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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TFEC_MITF_ARNTL_BHLHE41

Z-value: 1.20

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Transcription factors associated with TFEC_MITF_ARNTL_BHLHE41

Gene Symbol Gene ID Gene Info
TFEC
ENSG00000105967.11 transcription factor EC
MITF
ENSG00000187098.10 melanocyte inducing transcription factor
ARNTL
ENSG00000133794.13 aryl hydrocarbon receptor nuclear translocator like
BHLHE41
ENSG00000123095.5 basic helix-loop-helix family member e41

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BHLHE41hg19_v2_chr12_-_26278030_262780600.582.3e-01Click!
MITFhg19_v2_chr3_+_69811858_698118810.572.4e-01Click!
TFEChg19_v2_chr7_-_115608304_1156083520.532.7e-01Click!
ARNTLhg19_v2_chr11_+_13299186_132994320.404.3e-01Click!

Activity profile of TFEC_MITF_ARNTL_BHLHE41 motif

Sorted Z-values of TFEC_MITF_ARNTL_BHLHE41 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_109703663 1.56 ENST00000368961.5
CD164
CD164 molecule, sialomucin
chr10_-_46089939 1.52 ENST00000453980.3
MARCH8
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
chr6_-_33385854 1.39 ENST00000488478.1
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr19_+_5681011 1.37 ENST00000581893.1
ENST00000411793.2
ENST00000301382.4
ENST00000581773.1
ENST00000423665.2
ENST00000583928.1
ENST00000342970.2
ENST00000422535.2
ENST00000581521.1
ENST00000339423.2
HSD11B1L
hydroxysteroid (11-beta) dehydrogenase 1-like
chr13_+_113951607 1.37 ENST00000397181.3
LAMP1
lysosomal-associated membrane protein 1
chr11_+_67159416 1.15 ENST00000307980.2
ENST00000544620.1
RAD9A
RAD9 homolog A (S. pombe)
chr1_-_183604794 1.13 ENST00000367534.1
ENST00000359856.6
ENST00000294742.6
ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr2_-_176867534 0.93 ENST00000445472.1
KIAA1715
KIAA1715
chr6_-_84937314 0.93 ENST00000257766.4
ENST00000403245.3
KIAA1009
KIAA1009
chr8_+_103876528 0.93 ENST00000522939.1
ENST00000524007.1
KB-1507C5.2
HCG15011, isoform CRA_a; Protein LOC100996457
chr19_-_5680891 0.89 ENST00000309324.4
C19orf70
chromosome 19 open reading frame 70
chr10_-_46090334 0.88 ENST00000395771.3
ENST00000319836.3
MARCH8
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
chr19_+_5681153 0.87 ENST00000579559.1
ENST00000577222.1
HSD11B1L
RPL36
hydroxysteroid (11-beta) dehydrogenase 1-like
ribosomal protein L36
chr8_-_54755459 0.86 ENST00000524234.1
ENST00000521275.1
ENST00000396774.2
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr16_+_28986134 0.86 ENST00000352260.7
SPNS1
spinster homolog 1 (Drosophila)
chr5_+_133706865 0.85 ENST00000265339.2
UBE2B
ubiquitin-conjugating enzyme E2B
chr19_+_1275917 0.85 ENST00000469144.1
C19orf24
chromosome 19 open reading frame 24
chr1_+_42921761 0.83 ENST00000372562.1
PPCS
phosphopantothenoylcysteine synthetase
chr8_-_71157595 0.81 ENST00000519724.1
NCOA2
nuclear receptor coactivator 2
chr17_-_7137582 0.79 ENST00000575756.1
ENST00000575458.1
DVL2
dishevelled segment polarity protein 2
chr5_+_41904431 0.77 ENST00000381647.2
C5orf51
chromosome 5 open reading frame 51
chr17_+_42422629 0.76 ENST00000589536.1
ENST00000587109.1
ENST00000587518.1
GRN
granulin
chr18_+_9136758 0.75 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ANKRD12
ankyrin repeat domain 12
chr4_-_47465666 0.74 ENST00000381571.4
COMMD8
COMM domain containing 8
chr15_-_72668805 0.72 ENST00000268097.5
HEXA
hexosaminidase A (alpha polypeptide)
chrX_-_119693745 0.72 ENST00000371323.2
CUL4B
cullin 4B
chr1_+_42922173 0.71 ENST00000455780.1
ENST00000372560.3
ENST00000372561.3
ENST00000372556.3
PPCS
phosphopantothenoylcysteine synthetase
chr8_+_126103921 0.71 ENST00000523741.1
NSMCE2
non-SMC element 2, MMS21 homolog (S. cerevisiae)
chr14_-_54955721 0.70 ENST00000554908.1
GMFB
glia maturation factor, beta
chr17_-_7137857 0.70 ENST00000005340.5
DVL2
dishevelled segment polarity protein 2
chr16_+_28986085 0.68 ENST00000565975.1
ENST00000311008.11
ENST00000323081.8
ENST00000334536.8
SPNS1
spinster homolog 1 (Drosophila)
chr5_+_110074685 0.68 ENST00000355943.3
ENST00000447245.2
SLC25A46
solute carrier family 25, member 46
chr19_+_10812108 0.68 ENST00000250237.5
ENST00000592254.1
QTRT1
queuine tRNA-ribosyltransferase 1
chr6_+_87865262 0.66 ENST00000369577.3
ENST00000518845.1
ENST00000339907.4
ENST00000496806.2
ZNF292
zinc finger protein 292
chr3_-_49395892 0.66 ENST00000419783.1
GPX1
glutathione peroxidase 1
chr12_+_56110247 0.65 ENST00000551926.1
BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr13_+_113951532 0.65 ENST00000332556.4
LAMP1
lysosomal-associated membrane protein 1
chr3_-_49395705 0.65 ENST00000419349.1
GPX1
glutathione peroxidase 1
chr12_+_56109810 0.60 ENST00000550412.1
ENST00000257899.2
ENST00000548925.1
ENST00000549147.1
RP11-644F5.10
BLOC1S1
Uncharacterized protein
biogenesis of lysosomal organelles complex-1, subunit 1
chr7_+_99746514 0.60 ENST00000341942.5
ENST00000441173.1
LAMTOR4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
chr16_-_1525016 0.59 ENST00000262318.8
ENST00000448525.1
CLCN7
chloride channel, voltage-sensitive 7
chr1_-_154193091 0.58 ENST00000362076.4
ENST00000350592.3
ENST00000368516.1
C1orf43
chromosome 1 open reading frame 43
chr7_+_150758642 0.58 ENST00000488420.1
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr11_-_18343725 0.58 ENST00000531848.1
HPS5
Hermansky-Pudlak syndrome 5
chr16_-_5083917 0.58 ENST00000312251.3
ENST00000381955.3
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr3_-_113465065 0.58 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr12_+_56109926 0.58 ENST00000547076.1
BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr8_-_54755789 0.57 ENST00000359530.2
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr1_-_68962744 0.56 ENST00000525124.1
DEPDC1
DEP domain containing 1
chr10_+_70883908 0.56 ENST00000263559.6
ENST00000395098.1
ENST00000546041.1
ENST00000541711.1
VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr3_-_122512619 0.53 ENST00000383659.1
ENST00000306103.2
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr11_-_71814422 0.53 ENST00000278671.5
LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr22_-_36903101 0.52 ENST00000397224.4
FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr11_-_71814276 0.51 ENST00000538404.1
ENST00000535107.1
ENST00000545249.1
LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr19_-_5340730 0.51 ENST00000372412.4
ENST00000357368.4
ENST00000262963.6
ENST00000348075.2
ENST00000353284.2
PTPRS
protein tyrosine phosphatase, receptor type, S
chr6_-_109703634 0.50 ENST00000324953.5
ENST00000310786.4
ENST00000275080.7
ENST00000413644.2
CD164
CD164 molecule, sialomucin
chr14_-_81687197 0.50 ENST00000553612.1
GTF2A1
general transcription factor IIA, 1, 19/37kDa
chr17_-_76124812 0.49 ENST00000592063.1
ENST00000589271.1
ENST00000322933.4
ENST00000589553.1
TMC6
transmembrane channel-like 6
chr17_+_42422662 0.49 ENST00000593167.1
ENST00000585512.1
ENST00000591740.1
ENST00000592783.1
ENST00000587387.1
ENST00000588237.1
ENST00000589265.1
GRN
granulin
chr16_+_2570340 0.48 ENST00000568263.1
ENST00000293971.6
ENST00000302956.4
ENST00000413459.3
ENST00000566706.1
ENST00000569879.1
AMDHD2
amidohydrolase domain containing 2
chr4_+_76439095 0.48 ENST00000506261.1
THAP6
THAP domain containing 6
chr1_-_68962782 0.47 ENST00000456315.2
DEPDC1
DEP domain containing 1
chrX_+_150565038 0.47 ENST00000370361.1
VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr6_-_33385902 0.47 ENST00000374500.5
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr17_+_1627834 0.46 ENST00000419248.1
ENST00000418841.1
WDR81
WD repeat domain 81
chr12_-_76953513 0.46 ENST00000547540.1
OSBPL8
oxysterol binding protein-like 8
chr14_-_54955376 0.46 ENST00000553333.1
GMFB
glia maturation factor, beta
chr17_+_78075361 0.46 ENST00000577106.1
ENST00000390015.3
GAA
glucosidase, alpha; acid
chr1_-_33642151 0.45 ENST00000543586.1
TRIM62
tripartite motif containing 62
chr22_-_42343117 0.45 ENST00000407253.3
ENST00000215980.5
CENPM
centromere protein M
chr10_+_99258625 0.45 ENST00000370664.3
UBTD1
ubiquitin domain containing 1
chr22_-_36903069 0.45 ENST00000216187.6
ENST00000423980.1
FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr17_+_42422637 0.44 ENST00000053867.3
ENST00000588143.1
GRN
granulin
chr4_+_76439665 0.43 ENST00000508105.1
ENST00000311638.3
ENST00000380837.3
ENST00000507556.1
ENST00000504190.1
ENST00000507885.1
ENST00000502620.1
ENST00000514480.1
THAP6
THAP domain containing 6
chr8_-_145688231 0.43 ENST00000530374.1
CYHR1
cysteine/histidine-rich 1
chr17_-_79791118 0.43 ENST00000576431.1
ENST00000575061.1
ENST00000455127.2
ENST00000572645.1
ENST00000538396.1
ENST00000573478.1
FAM195B
family with sequence similarity 195, member B
chr2_-_40006289 0.42 ENST00000260619.6
ENST00000454352.2
THUMPD2
THUMP domain containing 2
chr5_-_176730733 0.42 ENST00000504395.1
RAB24
RAB24, member RAS oncogene family
chrX_+_102585124 0.42 ENST00000332431.4
ENST00000372666.1
TCEAL7
transcription elongation factor A (SII)-like 7
chrX_-_45629661 0.42 ENST00000602507.1
ENST00000602461.1
RP6-99M1.2
RP6-99M1.2
chr11_+_107879459 0.42 ENST00000393094.2
CUL5
cullin 5
chr19_-_1237990 0.42 ENST00000382477.2
ENST00000215376.6
ENST00000590083.1
C19orf26
chromosome 19 open reading frame 26
chr7_+_4815238 0.42 ENST00000348624.4
ENST00000401897.1
AP5Z1
adaptor-related protein complex 5, zeta 1 subunit
chrX_-_34675391 0.41 ENST00000275954.3
TMEM47
transmembrane protein 47
chr17_+_78075324 0.41 ENST00000570803.1
GAA
glucosidase, alpha; acid
chr2_-_40006357 0.40 ENST00000505747.1
THUMPD2
THUMP domain containing 2
chr19_-_49137762 0.40 ENST00000593500.1
DBP
D site of albumin promoter (albumin D-box) binding protein
chr16_-_4466565 0.40 ENST00000572467.1
ENST00000423908.2
ENST00000572044.1
ENST00000571052.1
CORO7-PAM16
CORO7
CORO7-PAM16 readthrough
coronin 7
chr19_+_41305330 0.40 ENST00000593972.1
EGLN2
egl-9 family hypoxia-inducible factor 2
chr11_-_6640585 0.39 ENST00000533371.1
ENST00000528657.1
ENST00000436873.2
ENST00000299427.6
TPP1
tripeptidyl peptidase I
chr7_+_100464760 0.39 ENST00000200457.4
TRIP6
thyroid hormone receptor interactor 6
chr13_+_42846272 0.38 ENST00000025301.2
AKAP11
A kinase (PRKA) anchor protein 11
chr2_+_240323439 0.38 ENST00000428471.1
ENST00000413029.1
AC062017.1
Uncharacterized protein
chr17_+_62223320 0.37 ENST00000580828.1
ENST00000582965.1
SNORA76
small nucleolar RNA, H/ACA box 76
chr6_-_109703600 0.37 ENST00000512821.1
CD164
CD164 molecule, sialomucin
chr12_-_76953284 0.37 ENST00000547544.1
ENST00000393249.2
OSBPL8
oxysterol binding protein-like 8
chr11_-_1785139 0.36 ENST00000236671.2
CTSD
cathepsin D
chr1_-_222886526 0.36 ENST00000541237.1
AIDA
axin interactor, dorsalization associated
chr17_+_78075498 0.36 ENST00000302262.3
GAA
glucosidase, alpha; acid
chr15_-_76352069 0.36 ENST00000305435.10
ENST00000563910.1
NRG4
neuregulin 4
chr11_+_65779283 0.36 ENST00000312134.2
CST6
cystatin E/M
chr8_-_82754427 0.35 ENST00000353788.4
ENST00000520618.1
ENST00000518183.1
ENST00000396330.2
ENST00000519119.1
ENST00000345957.4
SNX16
sorting nexin 16
chr22_-_42342692 0.35 ENST00000404067.1
ENST00000402338.1
CENPM
centromere protein M
chr19_-_36545128 0.35 ENST00000538849.1
THAP8
THAP domain containing 8
chr13_+_49684445 0.35 ENST00000398316.3
FNDC3A
fibronectin type III domain containing 3A
chr19_-_49137790 0.35 ENST00000599385.1
DBP
D site of albumin promoter (albumin D-box) binding protein
chr3_-_196987309 0.35 ENST00000453607.1
DLG1
discs, large homolog 1 (Drosophila)
chr17_+_6915730 0.34 ENST00000548577.1
RNASEK
ribonuclease, RNase K
chr5_+_43602750 0.34 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
NNT
nicotinamide nucleotide transhydrogenase
chr12_+_28343353 0.34 ENST00000539107.1
CCDC91
coiled-coil domain containing 91
chr17_+_6915798 0.34 ENST00000402093.1
RNASEK
ribonuclease, RNase K
chr9_-_90589586 0.34 ENST00000325303.8
ENST00000375883.3
CDK20
cyclin-dependent kinase 20
chr19_+_8386371 0.34 ENST00000600659.2
RPS28
ribosomal protein S28
chr22_-_50699972 0.33 ENST00000395778.3
MAPK12
mitogen-activated protein kinase 12
chr18_-_29522989 0.33 ENST00000582539.1
ENST00000283351.4
ENST00000582513.1
TRAPPC8
trafficking protein particle complex 8
chr11_-_18343669 0.32 ENST00000396253.3
ENST00000349215.3
ENST00000438420.2
HPS5
Hermansky-Pudlak syndrome 5
chr4_+_56719782 0.32 ENST00000381295.2
ENST00000346134.7
ENST00000349598.6
EXOC1
exocyst complex component 1
chr4_-_23891693 0.31 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr9_-_90589402 0.31 ENST00000375871.4
ENST00000605159.1
ENST00000336654.5
CDK20
cyclin-dependent kinase 20
chr6_-_33385870 0.31 ENST00000488034.1
CUTA
cutA divalent cation tolerance homolog (E. coli)
chr7_+_150758304 0.31 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr2_+_109204909 0.31 ENST00000393310.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr9_-_103115135 0.31 ENST00000537512.1
TEX10
testis expressed 10
chr7_+_99070527 0.31 ENST00000379724.3
ZNF789
zinc finger protein 789
chr2_+_46926326 0.30 ENST00000394861.2
SOCS5
suppressor of cytokine signaling 5
chr2_-_47572207 0.30 ENST00000441997.1
AC073283.4
AC073283.4
chr19_-_5680499 0.30 ENST00000587589.1
C19orf70
chromosome 19 open reading frame 70
chr22_-_39268192 0.30 ENST00000216083.6
CBX6
chromobox homolog 6
chr19_-_5720123 0.30 ENST00000587365.1
ENST00000585374.1
ENST00000593119.1
LONP1
lon peptidase 1, mitochondrial
chr6_+_139349817 0.30 ENST00000367660.3
ABRACL
ABRA C-terminal like
chr10_-_98031265 0.30 ENST00000224337.5
ENST00000371176.2
BLNK
B-cell linker
chr16_-_5083589 0.30 ENST00000563578.1
ENST00000562346.2
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr7_+_150759634 0.29 ENST00000392826.2
ENST00000461735.1
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr12_-_108154705 0.29 ENST00000547188.1
PRDM4
PR domain containing 4
chr3_-_20227619 0.29 ENST00000425061.1
ENST00000443724.1
ENST00000421451.1
ENST00000452020.1
ENST00000417364.1
ENST00000306698.2
ENST00000419233.2
ENST00000263753.4
ENST00000383774.1
ENST00000437051.1
ENST00000412868.1
ENST00000429446.3
ENST00000442720.1
SGOL1
shugoshin-like 1 (S. pombe)
chr1_-_68962805 0.29 ENST00000370966.5
DEPDC1
DEP domain containing 1
chr16_-_4466622 0.29 ENST00000570645.1
ENST00000574025.1
ENST00000572898.1
ENST00000537233.2
ENST00000571059.1
ENST00000251166.4
CORO7
coronin 7
chr21_+_45287112 0.29 ENST00000448287.1
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr9_-_125667494 0.29 ENST00000335387.5
ENST00000357244.2
ENST00000373665.2
RC3H2
ring finger and CCCH-type domains 2
chr14_-_54908043 0.28 ENST00000556113.1
ENST00000553660.1
ENST00000395573.4
ENST00000557690.1
ENST00000216416.4
CNIH1
cornichon family AMPA receptor auxiliary protein 1
chr15_-_50978965 0.27 ENST00000560955.1
ENST00000313478.7
TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr8_+_74903580 0.27 ENST00000284818.2
ENST00000518893.1
LY96
lymphocyte antigen 96
chr7_+_116593536 0.27 ENST00000417919.1
ST7
suppression of tumorigenicity 7
chr3_-_134204815 0.27 ENST00000514612.1
ENST00000510994.1
ENST00000354910.5
ANAPC13
anaphase promoting complex subunit 13
chr5_-_1799864 0.27 ENST00000510999.1
MRPL36
mitochondrial ribosomal protein L36
chr10_-_98031310 0.27 ENST00000427367.2
ENST00000413476.2
BLNK
B-cell linker
chr13_+_36920569 0.27 ENST00000379848.2
SPG20OS
SPG20 opposite strand
chr19_-_40854281 0.27 ENST00000392035.2
C19orf47
chromosome 19 open reading frame 47
chr12_+_53645870 0.27 ENST00000329548.4
MFSD5
major facilitator superfamily domain containing 5
chr8_+_109455830 0.27 ENST00000524143.1
EMC2
ER membrane protein complex subunit 2
chr19_-_5719860 0.27 ENST00000590729.1
LONP1
lon peptidase 1, mitochondrial
chr7_+_23286182 0.27 ENST00000258733.4
ENST00000381990.2
ENST00000409458.3
ENST00000539136.1
ENST00000453162.2
GPNMB
glycoprotein (transmembrane) nmb
chr2_+_46926048 0.27 ENST00000306503.5
SOCS5
suppressor of cytokine signaling 5
chr19_-_8386238 0.27 ENST00000301457.2
NDUFA7
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
chr16_+_2570431 0.27 ENST00000563556.1
AMDHD2
amidohydrolase domain containing 2
chr1_+_61869748 0.27 ENST00000357977.5
NFIA
nuclear factor I/A
chr16_-_70719925 0.26 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr2_-_148778323 0.26 ENST00000440042.1
ENST00000535373.1
ENST00000540442.1
ENST00000536575.1
ORC4
origin recognition complex, subunit 4
chr19_-_5720248 0.26 ENST00000360614.3
LONP1
lon peptidase 1, mitochondrial
chr4_-_54930790 0.26 ENST00000263921.3
CHIC2
cysteine-rich hydrophobic domain 2
chr6_-_80657292 0.26 ENST00000369816.4
ELOVL4
ELOVL fatty acid elongase 4
chr12_+_56110315 0.26 ENST00000548556.1
BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr17_-_18266818 0.26 ENST00000583780.1
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr2_-_148778258 0.25 ENST00000392857.5
ENST00000457954.1
ENST00000392858.1
ENST00000542387.1
ORC4
origin recognition complex, subunit 4
chr7_+_100271446 0.25 ENST00000419828.1
ENST00000427895.1
GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr3_-_120068143 0.25 ENST00000295628.3
LRRC58
leucine rich repeat containing 58
chr2_+_172864490 0.25 ENST00000315796.4
METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chr12_+_28343365 0.25 ENST00000545336.1
CCDC91
coiled-coil domain containing 91
chr19_+_797443 0.25 ENST00000394601.4
ENST00000589575.1
PTBP1
polypyrimidine tract binding protein 1
chr4_+_103790462 0.25 ENST00000503643.1
CISD2
CDGSH iron sulfur domain 2
chrX_+_102469997 0.25 ENST00000372695.5
ENST00000372691.3
BEX4
brain expressed, X-linked 4
chr2_+_228190066 0.25 ENST00000436237.1
ENST00000443428.2
ENST00000418961.1
MFF
mitochondrial fission factor
chr6_+_7590413 0.25 ENST00000342415.5
SNRNP48
small nuclear ribonucleoprotein 48kDa (U11/U12)
chr21_-_46237883 0.25 ENST00000397893.3
SUMO3
small ubiquitin-like modifier 3
chr2_-_183903133 0.25 ENST00000361354.4
NCKAP1
NCK-associated protein 1
chr8_+_26240414 0.24 ENST00000380629.2
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr6_-_43197189 0.24 ENST00000509253.1
ENST00000393987.2
ENST00000230431.6
DNPH1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr15_-_65282045 0.24 ENST00000558765.1
SPG21
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr7_+_100271355 0.24 ENST00000436220.1
ENST00000424361.1
GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr22_+_21996549 0.24 ENST00000248958.4
SDF2L1
stromal cell-derived factor 2-like 1
chr18_+_77867177 0.24 ENST00000560752.1
ADNP2
ADNP homeobox 2
chr10_-_13342051 0.24 ENST00000479604.1
PHYH
phytanoyl-CoA 2-hydroxylase
chr16_+_57139933 0.24 ENST00000566259.1
CPNE2
copine II
chr11_+_95523823 0.24 ENST00000538658.1
CEP57
centrosomal protein 57kDa
chr1_-_156265438 0.23 ENST00000362007.1
C1orf85
chromosome 1 open reading frame 85
chr3_+_51428704 0.23 ENST00000323686.4
RBM15B
RNA binding motif protein 15B
chr19_+_40697514 0.23 ENST00000253055.3
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr13_-_21635631 0.23 ENST00000382592.4
LATS2
large tumor suppressor kinase 2
chr4_+_38665810 0.23 ENST00000261438.5
ENST00000514033.1
KLF3
Kruppel-like factor 3 (basic)
chr3_-_45883558 0.23 ENST00000445698.1
ENST00000296135.6
LZTFL1
leucine zipper transcription factor-like 1
chr1_+_17248418 0.23 ENST00000375541.5
CROCC
ciliary rootlet coiled-coil, rootletin
chr20_-_2821271 0.23 ENST00000448755.1
ENST00000360652.2
PCED1A
PC-esterase domain containing 1A
chr13_-_79233314 0.23 ENST00000282003.6
RNF219
ring finger protein 219
chr9_+_131084846 0.23 ENST00000608951.1
COQ4
coenzyme Q4
chr16_+_83986827 0.22 ENST00000393306.1
ENST00000565123.1
OSGIN1
oxidative stress induced growth inhibitor 1
chr17_-_76124711 0.22 ENST00000306591.7
ENST00000590602.1
TMC6
transmembrane channel-like 6
chr8_-_103876340 0.22 ENST00000518353.1
AZIN1
antizyme inhibitor 1
chr2_+_241526126 0.22 ENST00000391984.2
ENST00000391982.2
ENST00000404753.3
ENST00000270364.7
ENST00000352879.4
ENST00000354082.4
CAPN10
calpain 10
chr19_-_11688260 0.22 ENST00000590832.1
ACP5
acid phosphatase 5, tartrate resistant
chr10_+_69644404 0.22 ENST00000212015.6
SIRT1
sirtuin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of TFEC_MITF_ARNTL_BHLHE41

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0043181 vacuolar sequestering(GO:0043181)
0.4 2.0 GO:0043321 regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.4 1.5 GO:0022007 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.3 1.0 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.3 0.8 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
0.3 0.8 GO:1904017 cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.3 1.3 GO:0009609 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609)
0.2 0.8 GO:0060620 regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.2 0.4 GO:0010737 protein kinase A signaling(GO:0010737) regulation of protein kinase A signaling(GO:0010738)
0.2 1.4 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.2 1.2 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.2 0.7 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.2 0.5 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.1 0.1 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.1 2.0 GO:0060155 platelet dense granule organization(GO:0060155)
0.1 1.1 GO:0021769 orbitofrontal cortex development(GO:0021769)
0.1 0.3 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 0.3 GO:1990828 response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586) hepatocyte dedifferentiation(GO:1990828)
0.1 0.6 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.1 0.3 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of mitochondrial DNA metabolic process(GO:1901860) response to methionine(GO:1904640)
0.1 0.7 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.1 0.3 GO:0010961 cellular magnesium ion homeostasis(GO:0010961) calcium-dependent cell-matrix adhesion(GO:0016340)
0.1 1.1 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.1 0.3 GO:1900063 regulation of peroxisome organization(GO:1900063)
0.1 0.4 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1 0.2 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 1.4 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.1 0.3 GO:1904481 response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.1 0.2 GO:1990619 histone H3-K9 deacetylation(GO:1990619)
0.1 0.5 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.5 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.1 0.2 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 0.2 GO:0001828 inner cell mass cellular morphogenesis(GO:0001828)
0.1 0.2 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.1 0.3 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.1 0.2 GO:0032053 ciliary basal body organization(GO:0032053) regulation of protein localization to cilium(GO:1903564) positive regulation of protein localization to cilium(GO:1903566)
0.1 0.2 GO:0000961 negative regulation of mitochondrial RNA catabolic process(GO:0000961)
0.1 0.2 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
0.1 0.5 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 0.2 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.1 0.2 GO:0015883 FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350)
0.0 0.6 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.2 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.6 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.2 GO:0072287 metanephric distal tubule morphogenesis(GO:0072287)
0.0 0.1 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.1 GO:0050787 detoxification of mercury ion(GO:0050787)
0.0 0.5 GO:0048262 determination of dorsal/ventral asymmetry(GO:0048262)
0.0 0.1 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0 0.4 GO:2000973 regulation of pro-B cell differentiation(GO:2000973)
0.0 0.6 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.0 1.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.2 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.0 0.2 GO:2000174 regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.0 0.1 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.0 0.1 GO:0019516 lactate oxidation(GO:0019516)
0.0 0.8 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.3 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0 0.1 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.2 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.3 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 0.3 GO:1903764 cortical microtubule organization(GO:0043622) establishment of centrosome localization(GO:0051660) regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 2.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.5 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.3 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.2 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.0 0.1 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.0 0.1 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.2 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.2 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.7 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.8 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.0 GO:0002877 acute inflammatory response to non-antigenic stimulus(GO:0002525) regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
0.0 0.3 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 0.1 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.2 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.2 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.9 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.1 GO:0044209 AMP salvage(GO:0044209)
0.0 0.1 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.0 0.1 GO:1904761 negative regulation of myofibroblast differentiation(GO:1904761)
0.0 0.1 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.4 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.1 GO:0097051 establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.1 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.0 0.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:0000921 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.0 0.0 GO:0036506 maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 0.8 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0019303 D-ribose catabolic process(GO:0019303)
0.0 0.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.3 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.3 GO:0051601 exocyst localization(GO:0051601)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.0 0.1 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.0 0.0 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.1 GO:0090472 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.0 0.4 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.2 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.6 GO:0061008 liver development(GO:0001889) hepaticobiliary system development(GO:0061008)
0.0 0.1 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 1.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.3 GO:0050942 positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.1 GO:0044789 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0 0.0 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0006771 riboflavin metabolic process(GO:0006771)
0.0 0.1 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.0 0.1 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.0 0.1 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0 0.2 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.3 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.2 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.0 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365)
0.0 0.9 GO:0061462 protein localization to lysosome(GO:0061462)
0.0 0.1 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.3 GO:0015886 heme transport(GO:0015886)
0.0 0.0 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 0.0 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.0 GO:0034059 response to anoxia(GO:0034059)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.0 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.0 0.1 GO:0021603 cranial nerve formation(GO:0021603)
0.0 0.5 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.1 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.3 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.1 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0 0.2 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0 0.1 GO:0006788 heme oxidation(GO:0006788) negative regulation of mast cell cytokine production(GO:0032764) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.0 0.3 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0 0.1 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.0 0.1 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.2 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.3 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.0 0.1 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.1 GO:0046689 response to mercury ion(GO:0046689)
0.0 0.1 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.0 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424)
0.0 0.1 GO:1904379 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.0 0.3 GO:0072189 ureter development(GO:0072189)
0.0 0.1 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.1 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.4 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.0 0.1 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.0 0.2 GO:0021554 optic nerve development(GO:0021554)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.1 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.6 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.0 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.0 0.1 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.4 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.1 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 0.1 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.0 0.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.2 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.0 0.4 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0061668 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.3 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0 0.0 GO:0016572 histone phosphorylation(GO:0016572)
0.0 0.2 GO:0051450 myoblast proliferation(GO:0051450)
0.0 0.6 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.0 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.0 0.0 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0 0.1 GO:0019374 galactosylceramide metabolic process(GO:0006681) galactolipid metabolic process(GO:0019374)
0.0 0.1 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.0 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
0.0 0.1 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.0 GO:0060592 mammary gland formation(GO:0060592)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0044194 cytolytic granule(GO:0044194)
0.3 1.5 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.2 0.9 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 1.3 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 1.6 GO:0071986 Ragulator complex(GO:0071986)
0.1 1.0 GO:0033503 HULC complex(GO:0033503)
0.1 0.5 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.3 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.1 0.7 GO:0097413 Lewy body(GO:0097413)
0.1 0.6 GO:0031415 NatA complex(GO:0031415)
0.1 0.7 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 2.3 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 0.4 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.1 0.9 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 1.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.6 GO:0010009 cytoplasmic side of endosome membrane(GO:0010009)
0.0 0.2 GO:0002133 polycystin complex(GO:0002133)
0.0 0.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0035101 FACT complex(GO:0035101)
0.0 0.5 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.2 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.2 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.3 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 0.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.4 GO:0043219 lateral loop(GO:0043219)
0.0 0.1 GO:0031085 BLOC-3 complex(GO:0031085)
0.0 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.3 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 1.5 GO:0016235 aggresome(GO:0016235)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.3 GO:0048500 signal recognition particle(GO:0048500)
0.0 0.1 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.0 0.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.0 2.0 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.0 2.6 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.1 GO:0001652 granular component(GO:0001652)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.0 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.0 GO:0072589 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0036128 CatSper complex(GO:0036128)
0.0 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.3 1.3 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.3 0.8 GO:0070361 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
0.2 0.7 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 1.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.2 0.5 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.2 0.8 GO:0010861 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.1 0.7 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1 0.4 GO:0015439 heme-transporting ATPase activity(GO:0015439)
0.1 1.6 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.3 GO:0048244 phytanoyl-CoA dioxygenase activity(GO:0048244)
0.1 0.2 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.1 0.2 GO:0032129 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.1 0.4 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 0.2 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 1.1 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.1 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.3 GO:0070905 serine binding(GO:0070905)
0.1 0.2 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.1 1.2 GO:0015929 hexosaminidase activity(GO:0015929)
0.1 0.2 GO:0031177 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) S-acetyltransferase activity(GO:0016418) phosphopantetheine binding(GO:0031177)
0.1 0.2 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.1 0.2 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 1.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.2 GO:0019770 IgG receptor activity(GO:0019770)
0.0 1.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.1 GO:0016898 D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.0 0.3 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.5 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.2 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.5 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.2 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 1.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.3 GO:0045545 syndecan binding(GO:0045545)
0.0 0.3 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 1.4 GO:0005109 frizzled binding(GO:0005109)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 1.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.3 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.2 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.3 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.3 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.1 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0 0.2 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.1 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
0.0 0.1 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.1 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.1 GO:0004853 uroporphyrinogen decarboxylase activity(GO:0004853)
0.0 0.1 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 1.8 GO:0005507 copper ion binding(GO:0005507)
0.0 0.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0036033 mediator complex binding(GO:0036033)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.1 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 1.9 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.5 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.4 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.0 0.2 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.1 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.0 GO:0004818 glutamate-tRNA ligase activity(GO:0004818)
0.0 0.1 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.5 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.0 0.2 GO:0000182 rDNA binding(GO:0000182)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.1 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.1 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.2 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.1 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.1 PID ATM PATHWAY ATM pathway
0.0 1.2 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.0 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 1.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 0.2 REACTOME PI3K AKT ACTIVATION Genes involved in PI3K/AKT activation
0.0 1.4 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0 0.7 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 2.0 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 1.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.1 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.4 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.3 REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING Genes involved in Activation of Kainate Receptors upon glutamate binding
0.0 0.5 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.1 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.2 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex