_6494285 0.01 ENST00000541102.1
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr6_+_30594619 0.01 ENST00000318999.7
ENST00000376485.4
ENST00000376478.2
ENST00000319027.5
ENST00000376483.4
ENST00000329992.8
ENST00000330083.5
ATAT1
alpha tubulin acetyltransferase 1
chr2_+_120124497 0.01 ENST00000355857.3
ENST00000535617.1
ENST00000535757.1
ENST00000409094.1
ENST00000311521.4
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr2_-_163099546 0.01 ENST00000447386.1
FAP
fibroblast activation protein, alpha
chr4_-_99064387 0.01 ENST00000295268.3
STPG2
sperm-tail PG-rich repeat containing 2
chr2_+_33701684 0.01 ENST00000442390.1
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chrX_-_132095419 0.01 ENST00000370836.2
ENST00000521489.1
HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr1_+_160097462 0.01 ENST00000447527.1
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr8_+_110656344 0.00 ENST00000499579.1
RP11-422N16.3
Uncharacterized protein
chr1_-_229569834 0.00 ENST00000366684.3
ENST00000366683.2
ACTA1
actin, alpha 1, skeletal muscle
chr2_-_96701722 0.00 ENST00000434632.1
GPAT2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr17_+_80674559 0.00 ENST00000269373.6
ENST00000535965.1
ENST00000577128.1
ENST00000573158.1
FN3KRP
fructosamine 3 kinase related protein
chr3_+_37284668 0.00 ENST00000361924.2
ENST00000444882.1
ENST00000356847.4
ENST00000450863.2
ENST00000429018.1
GOLGA4
golgin A4
chr11_+_7595136 0.00 ENST00000529575.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr11_+_94501497 0.00 ENST00000317829.8
ENST00000317837.9
ENST00000433060.2
AMOTL1
angiomotin like 1
chr1_+_44412577 0.00 ENST00000372343.3
IPO13
importin 13
chr15_-_43802769 0.00 ENST00000263801.3
TP53BP1
tumor protein p53 binding protein 1
chr22_+_30163340 0.00 ENST00000330029.6
ENST00000401406.3
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
chr11_-_64013663 0.00 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr2_+_33701286 0.00 ENST00000403687.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr4_-_111544254 0.00 ENST00000306732.3
PITX2
paired-like homeodomain 2
chr7_+_143080063 0.00 ENST00000446634.1
ZYX
zyxin
chr9_-_33402506 0.00 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
AQP7
aquaporin 7
chr1_-_29508321 0.00 ENST00000546138.1
SRSF4
serine/arginine-rich splicing factor 4
chr1_-_150944411 0.00 ENST00000368949.4
CERS2
ceramide synthase 2
chr16_+_30710462 0.00 ENST00000262518.4
ENST00000395059.2
ENST00000344771.4
SRCAP
Snf2-related CREBBP activator protein

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2C1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365)
0.0 0.1 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.1 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.0 0.1 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.1 GO:0042335 cuticle development(GO:0042335)
0.0 0.1 GO:0035565 regulation of pronephros size(GO:0035565) pronephric nephron tubule development(GO:0039020) mesenchymal cell apoptotic process involved in metanephros development(GO:1900200) regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900211) negative regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900212)
0.0 0.0 GO:1902362 melanocyte apoptotic process(GO:1902362)
0.0 0.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.0 GO:2000609 regulation of thyroid hormone generation(GO:2000609)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.0 0.1 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 0.1 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)