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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SREBF2
Z-value: 0.29
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Transcription factors associated with SREBF2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SREBF2
|
ENSG00000198911.7 | sterol regulatory element binding transcription factor 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SREBF2 | hg19_v2_chr22_+_42229100_42229146 | -0.18 | 7.3e-01 | Click! |
Activity profile of SREBF2 motif
Sorted Z-values of SREBF2 motif
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_159656437 | 0.14 |
ENST00000402432.3
|
FABP6
|
fatty acid binding protein 6, ileal |
| chr19_+_11200038 | 0.12 |
ENST00000558518.1
ENST00000557933.1 ENST00000455727.2 ENST00000535915.1 ENST00000545707.1 ENST00000558013.1 |
LDLR
|
low density lipoprotein receptor |
| chr1_+_206643787 | 0.11 |
ENST00000367120.3
|
IKBKE
|
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon |
| chr2_-_26205550 | 0.10 |
ENST00000405914.1
|
KIF3C
|
kinesin family member 3C |
| chr19_+_55591743 | 0.09 |
ENST00000588359.1
ENST00000245618.5 |
EPS8L1
|
EPS8-like 1 |
| chr1_+_206643806 | 0.09 |
ENST00000537984.1
|
IKBKE
|
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon |
| chr16_+_8736232 | 0.09 |
ENST00000562973.1
|
METTL22
|
methyltransferase like 22 |
| chr6_+_43968306 | 0.09 |
ENST00000442114.2
ENST00000336600.5 ENST00000439969.2 |
C6orf223
|
chromosome 6 open reading frame 223 |
| chr1_+_55505184 | 0.08 |
ENST00000302118.5
|
PCSK9
|
proprotein convertase subtilisin/kexin type 9 |
| chr11_+_65480222 | 0.08 |
ENST00000534681.1
|
KAT5
|
K(lysine) acetyltransferase 5 |
| chr3_-_16554403 | 0.08 |
ENST00000449415.1
ENST00000441460.1 |
RFTN1
|
raftlin, lipid raft linker 1 |
| chr20_+_33464407 | 0.08 |
ENST00000253382.5
|
ACSS2
|
acyl-CoA synthetase short-chain family member 2 |
| chr4_+_75230853 | 0.07 |
ENST00000244869.2
|
EREG
|
epiregulin |
| chr6_+_151561085 | 0.07 |
ENST00000402676.2
|
AKAP12
|
A kinase (PRKA) anchor protein 12 |
| chr2_-_26205340 | 0.07 |
ENST00000264712.3
|
KIF3C
|
kinesin family member 3C |
| chr8_+_104512976 | 0.06 |
ENST00000504942.2
|
RIMS2
|
regulating synaptic membrane exocytosis 2 |
| chr17_-_40075219 | 0.06 |
ENST00000537919.1
ENST00000352035.2 ENST00000353196.1 ENST00000393896.2 |
ACLY
|
ATP citrate lyase |
| chr5_-_43313574 | 0.06 |
ENST00000325110.6
ENST00000433297.2 |
HMGCS1
|
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) |
| chr20_+_33464238 | 0.06 |
ENST00000360596.2
|
ACSS2
|
acyl-CoA synthetase short-chain family member 2 |
| chr17_-_40075197 | 0.06 |
ENST00000590770.1
ENST00000590151.1 |
ACLY
|
ATP citrate lyase |
| chr2_+_232573208 | 0.05 |
ENST00000409115.3
|
PTMA
|
prothymosin, alpha |
| chr15_-_73076030 | 0.05 |
ENST00000311669.8
|
ADPGK
|
ADP-dependent glucokinase |
| chr16_+_2083265 | 0.05 |
ENST00000565855.1
ENST00000566198.1 |
SLC9A3R2
|
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 |
| chr12_-_91505608 | 0.05 |
ENST00000266718.4
|
LUM
|
lumican |
| chr10_-_3827371 | 0.05 |
ENST00000469435.1
|
KLF6
|
Kruppel-like factor 6 |
| chr2_+_232573222 | 0.04 |
ENST00000341369.7
ENST00000409683.1 |
PTMA
|
prothymosin, alpha |
| chr17_+_73257742 | 0.04 |
ENST00000579761.1
ENST00000245539.6 |
MRPS7
|
mitochondrial ribosomal protein S7 |
| chr5_-_149669612 | 0.04 |
ENST00000510347.1
|
CAMK2A
|
calcium/calmodulin-dependent protein kinase II alpha |
| chr11_+_2923499 | 0.04 |
ENST00000449793.2
|
SLC22A18
|
solute carrier family 22, member 18 |
| chr19_+_36266417 | 0.04 |
ENST00000378944.5
ENST00000007510.4 |
ARHGAP33
|
Rho GTPase activating protein 33 |
| chr3_+_5020801 | 0.04 |
ENST00000256495.3
|
BHLHE40
|
basic helix-loop-helix family, member e40 |
| chr11_+_2923619 | 0.04 |
ENST00000380574.1
|
SLC22A18
|
solute carrier family 22, member 18 |
| chr2_+_232572361 | 0.04 |
ENST00000409321.1
|
PTMA
|
prothymosin, alpha |
| chr4_+_185909970 | 0.04 |
ENST00000505053.1
|
RP11-386B13.4
|
RP11-386B13.4 |
| chr5_-_39425068 | 0.04 |
ENST00000515700.1
ENST00000339788.6 |
DAB2
|
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) |
| chr11_+_2923423 | 0.03 |
ENST00000312221.5
|
SLC22A18
|
solute carrier family 22, member 18 |
| chr17_-_27332931 | 0.03 |
ENST00000442608.3
ENST00000335960.6 |
SEZ6
|
seizure related 6 homolog (mouse) |
| chrX_-_103087136 | 0.03 |
ENST00000243298.2
|
RAB9B
|
RAB9B, member RAS oncogene family |
| chr11_+_22688150 | 0.03 |
ENST00000454584.2
|
GAS2
|
growth arrest-specific 2 |
| chr17_-_73257667 | 0.03 |
ENST00000538886.1
ENST00000580799.1 ENST00000351904.7 ENST00000537686.1 |
GGA3
|
golgi-associated, gamma adaptin ear containing, ARF binding protein 3 |
| chr9_-_99381660 | 0.03 |
ENST00000375240.3
ENST00000463569.1 |
CDC14B
|
cell division cycle 14B |
| chr6_-_31926208 | 0.03 |
ENST00000454913.1
ENST00000436289.2 |
NELFE
|
negative elongation factor complex member E |
| chr19_+_36266433 | 0.03 |
ENST00000314737.5
|
ARHGAP33
|
Rho GTPase activating protein 33 |
| chrX_-_153236819 | 0.03 |
ENST00000354233.3
|
HCFC1
|
host cell factor C1 (VP16-accessory protein) |
| chr15_-_73075964 | 0.03 |
ENST00000563907.1
|
ADPGK
|
ADP-dependent glucokinase |
| chr8_+_104513086 | 0.03 |
ENST00000406091.3
|
RIMS2
|
regulating synaptic membrane exocytosis 2 |
| chrX_-_153237258 | 0.03 |
ENST00000310441.7
|
HCFC1
|
host cell factor C1 (VP16-accessory protein) |
| chr3_+_46742823 | 0.02 |
ENST00000326431.3
|
TMIE
|
transmembrane inner ear |
| chr17_-_41738931 | 0.02 |
ENST00000329168.3
ENST00000549132.1 |
MEOX1
|
mesenchyme homeobox 1 |
| chr11_+_65383227 | 0.02 |
ENST00000355703.3
|
PCNXL3
|
pecanex-like 3 (Drosophila) |
| chrX_+_47229982 | 0.02 |
ENST00000377073.3
|
ZNF157
|
zinc finger protein 157 |
| chr10_-_3827417 | 0.02 |
ENST00000497571.1
ENST00000542957.1 |
KLF6
|
Kruppel-like factor 6 |
| chr5_-_43313269 | 0.02 |
ENST00000511774.1
|
HMGCS1
|
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) |
| chr9_+_100745615 | 0.02 |
ENST00000339399.4
|
ANP32B
|
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B |
| chr6_-_32151999 | 0.02 |
ENST00000375069.3
ENST00000538695.1 ENST00000438221.2 ENST00000375065.5 ENST00000450110.1 ENST00000375067.3 ENST00000375056.2 |
AGER
|
advanced glycosylation end product-specific receptor |
| chr5_-_139283982 | 0.02 |
ENST00000340391.3
|
NRG2
|
neuregulin 2 |
| chr11_+_65479702 | 0.02 |
ENST00000530446.1
ENST00000534104.1 ENST00000530605.1 ENST00000528198.1 ENST00000531880.1 ENST00000534650.1 |
KAT5
|
K(lysine) acetyltransferase 5 |
| chr1_-_155232047 | 0.02 |
ENST00000302631.3
|
SCAMP3
|
secretory carrier membrane protein 3 |
| chr17_+_73257945 | 0.02 |
ENST00000579002.1
|
MRPS7
|
mitochondrial ribosomal protein S7 |
| chr2_-_232571621 | 0.02 |
ENST00000595658.1
|
MGC4771
|
MGC4771 |
| chr1_+_197237352 | 0.02 |
ENST00000538660.1
ENST00000367400.3 ENST00000367399.2 |
CRB1
|
crumbs homolog 1 (Drosophila) |
| chr22_+_42229100 | 0.02 |
ENST00000361204.4
|
SREBF2
|
sterol regulatory element binding transcription factor 2 |
| chr12_-_53343602 | 0.02 |
ENST00000546897.1
ENST00000552551.1 |
KRT8
|
keratin 8 |
| chr18_-_21166841 | 0.02 |
ENST00000269228.5
|
NPC1
|
Niemann-Pick disease, type C1 |
| chr15_-_66858298 | 0.02 |
ENST00000537670.1
|
LCTL
|
lactase-like |
| chr1_+_39796810 | 0.02 |
ENST00000289893.4
|
MACF1
|
microtubule-actin crosslinking factor 1 |
| chr6_-_42713792 | 0.01 |
ENST00000372876.1
|
TBCC
|
tubulin folding cofactor C |
| chr6_-_39902160 | 0.01 |
ENST00000340692.5
|
MOCS1
|
molybdenum cofactor synthesis 1 |
| chr3_-_98620500 | 0.01 |
ENST00000326840.6
|
DCBLD2
|
discoidin, CUB and LCCL domain containing 2 |
| chr12_-_48398104 | 0.01 |
ENST00000337299.6
ENST00000380518.3 |
COL2A1
|
collagen, type II, alpha 1 |
| chr12_+_56495115 | 0.01 |
ENST00000548861.1
|
RP11-603J24.9
|
Uncharacterized protein |
| chr3_+_188889737 | 0.01 |
ENST00000345063.3
|
TPRG1
|
tumor protein p63 regulated 1 |
| chr11_-_73309228 | 0.01 |
ENST00000356467.4
ENST00000064778.4 |
FAM168A
|
family with sequence similarity 168, member A |
| chr20_+_58533471 | 0.01 |
ENST00000244047.5
ENST00000348616.4 |
CDH26
|
cadherin 26 |
| chr17_-_56065484 | 0.01 |
ENST00000581208.1
|
VEZF1
|
vascular endothelial zinc finger 1 |
| chrX_-_153236620 | 0.01 |
ENST00000369984.4
|
HCFC1
|
host cell factor C1 (VP16-accessory protein) |
| chr6_+_69942298 | 0.01 |
ENST00000238918.8
|
BAI3
|
brain-specific angiogenesis inhibitor 3 |
| chr5_-_39424961 | 0.01 |
ENST00000503513.1
|
DAB2
|
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) |
| chr7_-_44580861 | 0.01 |
ENST00000546276.1
ENST00000289547.4 ENST00000381160.3 ENST00000423141.1 |
NPC1L1
|
NPC1-like 1 |
| chr19_-_18392422 | 0.01 |
ENST00000252818.3
|
JUND
|
jun D proto-oncogene |
| chr1_+_247582097 | 0.01 |
ENST00000391827.2
|
NLRP3
|
NLR family, pyrin domain containing 3 |
| chr19_+_38664224 | 0.01 |
ENST00000601054.1
|
SIPA1L3
|
signal-induced proliferation-associated 1 like 3 |
| chr5_+_137774706 | 0.01 |
ENST00000378339.2
ENST00000254901.5 ENST00000506158.1 |
REEP2
|
receptor accessory protein 2 |
| chrX_+_27826107 | 0.01 |
ENST00000356790.2
|
MAGEB10
|
melanoma antigen family B, 10 |
| chr8_+_26434578 | 0.01 |
ENST00000493789.2
|
DPYSL2
|
dihydropyrimidinase-like 2 |
| chr2_-_219925189 | 0.00 |
ENST00000295731.6
|
IHH
|
indian hedgehog |
| chr8_+_21882244 | 0.00 |
ENST00000289820.6
ENST00000381530.5 |
NPM2
|
nucleophosmin/nucleoplasmin 2 |
| chr19_-_46285736 | 0.00 |
ENST00000291270.4
ENST00000447742.2 ENST00000354227.5 |
DMPK
|
dystrophia myotonica-protein kinase |
| chr3_-_171527560 | 0.00 |
ENST00000331659.2
|
PP13439
|
PP13439 |
| chr2_+_27435734 | 0.00 |
ENST00000419744.1
|
ATRAID
|
all-trans retinoic acid-induced differentiation factor |
| chr16_+_50187556 | 0.00 |
ENST00000561678.1
ENST00000357464.3 |
PAPD5
|
PAP associated domain containing 5 |
| chr12_-_53343560 | 0.00 |
ENST00000548998.1
|
KRT8
|
keratin 8 |
| chr6_+_42141029 | 0.00 |
ENST00000372958.1
|
GUCA1A
|
guanylate cyclase activator 1A (retina) |
| chr4_+_718896 | 0.00 |
ENST00000433814.1
|
PCGF3
|
polycomb group ring finger 3 |
| chr1_-_155232221 | 0.00 |
ENST00000355379.3
|
SCAMP3
|
secretory carrier membrane protein 3 |
| chr5_+_173416162 | 0.00 |
ENST00000340147.6
|
C5orf47
|
chromosome 5 open reading frame 47 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SREBF2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | GO:1903979 | negative regulation of microglial cell activation(GO:1903979) |
| 0.0 | 0.1 | GO:2000646 | positive regulation of receptor catabolic process(GO:2000646) |
| 0.0 | 0.1 | GO:0046618 | drug export(GO:0046618) |
| 0.0 | 0.1 | GO:0019046 | release from viral latency(GO:0019046) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | GO:1990666 | PCSK9-LDLR complex(GO:1990666) |
| 0.0 | 0.1 | GO:0009346 | citrate lyase complex(GO:0009346) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | GO:0036435 | IkappaB kinase activity(GO:0008384) K48-linked polyubiquitin binding(GO:0036435) |
| 0.0 | 0.1 | GO:0003878 | ATP citrate synthase activity(GO:0003878) |
| 0.0 | 0.1 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.0 | 0.1 | GO:0070326 | very-low-density lipoprotein particle binding(GO:0034189) very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 0.0 | 0.1 | GO:0015307 | drug:proton antiporter activity(GO:0015307) |
| 0.0 | 0.1 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.0 | 0.1 | GO:0032052 | bile acid binding(GO:0032052) |