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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RUNX3_BCL11A

Z-value: 1.13

Motif logo

Transcription factors associated with RUNX3_BCL11A

Gene Symbol Gene ID Gene Info
ENSG00000020633.14 RUNX family transcription factor 3
ENSG00000119866.16 BAF chromatin remodeling complex subunit BCL11A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BCL11Ahg19_v2_chr2_-_60780536_60780541-0.777.1e-02Click!
RUNX3hg19_v2_chr1_-_25291475_252915110.424.0e-01Click!

Activity profile of RUNX3_BCL11A motif

Sorted Z-values of RUNX3_BCL11A motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_131409476 3.04 ENST00000296871.2
colony stimulating factor 2 (granulocyte-macrophage)
chr5_+_159895275 1.08 ENST00000517927.1
microRNA 146a
chr5_+_35856951 0.95 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
interleukin 7 receptor
chr1_-_235098861 0.91 ENST00000458044.1
RP11-443B7.1
chr2_+_228678550 0.84 ENST00000409189.3
ENST00000358813.4
chemokine (C-C motif) ligand 20
chr15_+_67390920 0.79 ENST00000559092.1
ENST00000560175.1
SMAD family member 3
chr6_+_45296048 0.64 ENST00000465038.2
ENST00000352853.5
ENST00000541979.1
ENST00000371438.1
runt-related transcription factor 2
chr20_+_44637526 0.61 ENST00000372330.3
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr6_+_45296391 0.56 ENST00000371436.6
ENST00000576263.1
runt-related transcription factor 2
chr17_+_76037081 0.56 ENST00000588549.1
trinucleotide repeat containing 6C
chr2_-_214017151 0.55 ENST00000452786.1
IKAROS family zinc finger 2 (Helios)
chrX_-_19688475 0.53 ENST00000541422.1
SH3-domain kinase binding protein 1
chr6_+_30029008 0.49 ENST00000332435.5
ENST00000376782.2
ENST00000359374.4
ENST00000376785.2
zinc ribbon domain containing 1
chr19_-_42636617 0.48 ENST00000529067.1
ENST00000529952.1
ENST00000533720.1
ENST00000389341.5
ENST00000342301.4
POU class 2 homeobox 2
chr19_-_8567505 0.47 ENST00000600262.1
PML-RARA regulated adaptor molecule 1
chr21_-_36421401 0.47 ENST00000486278.2
runt-related transcription factor 1
chr15_-_60695071 0.46 ENST00000557904.1
annexin A2
chr2_+_33359473 0.45 ENST00000432635.1
latent transforming growth factor beta binding protein 1
chr14_-_74462922 0.44 ENST00000553284.1
ectonucleoside triphosphate diphosphohydrolase 5
chr15_+_86098670 0.42 ENST00000558811.1
A kinase (PRKA) anchor protein 13
chr22_-_30642782 0.41 ENST00000249075.3
leukemia inhibitory factor
chr1_+_152486950 0.41 ENST00000368790.3
cysteine-rich C-terminal 1
chr12_-_96793142 0.37 ENST00000552262.1
ENST00000551816.1
ENST00000552496.1
cyclin-dependent kinase 17
chr22_-_30642728 0.37 ENST00000403987.3
leukemia inhibitory factor
chr12_-_58145889 0.37 ENST00000547853.1
cyclin-dependent kinase 4
chr6_+_31543334 0.34 ENST00000449264.2
tumor necrosis factor
chr9_-_117853297 0.34 ENST00000542877.1
ENST00000537320.1
ENST00000341037.4
tenascin C
chr11_-_58345569 0.34 ENST00000528954.1
ENST00000528489.1
leupaxin
chr1_+_156308245 0.33 ENST00000368253.2
ENST00000470342.1
ENST00000368254.1
TSSK6 activating co-chaperone
chr2_-_61389168 0.33 ENST00000607743.1
ENST00000605902.1
RP11-493E12.1
chr1_+_164528437 0.32 ENST00000485769.1
pre-B-cell leukemia homeobox 1
chr12_-_4754339 0.32 ENST00000228850.1
A kinase (PRKA) anchor protein 3
chr16_+_82090028 0.30 ENST00000568090.1
hydroxysteroid (17-beta) dehydrogenase 2
chr1_-_25291475 0.29 ENST00000338888.3
ENST00000399916.1
runt-related transcription factor 3
chr1_+_110453608 0.29 ENST00000369801.1
colony stimulating factor 1 (macrophage)
chr19_-_42636543 0.29 ENST00000528894.4
ENST00000560804.2
ENST00000560558.1
ENST00000560398.1
ENST00000526816.2
POU class 2 homeobox 2
chr1_-_235098935 0.28 ENST00000423175.1
RP11-443B7.1
chr2_+_173955327 0.28 ENST00000422149.1
Mitogen-activated protein kinase kinase kinase MLT
chr7_+_18535321 0.28 ENST00000413380.1
ENST00000430454.1
histone deacetylase 9
chr17_+_7239821 0.28 ENST00000158762.3
ENST00000570457.2
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr3_+_50126341 0.28 ENST00000347869.3
ENST00000469838.1
ENST00000404526.2
ENST00000441305.1
RNA binding motif protein 5
chr9_+_75766763 0.28 ENST00000456643.1
ENST00000415424.1
annexin A1
chr17_+_65375082 0.27 ENST00000584471.1
phosphatidylinositol transfer protein, cytoplasmic 1
chr5_-_56778635 0.26 ENST00000423391.1
actin, beta-like 2
chr9_+_75766652 0.25 ENST00000257497.6
annexin A1
chr14_+_75988851 0.25 ENST00000555504.1
basic leucine zipper transcription factor, ATF-like
chr14_+_66578299 0.25 ENST00000554187.1
ENST00000556662.1
ENST00000556291.1
ENST00000557723.1
ENST00000557050.1
RP11-783L4.1
chr17_-_69198295 0.24 ENST00000569074.1
cancer susceptibility candidate 17 (non-protein coding)
chr17_+_27047570 0.24 ENST00000472628.1
ENST00000578181.1
ribosomal protein L23a
chr1_+_209859510 0.23 ENST00000367028.2
ENST00000261465.1
hydroxysteroid (11-beta) dehydrogenase 1
chr1_-_92951607 0.23 ENST00000427103.1
growth factor independent 1 transcription repressor
chr5_+_67535647 0.23 ENST00000520675.1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr20_+_36405665 0.22 ENST00000373469.1
catenin, beta like 1
chr1_+_53098862 0.22 ENST00000517870.1
family with sequence similarity 159, member A
chr3_+_49977440 0.22 ENST00000442092.1
ENST00000266022.4
ENST00000443081.1
RNA binding motif protein 6
chr10_+_17272608 0.22 ENST00000421459.2
vimentin
chr3_+_98699880 0.21 ENST00000473756.1
long intergenic non-protein coding RNA 973
chrX_-_54209640 0.21 ENST00000375180.2
ENST00000328235.4
ENST00000477084.1
family with sequence similarity 120C
chr3_+_51575596 0.21 ENST00000409535.2
RAD54-like 2 (S. cerevisiae)
chr21_-_31588365 0.21 ENST00000399899.1
claudin 8
chr11_-_128457446 0.21 ENST00000392668.4
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr5_+_148206156 0.20 ENST00000305988.4
adrenoceptor beta 2, surface
chr7_+_102389434 0.20 ENST00000409231.3
ENST00000418198.1
family with sequence similarity 185, member A
chr3_-_99569821 0.20 ENST00000487087.1
filamin A interacting protein 1-like
chr3_-_131756559 0.20 ENST00000505957.1
copine IV
chr17_-_61777090 0.19 ENST00000578061.1
LIM domain containing 2
chr6_+_12290586 0.19 ENST00000379375.5
endothelin 1
chr4_+_76481258 0.19 ENST00000311623.4
ENST00000435974.2
chromosome 4 open reading frame 26
chr6_-_152623231 0.19 ENST00000540663.1
ENST00000537033.1
spectrin repeat containing, nuclear envelope 1
chr1_-_153348067 0.18 ENST00000368737.3
S100 calcium binding protein A12
chr2_-_61389240 0.18 ENST00000606876.1
RP11-493E12.1
chr6_-_31508304 0.18 ENST00000376177.2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr17_+_7239904 0.18 ENST00000575425.1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr16_-_69418553 0.18 ENST00000569542.2
telomeric repeat binding factor 2
chr6_-_75912508 0.18 ENST00000416123.2
collagen, type XII, alpha 1
chr11_-_102826434 0.18 ENST00000340273.4
ENST00000260302.3
matrix metallopeptidase 13 (collagenase 3)
chr3_-_100558953 0.17 ENST00000533795.1
ABI family, member 3 (NESH) binding protein
chr11_-_71781096 0.17 ENST00000535087.1
ENST00000535838.1
nuclear mitotic apparatus protein 1
chr2_-_18741882 0.17 ENST00000381249.3
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
chr22_+_31488433 0.17 ENST00000455608.1
smoothelin
chr16_+_84801852 0.17 ENST00000569925.1
ENST00000567526.1
ubiquitin specific peptidase 10
chr17_-_73840614 0.17 ENST00000586108.1
unc-13 homolog D (C. elegans)
chr17_+_19281787 0.17 ENST00000482850.1
mitogen-activated protein kinase 7
chr6_+_139135648 0.17 ENST00000541398.1
epithelial cell transforming sequence 2 oncogene-like
chr3_+_15643140 0.17 ENST00000449107.1
biotinidase
chr15_-_72668185 0.16 ENST00000457859.2
ENST00000566304.1
ENST00000567159.1
ENST00000429918.2
hexosaminidase A (alpha polypeptide)
chr1_+_111772314 0.16 ENST00000466741.1
ENST00000477185.2
chitinase 3-like 2
chr14_-_23564320 0.16 ENST00000605057.1
