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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SOX30

Z-value: 0.47

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Transcription factors associated with SOX30

Gene Symbol Gene ID Gene Info
SOX30
ENSG00000039600.6 SRY-box transcription factor 30

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX30hg19_v2_chr5_-_157079428_1570794520.651.7e-01Click!

Activity profile of SOX30 motif

Sorted Z-values of SOX30 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_12290586 0.26 ENST00000379375.5
EDN1
endothelin 1
chr5_-_146461027 0.24 ENST00000394410.2
ENST00000508267.1
ENST00000504198.1
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr12_+_27623565 0.21 ENST00000535986.1
SMCO2
single-pass membrane protein with coiled-coil domains 2
chr8_+_24151553 0.21 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
ADAM28
ADAM metallopeptidase domain 28
chr12_-_49581152 0.20 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr6_+_131958436 0.19 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr1_-_243418650 0.18 ENST00000522995.1
CEP170
centrosomal protein 170kDa
chr6_+_126240442 0.18 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
NCOA7
nuclear receptor coactivator 7
chr18_+_68002675 0.18 ENST00000584919.1
RP11-41O4.1
Uncharacterized protein
chr2_+_143635067 0.17 ENST00000264170.4
KYNU
kynureninase
chr8_+_42195972 0.16 ENST00000532157.1
ENST00000265421.4
ENST00000520008.1
POLB
polymerase (DNA directed), beta
chr17_+_47448102 0.16 ENST00000576461.1
RP11-81K2.1
Uncharacterized protein
chr4_-_40516560 0.15 ENST00000513473.1
RBM47
RNA binding motif protein 47
chr8_-_49533521 0.15 ENST00000523038.1
RP11-567J20.1
RP11-567J20.1
chr3_-_57583130 0.14 ENST00000303436.6
ARF4
ADP-ribosylation factor 4
chr14_+_100070869 0.13 ENST00000502101.2
RP11-543C4.1
RP11-543C4.1
chr5_-_141338377 0.13 ENST00000510041.1
PCDH12
protocadherin 12
chr22_+_31488433 0.12 ENST00000455608.1
SMTN
smoothelin
chr9_-_134145880 0.11 ENST00000372269.3
ENST00000464831.1
FAM78A
family with sequence similarity 78, member A
chr1_+_154401791 0.11 ENST00000476006.1
IL6R
interleukin 6 receptor
chr11_-_89224638 0.11 ENST00000535633.1
ENST00000263317.4
NOX4
NADPH oxidase 4
chr5_-_141338627 0.11 ENST00000231484.3
PCDH12
protocadherin 12
chr12_-_11548496 0.10 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
PRB2
PRB1
proline-rich protein BstNI subfamily 2
proline-rich protein BstNI subfamily 1
chr12_-_11002063 0.10 ENST00000544994.1
ENST00000228811.4
ENST00000540107.1
PRR4
proline rich 4 (lacrimal)
chr18_+_32455201 0.09 ENST00000590831.2
DTNA
dystrobrevin, alpha
chr14_+_52456327 0.09 ENST00000556760.1
C14orf166
chromosome 14 open reading frame 166
chr1_-_201476274 0.09 ENST00000340006.2
CSRP1
cysteine and glycine-rich protein 1
chr15_+_57211318 0.09 ENST00000557947.1
TCF12
transcription factor 12
chr12_-_10588539 0.09 ENST00000381902.2
ENST00000381901.1
ENST00000539033.1
KLRC2
NKG2-E
killer cell lectin-like receptor subfamily C, member 2
Uncharacterized protein
chr2_+_232573208 0.09 ENST00000409115.3
PTMA
prothymosin, alpha
chr20_-_5426380 0.09 ENST00000609252.1
ENST00000422352.1
LINC00658
long intergenic non-protein coding RNA 658
chr1_-_198906528 0.09 ENST00000432296.1
MIR181A1HG
MIR181A1 host gene (non-protein coding)
chrX_+_70503037 0.08 ENST00000535149.1
NONO
non-POU domain containing, octamer-binding
chr4_+_54243798 0.07 ENST00000337488.6
ENST00000358575.5
ENST00000507922.1
FIP1L1
factor interacting with PAPOLA and CPSF1
chr12_+_95611536 0.07 ENST00000549002.1
VEZT
vezatin, adherens junctions transmembrane protein
chr16_+_4545853 0.07 ENST00000575129.1
ENST00000398595.3
ENST00000414777.1
HMOX2
heme oxygenase (decycling) 2
chr12_-_11508520 0.07 ENST00000545626.1
ENST00000500254.2
PRB1
proline-rich protein BstNI subfamily 1
chr10_+_35416223 0.07 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
CREM
cAMP responsive element modulator
chr1_-_26231589 0.06 ENST00000374291.1
STMN1
stathmin 1
chr6_-_11779174 0.06 ENST00000379413.2
ADTRP
androgen-dependent TFPI-regulating protein
chr1_-_243418344 0.06 ENST00000366542.1
CEP170
centrosomal protein 170kDa
chr15_+_76629064 0.06 ENST00000290759.4
ISL2
ISL LIM homeobox 2
chr19_+_107471 0.06 ENST00000585993.1
OR4F17
olfactory receptor, family 4, subfamily F, member 17
chrX_-_24690771 0.06 ENST00000379145.1
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr14_+_52456193 0.06 ENST00000261700.3
C14orf166
chromosome 14 open reading frame 166
chr2_+_232573222 0.05 ENST00000341369.7
ENST00000409683.1
PTMA
prothymosin, alpha
chr4_+_77356248 0.05 ENST00000296043.6
SHROOM3
shroom family member 3
chr1_-_21503337 0.05 ENST00000400422.1
ENST00000602326.1
ENST00000411888.1
ENST00000438975.1
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr3_-_122283424 0.05 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr8_+_24151620 0.05 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr2_+_27719697 0.05 ENST00000264717.2
ENST00000424318.2
GCKR
glucokinase (hexokinase 4) regulator
chr9_+_71394945 0.05 ENST00000394264.3
FAM122A
family with sequence similarity 122A
chr4_+_54243917 0.05 ENST00000507166.1
FIP1L1
factor interacting with PAPOLA and CPSF1
chr17_-_73149921 0.05 ENST00000481647.1
ENST00000470924.1
HN1
hematological and neurological expressed 1
chr5_+_140235469 0.05 ENST00000506939.2
ENST00000307360.5
PCDHA10
protocadherin alpha 10
chr20_+_30555805 0.05 ENST00000562532.2
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr1_+_228337553 0.05 ENST00000366714.2
GJC2
gap junction protein, gamma 2, 47kDa
chr20_-_45981138 0.05 ENST00000446994.2
ZMYND8
zinc finger, MYND-type containing 8
chr11_+_63137251 0.04 ENST00000310969.4
ENST00000279178.3
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr22_-_43485381 0.04 ENST00000331018.7
ENST00000266254.7
ENST00000445824.1
TTLL1
tubulin tyrosine ligase-like family, member 1
chr11_-_18548426 0.04 ENST00000357193.3
ENST00000536719.1
TSG101
tumor susceptibility 101
chr14_-_36645674 0.04 ENST00000556013.2
PTCSC3
papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding)
chr22_-_30970560 0.04 ENST00000402369.1
ENST00000406361.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr1_-_201476220 0.04 ENST00000526723.1
ENST00000524951.1
CSRP1
cysteine and glycine-rich protein 1
chr10_+_35416090 0.04 ENST00000354759.3
CREM
cAMP responsive element modulator
chr21_+_30671690 0.04 ENST00000399921.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr10_+_35415978 0.04 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
CREM
cAMP responsive element modulator
chrX_+_70503433 0.04 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
NONO
non-POU domain containing, octamer-binding
chr1_+_149239529 0.04 ENST00000457216.2
RP11-403I13.4
RP11-403I13.4
chr12_+_93096759 0.04 ENST00000544406.2
C12orf74
chromosome 12 open reading frame 74
chr12_+_95611569 0.04 ENST00000261219.6
ENST00000551472.1
ENST00000552821.1
VEZT
vezatin, adherens junctions transmembrane protein
chr4_+_54243862 0.04 ENST00000306932.6
FIP1L1
factor interacting with PAPOLA and CPSF1
chr5_+_66254698 0.04 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
MAST4
microtubule associated serine/threonine kinase family member 4
chrY_+_15016013 0.04 ENST00000360160.4
ENST00000454054.1
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr10_-_28270795 0.03 ENST00000545014.1
ARMC4
armadillo repeat containing 4
chr7_-_92855762 0.03 ENST00000453812.2
ENST00000394468.2
HEPACAM2
HEPACAM family member 2
chr6_+_22146851 0.03 ENST00000606197.1
CASC15
cancer susceptibility candidate 15 (non-protein coding)
chr1_+_47489240 0.03 ENST00000371901.3
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr5_+_140729649 0.03 ENST00000523390.1
PCDHGB1
protocadherin gamma subfamily B, 1
chr7_-_44229022 0.03 ENST00000403799.3
GCK
glucokinase (hexokinase 4)
chr11_-_75236867 0.03 ENST00000376282.3
ENST00000336898.3
GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr16_+_87636474 0.03 ENST00000284262.2
JPH3
junctophilin 3
chr12_+_9066472 0.03 ENST00000538657.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr1_-_167883327 0.03 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
ADCY10
adenylate cyclase 10 (soluble)
chr1_-_119532127 0.03 ENST00000207157.3
TBX15
T-box 15
chr5_+_140593509 0.03 ENST00000341948.4
PCDHB13
protocadherin beta 13
chr5_+_38148582 0.03 ENST00000508853.1
CTD-2207A17.1
CTD-2207A17.1
chr6_-_134639180 0.03 ENST00000367858.5
SGK1
serum/glucocorticoid regulated kinase 1
chr1_+_74701062 0.03 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr12_+_95611516 0.03 ENST00000436874.1
VEZT
vezatin, adherens junctions transmembrane protein
chr12_-_99288536 0.02 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr10_+_35415719 0.02 ENST00000474362.1
ENST00000374721.3
CREM
cAMP responsive element modulator
chr1_-_85930246 0.02 ENST00000426972.3
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr12_-_66317967 0.02 ENST00000601398.1
AC090673.2
Uncharacterized protein
chr17_-_38821373 0.02 ENST00000394052.3
KRT222
keratin 222
chr6_-_139613269 0.02 ENST00000358430.3
TXLNB
taxilin beta
chr1_-_243418621 0.02 ENST00000366544.1
ENST00000366543.1
CEP170
centrosomal protein 170kDa
chr10_-_61122934 0.02 ENST00000512919.1
FAM13C
family with sequence similarity 13, member C
chr2_-_166060571 0.02 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr11_+_128563948 0.02 ENST00000534087.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr1_-_200379129 0.02 ENST00000367353.1
ZNF281
zinc finger protein 281
chr11_+_128563652 0.02 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr2_-_158182410 0.02 ENST00000419116.2
ENST00000410096.1
ERMN
ermin, ERM-like protein
chr1_+_185703513 0.02 ENST00000271588.4
ENST00000367492.2
HMCN1
hemicentin 1
chr4_-_186570679 0.02 ENST00000451974.1
SORBS2
sorbin and SH3 domain containing 2
chr2_+_99953816 0.01 ENST00000289371.6
EIF5B
eukaryotic translation initiation factor 5B
chr2_-_166060552 0.01 ENST00000283254.7
ENST00000453007.1
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr5_+_179135246 0.01 ENST00000508787.1
CANX
calnexin
chr5_-_160279207 0.01 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr5_-_59481406 0.01 ENST00000546160.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_11422739 0.01 ENST00000279573.7
PRB3
proline-rich protein BstNI subfamily 3
chr3_-_8686479 0.01 ENST00000544814.1
ENST00000427408.1
SSUH2
ssu-2 homolog (C. elegans)
chrX_+_114874727 0.01 ENST00000543070.1
PLS3
plastin 3
chr14_+_101299520 0.01 ENST00000455531.1
MEG3
maternally expressed 3 (non-protein coding)
chr12_-_10251603 0.01 ENST00000457018.2
CLEC1A
C-type lectin domain family 1, member A
chr11_-_85430356 0.01 ENST00000526999.1
SYTL2
synaptotagmin-like 2
chr12_+_93096619 0.01 ENST00000397833.3
C12orf74
chromosome 12 open reading frame 74
chr1_-_167883353 0.01 ENST00000545172.1
ADCY10
adenylate cyclase 10 (soluble)
chr18_+_7946941 0.01 ENST00000444013.1
PTPRM
protein tyrosine phosphatase, receptor type, M
chr16_+_20499024 0.01 ENST00000593357.1
AC137056.1
Uncharacterized protein; cDNA FLJ34659 fis, clone KIDNE2018863
chr12_-_10251576 0.01 ENST00000315330.4
CLEC1A
C-type lectin domain family 1, member A
chr5_-_134734901 0.01 ENST00000312469.4
ENST00000423969.2
H2AFY
H2A histone family, member Y
chr6_-_49712123 0.01 ENST00000263045.4
CRISP3
cysteine-rich secretory protein 3
chr5_-_134735568 0.01 ENST00000510038.1
ENST00000304332.4
H2AFY
H2A histone family, member Y
chr17_+_67498295 0.01 ENST00000589295.1
MAP2K6
mitogen-activated protein kinase kinase 6
chr19_-_44439387 0.00 ENST00000269973.5
ZNF45
zinc finger protein 45
chr2_-_166060382 0.00 ENST00000409101.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr9_-_74383302 0.00 ENST00000377066.5
TMEM2
transmembrane protein 2
chr1_-_26324534 0.00 ENST00000374284.1
ENST00000441420.1
ENST00000374282.3
PAFAH2
platelet-activating factor acetylhydrolase 2, 40kDa
chr4_+_187148556 0.00 ENST00000264690.6
ENST00000446598.2
ENST00000414291.1
ENST00000513864.1
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr12_-_10251539 0.00 ENST00000420265.2
CLEC1A
C-type lectin domain family 1, member A
chr1_-_204463829 0.00 ENST00000429009.1
ENST00000415899.1
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr6_-_11779014 0.00 ENST00000229583.5
ADTRP
androgen-dependent TFPI-regulating protein

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX30

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0060584 nitric oxide transport(GO:0030185) negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 0.2 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 0.2 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.1 0.2 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.0 0.1 GO:0002384 hepatic immune response(GO:0002384)
0.0 0.1 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.0 0.1 GO:0006788 heme oxidation(GO:0006788)
0.0 0.0 GO:0009732 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.0 GO:0015747 urate transport(GO:0015747)
0.0 0.0 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:0045176 apical protein localization(GO:0045176)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031705 bombesin receptor binding(GO:0031705)
0.0 0.2 GO:0035529 phosphodiesterase I activity(GO:0004528) NADH pyrophosphatase activity(GO:0035529)
0.0 0.1 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.0 0.2 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.1 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.0 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.0 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)