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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SOX1

Z-value: 0.54

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Transcription factors associated with SOX1

Gene Symbol Gene ID Gene Info
SOX1
ENSG00000182968.3 SRY-box transcription factor 1

Activity profile of SOX1 motif

Sorted Z-values of SOX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_76955563 0.40 ENST00000441833.2
GSAP
gamma-secretase activating protein
chr19_-_50990785 0.33 ENST00000595005.1
CTD-2545M3.8
CTD-2545M3.8
chr17_+_74729060 0.24 ENST00000587459.1
RP11-318A15.7
Uncharacterized protein
chr12_+_55248289 0.20 ENST00000308796.6
MUCL1
mucin-like 1
chr17_+_80816395 0.19 ENST00000576160.2
ENST00000571712.1
TBCD
tubulin folding cofactor D
chr6_+_148593425 0.19 ENST00000367469.1
SASH1
SAM and SH3 domain containing 1
chr3_-_55539287 0.17 ENST00000472238.1
RP11-875H7.5
RP11-875H7.5
chr6_+_26183958 0.17 ENST00000356530.3
HIST1H2BE
histone cluster 1, H2be
chr3_-_126327398 0.16 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr19_-_44388116 0.15 ENST00000587539.1
ZNF404
zinc finger protein 404
chr2_+_171034646 0.14 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr14_+_35514323 0.14 ENST00000555211.1
FAM177A1
family with sequence similarity 177, member A1
chr1_+_32674675 0.14 ENST00000409358.1
DCDC2B
doublecortin domain containing 2B
chr11_+_125496124 0.13 ENST00000533778.2
ENST00000534070.1
CHEK1
checkpoint kinase 1
chr21_-_23058648 0.13 ENST00000416182.1
AF241725.6
AF241725.6
chr10_-_92681033 0.13 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_+_152957707 0.13 ENST00000368762.1
SPRR1A
small proline-rich protein 1A
chr8_-_86290333 0.13 ENST00000521846.1
ENST00000523022.1
ENST00000524324.1
ENST00000519991.1
ENST00000520663.1
ENST00000517590.1
ENST00000522579.1
ENST00000522814.1
ENST00000522662.1
ENST00000523858.1
ENST00000519129.1
CA1
carbonic anhydrase I
chr6_-_15548591 0.12 ENST00000509674.1
DTNBP1
dystrobrevin binding protein 1
chr12_+_9980069 0.12 ENST00000354855.3
ENST00000324214.4
ENST00000279544.3
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr15_+_42565393 0.12 ENST00000561871.1
GANC
glucosidase, alpha; neutral C
chr8_-_134501873 0.11 ENST00000523634.1
ST3GAL1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr2_-_96926313 0.11 ENST00000435268.1
TMEM127
transmembrane protein 127
chr2_-_14541060 0.11 ENST00000418420.1
ENST00000417751.1
LINC00276
long intergenic non-protein coding RNA 276
chr4_+_70861647 0.10 ENST00000246895.4
ENST00000381060.2
STATH
statherin
chr11_-_18062872 0.09 ENST00000250018.2
TPH1
tryptophan hydroxylase 1
chr14_+_38033252 0.09 ENST00000554829.1
RP11-356O9.1
RP11-356O9.1
chr19_+_21324827 0.09 ENST00000600692.1
ENST00000599296.1
ENST00000594425.1
ENST00000311048.7
ZNF431
zinc finger protein 431
chr11_+_29181503 0.09 ENST00000530960.1
RP11-466I1.1
RP11-466I1.1
chr3_+_132316081 0.09 ENST00000249887.2
ACKR4
atypical chemokine receptor 4
chr9_-_85882145 0.09 ENST00000328788.1
FRMD3
FERM domain containing 3
chr5_+_158654712 0.08 ENST00000520323.1
CTB-11I22.2
CTB-11I22.2
chr17_-_15519008 0.08 ENST00000261644.8
CDRT1
CMT1A duplicated region transcript 1
chr8_+_145133493 0.08 ENST00000316052.5
ENST00000525936.1
EXOSC4
exosome component 4
chr11_-_26593677 0.07 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr1_+_24646263 0.07 ENST00000524724.1
GRHL3
grainyhead-like 3 (Drosophila)
chr7_+_36450169 0.07 ENST00000428612.1
ANLN
anillin, actin binding protein
chr20_+_49575342 0.07 ENST00000244051.1
MOCS3
molybdenum cofactor synthesis 3
chr12_-_10607084 0.06 ENST00000408006.3
ENST00000544822.1
ENST00000536188.1
KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr12_-_11150474 0.06 ENST00000538986.1
TAS2R20
taste receptor, type 2, member 20
chr12_+_93096619 0.06 ENST00000397833.3
C12orf74
chromosome 12 open reading frame 74
chr10_+_23384435 0.06 ENST00000376510.3
MSRB2
methionine sulfoxide reductase B2
chr6_-_138866823 0.06 ENST00000342260.5
NHSL1
NHS-like 1
chr19_+_49588690 0.06 ENST00000221448.5
SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr3_-_58200398 0.06 ENST00000318316.3
ENST00000460422.1
ENST00000483681.1
DNASE1L3
deoxyribonuclease I-like 3
chr19_-_10491130 0.06 ENST00000530829.1
ENST00000529370.1
TYK2
tyrosine kinase 2
chr1_-_237167718 0.06 ENST00000464121.2
MT1HL1
metallothionein 1H-like 1
chr10_+_15085895 0.06 ENST00000378228.3
OLAH
oleoyl-ACP hydrolase
chr3_-_107596910 0.06 ENST00000464359.2
ENST00000464823.1
ENST00000466155.1
ENST00000473528.2
ENST00000608306.1
ENST00000488852.1
ENST00000608137.1
ENST00000608307.1
ENST00000609429.1
ENST00000601385.1
ENST00000475362.1
ENST00000600240.1
ENST00000600749.1
LINC00635
long intergenic non-protein coding RNA 635
chr3_-_44519131 0.06 ENST00000425708.2
ENST00000396077.2
ZNF445
zinc finger protein 445
chr2_+_171036635 0.05 ENST00000484338.2
ENST00000334231.6
MYO3B
myosin IIIB
chr1_-_52499443 0.05 ENST00000371614.1
KTI12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr2_+_11864458 0.05 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
LPIN1
lipin 1
chr2_+_87808725 0.05 ENST00000413202.1
LINC00152
long intergenic non-protein coding RNA 152
chr3_-_185655795 0.04 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B
transformer 2 beta homolog (Drosophila)
chr11_-_57177586 0.04 ENST00000529411.1
RP11-872D17.8
Uncharacterized protein
chr12_-_10605929 0.04 ENST00000347831.5
ENST00000359151.3
KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr5_-_54988559 0.04 ENST00000502247.1
SLC38A9
solute carrier family 38, member 9
chr8_-_134501937 0.04 ENST00000519924.1
ST3GAL1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr19_+_17830051 0.04 ENST00000594625.1
ENST00000324096.4
ENST00000600186.1
ENST00000597735.1
MAP1S
microtubule-associated protein 1S
chr9_-_123638633 0.04 ENST00000456291.1
PHF19
PHD finger protein 19
chr2_+_234296792 0.04 ENST00000409813.3
DGKD
diacylglycerol kinase, delta 130kDa
chr6_+_27833034 0.03 ENST00000357320.2
HIST1H2AL
histone cluster 1, H2al
chr11_-_26593649 0.03 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr22_-_17302589 0.03 ENST00000331428.5
XKR3
XK, Kell blood group complex subunit-related family, member 3
chrX_-_57021943 0.03 ENST00000374919.3
SPIN3
spindlin family, member 3
chr6_+_130742231 0.03 ENST00000545622.1
TMEM200A
transmembrane protein 200A
chr1_+_202789394 0.03 ENST00000330493.5
RP11-480I12.4
Putative inactive alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein LOC641515
chr6_-_130543958 0.03 ENST00000437477.2
ENST00000439090.2
SAMD3
sterile alpha motif domain containing 3
chr14_+_62462541 0.03 ENST00000430451.2
SYT16
synaptotagmin XVI
chr16_-_11876408 0.03 ENST00000396516.2
ZC3H7A
zinc finger CCCH-type containing 7A
chr15_+_57540230 0.03 ENST00000559703.1
TCF12
transcription factor 12
chr17_-_38821373 0.03 ENST00000394052.3
KRT222
keratin 222
chr19_+_49588677 0.02 ENST00000598984.1
ENST00000598441.1
SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr17_-_39646116 0.02 ENST00000328119.6
KRT36
keratin 36
chr1_+_174769006 0.02 ENST00000489615.1
RABGAP1L
RAB GTPase activating protein 1-like
chr13_-_22178284 0.02 ENST00000468222.2
ENST00000382374.4
MICU2
mitochondrial calcium uptake 2
chr11_+_55029628 0.02 ENST00000417545.2
TRIM48
tripartite motif containing 48
chr17_+_75316336 0.02 ENST00000591934.1
SEPT9
septin 9
chr11_-_78052923 0.02 ENST00000340149.2
GAB2
GRB2-associated binding protein 2
chr10_-_73976025 0.02 ENST00000342444.4
ENST00000533958.1
ENST00000527593.1
ENST00000394915.3
ENST00000530461.1
ENST00000317168.6
ENST00000524829.1
ASCC1
activating signal cointegrator 1 complex subunit 1
chr5_+_175740083 0.02 ENST00000332772.4
SIMC1
SUMO-interacting motifs containing 1
chr14_-_20801427 0.02 ENST00000557665.1
ENST00000358932.4
ENST00000353689.4
CCNB1IP1
cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
chr3_+_126113734 0.02 ENST00000352312.1
ENST00000393425.1
CCDC37
coiled-coil domain containing 37
chr5_+_140743859 0.02 ENST00000518069.1
PCDHGA5
protocadherin gamma subfamily A, 5
chrX_+_114874727 0.02 ENST00000543070.1
PLS3
plastin 3
chr5_-_173043591 0.02 ENST00000285908.5
ENST00000480951.1
ENST00000311086.4
BOD1
biorientation of chromosomes in cell division 1
chr10_-_75401500 0.02 ENST00000359322.4
MYOZ1
myozenin 1
chr1_+_70876926 0.02 ENST00000370938.3
ENST00000346806.2
CTH
cystathionase (cystathionine gamma-lyase)
chr6_-_71666732 0.02 ENST00000230053.6
B3GAT2
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr2_+_102615416 0.02 ENST00000393414.2
IL1R2
interleukin 1 receptor, type II
chr9_-_104249400 0.01 ENST00000374848.3
TMEM246
transmembrane protein 246
chr13_+_109248500 0.01 ENST00000356711.2
MYO16
myosin XVI
chr4_-_142134031 0.01 ENST00000420921.2
RNF150
ring finger protein 150
chr1_+_46805832 0.01 ENST00000474844.1
NSUN4
NOP2/Sun domain family, member 4
chr1_+_12806141 0.01 ENST00000288048.5
C1orf158
chromosome 1 open reading frame 158
chr8_-_102181718 0.01 ENST00000565617.1
KB-1460A1.5
KB-1460A1.5
chrX_+_129040122 0.01 ENST00000394422.3
ENST00000371051.5
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr12_-_110434183 0.01 ENST00000360185.4
ENST00000354574.4
ENST00000338373.5
ENST00000343646.5
ENST00000356259.4
ENST00000553118.1
GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chr14_+_21249200 0.01 ENST00000304677.2
RNASE6
ribonuclease, RNase A family, k6
chr19_+_3762645 0.01 ENST00000330133.4
MRPL54
mitochondrial ribosomal protein L54
chr7_-_105029812 0.01 ENST00000482897.1
SRPK2
SRSF protein kinase 2
chr1_+_152975488 0.01 ENST00000542696.1
SPRR3
small proline-rich protein 3
chr12_-_5849134 0.01 ENST00000545860.1
ANO2
anoctamin 2
chr1_-_19578003 0.01 ENST00000375199.3
ENST00000375208.3
ENST00000356068.2
ENST00000477853.1
EMC1
ER membrane protein complex subunit 1
chr11_-_104827425 0.01 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr4_+_26585538 0.01 ENST00000264866.4
TBC1D19
TBC1 domain family, member 19
chrX_+_2976652 0.01 ENST00000537104.1
ARSF
arylsulfatase F
chr11_-_76381029 0.01 ENST00000407242.2
ENST00000421973.1
LRRC32
leucine rich repeat containing 32
chr6_+_28249299 0.00 ENST00000405948.2
PGBD1
piggyBac transposable element derived 1
chr11_-_76381781 0.00 ENST00000260061.5
ENST00000404995.1
LRRC32
leucine rich repeat containing 32
chr9_-_2844058 0.00 ENST00000397885.2
KIAA0020
KIAA0020
chrX_-_62974941 0.00 ENST00000374872.1
ENST00000253401.6
ENST00000374870.4
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr14_+_20811722 0.00 ENST00000429687.3
PARP2
poly (ADP-ribose) polymerase 2
chrX_+_11129388 0.00 ENST00000321143.4
ENST00000380763.3
ENST00000380762.4
HCCS
holocytochrome c synthase
chr17_-_29624343 0.00 ENST00000247271.4
OMG
oligodendrocyte myelin glycoprotein

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 0.1 GO:0031106 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.0 0.1 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.1 GO:0018307 enzyme active site formation(GO:0018307)
0.0 0.4 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.1 GO:0061083 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.0 0.1 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.1 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.1 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0032450 alpha-1,4-glucosidase activity(GO:0004558) maltose alpha-glucosidase activity(GO:0032450)
0.0 0.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.1 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.1 GO:0016295 oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis