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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for POU6F2

Z-value: 0.51

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Transcription factors associated with POU6F2

Gene Symbol Gene ID Gene Info
POU6F2
ENSG00000106536.15 POU class 6 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F2hg19_v2_chr7_+_39017504_39017598-0.157.7e-01Click!

Activity profile of POU6F2 motif

Sorted Z-values of POU6F2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_76330355 0.37 ENST00000483859.2
SENP6
SUMO1/sentrin specific peptidase 6
chr17_-_71223839 0.33 ENST00000579872.1
ENST00000580032.1
FAM104A
family with sequence similarity 104, member A
chr20_+_5987890 0.32 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr5_-_134914673 0.31 ENST00000512158.1
CXCL14
chemokine (C-X-C motif) ligand 14
chr16_+_53133070 0.31 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr4_+_78829479 0.31 ENST00000504901.1
MRPL1
mitochondrial ribosomal protein L1
chr11_-_31531121 0.30 ENST00000532287.1
ENST00000526776.1
ENST00000534812.1
ENST00000529749.1
ENST00000278200.1
ENST00000530023.1
ENST00000533642.1
IMMP1L
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr9_-_3469181 0.27 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr1_-_193028426 0.26 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr4_-_36245561 0.26 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_193028621 0.26 ENST00000367455.4
ENST00000367454.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr15_+_96904487 0.24 ENST00000600790.1
AC087477.1
Uncharacterized protein
chr1_-_234667504 0.24 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr11_-_27494309 0.23 ENST00000389858.4
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr11_-_27494279 0.22 ENST00000379214.4
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr2_+_17997763 0.20 ENST00000281047.3
MSGN1
mesogenin 1
chr22_+_20905422 0.19 ENST00000424287.1
ENST00000423862.1
MED15
mediator complex subunit 15
chr12_+_28410128 0.18 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr5_+_136070614 0.18 ENST00000502421.1
CTB-1I21.1
CTB-1I21.1
chr11_-_93583697 0.18 ENST00000409977.1
VSTM5
V-set and transmembrane domain containing 5
chr2_-_61697862 0.18 ENST00000398571.2
USP34
ubiquitin specific peptidase 34
chr8_+_92261516 0.17 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr1_+_61869748 0.17 ENST00000357977.5
NFIA
nuclear factor I/A
chr3_+_141105705 0.17 ENST00000513258.1
ZBTB38
zinc finger and BTB domain containing 38
chr18_+_44812072 0.16 ENST00000598649.1
ENST00000586905.2
CTD-2130O13.1
CTD-2130O13.1
chr1_-_193028632 0.16 ENST00000421683.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr8_-_42396185 0.16 ENST00000518717.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr7_-_143582450 0.16 ENST00000485416.1
FAM115A
family with sequence similarity 115, member A
chr4_-_74486109 0.15 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr5_+_115177178 0.15 ENST00000316788.7
AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chr11_-_26593779 0.15 ENST00000529533.1
MUC15
mucin 15, cell surface associated
chr6_-_111804905 0.15 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr8_-_42358742 0.15 ENST00000517366.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr7_-_5465045 0.14 ENST00000399434.2
TNRC18
trinucleotide repeat containing 18
chr8_-_90996837 0.13 ENST00000519426.1
ENST00000265433.3
NBN
nibrin
chr9_-_13165457 0.13 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
MPDZ
multiple PDZ domain protein
chr15_+_58702742 0.12 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr1_+_62439037 0.12 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr11_+_30344595 0.12 ENST00000282032.3
ARL14EP
ADP-ribosylation factor-like 14 effector protein
chr22_+_20905269 0.12 ENST00000457322.1
MED15
mediator complex subunit 15
chr1_+_193028552 0.12 ENST00000400968.2
ENST00000432079.1
TROVE2
TROVE domain family, member 2
chr15_+_96869165 0.12 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr9_-_21482312 0.11 ENST00000448696.3
IFNE
interferon, epsilon
chr17_-_39553844 0.11 ENST00000251645.2
KRT31
keratin 31
chr10_+_94352956 0.11 ENST00000260731.3
KIF11
kinesin family member 11
chr8_+_26150628 0.11 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr8_+_42396274 0.11 ENST00000438528.3
SMIM19
small integral membrane protein 19
chrX_-_23926004 0.11 ENST00000379226.4
ENST00000379220.3
APOO
apolipoprotein O
chrX_-_38186775 0.10 ENST00000339363.3
ENST00000309513.3
ENST00000338898.3
ENST00000342811.3
ENST00000378505.2
RPGR
retinitis pigmentosa GTPase regulator
chr11_+_12302492 0.09 ENST00000533534.1
MICALCL
MICAL C-terminal like
chr3_-_33686925 0.09 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr17_+_73539339 0.09 ENST00000581713.1
LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr4_-_175204765 0.08 ENST00000513696.1
ENST00000503293.1
FBXO8
F-box protein 8
chr11_-_63439013 0.08 ENST00000398868.3
ATL3
atlastin GTPase 3
chr12_-_89746173 0.08 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr22_-_32767017 0.08 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr14_-_73360796 0.08 ENST00000556509.1
ENST00000541685.1
ENST00000546183.1
DPF3
D4, zinc and double PHD fingers, family 3
chr6_-_111136513 0.08 ENST00000368911.3
CDK19
cyclin-dependent kinase 19
chr4_-_74486347 0.07 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chrX_+_3189861 0.07 ENST00000457435.1
ENST00000420429.2
CXorf28
chromosome X open reading frame 28
chr10_-_94257512 0.07 ENST00000371581.5
IDE
insulin-degrading enzyme
chr8_-_90769422 0.07 ENST00000524190.1
ENST00000523859.1
RP11-37B2.1
RP11-37B2.1
chr13_+_98612446 0.07 ENST00000496368.1
ENST00000421861.2
ENST00000357602.3
IPO5
importin 5
chr15_+_80351977 0.06 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
ZFAND6
zinc finger, AN1-type domain 6
chrX_-_30877837 0.06 ENST00000378930.3
TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr5_+_159343688 0.06 ENST00000306675.3
ADRA1B
adrenoceptor alpha 1B
chr16_+_31885079 0.06 ENST00000300870.10
ENST00000394846.3
ZNF267
zinc finger protein 267
chr5_-_54988448 0.06 ENST00000503817.1
ENST00000512595.1
SLC38A9
solute carrier family 38, member 9
chr9_+_131902346 0.06 ENST00000432124.1
ENST00000435305.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr3_+_130648842 0.06 ENST00000508297.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr14_+_39583427 0.06 ENST00000308317.6
ENST00000396249.2
ENST00000250379.8
ENST00000534684.2
ENST00000527381.1
GEMIN2
gem (nuclear organelle) associated protein 2
chr17_-_33390667 0.06 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr6_-_32157947 0.06 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr15_-_33447055 0.06 ENST00000559047.1
ENST00000561249.1
FMN1
formin 1
chr8_+_22424551 0.05 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr2_-_158300556 0.05 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chrX_-_38186811 0.05 ENST00000318842.7
RPGR
retinitis pigmentosa GTPase regulator
chr3_-_127541194 0.05 ENST00000453507.2
MGLL
monoglyceride lipase
chr3_+_147657764 0.05 ENST00000467198.1
ENST00000485006.1
RP11-71N10.1
RP11-71N10.1
chr14_+_32798462 0.05 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr11_+_31531291 0.05 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chr5_-_111093167 0.04 ENST00000446294.2
ENST00000419114.2
NREP
neuronal regeneration related protein
chr4_+_40198527 0.04 ENST00000381799.5
RHOH
ras homolog family member H
chr4_+_175204818 0.04 ENST00000503780.1
CEP44
centrosomal protein 44kDa
chr20_+_58515417 0.04 ENST00000360816.3
FAM217B
family with sequence similarity 217, member B
chr14_-_36989336 0.04 ENST00000522719.2
NKX2-1
NK2 homeobox 1
chr11_-_26593677 0.04 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr3_-_18466787 0.04 ENST00000338745.6
ENST00000450898.1
SATB1
SATB homeobox 1
chr2_-_216003127 0.04 ENST00000412081.1
ENST00000272895.7
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr12_-_86230315 0.04 ENST00000361228.3
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr10_-_92681033 0.04 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr14_+_32798547 0.04 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chrX_-_13835147 0.04 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr1_-_159832438 0.04 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chrX_+_107288280 0.04 ENST00000458383.1
VSIG1
V-set and immunoglobulin domain containing 1
chr1_+_46379254 0.04 ENST00000372008.2
MAST2
microtubule associated serine/threonine kinase 2
chr11_-_26593649 0.03 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr14_-_50698276 0.03 ENST00000216373.5
SOS2
son of sevenless homolog 2 (Drosophila)
chr3_-_45838011 0.03 ENST00000358525.4
ENST00000413781.1
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chrX_-_106243451 0.03 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr2_+_102721023 0.03 ENST00000409589.1
ENST00000409329.1
IL1R1
interleukin 1 receptor, type I
chr17_-_2117600 0.03 ENST00000572369.1
SMG6
SMG6 nonsense mediated mRNA decay factor
chr5_+_67586465 0.03 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr8_-_42234745 0.03 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr11_-_70672645 0.03 ENST00000423696.2
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr4_-_109541539 0.02 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr7_+_115862858 0.02 ENST00000393481.2
TES
testis derived transcript (3 LIM domains)
chr3_-_33686743 0.02 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr1_+_10271674 0.02 ENST00000377086.1
KIF1B
kinesin family member 1B
chr2_-_182545603 0.02 ENST00000295108.3
NEUROD1
neuronal differentiation 1
chr12_-_87232644 0.02 ENST00000549405.2
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr7_+_129007964 0.02 ENST00000460109.1
ENST00000474594.1
ENST00000446212.1
AHCYL2
adenosylhomocysteinase-like 2
chr1_+_19967014 0.02 ENST00000428975.1
NBL1
neuroblastoma 1, DAN family BMP antagonist
chr13_+_46039037 0.02 ENST00000349995.5
COG3
component of oligomeric golgi complex 3
chrX_-_106243294 0.02 ENST00000255495.7
MORC4
MORC family CW-type zinc finger 4
chr19_-_7968427 0.02 ENST00000539278.1
AC010336.1
Uncharacterized protein
chr7_+_141478242 0.02 ENST00000247881.2
TAS2R4
taste receptor, type 2, member 4
chr13_-_44735393 0.02 ENST00000400419.1
SMIM2
small integral membrane protein 2
chr1_+_107683436 0.02 ENST00000370068.1
NTNG1
netrin G1
chr11_+_128563652 0.02 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr11_+_65554493 0.02 ENST00000335987.3
OVOL1
ovo-like zinc finger 1
chr15_+_80351910 0.02 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr15_-_37393406 0.02 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr3_-_101039402 0.01 ENST00000193391.7
IMPG2
interphotoreceptor matrix proteoglycan 2
chrX_-_122756660 0.01 ENST00000441692.1
THOC2
THO complex 2
chr4_-_74486217 0.01 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr3_+_189507432 0.01 ENST00000354600.5
TP63
tumor protein p63
chr6_-_138866823 0.01 ENST00000342260.5
NHSL1
NHS-like 1
chr17_-_10421853 0.01 ENST00000226207.5
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr7_-_55620433 0.01 ENST00000418904.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr8_+_77593474 0.01 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr15_-_74421477 0.01 ENST00000514871.1
RP11-247C2.2
HCG2004779; Uncharacterized protein
chr9_-_110251836 0.01 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr6_+_42123141 0.01 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
GUCA1A
RP1-139D8.6
guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr12_-_15815626 0.01 ENST00000540613.1
EPS8
epidermal growth factor receptor pathway substrate 8
chr22_+_20905286 0.01 ENST00000428629.1
MED15
mediator complex subunit 15
chr19_+_50016610 0.01 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr12_-_52946923 0.00 ENST00000267119.5
KRT71
keratin 71
chr3_-_11610255 0.00 ENST00000424529.2
VGLL4
vestigial like 4 (Drosophila)
chr10_-_23633720 0.00 ENST00000323327.4
C10orf67
chromosome 10 open reading frame 67
chr17_-_27418537 0.00 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr3_+_111717511 0.00 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr11_+_7598239 0.00 ENST00000525597.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr6_-_111136299 0.00 ENST00000457688.1
CDK19
cyclin-dependent kinase 19
chr2_+_44502597 0.00 ENST00000260649.6
ENST00000409387.1
SLC3A1
solute carrier family 3 (amino acid transporter heavy chain), member 1
chr11_+_45918092 0.00 ENST00000395629.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr21_-_42219065 0.00 ENST00000400454.1
DSCAM
Down syndrome cell adhesion molecule
chr12_+_54332535 0.00 ENST00000243056.3
HOXC13
homeobox C13
chr4_+_175204865 0.00 ENST00000505124.1
CEP44
centrosomal protein 44kDa
chr7_+_129015671 0.00 ENST00000466993.1
AHCYL2
adenosylhomocysteinase-like 2

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0061289 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 0.3 GO:2000501 regulation of natural killer cell chemotaxis(GO:2000501)
0.1 0.4 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.0 0.3 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.3 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.7 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 0.1 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.1 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:1901143 insulin catabolic process(GO:1901143)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.2 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.8 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.3 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.1 GO:0002947 tumor necrosis factor receptor superfamily complex(GO:0002947)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030572 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0 0.3 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.3 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.4 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.1 GO:0031626 beta-endorphin binding(GO:0031626)
0.0 0.7 GO:0070628 proteasome binding(GO:0070628)
0.0 0.0 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.1 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.6 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling