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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SPDEF

Z-value: 0.96

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Transcription factors associated with SPDEF

Gene Symbol Gene ID Gene Info
SPDEF
ENSG00000124664.6 SAM pointed domain containing ETS transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPDEFhg19_v2_chr6_-_34524049_34524091-0.971.2e-03Click!

Activity profile of SPDEF motif

Sorted Z-values of SPDEF motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_105212297 0.74 ENST00000556623.1
ENST00000555674.1
ADSSL1
adenylosuccinate synthase like 1
chr5_+_158690089 0.70 ENST00000296786.6
UBLCP1
ubiquitin-like domain containing CTD phosphatase 1
chr4_+_141445333 0.54 ENST00000507667.1
ELMOD2
ELMO/CED-12 domain containing 2
chr7_-_77427676 0.49 ENST00000257663.3
TMEM60
transmembrane protein 60
chr4_-_153700864 0.47 ENST00000304337.2
TIGD4
tigger transposable element derived 4
chr14_-_31926623 0.46 ENST00000356180.4
DTD2
D-tyrosyl-tRNA deacylase 2 (putative)
chr8_-_100025238 0.44 ENST00000521696.1
RP11-410L14.2
RP11-410L14.2
chr17_-_56065540 0.44 ENST00000583932.1
VEZF1
vascular endothelial zinc finger 1
chr18_-_19180681 0.43 ENST00000269214.5
ESCO1
establishment of sister chromatid cohesion N-acetyltransferase 1
chr14_-_67826538 0.41 ENST00000553687.1
ATP6V1D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
chr4_+_48833312 0.41 ENST00000508293.1
ENST00000513391.2
OCIAD1
OCIA domain containing 1
chr15_-_65282274 0.36 ENST00000204566.2
SPG21
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr1_+_84629976 0.35 ENST00000446538.1
ENST00000370684.1
ENST00000436133.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_-_71751715 0.34 ENST00000535947.1
NUMA1
nuclear mitotic apparatus protein 1
chr2_-_63815628 0.34 ENST00000409562.3
WDPCP
WD repeat containing planar cell polarity effector
chr4_+_166128735 0.34 ENST00000226725.6
KLHL2
kelch-like family member 2
chr1_+_67395922 0.34 ENST00000401042.3
ENST00000355356.3
MIER1
mesoderm induction early response 1, transcriptional regulator
chr15_-_65282232 0.33 ENST00000416889.2
SPG21
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr1_+_84630053 0.33 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr10_-_119806085 0.33 ENST00000355624.3
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr1_+_193028552 0.33 ENST00000400968.2
ENST00000432079.1
TROVE2
TROVE domain family, member 2
chr7_-_38948774 0.33 ENST00000395969.2
ENST00000414632.1
ENST00000310301.4
VPS41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr14_-_31926595 0.32 ENST00000547378.1
RP11-176H8.1
Uncharacterized protein
chr14_+_60716276 0.32 ENST00000528241.2
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr17_+_65714018 0.32 ENST00000581106.1
ENST00000535137.1
NOL11
nucleolar protein 11
chr9_-_72374848 0.32 ENST00000377200.5
ENST00000340434.4
ENST00000472967.2
PTAR1
protein prenyltransferase alpha subunit repeat containing 1
chr17_+_65713925 0.31 ENST00000253247.4
NOL11
nucleolar protein 11
chr14_-_64010006 0.31 ENST00000555899.1
PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr15_-_59949667 0.31 ENST00000396061.1
GTF2A2
general transcription factor IIA, 2, 12kDa
chr12_+_102513950 0.31 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr3_+_32023232 0.31 ENST00000360311.4
ZNF860
zinc finger protein 860
chr12_-_57914275 0.30 ENST00000547303.1
ENST00000552740.1
ENST00000547526.1
ENST00000551116.1
ENST00000346473.3
DDIT3
DNA-damage-inducible transcript 3
chr7_-_91875109 0.30 ENST00000412043.2
ENST00000430102.1
ENST00000425073.1
ENST00000394503.2
ENST00000454017.1
ENST00000440209.1
ENST00000413688.1
ENST00000452773.1
ENST00000433016.1
ENST00000394505.2
ENST00000422347.1
ENST00000458493.1
ENST00000425919.1
KRIT1
KRIT1, ankyrin repeat containing
chr7_+_77428066 0.30 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
PHTF2
putative homeodomain transcription factor 2
chr15_-_64648273 0.29 ENST00000607537.1
ENST00000303052.7
ENST00000303032.6
CSNK1G1
casein kinase 1, gamma 1
chr8_-_124665190 0.29 ENST00000325995.7
KLHL38
kelch-like family member 38
chr5_-_114961858 0.29 ENST00000282382.4
ENST00000456936.3
ENST00000408996.4
TMED7-TICAM2
TMED7
TICAM2
TMED7-TICAM2 readthrough
transmembrane emp24 protein transport domain containing 7
toll-like receptor adaptor molecule 2
chr4_+_48833183 0.28 ENST00000503016.1
OCIAD1
OCIA domain containing 1
chr10_-_14996070 0.28 ENST00000378258.1
ENST00000453695.2
ENST00000378246.2
DCLRE1C
DNA cross-link repair 1C
chr12_+_102514019 0.27 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARPBP
PARP1 binding protein
chr12_+_29302119 0.27 ENST00000536681.3
FAR2
fatty acyl CoA reductase 2
chr7_+_77428149 0.27 ENST00000415251.2
ENST00000275575.7
PHTF2
putative homeodomain transcription factor 2
chr8_+_15397732 0.27 ENST00000382020.4
ENST00000506802.1
ENST00000509380.1
ENST00000503731.1
TUSC3
tumor suppressor candidate 3
chr3_-_139108463 0.26 ENST00000512242.1
COPB2
coatomer protein complex, subunit beta 2 (beta prime)
chr2_+_198380289 0.26 ENST00000233892.4
ENST00000409916.1
MOB4
MOB family member 4, phocein
chr6_+_134274354 0.26 ENST00000367869.1
TBPL1
TBP-like 1
chr1_+_235492300 0.25 ENST00000476121.1
ENST00000497327.1
GGPS1
geranylgeranyl diphosphate synthase 1
chr2_+_162016827 0.25 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
TANK
TRAF family member-associated NFKB activator
chr15_+_80987617 0.25 ENST00000258884.4
ENST00000558464.1
ABHD17C
abhydrolase domain containing 17C
chr2_+_63816126 0.25 ENST00000454035.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr19_-_45004556 0.25 ENST00000587047.1
ENST00000391956.4
ENST00000221327.4
ENST00000586637.1
ENST00000591064.1
ENST00000592529.1
ZNF180
zinc finger protein 180
chr8_-_77912431 0.25 ENST00000357039.4
ENST00000522527.1
PEX2
peroxisomal biogenesis factor 2
chr14_-_31926701 0.24 ENST00000310850.4
DTD2
D-tyrosyl-tRNA deacylase 2 (putative)
chr12_+_29302023 0.24 ENST00000551451.1
FAR2
fatty acyl CoA reductase 2
chr4_+_39640787 0.24 ENST00000532680.1
RP11-539G18.2
RP11-539G18.2
chr7_-_91875358 0.24 ENST00000458177.1
ENST00000394507.1
ENST00000340022.2
ENST00000444960.1
KRIT1
KRIT1, ankyrin repeat containing
chr1_-_193028426 0.24 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr13_+_25670268 0.24 ENST00000281589.3
PABPC3
poly(A) binding protein, cytoplasmic 3
chr1_+_170501270 0.23 ENST00000367763.3
ENST00000367762.1
GORAB
golgin, RAB6-interacting
chr4_-_83812157 0.23 ENST00000513323.1
SEC31A
SEC31 homolog A (S. cerevisiae)
chr14_+_60716159 0.23 ENST00000325658.3
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr4_+_144106063 0.23 ENST00000510377.1
USP38
ubiquitin specific peptidase 38
chr14_-_69263043 0.23 ENST00000408913.2
ZFP36L1
ZFP36 ring finger protein-like 1
chr1_-_193028621 0.22 ENST00000367455.4
ENST00000367454.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr4_+_48833119 0.22 ENST00000444354.2
ENST00000509963.1
ENST00000509246.1
OCIAD1
OCIA domain containing 1
chr2_-_54014127 0.22 ENST00000394717.2
GPR75-ASB3
GPR75-ASB3 readthrough
chrX_-_131352152 0.22 ENST00000342983.2
RAP2C
RAP2C, member of RAS oncogene family
chr5_+_110074685 0.22 ENST00000355943.3
ENST00000447245.2
SLC25A46
solute carrier family 25, member 46
chr8_-_56986768 0.22 ENST00000523936.1
RPS20
ribosomal protein S20
chr18_+_48556470 0.21 ENST00000589076.1
ENST00000590061.1
ENST00000591914.1
ENST00000342988.3
SMAD4
SMAD family member 4
chr8_-_130951940 0.21 ENST00000522250.1
ENST00000522941.1
ENST00000522746.1
ENST00000520204.1
ENST00000519070.1
ENST00000520254.1
ENST00000519824.2
ENST00000519540.1
FAM49B
family with sequence similarity 49, member B
chr20_-_34287220 0.21 ENST00000306750.3
NFS1
NFS1 cysteine desulfurase
chr6_-_143832793 0.21 ENST00000438118.2
FUCA2
fucosidase, alpha-L- 2, plasma
chr19_+_38880695 0.21 ENST00000587947.1
ENST00000338502.4
SPRED3
sprouty-related, EVH1 domain containing 3
chr12_+_49961990 0.21 ENST00000551063.1
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr14_-_64010046 0.20 ENST00000337537.3
PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr2_+_27805880 0.20 ENST00000379717.1
ENST00000355467.4
ENST00000556601.1
ENST00000416005.2
ZNF512
zinc finger protein 512
chr9_+_36190853 0.20 ENST00000433436.2
ENST00000538225.1
ENST00000540080.1
CLTA
clathrin, light chain A
chr18_+_11851383 0.20 ENST00000526991.2
CHMP1B
charged multivesicular body protein 1B
chr2_+_101618691 0.20 ENST00000409000.1
ENST00000409028.4
ENST00000409320.3
ENST00000409733.1
ENST00000409650.1
ENST00000409038.1
RPL31
ribosomal protein L31
chr3_-_133380731 0.20 ENST00000260810.5
TOPBP1
topoisomerase (DNA) II binding protein 1
chr10_-_15902449 0.19 ENST00000277632.3
FAM188A
family with sequence similarity 188, member A
chr16_-_25122785 0.19 ENST00000563962.1
ENST00000569920.1
RP11-449H11.1
RP11-449H11.1
chr7_-_135662056 0.19 ENST00000393085.3
ENST00000435723.1
MTPN
myotrophin
chr19_-_53696587 0.19 ENST00000396424.3
ENST00000600412.1
ZNF665
zinc finger protein 665
chr9_+_36190905 0.19 ENST00000345519.5
ENST00000470744.1
ENST00000242285.6
ENST00000466396.1
ENST00000396603.2
CLTA
clathrin, light chain A
chr4_+_48833015 0.19 ENST00000509122.1
ENST00000509664.1
ENST00000505922.2
ENST00000514981.1
OCIAD1
OCIA domain containing 1
chr12_-_64616019 0.19 ENST00000311915.8
ENST00000398055.3
ENST00000544871.1
C12orf66
chromosome 12 open reading frame 66
chr1_+_235491714 0.19 ENST00000471812.1
ENST00000358966.2
ENST00000282841.5
ENST00000391855.2
GGPS1
geranylgeranyl diphosphate synthase 1
chr17_-_33905521 0.19 ENST00000225873.4
PEX12
peroxisomal biogenesis factor 12
chr2_+_217363793 0.19 ENST00000456586.1
ENST00000598925.1
ENST00000427280.2
RPL37A
ribosomal protein L37a
chr15_-_59949693 0.19 ENST00000396063.1
ENST00000396064.3
ENST00000484743.1
ENST00000559706.1
ENST00000396060.2
GTF2A2
general transcription factor IIA, 2, 12kDa
chr7_+_93551011 0.19 ENST00000248564.5
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr2_+_162016804 0.18 ENST00000392749.2
ENST00000440506.1
TANK
TRAF family member-associated NFKB activator
chr11_-_118122996 0.18 ENST00000525386.1
ENST00000527472.1
ENST00000278949.4
MPZL3
myelin protein zero-like 3
chr1_+_193028717 0.18 ENST00000415442.2
ENST00000506303.1
TROVE2
TROVE domain family, member 2
chr17_-_7108436 0.18 ENST00000493294.1
DLG4
discs, large homolog 4 (Drosophila)
chr1_-_169337176 0.18 ENST00000472647.1
ENST00000367811.3
NME7
NME/NM23 family member 7
chr14_+_60715928 0.18 ENST00000395076.4
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr8_-_101964738 0.18 ENST00000523938.1
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr4_+_48833160 0.18 ENST00000506801.1
OCIAD1
OCIA domain containing 1
chr14_+_67826709 0.17 ENST00000256383.4
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr2_+_63816087 0.17 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr3_-_37217736 0.17 ENST00000438374.1
LRRFIP2
leucine rich repeat (in FLII) interacting protein 2
chr2_-_54014055 0.17 ENST00000263634.3
ENST00000406687.1
GPR75-ASB3
GPR75-ASB3 readthrough
chr1_+_22351977 0.17 ENST00000420503.1
ENST00000416769.1
ENST00000404210.2
LINC00339
long intergenic non-protein coding RNA 339
chr5_+_76326187 0.17 ENST00000312916.7
ENST00000506806.1
AGGF1
angiogenic factor with G patch and FHA domains 1
chr3_+_197464046 0.17 ENST00000428738.1
FYTTD1
forty-two-three domain containing 1
chr2_+_162016916 0.16 ENST00000405852.1
TANK
TRAF family member-associated NFKB activator
chr14_-_69864993 0.16 ENST00000555373.1
ERH
enhancer of rudimentary homolog (Drosophila)
chr2_+_37311588 0.16 ENST00000409774.1
ENST00000608836.1
GPATCH11
G patch domain containing 11
chr2_+_39103103 0.16 ENST00000340556.6
ENST00000410014.1
ENST00000409665.1
ENST00000409077.2
ENST00000409131.2
MORN2
MORN repeat containing 2
chr20_+_60962143 0.16 ENST00000343986.4
RPS21
ribosomal protein S21
chr4_+_48833234 0.16 ENST00000510824.1
ENST00000425583.2
OCIAD1
OCIA domain containing 1
chr11_-_119993734 0.16 ENST00000533302.1
TRIM29
tripartite motif containing 29
chr14_+_21566980 0.16 ENST00000418511.2
ENST00000554329.2
TMEM253
transmembrane protein 253
chr1_+_84630574 0.16 ENST00000413538.1
ENST00000417530.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr7_+_99613195 0.15 ENST00000324306.6
ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr12_+_106751436 0.15 ENST00000228347.4
POLR3B
polymerase (RNA) III (DNA directed) polypeptide B
chr4_-_44728559 0.15 ENST00000509756.1
ENST00000507917.1
ENST00000295448.3
GNPDA2
glucosamine-6-phosphate deaminase 2
chr12_+_50135351 0.15 ENST00000549445.1
ENST00000550951.1
ENST00000549385.1
ENST00000548713.1
ENST00000548201.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr8_-_56987061 0.15 ENST00000009589.3
ENST00000524349.1
ENST00000519606.1
ENST00000519807.1
ENST00000521262.1
ENST00000520627.1
RPS20
ribosomal protein S20
chr2_+_48667898 0.15 ENST00000281394.4
ENST00000294952.8
PPP1R21
protein phosphatase 1, regulatory subunit 21
chr15_-_65809581 0.15 ENST00000341861.5
DPP8
dipeptidyl-peptidase 8
chr21_-_46221684 0.15 ENST00000330942.5
UBE2G2
ubiquitin-conjugating enzyme E2G 2
chr4_+_144106080 0.15 ENST00000307017.4
USP38
ubiquitin specific peptidase 38
chr18_+_21032781 0.15 ENST00000339486.3
RIOK3
RIO kinase 3
chr17_-_56082455 0.15 ENST00000578794.1
RP11-159D12.5
Uncharacterized protein
chr3_-_156272924 0.15 ENST00000467789.1
ENST00000265044.2
SSR3
signal sequence receptor, gamma (translocon-associated protein gamma)
chr4_+_41992489 0.14 ENST00000264451.7
SLC30A9
solute carrier family 30 (zinc transporter), member 9
chr14_+_24701870 0.14 ENST00000561035.1
ENST00000559409.1
ENST00000558865.1
ENST00000558279.1
GMPR2
guanosine monophosphate reductase 2
chr7_+_114562172 0.14 ENST00000393486.1
ENST00000257724.3
MDFIC
MyoD family inhibitor domain containing
chr3_+_29322437 0.14 ENST00000434693.2
RBMS3
RNA binding motif, single stranded interacting protein 3
chr6_-_150039249 0.14 ENST00000543571.1
LATS1
large tumor suppressor kinase 1
chr8_+_8860314 0.14 ENST00000250263.7
ENST00000519292.1
ERI1
exoribonuclease 1
chr2_+_27805971 0.14 ENST00000413371.2
ZNF512
zinc finger protein 512
chrX_-_122866874 0.14 ENST00000245838.8
ENST00000355725.4
THOC2
THO complex 2
chr2_+_65454926 0.13 ENST00000542850.1
ENST00000377982.4
ACTR2
ARP2 actin-related protein 2 homolog (yeast)
chr12_-_69080590 0.13 ENST00000433116.2
ENST00000500695.2
RP11-637A17.2
RP11-637A17.2
chr8_-_101964832 0.13 ENST00000523131.1
ENST00000418997.1
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr4_+_159593418 0.13 ENST00000507475.1
ENST00000307738.5
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr6_-_150039170 0.13 ENST00000458696.2
ENST00000392273.3
LATS1
large tumor suppressor kinase 1
chr2_+_47596634 0.13 ENST00000419334.1
EPCAM
epithelial cell adhesion molecule
chr7_+_99613212 0.13 ENST00000426572.1
ENST00000535170.1
ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr1_-_235324772 0.13 ENST00000408888.3
RBM34
RNA binding motif protein 34
chr12_+_69080734 0.13 ENST00000378905.2
NUP107
nucleoporin 107kDa
chr1_+_65886244 0.13 ENST00000344610.8
LEPR
leptin receptor
chr14_-_24615523 0.13 ENST00000559056.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr18_+_21033239 0.13 ENST00000581585.1
ENST00000577501.1
RIOK3
RIO kinase 3
chr1_+_84630645 0.13 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr18_+_19321281 0.12 ENST00000261537.6
MIB1
mindbomb E3 ubiquitin protein ligase 1
chr2_+_65454863 0.12 ENST00000260641.5
ACTR2
ARP2 actin-related protein 2 homolog (yeast)
chr3_-_37218023 0.12 ENST00000416425.1
LRRFIP2
leucine rich repeat (in FLII) interacting protein 2
chr12_+_50135327 0.12 ENST00000549966.1
ENST00000547832.1
ENST00000547187.1
ENST00000548894.1
ENST00000546914.1
ENST00000552699.1
ENST00000267115.5
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr5_+_93954039 0.12 ENST00000265140.5
ANKRD32
ankyrin repeat domain 32
chr11_-_61197406 0.12 ENST00000541963.1
ENST00000477890.2
CPSF7
cleavage and polyadenylation specific factor 7, 59kDa
chr14_+_24701819 0.11 ENST00000560139.1
ENST00000559910.1
GMPR2
guanosine monophosphate reductase 2
chr12_-_120663792 0.11 ENST00000546532.1
ENST00000548912.1
PXN
paxillin
chr2_+_37311645 0.11 ENST00000281932.5
GPATCH11
G patch domain containing 11
chr15_-_44092295 0.11 ENST00000249714.3
ENST00000299969.6
ENST00000319327.6
SERINC4
serine incorporator 4
chr10_+_5726764 0.11 ENST00000328090.5
ENST00000496681.1
FAM208B
family with sequence similarity 208, member B
chr1_+_24829384 0.11 ENST00000374395.4
ENST00000436717.2
RCAN3
RCAN family member 3
chr18_-_55288973 0.11 ENST00000423481.2
ENST00000587194.1
ENST00000591599.1
ENST00000588661.1
NARS
asparaginyl-tRNA synthetase
chr17_-_47755436 0.10 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
SPOP
speckle-type POZ protein
chr3_-_69101461 0.10 ENST00000543976.1
TMF1
TATA element modulatory factor 1
chr16_-_70557430 0.10 ENST00000393612.4
ENST00000564653.1
ENST00000323786.5
COG4
component of oligomeric golgi complex 4
chr12_+_132434439 0.10 ENST00000333577.4
ENST00000389561.2
ENST00000389562.2
ENST00000332482.4
ENST00000330386.6
EP400
E1A binding protein p400
chr19_-_8579030 0.10 ENST00000255616.8
ENST00000393927.4
ZNF414
zinc finger protein 414
chr5_-_114961673 0.10 ENST00000333314.3
TMED7-TICAM2
TMED7-TICAM2 readthrough
chr6_+_7541808 0.10 ENST00000379802.3
DSP
desmoplakin
chr1_+_213224572 0.10 ENST00000543470.1
ENST00000366960.3
ENST00000366959.3
ENST00000543354.1
RPS6KC1
ribosomal protein S6 kinase, 52kDa, polypeptide 1
chr1_+_169337172 0.10 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
BLZF1
basic leucine zipper nuclear factor 1
chr11_+_36616355 0.09 ENST00000532470.2
C11orf74
chromosome 11 open reading frame 74
chr22_-_41215291 0.09 ENST00000542412.1
ENST00000544408.1
SLC25A17
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
chr11_+_61197508 0.09 ENST00000541135.1
ENST00000301761.2
RP11-286N22.8
SDHAF2
Uncharacterized protein
succinate dehydrogenase complex assembly factor 2
chr21_-_36421626 0.09 ENST00000300305.3
RUNX1
runt-related transcription factor 1
chr1_-_193028632 0.09 ENST00000421683.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr6_-_116381918 0.09 ENST00000606080.1
FRK
fyn-related kinase
chr10_-_14996017 0.09 ENST00000378241.1
ENST00000456122.1
ENST00000418843.1
ENST00000378249.1
ENST00000396817.2
ENST00000378255.1
ENST00000378254.1
ENST00000378278.2
ENST00000357717.2
DCLRE1C
DNA cross-link repair 1C
chr11_-_46142948 0.09 ENST00000257821.4
PHF21A
PHD finger protein 21A
chr8_-_101734170 0.09 ENST00000522387.1
ENST00000518196.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr1_+_43124087 0.09 ENST00000304979.3
ENST00000372550.1
ENST00000440068.1
PPIH
peptidylprolyl isomerase H (cyclophilin H)
chr4_-_159592996 0.09 ENST00000508457.1
C4orf46
chromosome 4 open reading frame 46
chr19_-_56632592 0.09 ENST00000587279.1
ENST00000270459.3
ZNF787
zinc finger protein 787
chr5_+_31532373 0.09 ENST00000325366.9
ENST00000355907.3
ENST00000507818.2
C5orf22
chromosome 5 open reading frame 22
chr11_+_57480046 0.09 ENST00000378312.4
ENST00000278422.4
TMX2
thioredoxin-related transmembrane protein 2
chr20_+_49126881 0.09 ENST00000371621.3
ENST00000541713.1
PTPN1
protein tyrosine phosphatase, non-receptor type 1
chr11_-_61129306 0.08 ENST00000544118.1
CYB561A3
cytochrome b561 family, member A3
chr14_+_24702073 0.08 ENST00000399440.2
GMPR2
guanosine monophosphate reductase 2
chr6_-_143832820 0.08 ENST00000002165.6
FUCA2
fucosidase, alpha-L- 2, plasma
chr12_+_118814185 0.08 ENST00000543473.1
SUDS3
suppressor of defective silencing 3 homolog (S. cerevisiae)
chr16_-_2318111 0.08 ENST00000301730.8
ENST00000564822.1
RNPS1
RNA binding protein S1, serine-rich domain
chr3_-_69101413 0.08 ENST00000398559.2
TMF1
TATA element modulatory factor 1
chr15_-_55700457 0.08 ENST00000442196.3
ENST00000563171.1
ENST00000425574.3
CCPG1
cell cycle progression 1
chr1_+_169337412 0.08 ENST00000426663.1
BLZF1
basic leucine zipper nuclear factor 1
chr8_-_101965104 0.08 ENST00000437293.1
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr11_-_57479673 0.08 ENST00000337672.2
ENST00000431606.2
MED19
mediator complex subunit 19
chr2_+_187350883 0.08 ENST00000337859.6
ZC3H15
zinc finger CCCH-type containing 15
chr11_-_94706705 0.08 ENST00000279839.6
CWC15
CWC15 spliceosome-associated protein homolog (S. cerevisiae)
chr12_-_102513843 0.08 ENST00000551744.2
ENST00000552283.1
NUP37
nucleoporin 37kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of SPDEF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.1 0.4 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.1 1.1 GO:0097338 response to clozapine(GO:0097338)
0.1 0.7 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.1 0.5 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 0.3 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.1 0.6 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.4 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.2 GO:0006043 glucosamine catabolic process(GO:0006043)
0.1 0.2 GO:0035262 left ventricular cardiac muscle tissue morphogenesis(GO:0003220) cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) gonad morphogenesis(GO:0035262)
0.1 0.3 GO:0001828 inner cell mass cellular morphogenesis(GO:0001828)
0.1 0.3 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.1 0.3 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.1 0.3 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.1 0.2 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.1 0.2 GO:0035669 TRAM-dependent toll-like receptor signaling pathway(GO:0035668) TRAM-dependent toll-like receptor 4 signaling pathway(GO:0035669)
0.0 0.3 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.3 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.6 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:0043132 coenzyme A transport(GO:0015880) coenzyme A transmembrane transport(GO:0035349) NAD transport(GO:0043132) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.0 0.6 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 0.2 GO:2000843 testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
0.0 0.2 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.1 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.0 0.1 GO:0034553 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.2 GO:0035709 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.1 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.3 GO:2000535 regulation of entry of bacterium into host cell(GO:2000535)
0.0 0.1 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.0 0.2 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.0 0.3 GO:0032888 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.4 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.5 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.3 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.0 0.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.2 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) regulation of barbed-end actin filament capping(GO:2000812)
0.0 0.6 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 0.2 GO:0006235 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.0 0.1 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.0 0.2 GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.0 0.3 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0 0.3 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 0.1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.2 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.3 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.1 GO:0046833 snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.4 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.1 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.0 0.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.2 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.4 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 0.0 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0 0.4 GO:0043101 purine-containing compound salvage(GO:0043101)
0.0 0.5 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.4 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.2 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.4 GO:0090383 phagosome acidification(GO:0090383)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0034455 t-UTP complex(GO:0034455)
0.1 0.3 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 0.2 GO:0043614 multi-eIF complex(GO:0043614)
0.1 0.4 GO:1902560 GMP reductase complex(GO:1902560)
0.1 0.7 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.6 GO:0071439 clathrin complex(GO:0071439)
0.0 0.6 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.2 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 1.1 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.3 GO:0055028 cortical microtubule(GO:0055028)
0.0 0.3 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.3 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.1 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.3 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.2 0.7 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.1 0.4 GO:0047860 diiodophenylpyruvate reductase activity(GO:0047860)
0.1 0.3 GO:0015928 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.1 0.4 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.5 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.6 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.2 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 0.4 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 0.2 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 0.7 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 1.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.0 0.2 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.3 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.1 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.0 0.2 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0 0.4 GO:0030620 U2 snRNA binding(GO:0030620)
0.0 0.3 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.0 0.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.3 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.7 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.3 GO:0089720 caspase binding(GO:0089720)
0.0 0.6 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.2 GO:0043199 sulfate binding(GO:0043199)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0016018 cyclosporin A binding(GO:0016018)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.7 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.6 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.8 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.5 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.5 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.2 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.0 0.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes