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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for REST

Z-value: 0.61

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.11 RE1 silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_57774114-0.954.1e-03Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_4769117 0.73 ENST00000540211.1
ENST00000317292.3
ENST00000586721.1
ENST00000592709.1
ENST00000588711.1
ENST00000589639.1
ENST00000591008.1
ENST00000592663.1
ENST00000588758.1
MIR7-3HG
MIR7-3 host gene (non-protein coding)
chr15_-_79576156 0.67 ENST00000560452.1
ENST00000560872.1
ENST00000560732.1
ENST00000559979.1
ENST00000560533.1
ENST00000559225.1
RP11-17L5.4
RP11-17L5.4
chr10_+_99609996 0.57 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr22_+_31199037 0.39 ENST00000424224.1
OSBP2
oxysterol binding protein 2
chr20_+_62327996 0.34 ENST00000369996.1
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr12_-_29936731 0.29 ENST00000552618.1
ENST00000539277.1
ENST00000551659.1
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr20_+_30555805 0.28 ENST00000562532.2
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr13_-_111214015 0.27 ENST00000267328.3
RAB20
RAB20, member RAS oncogene family
chrX_-_153141302 0.24 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
L1CAM
L1 cell adhesion molecule
chr17_+_30813576 0.23 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chrX_+_153238220 0.22 ENST00000425274.1
TMEM187
transmembrane protein 187
chr9_+_140033862 0.21 ENST00000350902.5
ENST00000371550.4
ENST00000371546.4
ENST00000371555.4
ENST00000371553.3
ENST00000371559.4
ENST00000371560.3
GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr5_-_176037105 0.20 ENST00000303991.4
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr11_-_75141206 0.18 ENST00000376292.4
KLHL35
kelch-like family member 35
chr10_-_102790852 0.17 ENST00000470414.1
ENST00000370215.3
PDZD7
PDZ domain containing 7
chr3_+_75955817 0.17 ENST00000487694.3
ENST00000602589.1
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr14_+_93389425 0.16 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr11_+_64808675 0.16 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr6_+_43603552 0.16 ENST00000372171.4
MAD2L1BP
MAD2L1 binding protein
chr20_+_5892037 0.15 ENST00000378961.4
CHGB
chromogranin B (secretogranin 1)
chrX_-_47479246 0.13 ENST00000295987.7
ENST00000340666.4
SYN1
synapsin I
chr3_-_48700310 0.12 ENST00000164024.4
ENST00000544264.1
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3
chr16_+_3019246 0.12 ENST00000318782.8
ENST00000293978.8
PAQR4
progestin and adipoQ receptor family member IV
chr12_+_175930 0.11 ENST00000538872.1
ENST00000326261.4
IQSEC3
IQ motif and Sec7 domain 3
chr17_+_72667239 0.11 ENST00000402449.4
RAB37
RAB37, member RAS oncogene family
chr15_-_79576229 0.10 ENST00000557790.1
ENST00000558297.1
RP11-17L5.4
RP11-17L5.4
chr9_-_104357277 0.10 ENST00000374806.1
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr5_+_167956121 0.10 ENST00000338333.4
FBLL1
fibrillarin-like 1
chr7_-_65113280 0.10 ENST00000593865.1
AC104057.1
Protein LOC100996407
chr12_+_71833550 0.10 ENST00000266674.5
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr20_+_5892147 0.09 ENST00000455042.1
CHGB
chromogranin B (secretogranin 1)
chr11_-_125773085 0.09 ENST00000227474.3
ENST00000534158.1
ENST00000529801.1
PUS3
pseudouridylate synthase 3
chr15_-_83378611 0.09 ENST00000542200.1
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr15_-_72612470 0.09 ENST00000287202.5
CELF6
CUGBP, Elav-like family member 6
chr17_-_27332931 0.09 ENST00000442608.3
ENST00000335960.6
SEZ6
seizure related 6 homolog (mouse)
chr7_+_150748288 0.09 ENST00000490540.1
ASIC3
acid-sensing (proton-gated) ion channel 3
chr2_+_226265364 0.09 ENST00000272907.6
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr11_-_72492878 0.08 ENST00000535054.1
ENST00000545082.1
STARD10
StAR-related lipid transfer (START) domain containing 10
chr14_+_96039882 0.08 ENST00000556346.1
ENST00000553785.1
RP11-1070N10.4
RP11-1070N10.4
chr19_-_3971050 0.08 ENST00000545797.2
ENST00000596311.1
DAPK3
death-associated protein kinase 3
chrX_-_153237258 0.08 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr2_-_47798044 0.08 ENST00000327876.4
KCNK12
potassium channel, subfamily K, member 12
chr11_+_637246 0.08 ENST00000176183.5
DRD4
dopamine receptor D4
chr14_-_51562037 0.08 ENST00000338969.5
TRIM9
tripartite motif containing 9
chr12_+_119419294 0.08 ENST00000267260.4
SRRM4
serine/arginine repetitive matrix 4
chr17_-_3301704 0.08 ENST00000322608.2
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr7_+_8474150 0.07 ENST00000602349.1
NXPH1
neurexophilin 1
chr4_-_175750364 0.07 ENST00000340217.5
ENST00000274093.3
GLRA3
glycine receptor, alpha 3
chr2_-_30143525 0.07 ENST00000431873.1
ALK
anaplastic lymphoma receptor tyrosine kinase
chr12_+_71833756 0.07 ENST00000536515.1
ENST00000540815.2
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr10_+_102790980 0.06 ENST00000393459.1
ENST00000224807.5
SFXN3
sideroflexin 3
chr7_+_63361201 0.06 ENST00000450544.1
RP11-340I6.8
RP11-340I6.8
chr3_-_131753830 0.06 ENST00000429747.1
CPNE4
copine IV
chr12_+_113796347 0.06 ENST00000545182.2
ENST00000280800.3
PLBD2
phospholipase B domain containing 2
chr8_-_145752390 0.06 ENST00000529415.2
ENST00000533758.1
LRRC24
leucine rich repeat containing 24
chr8_-_145559943 0.06 ENST00000332135.4
SCRT1
scratch family zinc finger 1
chr10_+_26505179 0.06 ENST00000376261.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr8_-_91095099 0.06 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr17_-_27333311 0.06 ENST00000317338.12
ENST00000585644.1
SEZ6
seizure related 6 homolog (mouse)
chr2_-_51259641 0.05 ENST00000406316.2
ENST00000405581.1
NRXN1
neurexin 1
chr12_+_113229452 0.05 ENST00000389385.4
RPH3A
rabphilin 3A homolog (mouse)
chr12_+_113229543 0.05 ENST00000447659.2
RPH3A
rabphilin 3A homolog (mouse)
chr17_-_7218403 0.05 ENST00000570780.1
GPS2
G protein pathway suppressor 2
chr5_+_175298487 0.05 ENST00000393745.3
CPLX2
complexin 2
chr9_+_138606400 0.05 ENST00000486577.2
KCNT1
potassium channel, subfamily T, member 1
chr19_-_45926739 0.05 ENST00000589381.1
ENST00000591636.1
ENST00000013807.5
ENST00000592023.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr12_+_113229737 0.05 ENST00000551052.1
ENST00000415485.3
RPH3A
rabphilin 3A homolog (mouse)
chrX_-_153141434 0.05 ENST00000407935.2
ENST00000439496.1
L1CAM
L1 cell adhesion molecule
chr15_+_68117872 0.05 ENST00000380035.2
ENST00000389002.1
SKOR1
SKI family transcriptional corepressor 1
chr14_+_93897199 0.05 ENST00000553484.1
UNC79
unc-79 homolog (C. elegans)
chr2_-_51259528 0.05 ENST00000404971.1
NRXN1
neurexin 1
chr1_-_40105617 0.05 ENST00000372852.3
HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr5_+_175298674 0.04 ENST00000514150.1
CPLX2
complexin 2
chr14_+_93897272 0.04 ENST00000393151.2
UNC79
unc-79 homolog (C. elegans)
chrX_+_153237740 0.04 ENST00000369982.4
TMEM187
transmembrane protein 187
chr20_+_44657845 0.04 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr9_-_74061751 0.04 ENST00000357533.2
ENST00000423814.3
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr1_+_210111570 0.04 ENST00000367019.1
ENST00000472886.1
SYT14
synaptotagmin XIV
chr11_+_45907177 0.04 ENST00000241014.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr15_+_68117844 0.04 ENST00000554054.1
SKOR1
SKI family transcriptional corepressor 1
chr3_+_9745510 0.03 ENST00000383831.3
CPNE9
copine family member IX
chr15_-_83378638 0.03 ENST00000261722.3
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chrX_-_49056635 0.03 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
SYP
synaptophysin
chr3_+_120626919 0.03 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
STXBP5L
syntaxin binding protein 5-like
chr10_+_60936921 0.03 ENST00000373878.3
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr15_-_83378526 0.03 ENST00000535348.1
ENST00000535359.1
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr14_-_74892805 0.03 ENST00000331628.3
ENST00000554953.1
SYNDIG1L
synapse differentiation inducing 1-like
chr1_-_175712665 0.03 ENST00000263525.2
TNR
tenascin R
chr20_+_36012051 0.03 ENST00000373567.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr7_-_100808394 0.03 ENST00000445482.2
VGF
VGF nerve growth factor inducible
chr1_+_171750776 0.03 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
METTL13
methyltransferase like 13
chr16_+_3019309 0.03 ENST00000576565.1
PAQR4
progestin and adipoQ receptor family member IV
chr5_-_135701164 0.02 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7
transient receptor potential cation channel, subfamily C, member 7
chr12_-_99288536 0.02 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr3_+_9745487 0.02 ENST00000383832.3
CPNE9
copine family member IX
chr19_-_45927622 0.02 ENST00000300853.3
ENST00000589165.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr3_+_193853927 0.01 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr2_-_51259292 0.01 ENST00000401669.2
NRXN1
neurexin 1
chr6_+_153071925 0.01 ENST00000367244.3
ENST00000367243.3
VIP
vasoactive intestinal peptide
chr1_+_212606219 0.01 ENST00000366988.3
NENF
neudesin neurotrophic factor
chr6_+_158957431 0.01 ENST00000367090.3
TMEM181
transmembrane protein 181
chr2_+_46524537 0.01 ENST00000263734.3
EPAS1
endothelial PAS domain protein 1
chr7_-_100808843 0.01 ENST00000249330.2
VGF
VGF nerve growth factor inducible
chr12_-_24737089 0.01 ENST00000483544.1
LINC00477
long intergenic non-protein coding RNA 477
chr11_-_6677018 0.01 ENST00000299441.3
DCHS1
dachsous cadherin-related 1
chr14_-_51561784 0.01 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr2_-_51259229 0.00 ENST00000405472.3
NRXN1
neurexin 1
chr17_-_27333163 0.00 ENST00000360295.9
SEZ6
seizure related 6 homolog (mouse)

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0021586 pons maturation(GO:0021586)
0.1 0.2 GO:1900738 dense core granule biogenesis(GO:0061110) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of muscle(GO:1901079) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.6 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:1990258 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.0 0.2 GO:0061364 negative regulation of negative chemotaxis(GO:0050925) apoptotic process involved in luteolysis(GO:0061364)
0.0 0.1 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 0.3 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.1 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.0 0.1 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.0 0.1 GO:0036269 swimming behavior(GO:0036269)
0.0 0.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.1 GO:0051582 positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.0 0.1 GO:0072221 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221)
0.0 0.1 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.1 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.2 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.1 GO:0097091 synaptic vesicle clustering(GO:0097091)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.2 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.6 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.1 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.0 0.2 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.5 GO:0097440 apical dendrite(GO:0097440)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.2 GO:0042583 chromaffin granule(GO:0042583)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.2 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.1 GO:0036009 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.6 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.0 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)