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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SPIB

Z-value: 1.02

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Transcription factors associated with SPIB

Gene Symbol Gene ID Gene Info
ENSG00000269404.2 Spi-B transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPIBhg19_v2_chr19_+_50922187_50922215-0.187.3e-01Click!

Activity profile of SPIB motif

Sorted Z-values of SPIB motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_25205155 0.81 ENST00000550945.1
lymphoid-restricted membrane protein
chr3_+_121774202 0.58 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86 molecule
chr12_+_25205446 0.57 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
lymphoid-restricted membrane protein
chr14_+_38065052 0.55 ENST00000556845.1
tetratricopeptide repeat domain 6
chr12_-_15114191 0.55 ENST00000541380.1
Rho GDP dissociation inhibitor (GDI) beta
chr1_-_179851611 0.53 ENST00000610272.1
RP11-533E19.7
chr8_-_101733794 0.52 ENST00000523555.1
poly(A) binding protein, cytoplasmic 1
chr11_+_27062272 0.49 ENST00000529202.1
ENST00000533566.1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr3_+_121796697 0.45 ENST00000482356.1
ENST00000393627.2
CD86 molecule
chr8_+_125860939 0.45 ENST00000525292.1
ENST00000528090.1
long intergenic non-protein coding RNA 964
chr10_-_98031265 0.44 ENST00000224337.5
ENST00000371176.2
B-cell linker
chr17_-_39123144 0.44 ENST00000355612.2
keratin 39
chr11_+_27062860 0.43 ENST00000528583.1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr12_+_25205568 0.43 ENST00000548766.1
ENST00000556887.1
lymphoid-restricted membrane protein
chr12_+_25205666 0.42 ENST00000547044.1
lymphoid-restricted membrane protein
chr10_-_98031310 0.42 ENST00000427367.2
ENST00000413476.2
B-cell linker
chr12_-_15114492 0.40 ENST00000541546.1
Rho GDP dissociation inhibitor (GDI) beta
chr12_+_25205628 0.40 ENST00000554942.1
lymphoid-restricted membrane protein
chr8_+_74903580 0.40 ENST00000284818.2
ENST00000518893.1
lymphocyte antigen 96
chr15_-_83224682 0.39 ENST00000562833.1
RP11-152F13.10
chr7_+_23636992 0.38 ENST00000307471.3
ENST00000409765.1
coiled-coil domain containing 126
chr8_-_131028782 0.38 ENST00000519020.1
family with sequence similarity 49, member B
chr17_-_5138099 0.36 ENST00000571800.1
ENST00000574081.1
ENST00000399600.4
ENST00000574297.1
SLP adaptor and CSK interacting membrane protein
chr13_+_108921977 0.33 ENST00000430559.1
ENST00000375887.4
tumor necrosis factor (ligand) superfamily, member 13b
chr11_+_27062502 0.33 ENST00000263182.3
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr9_-_35618364 0.32 ENST00000378431.1
ENST00000378430.3
ENST00000259633.4
CD72 molecule
chrX_-_11129229 0.32 ENST00000608176.1
ENST00000433747.2
ENST00000608576.1
ENST00000608916.1
RP11-120D5.1
chr15_-_33360085 0.30 ENST00000334528.9
formin 1
chr3_-_180397256 0.30 ENST00000442201.2
coiled-coil domain containing 39
chr20_-_20033052 0.28 ENST00000536226.1
crooked neck pre-mRNA splicing factor 1
chr12_-_15114658 0.28 ENST00000542276.1
Rho GDP dissociation inhibitor (GDI) beta
chr1_+_112016414 0.27 ENST00000343534.5
ENST00000369718.3
chromosome 1 open reading frame 162
chr1_+_120839005 0.27 ENST00000369390.3
ENST00000452190.1
family with sequence similarity 72, member B
chr19_+_42381337 0.27 ENST00000597454.1
ENST00000444740.2
CD79a molecule, immunoglobulin-associated alpha
chr5_-_39270725 0.27 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYN binding protein
chr12_-_51785083 0.27 ENST00000603563.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
chr16_+_70695570 0.26 ENST00000597002.1
FLJ00418
chr6_-_56708459 0.26 ENST00000370788.2
dystonin
chr11_-_64570624 0.26 ENST00000439069.1
mitogen-activated protein kinase kinase kinase kinase 2
chr3_-_176914191 0.25 ENST00000437738.1
ENST00000424913.1
ENST00000443315.1
transducin (beta)-like 1 X-linked receptor 1
chr8_-_74206133 0.25 ENST00000352983.2
ribosomal protein L7
chr1_+_164528616 0.25 ENST00000340699.3
pre-B-cell leukemia homeobox 1
chr4_+_86525299 0.25 ENST00000512201.1
Rho GTPase activating protein 24
chr3_-_20227720 0.25 ENST00000412997.1
shugoshin-like 1 (S. pombe)
chrX_+_105937068 0.25 ENST00000324342.3
ring finger protein 128, E3 ubiquitin protein ligase
chr1_+_206138884 0.24 ENST00000341209.5
ENST00000607379.1
family with sequence similarity 72, member A
chr3_+_184530173 0.24 ENST00000453056.1
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr16_+_30960375 0.24 ENST00000318663.4
ENST00000566237.1
ENST00000562699.1
ORAI calcium release-activated calcium modulator 3
chr3_+_184529948 0.24 ENST00000436792.2
ENST00000446204.2
ENST00000422105.1
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr12_+_7060508 0.24 ENST00000541698.1
ENST00000542462.1
protein tyrosine phosphatase, non-receptor type 6
chr3_-_20227619 0.24 ENST00000425061.1
ENST00000443724.1
ENST00000421451.1
ENST00000452020.1
ENST00000417364.1
ENST00000306698.2
ENST00000419233.2
ENST00000263753.4
ENST00000383774.1
ENST00000437051.1
ENST00000412868.1
ENST00000429446.3
ENST00000442720.1
shugoshin-like 1 (S. pombe)
chr19_-_54726850 0.23 ENST00000245620.9
ENST00000346401.6
ENST00000424807.1
ENST00000445347.1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chr5_-_142783365 0.22 ENST00000508760.1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr3_+_184529929 0.22 ENST00000287546.4
ENST00000437079.3
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr3_-_176914238 0.22 ENST00000430069.1
ENST00000428970.1
transducin (beta)-like 1 X-linked receptor 1
chr13_+_53602894 0.22 ENST00000219022.2
olfactomedin 4
chr11_-_1606513 0.21 ENST00000382171.2
keratin associated protein 5-1
chr20_-_46415341 0.21 ENST00000484875.1
ENST00000361612.4
sulfatase 2
chr8_-_101734170 0.21 ENST00000522387.1
ENST00000518196.1
poly(A) binding protein, cytoplasmic 1
chr1_+_26644441 0.21 ENST00000374213.2
CD52 molecule
chr14_+_32546145 0.21 ENST00000556611.1
ENST00000539826.2
Rho GTPase activating protein 5
chr1_+_120839412 0.21 ENST00000355228.4
family with sequence similarity 72, member B
chr7_+_23637118 0.21 ENST00000448353.1
coiled-coil domain containing 126
chr9_+_36190853 0.20 ENST00000433436.2
ENST00000538225.1
ENST00000540080.1
clathrin, light chain A
chr3_-_143567262 0.20 ENST00000474151.1
ENST00000316549.6
solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
chr15_+_86098670 0.20 ENST00000558811.1
A kinase (PRKA) anchor protein 13
chr3_-_9291063 0.20 ENST00000383836.3
SLIT-ROBO Rho GTPase activating protein 3
chr1_+_110158726 0.20 ENST00000531734.1
adenosine monophosphate deaminase 2
chr6_-_56707943 0.20 ENST00000370769.4
ENST00000421834.2
ENST00000312431.6
ENST00000361203.3
ENST00000523817.1
dystonin
chr9_+_36190905 0.20 ENST00000345519.5
ENST00000470744.1
ENST00000242285.6
ENST00000466396.1
ENST00000396603.2
clathrin, light chain A
chr10_+_104613980 0.20 ENST00000339834.5
chromosome 10 open reading frame 32
chr1_-_31230650 0.20 ENST00000294507.3
lysosomal protein transmembrane 5
chr12_+_32638897 0.19 ENST00000531134.1
FYVE, RhoGEF and PH domain containing 4
chr19_-_51471362 0.19 ENST00000376853.4
ENST00000424910.2
kallikrein-related peptidase 6
chr8_-_101734308 0.19 ENST00000519004.1
ENST00000519363.1
ENST00000520142.1
poly(A) binding protein, cytoplasmic 1
chr5_-_158757895 0.19 ENST00000231228.2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
chr9_+_34653861 0.19 ENST00000556792.1
ENST00000318041.9
ENST00000378817.4
interleukin 11 receptor, alpha
chr12_+_7060414 0.18 ENST00000538715.1
protein tyrosine phosphatase, non-receptor type 6
chr4_+_30721968 0.18 ENST00000361762.2
protocadherin 7
chr2_+_233925064 0.18 ENST00000359570.5
ENST00000538935.1
inositol polyphosphate-5-phosphatase, 145kDa
chr20_-_46415297 0.18 ENST00000467815.1
ENST00000359930.4
sulfatase 2
chr6_-_110012380 0.18 ENST00000424296.2
ENST00000341338.6
ENST00000368948.2
ENST00000285397.5
adenylate kinase 9
chr5_-_140013275 0.17 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
CD14 molecule
chr18_-_52989525 0.17 ENST00000457482.3
transcription factor 4
chr22_-_37880543 0.17 ENST00000442496.1
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr1_+_104068312 0.17 ENST00000524631.1
ENST00000531883.1
ENST00000533099.1
ENST00000527062.1
RNA-binding region (RNP1, RRM) containing 3
chr2_+_102758271 0.17 ENST00000428279.1
interleukin 1 receptor, type I
chr4_-_140005443 0.17 ENST00000510408.1
ENST00000420916.2
ENST00000358635.3
E74-like factor 2 (ets domain transcription factor)
chr3_+_23847432 0.17 ENST00000346855.3
ubiquitin-conjugating enzyme E2E 1
chr2_+_127413677 0.17 ENST00000356887.7
glycophorin C (Gerbich blood group)
chr10_+_7830125 0.17 ENST00000335698.4
ENST00000541227.1
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
chrX_-_47489244 0.17 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
complement factor properdin
chr11_+_45168182 0.16 ENST00000526442.1
PR domain containing 11
chr2_-_74405929 0.16 ENST00000396049.4
MOB kinase activator 1A
chr8_-_121457608 0.16 ENST00000306185.3
mitochondrial ribosomal protein L13
chr2_-_8723918 0.16 ENST00000454224.1
AC011747.4
chr2_-_231084820 0.16 ENST00000258382.5
ENST00000338556.3
SP110 nuclear body protein
chr5_+_96079240 0.16 ENST00000515663.1
calpastatin
chr3_+_46283863 0.16 ENST00000545097.1
ENST00000541018.1
chemokine (C-C motif) receptor 3
chrX_+_123094672 0.16 ENST00000354548.5
ENST00000458700.1
stromal antigen 2
chr1_+_167599532 0.16 ENST00000537350.1
RCSD domain containing 1
chr5_+_95997769 0.16 ENST00000338252.3
ENST00000508830.1
calpastatin
chr10_+_32856764 0.16 ENST00000375030.2
ENST00000375028.3
Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 5, mRNA.
chr14_+_75536335 0.16 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
zinc finger, C2HC-type containing 1C
chr20_-_57607347 0.16 ENST00000395663.1
ENST00000395659.1
ENST00000243997.3
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
chr19_+_48828582 0.16 ENST00000270221.6
ENST00000596315.1
epithelial membrane protein 3
chr11_-_64889252 0.16 ENST00000525297.1
ENST00000529259.1
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
chrX_+_105936982 0.15 ENST00000418562.1
ring finger protein 128, E3 ubiquitin protein ligase
chr13_-_36050819 0.15 ENST00000379919.4
mab-21-like 1 (C. elegans)
chr19_+_35940486 0.15 ENST00000246549.2
free fatty acid receptor 2
chr13_-_95364389 0.15 ENST00000376945.2
SRY (sex determining region Y)-box 21
chr12_-_15082050 0.15 ENST00000540097.1
endoplasmic reticulum protein 27
chr1_-_45956822 0.15 ENST00000372086.3
ENST00000341771.6
testis-specific kinase 2
chr10_+_7830092 0.15 ENST00000356708.7
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
chr15_+_50716576 0.15 ENST00000560297.1
ENST00000307179.4
ENST00000396444.3
ENST00000433963.1
ENST00000425032.3
ubiquitin specific peptidase 8
chrX_+_152990302 0.15 ENST00000218104.3
ATP-binding cassette, sub-family D (ALD), member 1
chr14_+_75536280 0.15 ENST00000238686.8
zinc finger, C2HC-type containing 1C
chr11_+_1860832 0.15 ENST00000252898.7
troponin I type 2 (skeletal, fast)
chr2_-_64751227 0.15 ENST00000561559.1
RP11-568N6.1
chr17_-_27467418 0.15 ENST00000528564.1
myosin XVIIIA
chr3_-_11685345 0.15 ENST00000430365.2
vestigial like 4 (Drosophila)
chr4_+_95129061 0.15 ENST00000354268.4
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr6_+_130339710 0.15 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr11_-_61124711 0.15 ENST00000536915.1
cytochrome b561 family, member A3
chr19_-_13213662 0.15 ENST00000264824.4
lymphoblastic leukemia derived sequence 1
chr2_+_127413704 0.15 ENST00000409836.3
glycophorin C (Gerbich blood group)
chr3_-_179169330 0.15 ENST00000232564.3
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr5_+_159848854 0.15 ENST00000517480.1
ENST00000520452.1
ENST00000393964.1
pituitary tumor-transforming 1
chr2_-_152830441 0.14 ENST00000534999.1
ENST00000397327.2
calcium channel, voltage-dependent, beta 4 subunit
chr15_+_83209620 0.14 ENST00000568285.1
Uncharacterized protein
chr1_+_222886694 0.14 ENST00000426638.1
ENST00000537020.1
ENST00000539697.1
BRO1 domain and CAAX motif containing
chr19_-_17375541 0.14 ENST00000252597.3
Usher syndrome 1C binding protein 1
chr7_-_135662056 0.14 ENST00000393085.3
ENST00000435723.1
myotrophin
chr4_+_110834033 0.14 ENST00000509793.1
ENST00000265171.5
epidermal growth factor
chr10_-_62149433 0.14 ENST00000280772.2
ankyrin 3, node of Ranvier (ankyrin G)
chr11_+_1861399 0.14 ENST00000381905.3
troponin I type 2 (skeletal, fast)
chr14_+_85996507 0.13 ENST00000554746.1
fibronectin leucine rich transmembrane protein 2
chr14_+_24616588 0.13 ENST00000324103.6
ENST00000559260.1
ring finger protein 31
chr2_-_174830430 0.13 ENST00000310015.6
ENST00000455789.2
Sp3 transcription factor
chr11_-_61124776 0.13 ENST00000542361.1
cytochrome b561 family, member A3
chr15_+_51973550 0.13 ENST00000220478.3
secretogranin III
chr4_+_159727222 0.13 ENST00000512986.1
folliculin interacting protein 2
chr14_+_63671105 0.13 ENST00000316754.3
ras homolog family member J
chr1_-_145039949 0.13 ENST00000313382.9
phosphodiesterase 4D interacting protein
chr14_+_85996471 0.13 ENST00000330753.4
fibronectin leucine rich transmembrane protein 2
chr4_-_87281224 0.13 ENST00000395169.3
ENST00000395161.2
mitogen-activated protein kinase 10
chr11_+_3875757 0.13 ENST00000525403.1
stromal interaction molecule 1
chr5_-_142783175 0.13 ENST00000231509.3
ENST00000394464.2
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr6_-_49430886 0.12 ENST00000274813.3
methylmalonyl CoA mutase
chr5_-_142782862 0.12 ENST00000415690.2
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr4_+_159727272 0.12 ENST00000379346.3
folliculin interacting protein 2
chr2_+_196440692 0.12 ENST00000458054.1
solute carrier family 39 (zinc transporter), member 10
chr10_-_33623310 0.12 ENST00000395995.1
ENST00000374823.5
ENST00000374821.5
ENST00000374816.3
neuropilin 1
chr1_-_43282906 0.12 ENST00000372521.4
coiled-coil domain containing 23
chr8_-_74205851 0.12 ENST00000396467.1
ribosomal protein L7
chr3_-_28390581 0.12 ENST00000479665.1
5-azacytidine induced 2
chr9_-_21995249 0.12 ENST00000494262.1
cyclin-dependent kinase inhibitor 2A
chr9_+_214842 0.12 ENST00000453981.1
ENST00000432829.2
dedicator of cytokinesis 8
chr1_-_222886526 0.12 ENST00000541237.1
axin interactor, dorsalization associated
chr5_+_64859066 0.12 ENST00000261308.5
ENST00000535264.1
ENST00000538977.1
peptidylprolyl isomerase domain and WD repeat containing 1
chr8_+_98656693 0.12 ENST00000519934.1
metadherin
chr9_-_21995300 0.12 ENST00000498628.2
cyclin-dependent kinase inhibitor 2A
chr2_-_152118352 0.11 ENST00000331426.5
RNA binding motif protein 43
chr5_+_102455968 0.11 ENST00000358359.3
diphosphoinositol pentakisphosphate kinase 2
chr1_-_45956800 0.11 ENST00000538496.1
testis-specific kinase 2
chr1_+_161551101 0.11 ENST00000367962.4
ENST00000367960.5
ENST00000403078.3
ENST00000428605.2
Fc fragment of IgG, low affinity IIb, receptor (CD32)
chr2_-_153573887 0.11 ENST00000493468.2
ENST00000545856.1
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr4_-_140005341 0.11 ENST00000379549.2
ENST00000512627.1
E74-like factor 2 (ets domain transcription factor)
chr3_+_28390637 0.11 ENST00000420223.1
ENST00000383768.2
zinc finger, CW type with PWWP domain 2
chr3_+_29322437 0.11 ENST00000434693.2
RNA binding motif, single stranded interacting protein 3
chr1_+_46713404 0.11 ENST00000371975.4
ENST00000469835.1
RAD54-like (S. cerevisiae)
chr10_-_65028817 0.11 ENST00000542921.1
jumonji domain containing 1C
chr5_-_124084493 0.11 ENST00000509799.1
zinc finger protein 608
chr17_+_28443819 0.11 ENST00000479218.2
nuclear speckle splicing regulatory protein 1
chr19_+_7413835 0.11 ENST00000576789.1
CTB-133G6.1
chrX_+_48398053 0.11 ENST00000537536.1
ENST00000418627.1
TBC1 domain family, member 25
chr17_+_28443799 0.11 ENST00000584423.1
ENST00000247026.5
nuclear speckle splicing regulatory protein 1
chr15_-_65809991 0.11 ENST00000559526.1
ENST00000358939.4
ENST00000560665.1
ENST00000321118.7
ENST00000339244.5
ENST00000300141.6
dipeptidyl-peptidase 8
chr3_-_178984759 0.11 ENST00000349697.2
ENST00000497599.1
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr8_-_121457332 0.11 ENST00000518918.1
mitochondrial ribosomal protein L13
chr7_-_117512264 0.11 ENST00000454375.1
cortactin binding protein 2
chr18_-_47018769 0.11 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
ribosomal protein L17
chr14_+_96968707 0.10 ENST00000216277.8
ENST00000557320.1
ENST00000557471.1
poly(A) polymerase alpha
chr11_-_8680383 0.10 ENST00000299550.6
tripartite motif containing 66
chr14_+_96968802 0.10 ENST00000556619.1
ENST00000392990.2
poly(A) polymerase alpha
chrX_-_30595959 0.10 ENST00000378962.3
chromosome X open reading frame 21
chr15_-_33360342 0.10 ENST00000558197.1
formin 1
chr10_-_52008313 0.10 ENST00000329428.6
ENST00000395526.4
ENST00000447815.1
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
chr2_+_138722028 0.10 ENST00000280096.5
histamine N-methyltransferase
chr14_-_75536182 0.10 ENST00000555463.1
acylphosphatase 1, erythrocyte (common) type
chr14_-_98444369 0.10 ENST00000554822.1
chromosome 14 open reading frame 64
chr19_-_16770915 0.10 ENST00000593459.1
ENST00000358726.6
ENST00000597711.1
ENST00000487416.2
Small integral membrane protein 7; Uncharacterized protein
small integral membrane protein 7
chr8_-_131028869 0.10 ENST00000518283.1
ENST00000519110.1
family with sequence similarity 49, member B
chr3_+_4535155 0.10 ENST00000544951.1
inositol 1,4,5-trisphosphate receptor, type 1
chr17_+_34948228 0.10 ENST00000251312.5
ENST00000590554.1
dehydrogenase/reductase (SDR family) member 11
chr18_-_32924372 0.10 ENST00000261332.6
ENST00000399061.3
zinc finger protein 24
chr1_-_220445757 0.10 ENST00000358951.2
RAB3 GTPase activating protein subunit 2 (non-catalytic)
chr8_-_95449155 0.10 ENST00000481490.2
fibrinogen silencer binding protein
chr1_+_167298281 0.10 ENST00000367862.5
POU class 2 homeobox 1
chr20_-_35274548 0.10 ENST00000262866.4
Src-like-adaptor 2

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0032641 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.2 1.3 GO:0071461 cellular response to redox state(GO:0071461)
0.1 1.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.3 GO:0006756 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.1 0.3 GO:0002636 positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296)
0.1 0.5 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.1 0.9 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 0.5 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.1 0.2 GO:0002877 acute inflammatory response to non-antigenic stimulus(GO:0002525) regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
0.1 0.2 GO:0045659 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.1 0.3 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 0.4 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.6 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.1 0.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.7 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.7 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.3 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.4 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.0 0.1 GO:0043317 negative regulation of dendritic cell antigen processing and presentation(GO:0002605) regulation of cytotoxic T cell degranulation(GO:0043317) negative regulation of cytotoxic T cell degranulation(GO:0043318)
0.0 0.2 GO:1905205 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) positive regulation of connective tissue replacement(GO:1905205)
0.0 0.2 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.1 GO:1903028 positive regulation of opsonization(GO:1903028)
0.0 0.3 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.1 GO:0042223 positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.1 GO:1903371 establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.5 GO:0060613 fat pad development(GO:0060613)
0.0 0.2 GO:0051142 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0 0.0 GO:0010324 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.4 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.5 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.1 GO:1903615 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.0 0.1 GO:1902378 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) sensory neuron axon guidance(GO:0097374) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.0 0.1 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.0 GO:0051795 positive regulation of catagen(GO:0051795)
0.0 0.1 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.1 GO:0045730 respiratory burst(GO:0045730)
0.0 0.1 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.0 0.0 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.2 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.0 0.1 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 0.3 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 0.1 GO:0044691 tooth eruption(GO:0044691)
0.0 0.4 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.1 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) regulation of barbed-end actin filament capping(GO:2000812)
0.0 2.8 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.1 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.0 GO:0097359 UDP-glucosylation(GO:0097359)
0.0 0.1 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.0 0.1 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.2 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.1 GO:0023035 CD40 signaling pathway(GO:0023035) protein linear polyubiquitination(GO:0097039)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.4 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.0 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.0 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.4 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.0 0.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0044565 dendritic cell proliferation(GO:0044565)
0.0 0.1 GO:0052148 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.0 0.1 GO:0044855 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.1 GO:0042335 cuticle development(GO:0042335)
0.0 0.0 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.0 GO:0061485 memory T cell proliferation(GO:0061485)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0031673 H zone(GO:0031673)
0.1 0.4 GO:0019815 B cell receptor complex(GO:0019815)
0.1 0.7 GO:0033263 CORVET complex(GO:0033263)
0.1 0.6 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.5 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.4 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.0 0.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.0 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 2.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.1 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.2 GO:0031906 late endosome lumen(GO:0031906)
0.0 0.0 GO:0071203 WASH complex(GO:0071203)
0.0 0.1 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993)
0.0 0.1 GO:0097635 extrinsic component of autophagosome membrane(GO:0097635)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.3 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0032044 DSIF complex(GO:0032044)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 0.7 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 1.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.5 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.1 0.2 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 0.5 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.9 GO:0008494 translation activator activity(GO:0008494)
0.0 0.4 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.3 GO:0071723 peptidoglycan receptor activity(GO:0016019) lipopeptide binding(GO:0071723)
0.0 0.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.2 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.3 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.2 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 0.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.7 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.3 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0019770 IgG receptor activity(GO:0019770)
0.0 1.2 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.2 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.2 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.3 GO:0031014 troponin T binding(GO:0031014)
0.0 0.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.0 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.0 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.0 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.0 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.0 0.5 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.3 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.3 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.6 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.5 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 1.4 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.5 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.8 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.5 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.1 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 1.0 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.5 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers