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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PRRX1_ALX4_PHOX2A

Z-value: 0.90

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Transcription factors associated with PRRX1_ALX4_PHOX2A

Gene Symbol Gene ID Gene Info
PRRX1
ENSG00000116132.7 paired related homeobox 1
ALX4
ENSG00000052850.5 ALX homeobox 4
PHOX2A
ENSG00000165462.5 paired like homeobox 2A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRRX1hg19_v2_chr1_+_170633047_1706330840.532.8e-01Click!
ALX4hg19_v2_chr11_-_44331679_44331716-0.295.7e-01Click!

Activity profile of PRRX1_ALX4_PHOX2A motif

Sorted Z-values of PRRX1_ALX4_PHOX2A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_107235331 1.10 ENST00000433965.1
ENST00000430094.1
RP1-60O19.1
RP1-60O19.1
chr5_+_36606700 1.06 ENST00000416645.2
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr8_+_86999516 0.82 ENST00000521564.1
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr10_+_69865866 0.65 ENST00000354393.2
MYPN
myopalladin
chr14_+_95078714 0.65 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr18_+_20714525 0.60 ENST00000400473.2
CABLES1
Cdk5 and Abl enzyme substrate 1
chr1_+_50459990 0.60 ENST00000448346.1
AL645730.2
AL645730.2
chr2_-_114461655 0.57 ENST00000424612.1
AC017074.2
AC017074.2
chr4_-_103940791 0.56 ENST00000510559.1
ENST00000394789.3
ENST00000296422.7
SLC9B1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chr13_-_81801115 0.48 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr1_-_151148442 0.46 ENST00000441701.1
ENST00000416280.2
TMOD4
tropomodulin 4 (muscle)
chr7_+_30589829 0.46 ENST00000579437.1
RP4-777O23.1
RP4-777O23.1
chr20_+_31823792 0.46 ENST00000375413.4
ENST00000354297.4
ENST00000375422.2
BPIFA1
BPI fold containing family A, member 1
chr9_-_71869642 0.43 ENST00000600472.1
AL358113.1
Tight junction protein 2 (Zona occludens 2) isoform 1 variant; Uncharacterized protein
chr3_-_186262166 0.42 ENST00000307944.5
CRYGS
crystallin, gamma S
chr17_+_61151306 0.41 ENST00000580068.1
ENST00000580466.1
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr10_+_67330096 0.40 ENST00000433152.4
ENST00000601979.1
ENST00000599409.1
ENST00000608678.1
RP11-222A11.1
RP11-222A11.1
chr5_+_140514782 0.39 ENST00000231134.5
PCDHB5
protocadherin beta 5
chr14_-_75083313 0.34 ENST00000556652.1
ENST00000555313.1
CTD-2207P18.2
CTD-2207P18.2
chr3_-_27764190 0.34 ENST00000537516.1
EOMES
eomesodermin
chr14_-_57197224 0.32 ENST00000554597.1
ENST00000556696.1
RP11-1085N6.3
Uncharacterized protein
chr5_-_111093759 0.32 ENST00000509979.1
ENST00000513100.1
ENST00000508161.1
ENST00000455559.2
NREP
neuronal regeneration related protein
chr6_+_88106840 0.31 ENST00000369570.4
C6orf164
chromosome 6 open reading frame 164
chr2_+_228678550 0.31 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr4_+_95916947 0.30 ENST00000506363.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr12_+_116985896 0.30 ENST00000547114.1
RP11-809C9.2
RP11-809C9.2
chr6_-_32908765 0.30 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr8_+_86851932 0.29 ENST00000517368.1
CTA-392E5.1
CTA-392E5.1
chr14_+_23709555 0.28 ENST00000430154.2
C14orf164
chromosome 14 open reading frame 164
chr6_+_12007897 0.28 ENST00000437559.1
RP11-456H18.2
RP11-456H18.2
chr12_-_91546926 0.28 ENST00000550758.1
DCN
decorin
chr3_-_27763803 0.27 ENST00000449599.1
EOMES
eomesodermin
chr19_-_58485895 0.26 ENST00000314391.3
C19orf18
chromosome 19 open reading frame 18
chr7_-_117512264 0.25 ENST00000454375.1
CTTNBP2
cortactin binding protein 2
chr1_+_154401791 0.24 ENST00000476006.1
IL6R
interleukin 6 receptor
chr11_-_16419067 0.23 ENST00000533411.1
SOX6
SRY (sex determining region Y)-box 6
chr6_-_107235378 0.22 ENST00000606430.1
RP1-60O19.1
RP1-60O19.1
chr14_-_81425828 0.22 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chr6_-_154751629 0.22 ENST00000424998.1
CNKSR3
CNKSR family member 3
chr6_+_12007963 0.22 ENST00000607445.1
RP11-456H18.2
RP11-456H18.2
chr3_-_130465604 0.22 ENST00000356763.3
PIK3R4
phosphoinositide-3-kinase, regulatory subunit 4
chr6_-_134639180 0.22 ENST00000367858.5
SGK1
