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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZNF423

Z-value: 0.32

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Transcription factors associated with ZNF423

Gene Symbol Gene ID Gene Info
ENSG00000102935.7 zinc finger protein 423

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF423hg19_v2_chr16_-_49891694_49891830-0.721.1e-01Click!

Activity profile of ZNF423 motif

Sorted Z-values of ZNF423 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_77020325 0.22 ENST00000311661.4
C1q and tumor necrosis factor related protein 1
chr17_+_77020224 0.22 ENST00000339142.2
C1q and tumor necrosis factor related protein 1
chr15_-_41522889 0.18 ENST00000458580.2
ENST00000314992.5
ENST00000558396.1
exonuclease 3'-5' domain containing 1
chr17_+_6347761 0.17 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
family with sequence similarity 64, member A
chr11_-_44972299 0.16 ENST00000528473.1
tumor protein p53 inducible protein 11
chr4_+_74735102 0.15 ENST00000395761.3
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr7_+_150748288 0.15 ENST00000490540.1
acid-sensing (proton-gated) ion channel 3
chr20_-_36794902 0.14 ENST00000373403.3
transglutaminase 2
chr17_+_77020146 0.14 ENST00000579760.1
C1q and tumor necrosis factor related protein 1
chr11_-_44972418 0.12 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
tumor protein p53 inducible protein 11
chr20_-_36794938 0.12 ENST00000453095.1
transglutaminase 2
chr11_+_60691924 0.11 ENST00000544065.1
ENST00000453848.2
ENST00000005286.4
transmembrane protein 132A
chr12_-_50101165 0.11 ENST00000352151.5
ENST00000335154.5
ENST00000293590.5
formin-like 3
chr17_-_79212825 0.10 ENST00000374769.2
ENTH domain containing 2
chr6_-_31080336 0.10 ENST00000259870.3
chromosome 6 open reading frame 15
chr11_-_61658853 0.09 ENST00000525588.1
ENST00000540820.1
fatty acid desaturase 3
chr12_-_50101003 0.09 ENST00000550488.1
formin-like 3
chr11_-_61659006 0.08 ENST00000278829.2
fatty acid desaturase 3
chr17_+_6347729 0.08 ENST00000572447.1
family with sequence similarity 64, member A
chr7_-_150754935 0.08 ENST00000297518.4
cyclin-dependent kinase 5
chr9_+_116638630 0.08 ENST00000452710.1
ENST00000374124.4
zinc finger protein 618
chr9_-_131486367 0.08 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
zinc finger, DHHC-type containing 12
chr22_+_35653445 0.07 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMG box domain containing 4
chr11_-_44971702 0.07 ENST00000533940.1
ENST00000533937.1
tumor protein p53 inducible protein 11
chr11_-_64013663 0.07 ENST00000392210.2
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_+_155278625 0.07 ENST00000368356.4
ENST00000356657.6
farnesyl diphosphate synthase
chr19_+_45971246 0.07 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
FBJ murine osteosarcoma viral oncogene homolog B
chr6_-_32160622 0.07 ENST00000487761.1
ENST00000375040.3
G-protein signaling modulator 3
chr15_-_75660919 0.07 ENST00000569482.1
ENST00000565683.1
ENST00000561615.1
ENST00000563622.1
ENST00000568374.1
ENST00000566256.1
ENST00000267978.5
mannosidase, alpha, class 2C, member 1
chr20_+_44462430 0.07 ENST00000462307.1
sorting nexin family member 21
chr17_-_1029052 0.07 ENST00000574437.1
active BCR-related
chr9_+_116638562 0.07 ENST00000374126.5
ENST00000288466.7
zinc finger protein 618
chr6_-_91296737 0.07 ENST00000369332.3
ENST00000369329.3
mitogen-activated protein kinase kinase kinase 7
chr4_+_152330409 0.06 ENST00000513086.1
family with sequence similarity 160, member A1
chr19_+_20011744 0.06 ENST00000588146.1
zinc finger protein 93
chr17_-_27230035 0.06 ENST00000378895.4
ENST00000394901.3
dehydrogenase/reductase (SDR family) member 13
chr22_+_39853258 0.06 ENST00000341184.6
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr9_-_16870704 0.06 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
basonuclin 2
chr11_-_44972476 0.06 ENST00000527685.1
ENST00000308212.5
tumor protein p53 inducible protein 11
chr20_+_44462749 0.06 ENST00000372541.1
sorting nexin family member 21
chr16_+_30675654 0.06 ENST00000287468.5
ENST00000395073.2
fibrosin
chr8_+_22022800 0.06 ENST00000397814.3
bone morphogenetic protein 1
chr1_+_17914907 0.06 ENST00000375420.3
Rho guanine nucleotide exchange factor (GEF) 10-like
chr16_+_27324983 0.05 ENST00000566117.1
interleukin 4 receptor
chr22_-_38484922 0.05 ENST00000428572.1
BAI1-associated protein 2-like 2
chr6_-_91296602 0.05 ENST00000369325.3
ENST00000369327.3
mitogen-activated protein kinase kinase kinase 7
chr7_-_5570229 0.05 ENST00000331789.5
actin, beta
chr5_+_141303461 0.05 ENST00000508751.1
KIAA0141
chr6_+_33589161 0.05 ENST00000605930.1
inositol 1,4,5-trisphosphate receptor, type 3
chr10_-_121296045 0.04 ENST00000392865.1
regulator of G-protein signaling 10
chr21_-_18985158 0.04 ENST00000339775.6
BTG family, member 3
chr11_-_504489 0.04 ENST00000529368.1
ribonuclease/angiogenin inhibitor 1
chr5_+_154181816 0.04 ENST00000518677.1
La ribonucleoprotein domain family, member 1
chr19_-_10450287 0.04 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
intercellular adhesion molecule 3
chr2_+_219125714 0.04 ENST00000522678.1
ENST00000519574.1
ENST00000521462.1
G protein-coupled bile acid receptor 1
chr2_-_206950996 0.04 ENST00000414320.1
INO80 complex subunit D
chr19_-_10679644 0.04 ENST00000393599.2
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr2_+_171785012 0.04 ENST00000234160.4
golgi reassembly stacking protein 2, 55kDa
chr19_-_36391434 0.04 ENST00000396901.1
ENST00000585925.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chr3_-_48594248 0.04 ENST00000545984.1
ENST00000232375.3
ENST00000416568.1
ENST00000383734.2
ENST00000541519.1
ENST00000412035.1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr12_+_7037461 0.04 ENST00000396684.2
atrophin 1
chr13_+_96743093 0.04 ENST00000376705.2
heparan sulfate 6-O-sulfotransferase 3
chrX_-_51239425 0.04 ENST00000375992.3
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr5_-_176057365 0.04 ENST00000310112.3
synuclein, beta
chr11_+_73019282 0.04 ENST00000263674.3
Rho guanine nucleotide exchange factor (GEF) 17
chr12_+_7342271 0.04 ENST00000434354.2
ENST00000544456.1
ENST00000545574.1
ENST00000420616.2
peroxisomal biogenesis factor 5
chr1_+_1222489 0.04 ENST00000379099.3
sodium channel, non-voltage-gated 1, delta subunit
chr19_+_41770349 0.03 ENST00000602130.1
heterogeneous nuclear ribonucleoprotein U-like 1
chr15_+_41523417 0.03 ENST00000560397.1
calcineurin-like EF-hand protein 1
chr9_-_130659679 0.03 ENST00000373141.1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr21_+_45432174 0.03 ENST00000380221.3
ENST00000291574.4
trafficking protein particle complex 10
chr1_+_10459111 0.03 ENST00000541529.1
ENST00000270776.8
ENST00000483936.1
ENST00000538557.1
phosphogluconate dehydrogenase
chr6_-_143266297 0.03 ENST00000367603.2
human immunodeficiency virus type I enhancer binding protein 2
chr7_+_20370300 0.03 ENST00000537992.1
integrin, beta 8
chrX_+_136648297 0.03 ENST00000287538.5
Zic family member 3
chr19_-_10450328 0.03 ENST00000160262.5
intercellular adhesion molecule 3
chr10_+_124914285 0.03 ENST00000407911.2
BUB3 mitotic checkpoint protein
chr8_+_22022223 0.03 ENST00000306385.5
bone morphogenetic protein 1
chr3_+_9958870 0.03 ENST00000413608.1
interleukin 17 receptor C
chr14_-_93582214 0.03 ENST00000556603.2
ENST00000354313.3
inositol-tetrakisphosphate 1-kinase
chr6_+_42896865 0.03 ENST00000372836.4
ENST00000394142.3
canopy FGF signaling regulator 3
chr7_-_27219632 0.03 ENST00000470747.4
Uncharacterized protein
chr7_+_20370746 0.03 ENST00000222573.4
integrin, beta 8
chr6_+_151186554 0.03 ENST00000367321.3
ENST00000367307.4
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr8_+_22022653 0.03 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
bone morphogenetic protein 1
chr11_-_67120974 0.03 ENST00000539074.1
ENST00000312419.3
polymerase (DNA-directed), delta 4, accessory subunit
chr22_-_43045574 0.03 ENST00000352397.5
cytochrome b5 reductase 3
chr2_+_171785824 0.03 ENST00000452526.2
golgi reassembly stacking protein 2, 55kDa
chr9_-_130659569 0.03 ENST00000542456.1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr10_+_124913930 0.02 ENST00000368858.5
BUB3 mitotic checkpoint protein
chr14_-_93582148 0.02 ENST00000267615.6
ENST00000553452.1
inositol-tetrakisphosphate 1-kinase
chr13_-_46626820 0.02 ENST00000428921.1
zinc finger CCCH-type containing 13
chr17_-_48227877 0.02 ENST00000316878.6
protein phosphatase 1, regulatory subunit 9B
chr4_-_20985632 0.02 ENST00000359001.5
Kv channel interacting protein 4
chr11_+_61595752 0.02 ENST00000521849.1
fatty acid desaturase 2
chr1_-_48462566 0.02 ENST00000606738.2
TraB domain containing 2B
chr19_+_41770269 0.02 ENST00000378215.4
heterogeneous nuclear ribonucleoprotein U-like 1
chr3_-_195808980 0.02 ENST00000360110.4
transferrin receptor
chr12_-_125348448 0.02 ENST00000339570.5
scavenger receptor class B, member 1
chrX_+_136648643 0.02 ENST00000370606.3
Zic family member 3
chr8_-_42234745 0.02 ENST00000220812.2
dickkopf WNT signaling pathway inhibitor 4
chr12_+_7342441 0.02 ENST00000412720.2
ENST00000396637.3
peroxisomal biogenesis factor 5
chr11_+_61595572 0.02 ENST00000517312.1
fatty acid desaturase 2
chr6_+_168841817 0.02 ENST00000356284.2
ENST00000354536.5
SPARC related modular calcium binding 2
chr1_-_155177677 0.02 ENST00000368378.3
ENST00000541990.1
ENST00000457183.2
thrombospondin 3
chr21_-_18985230 0.02 ENST00000457956.1
ENST00000348354.6
BTG family, member 3
chr8_-_133493200 0.02 ENST00000388996.4
potassium voltage-gated channel, KQT-like subfamily, member 3
chr20_-_45976816 0.02 ENST00000441977.1
zinc finger, MYND-type containing 8
chr3_+_9958758 0.02 ENST00000383812.4
ENST00000438091.1
ENST00000295981.3
ENST00000436503.1
ENST00000403601.3
ENST00000416074.2
ENST00000455057.1
interleukin 17 receptor C
chr19_+_6740888 0.02 ENST00000596673.1
thyroid hormone receptor interactor 10
chr19_-_57183114 0.02 ENST00000537055.2
ENST00000601659.1
zinc finger protein 835
chr19_-_15311713 0.02 ENST00000601011.1
ENST00000263388.2
notch 3
chr12_+_54410664 0.02 ENST00000303406.4
homeobox C4
chr1_+_55271736 0.02 ENST00000358193.3
ENST00000371273.3
chromosome 1 open reading frame 177
chr1_-_204121013 0.02 ENST00000367201.3
ethanolamine kinase 2
chr3_+_180630090 0.02 ENST00000357559.4
ENST00000305586.7
fragile X mental retardation, autosomal homolog 1
chr16_+_27325202 0.01 ENST00000395762.2
ENST00000562142.1
ENST00000561742.1
ENST00000543915.2
ENST00000449195.1
ENST00000380922.3
ENST00000563002.1
interleukin 4 receptor
chr16_+_71392616 0.01 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
calbindin 2
chr9_+_112542572 0.01 ENST00000374530.3
PALM2-AKAP2 readthrough
chr11_-_47207950 0.01 ENST00000298838.6
ENST00000531226.1
ENST00000524509.1
ENST00000528201.1
ENST00000530513.1
protein kinase C and casein kinase substrate in neurons 3
chr1_-_165414414 0.01 ENST00000359842.5
retinoid X receptor, gamma
chr6_-_35480640 0.01 ENST00000428978.1
ENST00000322263.4
tubby like protein 1
chr19_+_45582453 0.01 ENST00000591607.1
ENST00000591747.1
ENST00000270257.4
ENST00000391951.2
ENST00000587566.1
gem (nuclear organelle) associated protein 7
MAP/microtubule affinity-regulating kinase 4
chr4_+_128982490 0.01 ENST00000394288.3
ENST00000432347.2
ENST00000264584.5
ENST00000441387.1
ENST00000427266.1
ENST00000354456.3
La ribonucleoprotein domain family, member 1B
chr1_-_33366931 0.01 ENST00000373463.3
ENST00000329151.5
transmembrane protein 54
chr5_-_176057518 0.01 ENST00000393693.2
synuclein, beta
chr8_-_103668114 0.01 ENST00000285407.6
Kruppel-like factor 10
chr19_-_4043154 0.01 ENST00000535853.1
AC016586.1
chr4_+_128982430 0.01 ENST00000512292.1
ENST00000508819.1
La ribonucleoprotein domain family, member 1B
chr20_+_44462481 0.01 ENST00000491381.1
ENST00000342644.5
ENST00000372542.1
sorting nexin family member 21
chr4_-_152329987 0.01 ENST00000508847.1
RP11-610P16.1
chr14_-_77608121 0.01 ENST00000319374.4
zinc finger, DHHC-type containing 22
chr10_+_135340859 0.01 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr9_+_131549610 0.01 ENST00000223865.8
TBC1 domain family, member 13
chr3_+_196439275 0.01 ENST00000296333.5
phosphatidylinositol glycan anchor biosynthesis, class X
chr11_-_6495082 0.01 ENST00000536344.1
tripartite motif containing 3
chr7_-_23053693 0.01 ENST00000409763.1
ENST00000409923.1
family with sequence similarity 126, member A
chr7_-_30029328 0.01 ENST00000425819.2
ENST00000409570.1
secernin 1
chr7_-_23053719 0.01 ENST00000432176.2
ENST00000440481.1
family with sequence similarity 126, member A
chrX_+_49028265 0.01 ENST00000376322.3
ENST00000376327.5
proteolipid protein 2 (colonic epithelium-enriched)
chr9_+_112542591 0.01 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr12_-_125348329 0.01 ENST00000546215.1
ENST00000415380.2
ENST00000261693.6
ENST00000376788.1
ENST00000545493.1
scavenger receptor class B, member 1
chr4_+_152330390 0.01 ENST00000503146.1
ENST00000435205.1
family with sequence similarity 160, member A1
chr19_+_10531150 0.01 ENST00000352831.6
phosphodiesterase 4A, cAMP-specific
chr8_+_145065705 0.01 ENST00000533044.1
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr15_-_59225844 0.01 ENST00000380516.2
SAFB-like, transcription modulator
chr2_-_46769694 0.01 ENST00000522587.1
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
chr8_+_22423168 0.01 ENST00000518912.1
ENST00000428103.1
sorbin and SH3 domain containing 3
chr3_-_114173530 0.00 ENST00000470311.1
zinc finger and BTB domain containing 20
chr16_+_3014217 0.00 ENST00000572045.1
kringle containing transmembrane protein 2
chr11_-_64510409 0.00 ENST00000394429.1
ENST00000394428.1
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr7_-_27219849 0.00 ENST00000396344.4
homeobox A10
chr11_-_107729504 0.00 ENST00000265836.7
solute carrier family 35, member F2
chr15_-_66649010 0.00 ENST00000367709.4
ENST00000261881.4
TIMELESS interacting protein
chr6_-_35480705 0.00 ENST00000229771.6
tubby like protein 1
chr11_-_1036706 0.00 ENST00000421673.2
mucin 6, oligomeric mucus/gel-forming
chr3_-_52931557 0.00 ENST00000504329.1
ENST00000355083.5
TMEM110-MUSTN1 readthrough
transmembrane protein 110
chr19_+_14544099 0.00 ENST00000242783.6
ENST00000586557.1
ENST00000590097.1
protein kinase N1
chr5_+_169011033 0.00 ENST00000513795.1
spindle apparatus coiled-coil protein 1
chr8_+_145065521 0.00 ENST00000534791.1
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr2_+_62932779 0.00 ENST00000427809.1
ENST00000405482.1
ENST00000431489.1
EH domain binding protein 1
chr10_+_17271266 0.00 ENST00000224237.5
vimentin
chr19_+_41770236 0.00 ENST00000392006.3
heterogeneous nuclear ribonucleoprotein U-like 1
chr19_+_20011775 0.00 ENST00000592245.1
ENST00000592160.1
ENST00000343769.5
AC007204.2
zinc finger protein 93

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF423

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 0.3 GO:0018262 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.0 0.1 GO:0015688 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.0 0.1 GO:0033383 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.0 0.0 GO:0038183 bile acid signaling pathway(GO:0038183)
0.0 0.0 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.1 GO:0045626 negative regulation of T-helper 1 cell differentiation(GO:0045626)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:1990923 PET complex(GO:1990923)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.0 0.1 GO:0033597 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0004913 interleukin-4 receptor activity(GO:0004913)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.1 GO:0052726 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835)
0.0 0.1 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.0 GO:0038181 bile acid receptor activity(GO:0038181)
0.0 0.0 GO:0000822 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)