apoptotic chromatin condensation inducer 1
chr1_-_161039647 0.16 ENST00000368013.3
Rho GTPase activating protein 30
chr3_+_49977523 0.16 ENST00000422955.1
RNA binding motif protein 6
chr1_-_161039753 0.16 ENST00000368015.1
Rho GTPase activating protein 30
chr1_-_217250231 0.16 ENST00000493748.1
ENST00000463665.1
estrogen-related receptor gamma
chr13_-_99910673 0.16 ENST00000397473.2
ENST00000397470.2
G protein-coupled receptor 18
chr6_-_112081113 0.16 ENST00000517419.1
FYN oncogene related to SRC, FGR, YES
chr6_+_15401075 0.16 ENST00000541660.1
jumonji, AT rich interactive domain 2
chr8_-_60031762 0.15 ENST00000361421.1
thymocyte selection-associated high mobility group box
chr1_+_111772375 0.15 ENST00000467038.2
ENST00000497587.2
chitinase 3-like 2
chr2_+_33359687 0.15 ENST00000402934.1
ENST00000404525.1
ENST00000407925.1
latent transforming growth factor beta binding protein 1
chr5_-_127674883 0.15 ENST00000507835.1
fibrillin 2
chr8_-_72274095 0.15 ENST00000303824.7
eyes absent homolog 1 (Drosophila)
chr2_+_33359646 0.15 ENST00000390003.4
ENST00000418533.2
latent transforming growth factor beta binding protein 1
chr1_+_155099927 0.15 ENST00000368407.3
ephrin-A1
chr2_+_234545148 0.15 ENST00000373445.1
UDP glucuronosyltransferase 1 family, polypeptide A10
chr2_+_73461364 0.15 ENST00000540468.1
ENST00000539919.1
ENST00000258091.5
chaperonin containing TCP1, subunit 7 (eta)
chr21_-_31588338 0.14 ENST00000286809.1
claudin 8
chr3_+_49977490 0.14 ENST00000539992.1
RNA binding motif protein 6
chr1_+_149553003 0.14 ENST00000369222.3
peptidylprolyl isomerase A (cyclophilin A)-like 4C
chr3_+_40518599 0.14 ENST00000314686.5
ENST00000447116.2
ENST00000429348.2
ENST00000456778.1
zinc finger protein 619
chr17_-_61776522 0.14 ENST00000582055.1
LIM domain containing 2
chr1_-_144364246 0.14 ENST00000540273.1
peptidylprolyl isomerase A (cyclophilin A)-like 4B
chr16_+_58033450 0.14 ENST00000561743.1
U6 snRNA biogenesis 1
chr3_+_14061155 0.14 ENST00000532924.1
tetra-peptide repeat homeobox-like
chr10_+_25463951 0.13 ENST00000376351.3
G protein-coupled receptor 158
chr1_+_155579979 0.13 ENST00000452804.2
ENST00000538143.1
ENST00000245564.2
ENST00000368341.4
misato 1, mitochondrial distribution and morphology regulator
chr17_-_7164410 0.13 ENST00000574070.1
claudin 7
chr1_-_161039456 0.13 ENST00000368016.3
Rho GTPase activating protein 30
chr13_-_46756351 0.13 ENST00000323076.2
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_110453109 0.13 ENST00000525659.1
colony stimulating factor 1 (macrophage)
chr2_+_169659121 0.13 ENST00000397206.2
ENST00000397209.2
ENST00000421711.2
nitric oxide synthase trafficking
chr7_-_10979750 0.13 ENST00000339600.5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
chr2_+_73461410 0.13 ENST00000399032.2
ENST00000398422.2
ENST00000537131.1
ENST00000538797.1
chaperonin containing TCP1, subunit 7 (eta)
chr12_-_16760021 0.13 ENST00000540445.1
LIM domain only 3 (rhombotin-like 2)
chr14_-_21493884 0.13 ENST00000556974.1
ENST00000554419.1
ENST00000298687.5
ENST00000397858.1
ENST00000360463.3
ENST00000350792.3
ENST00000397847.2
NDRG family member 2
chr5_+_145316120 0.13 ENST00000359120.4
SH3 domain containing ring finger 2
chr7_-_87104963 0.13 ENST00000359206.3
ENST00000358400.3
ENST00000265723.4
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr12_-_4754318 0.13 ENST00000536414.1
A kinase (PRKA) anchor protein 3
chr9_-_130541017 0.13 ENST00000314830.8
SH2 domain containing 3C
chr15_+_67418047 0.13 ENST00000540846.2
SMAD family member 3
chr7_+_18330035 0.12 ENST00000413509.2
histone deacetylase 9
chr4_+_89299885 0.12 ENST00000380265.5
ENST00000273960.3
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr14_+_35761580 0.12 ENST00000553809.1
ENST00000555764.1
ENST00000556506.1
proteasome (prosome, macropain) subunit, alpha type, 6
chr2_-_71221942 0.12 ENST00000272438.4
testis expressed 261
chr17_+_9745786 0.12 ENST00000304773.5
glucagon-like peptide 2 receptor
chr14_-_21493649 0.12 ENST00000553442.1
ENST00000555869.1
ENST00000556457.1
ENST00000397844.2
ENST00000554415.1
NDRG family member 2
chr15_-_78358465 0.12 ENST00000435468.1
TBC1 domain family, member 2B
chr9_-_123342415 0.12 ENST00000349780.4
ENST00000360190.4
ENST00000360822.3
ENST00000359309.3
CDK5 regulatory subunit associated protein 2
chr17_+_7462103 0.12 ENST00000396545.4
tumor necrosis factor (ligand) superfamily, member 13
chrX_-_106146547 0.12 ENST00000276173.4
ENST00000411805.1
ripply transcriptional repressor 1
chr1_+_209929377 0.12 ENST00000400959.3
ENST00000367025.3
TRAF3 interacting protein 3
chr16_+_67312049 0.12 ENST00000565899.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr7_-_99679324 0.12 ENST00000292393.5
ENST00000413658.2
ENST00000412947.1
ENST00000441298.1
ENST00000449785.1
ENST00000299667.4
ENST00000424697.1
zinc finger protein 3
chr3_-_49941042 0.12 ENST00000344206.4
ENST00000296474.3
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
chr18_-_43678241 0.12 ENST00000593152.2
ENST00000589252.1
ENST00000590665.1
ENST00000398752.6
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr2_+_44001172 0.11 ENST00000260605.8
ENST00000406852.3
ENST00000443170.3
ENST00000398823.2
ENST00000605786.1
dynein, cytoplasmic 2, light intermediate chain 1
chr2_+_169658928 0.11 ENST00000317647.7
ENST00000445023.2
nitric oxide synthase trafficking
chr3_+_142342240 0.11 ENST00000497199.1
plastin 1
chr9_-_93925369 0.11 ENST00000457976.1
RP11-305L7.3
chr18_+_5238549 0.11 ENST00000580684.1
long intergenic non-protein coding RNA 667
chr1_+_110453462 0.11 ENST00000488198.1
colony stimulating factor 1 (macrophage)
chr10_-_99205607 0.11 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
exosome component 1
chr17_+_38673270 0.11 ENST00000578280.1
RP5-1028K7.2
chr11_+_71238313 0.11 ENST00000398536.4
keratin associated protein 5-7
chr6_+_30294612 0.11 ENST00000440271.1
ENST00000396551.3
ENST00000376656.4
ENST00000540416.1
ENST00000428728.1
ENST00000396548.1
ENST00000428404.1
tripartite motif containing 39
chr6_+_37787704 0.11 ENST00000474522.1
zinc finger, AN1-type domain 3
chr3_+_15643245 0.11 ENST00000303498.5
ENST00000437172.1
biotinidase
chr11_+_60739115 0.11 ENST00000344028.5
ENST00000346437.4
CD6 molecule
chr10_+_89420706 0.11 ENST00000427144.2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr2_+_30455016 0.11 ENST00000401506.1
ENST00000407930.2
limb bud and heart development
chr6_+_27925019 0.11 ENST00000244623.1
olfactory receptor, family 2, subfamily B, member 6
chr6_+_30295036 0.11 ENST00000376659.5
ENST00000428555.1
tripartite motif containing 39
chr20_-_25062767 0.11 ENST00000429762.3
ENST00000444511.2
ENST00000376707.3
visual system homeobox 1
chr4_+_89299994 0.10 ENST00000264346.7
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr19_-_50868882 0.10 ENST00000598915.1
napsin A aspartic peptidase
chr19_-_49496557 0.10 ENST00000323798.3
ENST00000541188.1
ENST00000544287.1
ENST00000540532.1
ENST00000263276.6
glycogen synthase 1 (muscle)
chr12_-_49245916 0.10 ENST00000552512.1
ENST00000551468.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
chr11_+_61015594 0.10 ENST00000451616.2
pepsinogen 5, group I (pepsinogen A)
chr17_-_42188598 0.10 ENST00000591714.1
histone deacetylase 5
chr15_-_37393406 0.10 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
Meis homeobox 2
chr16_+_72088376 0.10 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
haptoglobin
haptoglobin-related protein
chr15_+_63889552 0.10 ENST00000360587.2
F-box and leucine-rich repeat protein 22
chr3_-_71179699 0.10 ENST00000497355.1
forkhead box P1
chr12_-_49245936 0.10 ENST00000308025.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
chr17_-_56494713 0.10 ENST00000407977.2
ring finger protein 43
chr9_-_34048873 0.10 ENST00000449054.1
ENST00000379239.4
ENST00000539807.1
ENST00000379238.1
ENST00000418786.2
ENST00000360802.1
ENST00000412543.1
ubiquitin associated protein 2
chr3_+_15643476 0.10 ENST00000436193.1
ENST00000383778.4
biotinidase
chrX_-_119005735 0.10 ENST00000371442.2
ring finger protein 113A
chrX_+_37639302 0.10 ENST00000545017.1
ENST00000536160.1
cytochrome b-245, beta polypeptide
chr15_-_41805994 0.09 ENST00000561619.1
ENST00000263800.6
ENST00000355166.5
ENST00000453182.2
leukocyte receptor tyrosine kinase
chr4_+_152020736 0.09 ENST00000509736.1
ENST00000505243.1
ENST00000514682.1
ENST00000322686.6
ENST00000503002.1
ribosomal protein S3A
chr3_+_187957646 0.09 ENST00000457242.1
LIM domain containing preferred translocation partner in lipoma
chr1_-_86043921 0.09 ENST00000535924.2
dimethylarginine dimethylaminohydrolase 1
chr5_+_132149017 0.09 ENST00000378693.2
sosondowah ankyrin repeat domain family member A
chr9_-_130517522 0.09 ENST00000373274.3
ENST00000420366.1
SH2 domain containing 3C
chr12_-_16759440 0.09 ENST00000537304.1
LIM domain only 3 (rhombotin-like 2)
chr6_+_5030205 0.09 ENST00000606761.1
ENST00000607327.1
ENST00000606767.1
RP11-428J1.5
chr11_+_62475130 0.09 ENST00000294117.5
guanine nucleotide binding protein (G protein), gamma 3
chr12_+_57916466 0.09 ENST00000355673.3
methyl-CpG binding domain protein 6
chr2_-_74779744 0.09 ENST00000409249.1
lysyl oxidase-like 3
chr6_-_34524049 0.09 ENST00000374037.3
SAM pointed domain containing ETS transcription factor
chr3_+_42892458 0.09 ENST00000494619.1
atypical chemokine receptor 2
chr1_-_94147385 0.09 ENST00000260502.6
breast cancer anti-estrogen resistance 3
chr12_-_51717875 0.09 ENST00000604560.1
bridging integrator 2
chr12_-_51717948 0.09 ENST00000267012.4
bridging integrator 2
chr15_+_63889577 0.09 ENST00000534939.1
ENST00000539570.3
F-box and leucine-rich repeat protein 22
chr1_+_207238326 0.09 ENST00000541914.1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
chr12_-_51717922 0.09 ENST00000452142.2
bridging integrator 2
chr5_-_65018834 0.09 ENST00000506816.1
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr8_+_31497271 0.09 ENST00000520407.1
neuregulin 1
chr19_-_40786733 0.09 ENST00000486368.2
v-akt murine thymoma viral oncogene homolog 2
chr1_+_172628154 0.08 ENST00000340030.3
ENST00000367721.2
Fas ligand (TNF superfamily, member 6)

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX3_BCL11A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.3 0.8 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.2 0.5 GO:0031394 myoblast migration involved in skeletal muscle regeneration(GO:0014839) positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.2 0.8 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.9 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 0.5 GO:0052361 multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419)
0.1 0.6 GO:1904141 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141)
0.1 0.3 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) positive regulation of translational initiation by iron(GO:0045994)
0.1 0.3 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.1 1.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.9 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 0.9 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 0.2 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.1 0.4 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1 0.2 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.1 0.2 GO:0002304 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.1 0.2 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.0 0.1 GO:0014028 notochord formation(GO:0014028)
0.0 0.3 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.2 GO:0060585 nitric oxide transport(GO:0030185) negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.6 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 0.1 GO:0070377 regulation of ERK5 cascade(GO:0070376) negative regulation of ERK5 cascade(GO:0070377)
0.0 0.1 GO:1901656 cellular response to mycotoxin(GO:0036146) glycoside transport(GO:1901656)
0.0 0.2 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.0 0.0 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.0 0.4 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.0 0.1 GO:0002432 granuloma formation(GO:0002432)
0.0 0.1 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.5 GO:1902563 regulation of neutrophil degranulation(GO:0043313) regulation of neutrophil activation(GO:1902563)
0.0 0.1 GO:2000525 negative regulation of regulatory T cell differentiation(GO:0045590) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 0.1 GO:1903824 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.0 1.0 GO:0002335 mature B cell differentiation(GO:0002335)
0.0 0.1 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.2 GO:1904674 positive regulation of somatic stem cell population maintenance(GO:1904674)
0.0 0.1 GO:0044727 DNA demethylation of male pronucleus(GO:0044727)
0.0 0.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.4 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.0 0.1 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.0 0.1 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.0 0.4 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.1 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.0 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.0 0.3 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.1 GO:0071461 cellular response to redox state(GO:0071461)
0.0 0.2 GO:0051552 flavone metabolic process(GO:0051552)
0.0 0.2 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.0 0.1 GO:0071104 response to interleukin-9(GO:0071104)
0.0 0.4 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.0 0.1 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.0 0.2 GO:0071988 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0 0.3 GO:1904869 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.0 0.1 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.1 GO:0060480 lung goblet cell differentiation(GO:0060480) lobar bronchus epithelium development(GO:0060481)
0.0 0.2 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.0 GO:0050760 negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.1 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0 0.1 GO:2000053 regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.0 0.3 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.4 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.1 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.0 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.0 GO:0032827 negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.0 0.1 GO:0043129 surfactant homeostasis(GO:0043129)
0.0 0.3 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.1 GO:2000295 regulation of hydrogen peroxide catabolic process(GO:2000295)
0.0 0.2 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0015688 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.0 0.1 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.1 GO:0050917 sensory perception of umami taste(GO:0050917)
0.0 0.1 GO:0033133 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.1 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.1 GO:0071486 cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.0 0.1 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.0 GO:0002884 negative regulation of type IV hypersensitivity(GO:0001808) negative regulation of hypersensitivity(GO:0002884)
0.0 0.2 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.1 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.2 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.5 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.1 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627) negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.1 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.0 GO:0050894 determination of affect(GO:0050894)
0.0 0.1 GO:0051414 response to cortisol(GO:0051414)
0.0 0.2 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.0 GO:1990791 glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793) dorsal root ganglion development(GO:1990791)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.3 GO:0006768 biotin metabolic process(GO:0006768)
0.0 0.0 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466) regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 0.1 GO:0031291 Ran protein signal transduction(GO:0031291)
0.0 0.0 GO:0033488 cholesterol biosynthetic process via 24,25-dihydrolanosterol(GO:0033488)
0.0 0.1 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.1 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 0.1 GO:0071898 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.0 0.3 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.0 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.0 GO:1904204 skeletal muscle hypertrophy(GO:0014734) regulation of skeletal muscle hypertrophy(GO:1904204)
0.0 0.1 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 0.5 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 0.9 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.6 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 0.2 GO:0005595 collagen type XII trimer(GO:0005595)
0.0 0.4 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.9 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.1 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 0.2 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.7 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.2 GO:0055028 cortical microtubule(GO:0055028)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 0.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.1 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.3 0.8 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.3 0.8 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 0.7 GO:0050436 microfibril binding(GO:0050436)
0.1 0.9 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 0.4 GO:0047708 biotinidase activity(GO:0047708)
0.1 1.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.4 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.1 0.6 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.2 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.2 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.1 0.2 GO:0031705 bombesin receptor binding(GO:0031705)
0.0 0.3 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.0 0.1 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.0 0.3 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.3 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.4 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.4 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
0.0 0.1 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.0 0.5 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.2 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.1 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.1 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.1 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.2 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.1 GO:0042835 BRE binding(GO:0042835)
0.0 0.5 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.2 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.1 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 2.5 GO:0005125 cytokine activity(GO:0005125)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.0 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.0 GO:0031877 somatostatin receptor binding(GO:0031877)
0.0 0.1 GO:0004331 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.0 GO:0008398 sterol 14-demethylase activity(GO:0008398)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.0 PID FGF PATHWAY FGF signaling pathway
0.0 0.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID ARF6 PATHWAY Arf6 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 3.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions