Project

NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation
Downloads

Results for SIX6

Z-value: 0.45

Motif logo

logo of

Transcription factors associated with SIX6

Gene Symbol Gene ID Gene Info
SIX6
ENSG00000184302.6 SIX homeobox 6

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_71104588 0.62 ENST00000418403.1
RP11-462G2.1
RP11-462G2.1
chr3_+_186742464 0.47 ENST00000416235.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr8_-_82598067 0.42 ENST00000523942.1
ENST00000522997.1
IMPA1
inositol(myo)-1(or 4)-monophosphatase 1
chr9_+_93759317 0.41 ENST00000563268.1
RP11-367F23.2
RP11-367F23.2
chr11_-_104916034 0.20 ENST00000528513.1
ENST00000375706.2
ENST00000375704.3
CARD16
caspase recruitment domain family, member 16
chr11_+_74699703 0.18 ENST00000529024.1
ENST00000544263.1
NEU3
sialidase 3 (membrane sialidase)
chr1_+_160709076 0.18 ENST00000359331.4
ENST00000495334.1
SLAMF7
SLAM family member 7
chr1_+_160709029 0.17 ENST00000444090.2
ENST00000441662.2
SLAMF7
SLAM family member 7
chr1_+_40942887 0.16 ENST00000372706.1
ZFP69
ZFP69 zinc finger protein
chr1_+_160709055 0.15 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7
SLAM family member 7
chr10_+_91061712 0.15 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr1_-_67142710 0.13 ENST00000502413.2
AL139147.1
Uncharacterized protein
chr12_+_122018697 0.12 ENST00000541574.1
RP13-941N14.1
RP13-941N14.1
chr5_+_55147205 0.11 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA
interleukin 31 receptor A
chr3_+_8543561 0.11 ENST00000397386.3
LMCD1
LIM and cysteine-rich domains 1
chr12_+_133707570 0.11 ENST00000416488.1
ENST00000540096.2
ZNF268
CTD-2140B24.4
zinc finger protein 268
Zinc finger protein 268
chr11_-_104972158 0.11 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr2_-_134326009 0.10 ENST00000409261.1
ENST00000409213.1
NCKAP5
NCK-associated protein 5
chr16_+_22524379 0.10 ENST00000536620.1
NPIPB5
nuclear pore complex interacting protein family, member B5
chr9_-_21142144 0.10 ENST00000380229.2
IFNW1
interferon, omega 1
chr12_-_14849470 0.10 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr20_+_54987305 0.09 ENST00000371336.3
ENST00000434344.1
CASS4
Cas scaffolding protein family member 4
chr1_+_179263308 0.09 ENST00000426956.1
SOAT1
sterol O-acyltransferase 1
chrX_+_12809463 0.09 ENST00000380663.3
ENST00000380668.5
ENST00000398491.2
ENST00000489404.1
PRPS2
phosphoribosyl pyrophosphate synthetase 2
chr8_+_1993173 0.09 ENST00000523438.1
MYOM2
myomesin 2
chr18_-_69246167 0.09 ENST00000566582.1
RP11-510D19.1
RP11-510D19.1
chr20_+_54987168 0.08 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr5_-_78281775 0.08 ENST00000396151.3
ENST00000565165.1
ARSB
arylsulfatase B
chr16_+_28648975 0.08 ENST00000529716.1
NPIPB8
nuclear pore complex interacting protein family, member B8
chr22_+_20877924 0.07 ENST00000445189.1
MED15
mediator complex subunit 15
chr2_+_27760247 0.07 ENST00000447166.1
AC109829.1
Uncharacterized protein
chr14_-_46185155 0.07 ENST00000555442.1
RP11-369C8.1
RP11-369C8.1
chr10_+_81891416 0.07 ENST00000372270.2
PLAC9
placenta-specific 9
chr15_-_51397473 0.07 ENST00000327536.5
TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr7_-_123198284 0.06 ENST00000355749.2
NDUFA5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr14_-_31926595 0.06 ENST00000547378.1
RP11-176H8.1
Uncharacterized protein
chr1_-_150669604 0.06 ENST00000427665.1
ENST00000540514.1
GOLPH3L
golgi phosphoprotein 3-like
chr16_+_19467772 0.06 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
TMC5
transmembrane channel-like 5
chr7_-_81635106 0.06 ENST00000443883.1
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr12_+_40787194 0.06 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr9_-_135230336 0.06 ENST00000224140.5
ENST00000372169.2
ENST00000393220.1
SETX
senataxin
chr8_+_1993152 0.05 ENST00000262113.4
MYOM2
myomesin 2
chr9_+_109685630 0.05 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr6_+_37012607 0.05 ENST00000423336.1
COX6A1P2
cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
chr20_+_34802295 0.05 ENST00000432603.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr12_+_119616447 0.05 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr18_-_69246186 0.05 ENST00000568095.1
RP11-510D19.1
RP11-510D19.1
chr12_+_19282643 0.05 ENST00000317589.4
ENST00000355397.3
ENST00000359180.3
ENST00000309364.4
ENST00000540972.1
ENST00000429027.2
PLEKHA5
pleckstrin homology domain containing, family A member 5
chr8_+_32579321 0.05 ENST00000522402.1
NRG1
neuregulin 1
chrX_-_18238999 0.05 ENST00000380033.4
ENST00000380030.3
BEND2
BEN domain containing 2
chr19_-_16008880 0.05 ENST00000011989.7
ENST00000221700.6
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr5_+_115420688 0.05 ENST00000274458.4
COMMD10
COMM domain containing 10
chr11_+_122709200 0.05 ENST00000227348.4
CRTAM
cytotoxic and regulatory T cell molecule
chr6_+_80816342 0.05 ENST00000369760.4
ENST00000356489.5
ENST00000320393.6
BCKDHB
branched chain keto acid dehydrogenase E1, beta polypeptide
chr19_+_31658405 0.05 ENST00000589511.1
CTC-439O9.3
CTC-439O9.3
chr2_-_228497888 0.04 ENST00000264387.4
ENST00000409066.1
C2orf83
chromosome 2 open reading frame 83
chr19_+_46000479 0.04 ENST00000456399.2
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr4_+_113739244 0.04 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
ANK2
ankyrin 2, neuronal
chr9_-_23821842 0.04 ENST00000544538.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr8_-_124553437 0.04 ENST00000517956.1
ENST00000443022.2
FBXO32
F-box protein 32
chr5_+_140201183 0.04 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
PCDHA5
protocadherin alpha 5
chr10_-_61720640 0.04 ENST00000521074.1
ENST00000444900.1
C10orf40
chromosome 10 open reading frame 40
chr11_+_34999328 0.04 ENST00000526309.1
PDHX
pyruvate dehydrogenase complex, component X
chr12_-_46385811 0.04 ENST00000419565.2
SCAF11
SR-related CTD-associated factor 11
chr2_-_71222466 0.03 ENST00000606025.1
AC007040.11
Uncharacterized protein
chr1_-_182369751 0.03 ENST00000367565.1
TEDDM1
transmembrane epididymal protein 1
chr10_-_79397479 0.03 ENST00000404771.3
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr12_-_121476750 0.03 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr15_+_63414760 0.03 ENST00000557972.1
LACTB
lactamase, beta
chr14_+_21525981 0.03 ENST00000308227.2
RNASE8
ribonuclease, RNase A family, 8
chr3_-_9994021 0.03 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr1_+_212738676 0.03 ENST00000366981.4
ENST00000366987.2
ATF3
activating transcription factor 3
chr9_-_67786624 0.03 ENST00000455764.2
FAM27E3
family with sequence similarity 27, member E3
chr17_-_5342380 0.03 ENST00000225698.4
C1QBP
complement component 1, q subcomponent binding protein
chr14_+_21510385 0.03 ENST00000298690.4
RNASE7
ribonuclease, RNase A family, 7
chr2_+_62132781 0.03 ENST00000311832.5
COMMD1
copper metabolism (Murr1) domain containing 1
chr1_+_156119466 0.03 ENST00000414683.1
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr22_-_17702729 0.02 ENST00000449907.2
ENST00000441548.1
ENST00000399839.1
CECR1
cat eye syndrome chromosome region, candidate 1
chr19_-_14628645 0.02 ENST00000598235.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr18_+_158327 0.02 ENST00000582707.1
USP14
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr3_+_125694347 0.02 ENST00000505382.1
ENST00000511082.1
ROPN1B
rhophilin associated tail protein 1B
chr1_-_157014865 0.02 ENST00000361409.2
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr1_-_10003372 0.02 ENST00000377223.1
ENST00000541052.1
ENST00000377213.1
LZIC
leucine zipper and CTNNBIP1 domain containing
chr3_+_8543393 0.02 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
LMCD1
LIM and cysteine-rich domains 1
chr1_-_36235559 0.02 ENST00000251195.5
CLSPN
claspin
chr11_+_74699942 0.02 ENST00000526068.1
ENST00000532963.1
ENST00000531619.1
ENST00000534628.1
ENST00000545272.1
NEU3
sialidase 3 (membrane sialidase)
chr20_-_4990931 0.02 ENST00000379333.1
SLC23A2
solute carrier family 23 (ascorbic acid transporter), member 2
chr3_-_196242233 0.02 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chrX_+_8433376 0.02 ENST00000440654.2
ENST00000381029.4
VCX3B
variable charge, X-linked 3B
chr12_-_11091862 0.02 ENST00000537503.1
TAS2R14
taste receptor, type 2, member 14
chr12_-_121477039 0.02 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr9_-_99382065 0.02 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
CDC14B
cell division cycle 14B
chr6_+_127898312 0.02 ENST00000329722.7
C6orf58
chromosome 6 open reading frame 58
chr5_+_40909354 0.02 ENST00000313164.9
C7
complement component 7
chr10_-_14614311 0.02 ENST00000479731.1
ENST00000468492.1
FAM107B
family with sequence similarity 107, member B
chr2_-_62081148 0.01 ENST00000404929.1
FAM161A
family with sequence similarity 161, member A
chr12_+_133614062 0.01 ENST00000540031.1
ENST00000536123.1
ZNF84
zinc finger protein 84
chr11_+_112041253 0.01 ENST00000532612.1
AP002884.3
AP002884.3
chr10_-_75008620 0.01 ENST00000372950.4
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr12_-_498620 0.01 ENST00000399788.2
ENST00000382815.4
KDM5A
lysine (K)-specific demethylase 5A
chr2_+_177134134 0.01 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
MTX2
metaxin 2
chr12_-_10601963 0.01 ENST00000543893.1
KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr15_+_58430567 0.01 ENST00000536493.1
AQP9
aquaporin 9
chr16_-_21436459 0.01 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
NPIPB3
nuclear pore complex interacting protein family, member B3
chr7_-_44530479 0.01 ENST00000355451.7
NUDCD3
NudC domain containing 3
chr8_+_26247878 0.01 ENST00000518611.1
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr5_-_117897751 0.00 ENST00000515704.1
ENST00000506769.1
CTD-2281M20.1
CTD-2281M20.1
chr16_+_66410244 0.00 ENST00000562048.1
ENST00000568155.2
CDH5
cadherin 5, type 2 (vascular endothelium)
chr13_-_46679185 0.00 ENST00000439329.3
CPB2
carboxypeptidase B2 (plasma)
chr11_-_45307817 0.00 ENST00000020926.3
SYT13
synaptotagmin XIII
chr22_+_18721427 0.00 ENST00000342888.3
AC008132.1
Uncharacterized protein
chr17_-_6524159 0.00 ENST00000589033.1
KIAA0753
KIAA0753
chr15_+_58430368 0.00 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr8_+_32579341 0.00 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chrX_+_128674213 0.00 ENST00000371113.4
ENST00000357121.5
OCRL
oculocerebrorenal syndrome of Lowe
chr1_-_161015663 0.00 ENST00000534633.1
USF1
upstream transcription factor 1
chr4_+_189321881 0.00 ENST00000512839.1
ENST00000513313.1
LINC01060
long intergenic non-protein coding RNA 1060

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0006021 inositol biosynthetic process(GO:0006021)
0.0 0.1 GO:0046022 positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.3 GO:0071494 cellular response to UV-C(GO:0071494)
0.0 0.2 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0061582 intestinal epithelial cell migration(GO:0061582)
0.0 0.1 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.5 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.0 GO:0003095 pressure natriuresis(GO:0003095)
0.0 0.1 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.1 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.0 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097179 protease inhibitor complex(GO:0097179)
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031403 lithium ion binding(GO:0031403)
0.1 0.2 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.1 0.5 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.1 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.0 0.1 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.0 0.3 GO:0089720 caspase binding(GO:0089720)
0.0 0.1 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.0 0.1 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.0 GO:0018685 alkane 1-monooxygenase activity(GO:0018685) tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.0 0.0 GO:0003826 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.0 0.0 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation