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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SIX4

Z-value: 0.46

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Transcription factors associated with SIX4

Gene Symbol Gene ID Gene Info
SIX4
ENSG00000100625.8 SIX homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX4hg19_v2_chr14_-_61191049_611910800.325.3e-01Click!

Activity profile of SIX4 motif

Sorted Z-values of SIX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_123139423 0.42 ENST00000523792.1
RP11-398G24.2
RP11-398G24.2
chr20_-_45530365 0.33 ENST00000414085.1
RP11-323C15.2
RP11-323C15.2
chr8_-_6115044 0.31 ENST00000519555.1
RP11-124B13.1
RP11-124B13.1
chr16_+_640201 0.29 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr12_+_30948600 0.28 ENST00000550292.1
LINC00941
long intergenic non-protein coding RNA 941
chr14_+_38065052 0.24 ENST00000556845.1
TTC6
tetratricopeptide repeat domain 6
chr17_-_191188 0.18 ENST00000575634.1
RPH3AL
rabphilin 3A-like (without C2 domains)
chr3_-_93692681 0.15 ENST00000348974.4
PROS1
protein S (alpha)
chr12_-_10282742 0.13 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr5_+_78365536 0.13 ENST00000255192.3
BHMT2
betaine--homocysteine S-methyltransferase 2
chr1_+_35734616 0.12 ENST00000441447.1
ZMYM4
zinc finger, MYM-type 4
chr2_+_85811525 0.10 ENST00000306384.4
VAMP5
vesicle-associated membrane protein 5
chr4_+_11470867 0.10 ENST00000515343.1
RP11-281P23.1
RP11-281P23.1
chr1_-_32264356 0.10 ENST00000452755.2
SPOCD1
SPOC domain containing 1
chr1_+_149239529 0.10 ENST00000457216.2
RP11-403I13.4
RP11-403I13.4
chr11_-_96076334 0.08 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr1_-_109849612 0.08 ENST00000357155.1
MYBPHL
myosin binding protein H-like
chr11_-_18956556 0.07 ENST00000302797.3
MRGPRX1
MAS-related GPR, member X1
chr19_+_13135439 0.07 ENST00000586873.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr10_+_71444655 0.07 ENST00000434931.2
RP11-242G20.1
Uncharacterized protein
chr7_-_111428957 0.07 ENST00000417165.1
DOCK4
dedicator of cytokinesis 4
chr9_-_95298314 0.07 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr7_+_69064300 0.07 ENST00000342771.4
AUTS2
autism susceptibility candidate 2
chr12_+_43086018 0.07 ENST00000550177.1
RP11-25I15.3
RP11-25I15.3
chr10_+_7860460 0.07 ENST00000344293.5
TAF3
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
chr19_+_13135386 0.07 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_-_152196669 0.06 ENST00000368801.2
HRNR
hornerin
chr2_+_219135115 0.06 ENST00000248451.3
ENST00000273077.4
PNKD
paroxysmal nonkinesigenic dyskinesia
chr12_+_133757995 0.06 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
ZNF268
zinc finger protein 268
chr1_+_8378140 0.05 ENST00000377479.2
SLC45A1
solute carrier family 45, member 1
chr3_+_32147997 0.05 ENST00000282541.5
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr22_-_39268192 0.05 ENST00000216083.6
CBX6
chromobox homolog 6
chr2_-_74710078 0.05 ENST00000290418.4
CCDC142
coiled-coil domain containing 142
chr8_+_132916318 0.05 ENST00000254624.5
ENST00000522709.1
EFR3A
EFR3 homolog A (S. cerevisiae)
chr19_+_13134772 0.05 ENST00000587760.1
ENST00000585575.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_+_128458514 0.05 ENST00000310981.4
SFT2D3
SFT2 domain containing 3
chr20_+_816695 0.05 ENST00000246100.3
FAM110A
family with sequence similarity 110, member A
chr7_+_2687173 0.05 ENST00000403167.1
TTYH3
tweety family member 3
chr2_-_169104651 0.05 ENST00000355999.4
STK39
serine threonine kinase 39
chr11_-_35547572 0.05 ENST00000378880.2
PAMR1
peptidase domain containing associated with muscle regeneration 1
chr1_+_38022572 0.05 ENST00000541606.1
DNALI1
dynein, axonemal, light intermediate chain 1
chr22_-_39268308 0.04 ENST00000407418.3
CBX6
chromobox homolog 6
chr9_-_95298254 0.04 ENST00000444490.2
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr3_-_49158218 0.04 ENST00000417901.1
ENST00000306026.5
ENST00000434032.2
USP19
ubiquitin specific peptidase 19
chr12_-_58135903 0.04 ENST00000257897.3
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr3_-_183967296 0.04 ENST00000455059.1
ENST00000445626.2
ALG3
ALG3, alpha-1,3- mannosyltransferase
chr6_-_27840099 0.04 ENST00000328488.2
HIST1H3I
histone cluster 1, H3i
chr11_+_117049445 0.04 ENST00000324225.4
ENST00000532960.1
SIDT2
SID1 transmembrane family, member 2
chr11_-_130184470 0.04 ENST00000357899.4
ENST00000397753.1
ZBTB44
zinc finger and BTB domain containing 44
chr17_-_39684550 0.04 ENST00000455635.1
ENST00000361566.3
KRT19
keratin 19
chr1_+_26737292 0.04 ENST00000254231.4
LIN28A
lin-28 homolog A (C. elegans)
chr15_+_41245160 0.04 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr11_+_117947724 0.04 ENST00000534111.1
TMPRSS4
transmembrane protease, serine 4
chr19_+_50887585 0.04 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr13_+_33160553 0.04 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr14_-_67981916 0.04 ENST00000357461.2
TMEM229B
transmembrane protein 229B
chr5_+_179135246 0.03 ENST00000508787.1
CANX
calnexin
chr11_-_113644491 0.03 ENST00000200135.3
ZW10
zw10 kinetochore protein
chr11_+_117049854 0.03 ENST00000278951.7
SIDT2
SID1 transmembrane family, member 2
chr1_+_156611704 0.03 ENST00000329117.5
BCAN
brevican
chr5_-_78365437 0.03 ENST00000380311.4
ENST00000540686.1
ENST00000255189.3
DMGDH
dimethylglycine dehydrogenase
chr11_+_117947782 0.03 ENST00000522307.1
ENST00000523251.1
ENST00000437212.3
ENST00000522824.1
ENST00000522151.1
TMPRSS4
transmembrane protease, serine 4
chr14_-_67981870 0.03 ENST00000555994.1
TMEM229B
transmembrane protein 229B
chr17_-_61523622 0.02 ENST00000448884.2
ENST00000582297.1
ENST00000582034.1
ENST00000578072.1
ENST00000360793.3
CYB561
cytochrome b561
chr14_-_106692191 0.02 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr10_+_89622870 0.02 ENST00000371953.3
PTEN
phosphatase and tensin homolog
chr5_+_78365577 0.02 ENST00000518666.1
ENST00000521567.1
BHMT2
betaine--homocysteine S-methyltransferase 2
chr1_+_116184566 0.02 ENST00000355485.2
ENST00000369510.4
VANGL1
VANGL planar cell polarity protein 1
chr2_+_120687335 0.02 ENST00000544261.1
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr19_+_30414551 0.02 ENST00000360605.4
ENST00000570564.1
ENST00000574233.1
ENST00000585655.1
URI1
URI1, prefoldin-like chaperone
chr11_+_2415061 0.02 ENST00000481687.1
CD81
CD81 molecule
chr11_+_117049910 0.02 ENST00000431081.2
ENST00000524842.1
SIDT2
SID1 transmembrane family, member 2
chr5_+_85913721 0.02 ENST00000247655.3
ENST00000509578.1
ENST00000515763.1
COX7C
cytochrome c oxidase subunit VIIc
chr17_-_72527605 0.02 ENST00000392621.1
ENST00000314401.3
CD300LB
CD300 molecule-like family member b
chr14_-_92413353 0.02 ENST00000556154.1
FBLN5
fibulin 5
chr19_+_50270219 0.01 ENST00000354293.5
ENST00000359032.5
AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr4_-_2420357 0.01 ENST00000511071.1
ENST00000509171.1
ENST00000290974.2
ZFYVE28
zinc finger, FYVE domain containing 28
chrX_-_119763835 0.01 ENST00000371313.2
ENST00000304661.5
C1GALT1C1
C1GALT1-specific chaperone 1
chr7_-_26578407 0.01 ENST00000242109.3
KIAA0087
KIAA0087
chr3_-_183966717 0.01 ENST00000446569.1
ENST00000418734.2
ENST00000397676.3
ALG3
ALG3, alpha-1,3- mannosyltransferase
chr11_+_33279850 0.01 ENST00000531504.1
ENST00000456517.1
HIPK3
homeodomain interacting protein kinase 3
chr20_-_52687059 0.01 ENST00000371435.2
ENST00000395961.3
BCAS1
breast carcinoma amplified sequence 1
chr11_-_130184555 0.01 ENST00000525842.1
ZBTB44
zinc finger and BTB domain containing 44
chr20_-_43150601 0.01 ENST00000541235.1
ENST00000255175.1
ENST00000342374.4
SERINC3
serine incorporator 3
chr2_-_180427304 0.01 ENST00000336917.5
ZNF385B
zinc finger protein 385B
chr1_+_231473743 0.01 ENST00000295050.7
SPRTN
SprT-like N-terminal domain
chr1_-_247335269 0.01 ENST00000543802.2
ENST00000491356.1
ENST00000472531.1
ENST00000340684.6
ZNF124
zinc finger protein 124
chr11_+_34073195 0.01 ENST00000341394.4
CAPRIN1
cell cycle associated protein 1
chr11_-_64511575 0.01 ENST00000431822.1
ENST00000377486.3
ENST00000394432.3
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr11_-_2906979 0.01 ENST00000380725.1
ENST00000313407.6
ENST00000430149.2
ENST00000440480.2
ENST00000414822.3
CDKN1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr5_+_149569520 0.01 ENST00000230671.2
ENST00000524041.1
SLC6A7
solute carrier family 6 (neurotransmitter transporter), member 7
chr3_-_69249863 0.01 ENST00000478263.1
ENST00000462512.1
FRMD4B
FERM domain containing 4B
chr19_+_11466167 0.00 ENST00000591608.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr19_+_19174795 0.00 ENST00000318596.7
SLC25A42
solute carrier family 25, member 42
chr2_-_61244308 0.00 ENST00000407787.1
ENST00000398658.2
PUS10
pseudouridylate synthase 10
chr17_+_7465216 0.00 ENST00000321337.7
SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr1_+_116915855 0.00 ENST00000295598.5
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr7_+_97361388 0.00 ENST00000350485.4
ENST00000346867.4
TAC1
tachykinin, precursor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.1 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.1 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
0.0 0.0 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.0 0.0 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.0 0.2 GO:0043102 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.0 0.0 GO:0046022 positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway