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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SOX21

Z-value: 0.34

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Transcription factors associated with SOX21

Gene Symbol Gene ID Gene Info
SOX21
ENSG00000125285.4 SRY-box transcription factor 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX21hg19_v2_chr13_-_95364389_953643890.059.3e-01Click!

Activity profile of SOX21 motif

Sorted Z-values of SOX21 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_75174180 0.30 ENST00000413830.1
EPGN
epithelial mitogen
chr17_-_65235916 0.25 ENST00000579861.1
HELZ
helicase with zinc finger
chr13_-_45048386 0.17 ENST00000472477.1
TSC22D1
TSC22 domain family, member 1
chr8_-_50466973 0.17 ENST00000520800.1
RP11-738G5.2
Uncharacterized protein
chr14_+_22600515 0.13 ENST00000390456.3
TRAV8-7
T cell receptor alpha variable 8-7 (non-functional)
chr7_-_86849836 0.13 ENST00000455575.1
TMEM243
transmembrane protein 243, mitochondrial
chr12_-_10588539 0.12 ENST00000381902.2
ENST00000381901.1
ENST00000539033.1
KLRC2
NKG2-E
killer cell lectin-like receptor subfamily C, member 2
Uncharacterized protein
chr9_+_109685630 0.11 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr4_-_39034542 0.11 ENST00000344606.6
TMEM156
transmembrane protein 156
chr3_-_37034702 0.10 ENST00000322716.5
EPM2AIP1
EPM2A (laforin) interacting protein 1
chr8_+_74271144 0.09 ENST00000519134.1
ENST00000518355.1
RP11-434I12.3
RP11-434I12.3
chrX_-_153210107 0.09 ENST00000369997.3
ENST00000393700.3
ENST00000412763.1
RENBP
renin binding protein
chr7_+_7196565 0.09 ENST00000429911.1
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr17_-_71410794 0.08 ENST00000424778.1
SDK2
sidekick cell adhesion molecule 2
chr5_+_67588312 0.08 ENST00000519025.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr10_-_18944123 0.07 ENST00000606425.1
RP11-139J15.7
Uncharacterized protein
chrX_-_138724677 0.07 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2
MCF.2 cell line derived transforming sequence
chr8_+_26150628 0.07 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr1_+_2487631 0.07 ENST00000409119.1
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr1_-_151148492 0.07 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chr1_-_169455169 0.06 ENST00000367804.4
ENST00000236137.5
SLC19A2
solute carrier family 19 (thiamine transporter), member 2
chr12_+_123011776 0.06 ENST00000450485.2
ENST00000333479.7
KNTC1
kinetochore associated 1
chr4_-_83931862 0.06 ENST00000506560.1
ENST00000442461.2
ENST00000446851.2
ENST00000340417.3
LIN54
lin-54 homolog (C. elegans)
chr6_-_121655850 0.06 ENST00000422369.1
TBC1D32
TBC1 domain family, member 32
chr11_+_114168085 0.05 ENST00000541754.1
NNMT
nicotinamide N-methyltransferase
chr14_+_60712463 0.05 ENST00000325642.3
ENST00000529574.1
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr3_-_45957088 0.05 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr3_-_164875850 0.05 ENST00000472120.1
RP11-747D18.1
RP11-747D18.1
chr1_-_54303934 0.05 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr8_-_94029882 0.05 ENST00000520686.1
TRIQK
triple QxxK/R motif containing
chr8_+_67687413 0.05 ENST00000521960.1
ENST00000522398.1
ENST00000522629.1
ENST00000520976.1
ENST00000396596.1
SGK3
serum/glucocorticoid regulated kinase family, member 3
chr11_+_114549108 0.04 ENST00000389586.4
ENST00000375475.5
NXPE2
neurexophilin and PC-esterase domain family, member 2
chr3_-_45957534 0.04 ENST00000536047.1
LZTFL1
leucine zipper transcription factor-like 1
chr14_-_38028689 0.04 ENST00000553425.1
RP11-356O9.2
RP11-356O9.2
chrX_-_55208866 0.04 ENST00000545075.1
MTRNR2L10
MT-RNR2-like 10
chr3_-_155572164 0.04 ENST00000392845.3
ENST00000359479.3
SLC33A1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr19_-_2783255 0.04 ENST00000589251.1
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr8_-_146078376 0.04 ENST00000533270.1
ENST00000305103.3
ENST00000402718.3
COMMD5
COMM domain containing 5
chr14_-_102771462 0.04 ENST00000522874.1
MOK
MOK protein kinase
chr4_+_69313145 0.03 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr10_-_61495760 0.03 ENST00000395347.1
SLC16A9
solute carrier family 16, member 9
chr17_+_66245341 0.03 ENST00000577985.1
AMZ2
archaelysin family metallopeptidase 2
chr20_+_43343886 0.03 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr3_+_154741907 0.03 ENST00000492661.1
MME
membrane metallo-endopeptidase
chr7_-_86849883 0.03 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr3_+_38537763 0.03 ENST00000287675.5
ENST00000358249.2
ENST00000422077.2
EXOG
endo/exonuclease (5'-3'), endonuclease G-like
chr6_-_121655593 0.03 ENST00000398212.2
TBC1D32
TBC1 domain family, member 32
chr21_+_30672433 0.03 ENST00000451655.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr7_+_6713376 0.03 ENST00000399484.3
ENST00000544825.1
ENST00000401847.1
AC073343.1
Uncharacterized protein
chr3_+_38537960 0.03 ENST00000453767.1
EXOG
endo/exonuclease (5'-3'), endonuclease G-like
chr6_+_151815143 0.03 ENST00000239374.7
ENST00000367290.5
CCDC170
coiled-coil domain containing 170
chr12_+_69742121 0.02 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
LYZ
lysozyme
chr16_-_15149828 0.02 ENST00000566419.1
ENST00000568320.1
NTAN1
N-terminal asparagine amidase
chr1_+_158901329 0.02 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1
pyrin and HIN domain family, member 1
chr4_-_103747011 0.02 ENST00000350435.7
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr14_+_92588281 0.02 ENST00000298875.4
ENST00000553427.1
CPSF2
cleavage and polyadenylation specific factor 2, 100kDa
chr19_+_42381337 0.02 ENST00000597454.1
ENST00000444740.2
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr8_-_66750978 0.02 ENST00000523253.1
PDE7A
phosphodiesterase 7A
chr15_+_58702742 0.02 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr3_-_155524049 0.02 ENST00000534941.1
ENST00000340171.2
C3orf33
chromosome 3 open reading frame 33
chr17_-_8702667 0.02 ENST00000329805.4
MFSD6L
major facilitator superfamily domain containing 6-like
chr6_-_52926539 0.02 ENST00000350082.5
ENST00000356971.3
ICK
intestinal cell (MAK-like) kinase
chr6_-_3195981 0.02 ENST00000425384.2
ENST00000435043.2
RP1-40E16.9
RP1-40E16.9
chr4_+_81951957 0.02 ENST00000282701.2
BMP3
bone morphogenetic protein 3
chr12_+_59194154 0.02 ENST00000548969.1
RP11-362K2.2
Protein LOC100506869
chr14_-_92588246 0.02 ENST00000329559.3
NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr5_-_179045199 0.02 ENST00000523921.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr14_-_66471241 0.02 ENST00000554907.1
CTD-2014B16.3
Uncharacterized protein
chr14_+_50291993 0.02 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr5_+_134181755 0.01 ENST00000504727.1
ENST00000435259.2
ENST00000508791.1
C5orf24
chromosome 5 open reading frame 24
chr19_-_45737469 0.01 ENST00000413988.1
EXOC3L2
exocyst complex component 3-like 2
chr16_-_15982440 0.01 ENST00000575938.1
ENST00000573396.1
ENST00000573968.1
ENST00000575744.1
ENST00000573429.1
ENST00000255759.6
ENST00000575073.1
FOPNL
FGFR1OP N-terminal like
chr14_+_85994943 0.01 ENST00000553678.1
RP11-497E19.2
Uncharacterized protein
chr6_+_42531798 0.01 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr1_-_202776392 0.01 ENST00000235790.4
KDM5B
lysine (K)-specific demethylase 5B
chr10_+_5005445 0.01 ENST00000380872.4
AKR1C1
aldo-keto reductase family 1, member C1
chrX_-_131353461 0.01 ENST00000370874.1
RAP2C
RAP2C, member of RAS oncogene family
chr12_+_101673872 0.01 ENST00000261637.4
UTP20
UTP20, small subunit (SSU) processome component, homolog (yeast)
chr18_+_28923589 0.01 ENST00000462981.2
DSG1
desmoglein 1
chr4_-_103746924 0.01 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chrX_+_65384052 0.01 ENST00000336279.5
ENST00000458621.1
HEPH
hephaestin
chr4_-_103746683 0.01 ENST00000504211.1
ENST00000508476.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr12_+_1099675 0.01 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr5_-_124084493 0.00 ENST00000509799.1
ZNF608
zinc finger protein 608
chr11_+_2482661 0.00 ENST00000335475.5
KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr8_+_101170563 0.00 ENST00000520508.1
ENST00000388798.2
SPAG1
sperm associated antigen 1
chr7_+_34697973 0.00 ENST00000381539.3
NPSR1
neuropeptide S receptor 1
chr20_+_56964253 0.00 ENST00000395802.3
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr2_-_106013207 0.00 ENST00000447958.1
FHL2
four and a half LIM domains 2
chr3_-_186288097 0.00 ENST00000446782.1
TBCCD1
TBCC domain containing 1
chrX_+_52927576 0.00 ENST00000416841.2
FAM156B
family with sequence similarity 156, member B
chr7_-_37382683 0.00 ENST00000455879.1
ELMO1
engulfment and cell motility 1
chr1_+_151171012 0.00 ENST00000349792.5
ENST00000409426.1
ENST00000441902.2
ENST00000368890.4
ENST00000424999.1
ENST00000368888.4
PIP5K1A
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
chr18_-_47018897 0.00 ENST00000418495.1
RPL17
ribosomal protein L17
chr19_+_16308711 0.00 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
AP1M1
adaptor-related protein complex 1, mu 1 subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.1 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.0 0.1 GO:0006050 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.0 0.0 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.0 0.1 GO:0071934 thiamine transmembrane transport(GO:0071934)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.0 0.1 GO:1990423 RZZ complex(GO:1990423)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.1 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.0 0.1 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.1 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)