Motif ID: Aire

Z-value: 0.978


Transcription factors associated with Aire:

Gene SymbolEntrez IDGene Name
Aire ENSMUSG00000000731.9 Aire



Activity profile for motif Aire.

activity profile for motif Aire


Sorted Z-values histogram for motif Aire

Sorted Z-values for motif Aire



Network of associatons between targets according to the STRING database.


Top targets:


Showing 1 to 20 of 89 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_61185558 58.851 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr13_-_110280103 11.086 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr8_+_69808672 9.647 ENSMUST00000036074.8
ENSMUST00000123453.1
 Gmip

Gem-interacting protein

chr12_-_78983476 8.650 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr5_-_84417359 7.837 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr10_+_123264076 7.628 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr3_-_116968969 7.128 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr2_+_55435918 5.636 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr18_+_37400845 5.003 ENSMUST00000057228.1
 Pcdhb9
protocadherin beta 9
chr9_-_53610329 4.919 ENSMUST00000034547.5
 Acat1
acetyl-Coenzyme A acetyltransferase 1
chr7_-_127895578 4.642 ENSMUST00000033074.6
 Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr16_+_36875119 4.416 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
 Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chr14_+_76476913 4.415 ENSMUST00000140251.2
 Tsc22d1
TSC22 domain family, member 1
chr7_+_60155538 4.066 ENSMUST00000057611.4
 Gm7367
predicted pseudogene 7367
chr2_-_134644079 4.001 ENSMUST00000110119.1
 Tmx4
thioredoxin-related transmembrane protein 4
chr18_+_37725706 3.945 ENSMUST00000066149.6
 Pcdhga9
protocadherin gamma subfamily A, 9
chr10_+_86021961 3.874 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chr19_-_28963863 3.627 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr16_-_91618986 2.683 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr10_-_130280218 2.665 ENSMUST00000061571.3
 Neurod4
neurogenic differentiation 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.1 GO:0019882 antigen processing and presentation(GO:0019882)
0.8 7.8 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 7.1 GO:0008360 regulation of cell shape(GO:0008360)
0.2 5.6 GO:0010107 potassium ion import(GO:0010107)
0.1 5.3 GO:0045454 cell redox homeostasis(GO:0045454)
1.5 4.6 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 3.9 GO:0045620 negative regulation of lymphocyte differentiation(GO:0045620)
0.3 2.7 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 2.7 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.3 2.6 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 2.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 2.6 GO:0015992 proton transport(GO:0015992)
0.6 2.3 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0 2.3 GO:0098792 xenophagy(GO:0098792)
0.4 2.1 GO:0033762 response to glucagon(GO:0033762)
0.1 2.0 GO:0006862 nucleotide transport(GO:0006862)
0.0 2.0 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.6 1.9 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 1.9 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.1 1.8 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.1 GO:0008021 synaptic vesicle(GO:0008021)
0.1 7.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 7.1 GO:0043197 dendritic spine(GO:0043197)
0.1 5.6 GO:0030315 T-tubule(GO:0030315)
0.1 4.4 GO:0005801 cis-Golgi network(GO:0005801)
0.0 4.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 3.9 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.1 2.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 2.3 GO:0017119 Golgi transport complex(GO:0017119)
0.2 2.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 2.1 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 1.8 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 1.7 GO:0000786 nucleosome(GO:0000786)
0.1 1.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 1.3 GO:0001527 microfibril(GO:0001527)
0.3 1.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 1.1 GO:0005643 nuclear pore(GO:0005643)
0.2 1.0 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 1.0 GO:0070971 endoplasmic reticulum exit site(GO:0070971)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 11.1 GO:0031489 myosin V binding(GO:0031489)
1.0 7.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 6.9 GO:0005096 GTPase activator activity(GO:0005096)
1.1 5.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 5.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.8 4.9 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.4 4.6 GO:0048038 quinone binding(GO:0048038)
0.0 2.6 GO:0030246 carbohydrate binding(GO:0030246)
0.1 2.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 2.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 2.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.3 2.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 2.0 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.2 1.8 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.1 1.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 1.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.6 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.2 1.5 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 1.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)