serum/glucocorticoid regulated kinase 1
chr1_+_183774285 0.22 ENST00000539189.1
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr4_+_76649753 0.21 ENST00000603759.1
USO1
USO1 vesicle transport factor
chr4_+_74606223 0.20 ENST00000307407.3
ENST00000401931.1
IL8
interleukin 8
chr12_+_59989918 0.20 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr18_+_616672 0.20 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr12_-_118628315 0.20 ENST00000540561.1
TAOK3
TAO kinase 3
chr7_-_111032971 0.19 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr7_+_90338547 0.19 ENST00000446790.1
CDK14
cyclin-dependent kinase 14
chr22_-_30642728 0.19 ENST00000403987.3
LIF
leukemia inhibitory factor
chr5_+_40909354 0.19 ENST00000313164.9
C7
complement component 7
chr9_+_99449322 0.18 ENST00000423924.1
RP11-535M15.1
RP11-535M15.1
chr2_+_162272605 0.18 ENST00000389554.3
TBR1
T-box, brain, 1
chr21_-_31588365 0.18 ENST00000399899.1
CLDN8
claudin 8
chr19_-_38183228 0.18 ENST00000587199.1
ZFP30
ZFP30 zinc finger protein
chr4_+_160188889 0.17 ENST00000264431.4
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr6_-_76072719 0.17 ENST00000370020.1
FILIP1
filamin A interacting protein 1
chr8_-_57123815 0.17 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr4_-_184243561 0.17 ENST00000514470.1
ENST00000541814.1
CLDN24
claudin 24
chr6_-_27835357 0.16 ENST00000331442.3
HIST1H1B
histone cluster 1, H1b
chr16_+_89334512 0.16 ENST00000602042.1
AC137932.1
AC137932.1
chr5_-_70272055 0.16 ENST00000514857.2
NAIP
NLR family, apoptosis inhibitory protein
chr1_+_81106951 0.16 ENST00000443565.1
RP5-887A10.1
RP5-887A10.1
chr2_+_119699864 0.15 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr11_+_1295809 0.15 ENST00000598274.1
AC136297.1
Uncharacterized protein
chr12_-_25150373 0.15 ENST00000549828.1
C12orf77
chromosome 12 open reading frame 77
chr21_-_35899113 0.15 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr6_-_133055815 0.15 ENST00000509351.1
ENST00000417437.2
ENST00000414302.2
ENST00000423615.2
ENST00000427187.2
ENST00000275223.3
ENST00000519686.2
VNN3
vanin 3
chr14_-_38064198 0.14 ENST00000250448.2
FOXA1
forkhead box A1
chr3_-_141747950 0.14 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr17_-_39123144 0.14 ENST00000355612.2
KRT39
keratin 39
chr5_-_160279207 0.14 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr1_+_15668240 0.14 ENST00000444385.1
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chrX_+_68835911 0.14 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
EDA
ectodysplasin A
chrX_+_107288239 0.14 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr17_+_53342311 0.14 ENST00000226067.5
HLF
hepatic leukemia factor
chr4_-_87028478 0.13 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr19_-_11456905 0.13 ENST00000588560.1
ENST00000592952.1
TMEM205
transmembrane protein 205
chrX_-_124097620 0.13 ENST00000371130.3
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr13_+_102142296 0.13 ENST00000376162.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr5_-_115872124 0.13 ENST00000515009.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr4_-_68829226 0.13 ENST00000396188.2
TMPRSS11A
transmembrane protease, serine 11A
chr2_-_214013353 0.12 ENST00000451136.2
ENST00000421754.2
ENST00000374327.4
ENST00000413091.3
IKZF2
IKAROS family zinc finger 2 (Helios)
chr10_+_52094298 0.12 ENST00000595931.1
AC069547.1
HCG1745369; PRO3073; Uncharacterized protein
chr1_-_21377383 0.12 ENST00000374935.3
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr19_-_11456722 0.12 ENST00000354882.5
TMEM205
transmembrane protein 205
chr3_-_48956818 0.12 ENST00000408959.2
ARIH2OS
ariadne homolog 2 opposite strand
chr15_-_75748115 0.12 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr15_+_75628394 0.12 ENST00000564815.1
ENST00000338995.6
COMMD4
COMM domain containing 4
chrX_+_107288197 0.12 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr3_-_196242233 0.11 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr17_-_60885645 0.11 ENST00000544856.2
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr6_-_133055896 0.11 ENST00000367927.5
ENST00000425515.2
ENST00000207771.3
ENST00000392393.3
ENST00000450865.2
ENST00000392394.2
VNN3
vanin 3
chr12_+_58003935 0.11 ENST00000333972.7
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr19_-_11456872 0.11 ENST00000586218.1
TMEM205
transmembrane protein 205
chr2_+_119699742 0.11 ENST00000327097.4
MARCO
macrophage receptor with collagenous structure
chr4_-_68829144 0.11 ENST00000508048.1
TMPRSS11A
transmembrane protease, serine 11A
chr7_+_18548924 0.11 ENST00000524023.1
HDAC9
histone deacetylase 9
chr1_+_114472992 0.11 ENST00000514621.1
HIPK1
homeodomain interacting protein kinase 1
chr17_+_48556158 0.11 ENST00000258955.2
RSAD1
radical S-adenosyl methionine domain containing 1
chr18_-_52989217 0.11 ENST00000570287.2
TCF4
transcription factor 4
chr8_-_122653630 0.11 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr3_-_101039402 0.11 ENST00000193391.7
IMPG2
interphotoreceptor matrix proteoglycan 2
chrX_+_149887090 0.11 ENST00000538506.1
MTMR1
myotubularin related protein 1
chr10_-_25304889 0.10 ENST00000483339.2
ENKUR
enkurin, TRPC channel interacting protein
chr14_-_75536182 0.10 ENST00000555463.1
ACYP1
acylphosphatase 1, erythrocyte (common) type
chr12_-_47219733 0.10 ENST00000547477.1
ENST00000447411.1
ENST00000266579.4
SLC38A4
solute carrier family 38, member 4
chr10_-_21186144 0.10 ENST00000377119.1
NEBL
nebulette
chr17_+_67759813 0.10 ENST00000587241.1
AC003051.1
AC003051.1
chr6_-_32908792 0.10 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr14_+_101293687 0.10 ENST00000455286.1
MEG3
maternally expressed 3 (non-protein coding)
chr7_-_115799942 0.10 ENST00000484212.1
TFEC
transcription factor EC
chr10_+_97709725 0.10 ENST00000472454.2
RP11-248J23.6
Protein LOC100652732
chr14_+_21566980 0.10 ENST00000418511.2
ENST00000554329.2
TMEM253
transmembrane protein 253
chr10_+_89420706 0.10 ENST00000427144.2
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr11_+_49050504 0.10 ENST00000332682.7
TRIM49B
tripartite motif containing 49B
chr9_-_95298254 0.10 ENST00000444490.2
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr1_-_234667504 0.10 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr9_+_27524283 0.10 ENST00000276943.2
IFNK
interferon, kappa
chr7_+_18548878 0.09 ENST00000456174.2
HDAC9
histone deacetylase 9
chr12_-_21928515 0.09 ENST00000537950.1
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr1_+_109756523 0.09 ENST00000234677.2
ENST00000369923.4
SARS
seryl-tRNA synthetase
chr12_+_1099675 0.09 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr12_-_7656357 0.09 ENST00000396620.3
ENST00000432237.2
ENST00000359156.4
CD163
CD163 molecule
chr3_-_195310802 0.09 ENST00000421243.1
ENST00000453131.1
APOD
apolipoprotein D
chr10_+_35464513 0.09 ENST00000494479.1
ENST00000463314.1
ENST00000342105.3
ENST00000495301.1
ENST00000463960.1
CREM
cAMP responsive element modulator
chr15_+_75628232 0.09 ENST00000267935.8
ENST00000567195.1
COMMD4
COMM domain containing 4
chrX_-_68385354 0.09 ENST00000361478.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr19_-_44174330 0.09 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr4_-_70653673 0.09 ENST00000512870.1
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr1_+_206557366 0.09 ENST00000414007.1
ENST00000419187.2
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr9_+_44867571 0.08 ENST00000377548.2
RP11-160N1.10
RP11-160N1.10
chr1_+_186265399 0.08 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr6_+_26087646 0.08 ENST00000309234.6
HFE
hemochromatosis
chr1_+_170632250 0.08 ENST00000367760.3
PRRX1
paired related homeobox 1
chr5_-_54468974 0.08 ENST00000381375.2
ENST00000296733.1
ENST00000322374.6
ENST00000334206.5
ENST00000331730.3
CDC20B
cell division cycle 20B
chr17_+_22022437 0.08 ENST00000540040.1
MTRNR2L1
MT-RNR2-like 1
chr17_-_61045902 0.08 ENST00000581596.1
RP11-180P8.3
RP11-180P8.3
chr14_-_101036119 0.08 ENST00000355173.2
BEGAIN
brain-enriched guanylate kinase-associated
chrX_+_100224676 0.08 ENST00000450049.2
ARL13A
ADP-ribosylation factor-like 13A
chr19_+_13842559 0.08 ENST00000586600.1
CCDC130
coiled-coil domain containing 130
chr1_+_42846443 0.08 ENST00000410070.2
ENST00000431473.3
RIMKLA
ribosomal modification protein rimK-like family member A
chr8_+_87111059 0.08 ENST00000285393.3
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr22_+_25615489 0.08 ENST00000398215.2
CRYBB2
crystallin, beta B2
chr7_-_33842742 0.08 ENST00000420185.1
ENST00000440034.1
RP11-89N17.4
RP11-89N17.4
chr12_+_72061563 0.08 ENST00000551238.1
THAP2
THAP domain containing, apoptosis associated protein 2
chr2_+_58655461 0.07 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1
long intergenic non-protein coding RNA 1122
chr1_-_241799232 0.07 ENST00000366553.1
CHML
choroideremia-like (Rab escort protein 2)
chr7_+_80255472 0.07 ENST00000428497.1
CD36
CD36 molecule (thrombospondin receptor)
chr12_+_2912363 0.07 ENST00000544366.1
FKBP4
FK506 binding protein 4, 59kDa
chr4_+_169575875 0.07 ENST00000503457.1
PALLD
palladin, cytoskeletal associated protein
chr5_+_81601166 0.07 ENST00000439350.1
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr10_-_48050538 0.07 ENST00000420079.2
ASAH2C
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2C
chr15_+_51669444 0.07 ENST00000396399.2
GLDN
gliomedin
chr15_+_66874502 0.07 ENST00000558797.1
RP11-321F6.1
HCG2003567; Uncharacterized protein
chr7_+_129015671 0.07 ENST00000466993.1
AHCYL2
adenosylhomocysteinase-like 2
chr10_+_77056181 0.07 ENST00000526759.1
ENST00000533822.1
ZNF503-AS1
ZNF503 antisense RNA 1
chr4_+_113568207 0.07 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr1_+_67632083 0.07 ENST00000347310.5
ENST00000371002.1
IL23R
interleukin 23 receptor
chr21_-_27423339 0.07 ENST00000415997.1
APP
amyloid beta (A4) precursor protein
chr10_-_45811056 0.07 ENST00000553795.1
OR13A1
olfactory receptor, family 13, subfamily A, member 1
chr19_+_50016610 0.07 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr14_+_67831576 0.07 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr12_-_118628350 0.07 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr5_+_140743859 0.07 ENST00000518069.1
PCDHGA5
protocadherin gamma subfamily A, 5
chr2_+_44001172 0.07 ENST00000260605.8
ENST00000406852.3
ENST00000443170.3
ENST00000398823.2
ENST00000605786.1
DYNC2LI1
dynein, cytoplasmic 2, light intermediate chain 1
chr18_-_21891460 0.07 ENST00000357041.4
OSBPL1A
oxysterol binding protein-like 1A
chr8_-_80942061 0.07 ENST00000519386.1
MRPS28
mitochondrial ribosomal protein S28
chr12_-_16761007 0.07 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_+_69313145 0.07 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr5_+_137203557 0.07 ENST00000515645.1
MYOT
myotilin
chr17_-_38911580 0.06 ENST00000312150.4
KRT25
keratin 25
chr18_+_616711 0.06 ENST00000579494.1
CLUL1
clusterin-like 1 (retinal)
chr1_-_209957882 0.06 ENST00000294811.1
C1orf74
chromosome 1 open reading frame 74
chr3_+_111753690 0.06 ENST00000452346.2
TMPRSS7
transmembrane protease, serine 7
chr8_-_6420930 0.06 ENST00000325203.5
ANGPT2
angiopoietin 2
chr1_+_12976450 0.06 ENST00000361079.2
PRAMEF7
PRAME family member 7
chr2_+_166150541 0.06 ENST00000283256.6
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr17_-_7167279 0.06 ENST00000571932.2
CLDN7
claudin 7
chr3_+_186692745 0.06 ENST00000438590.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr12_-_49581152 0.06 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr3_-_193272874 0.06 ENST00000342695.4
ATP13A4
ATPase type 13A4
chrX_+_9431324 0.06 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr19_-_44174305 0.06 ENST00000601723.1
ENST00000339082.3
PLAUR
plasminogen activator, urokinase receptor
chr5_+_140571902 0.06 ENST00000239446.4
PCDHB10
protocadherin beta 10
chr13_+_53602894 0.06 ENST00000219022.2
OLFM4
olfactomedin 4
chr10_+_78078088 0.06 ENST00000496424.2
C10orf11
chromosome 10 open reading frame 11
chr6_+_42896865 0.06 ENST00000372836.4
ENST00000394142.3
CNPY3
canopy FGF signaling regulator 3
chr1_+_114473350 0.06 ENST00000503968.1
HIPK1
homeodomain interacting protein kinase 1
chr2_-_172967621 0.06 ENST00000234198.4
ENST00000466293.2
DLX2
distal-less homeobox 2
chr9_-_70465758 0.06 ENST00000489273.1
CBWD5
COBW domain containing 5
chr10_-_111713633 0.06 ENST00000538668.1
ENST00000369657.1
ENST00000369655.1
RP11-451M19.3
Uncharacterized protein
chr2_+_176994408 0.06 ENST00000429017.1
ENST00000313173.4
ENST00000544999.1
HOXD8
homeobox D8
chr8_-_95229531 0.06 ENST00000450165.2
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr13_-_52980263 0.05 ENST00000258613.4
ENST00000544466.1
THSD1
thrombospondin, type I, domain containing 1
chrX_+_1710484 0.05 ENST00000313871.3
ENST00000381261.3
AKAP17A
A kinase (PRKA) anchor protein 17A
chr14_+_38264418 0.05 ENST00000267368.7
ENST00000382320.3
TTC6
tetratricopeptide repeat domain 6
chr2_+_102413726 0.05 ENST00000350878.4
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr12_-_10324716 0.05 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PRRX1_ALX4_PHOX2A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 1.1 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.5 GO:0042710 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.1 0.3 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.1 0.6 GO:0060809 mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.1 0.2 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 0.2 GO:0002384 hepatic immune response(GO:0002384)
0.1 0.2 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.3 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.3 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.2 GO:0021764 amygdala development(GO:0021764)
0.0 0.1 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.7 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.1 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440)
0.0 0.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.2 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.9 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.1 GO:2000097 negative regulation of lipoprotein oxidation(GO:0034443) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.1 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.0 0.2 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.1 GO:0003363 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.1 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.1 GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.0 0.1 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.0 0.1 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.1 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.0 0.3 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.2 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.0 0.1 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.1 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.1 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.0 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.0 0.2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.0 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.2 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.2 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.9 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.2 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0043614 multi-eIF complex(GO:0043614)
0.0 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.7 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.3 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 0.9 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.2 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.1 0.2 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 0.3 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.0 0.1 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.6 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.0 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
0.0 0.1 GO:0015322 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.5 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.0 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 0.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.0 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST STAT3 PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 1.1 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling