Motif ID: Aire
Z-value: 0.978
Transcription factors associated with Aire:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Aire | ENSMUSG00000000731.9 | Aire |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.5 | 4.6 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
0.8 | 7.8 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
0.6 | 1.9 | GO:0042726 | flavin-containing compound metabolic process(GO:0042726) |
0.6 | 2.3 | GO:0032788 | saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789) |
0.4 | 2.1 | GO:0033762 | response to glucagon(GO:0033762) |
0.4 | 1.1 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
0.3 | 1.0 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
0.3 | 1.0 | GO:0034241 | positive regulation of macrophage fusion(GO:0034241) regulation of osteoclast proliferation(GO:0090289) |
0.3 | 1.5 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549) positive regulation of receptor binding(GO:1900122) |
0.3 | 2.7 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
0.3 | 2.6 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
0.2 | 0.7 | GO:0006097 | glyoxylate cycle(GO:0006097) |
0.2 | 5.6 | GO:0010107 | potassium ion import(GO:0010107) |
0.2 | 0.8 | GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) positive regulation of extracellular exosome assembly(GO:1903553) |
0.2 | 0.5 | GO:0001803 | antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805) |
0.1 | 1.8 | GO:0090244 | Wnt signaling pathway involved in somitogenesis(GO:0090244) |
0.1 | 1.4 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.1 | 0.5 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.1 | 2.7 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
0.1 | 11.1 | GO:0019882 | antigen processing and presentation(GO:0019882) |
0.1 | 0.9 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
0.1 | 3.9 | GO:0045620 | negative regulation of lymphocyte differentiation(GO:0045620) |
0.1 | 1.2 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
0.1 | 5.3 | GO:0045454 | cell redox homeostasis(GO:0045454) |
0.1 | 2.0 | GO:0006862 | nucleotide transport(GO:0006862) |
0.1 | 0.6 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
0.1 | 1.5 | GO:0032288 | myelin assembly(GO:0032288) |
0.1 | 2.6 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
0.1 | 1.5 | GO:0015813 | L-glutamate transport(GO:0015813) |
0.0 | 1.4 | GO:0043330 | response to exogenous dsRNA(GO:0043330) |
0.0 | 0.5 | GO:0086023 | adrenergic receptor signaling pathway involved in heart process(GO:0086023) |
0.0 | 1.1 | GO:0033006 | regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304) |
0.0 | 7.1 | GO:0008360 | regulation of cell shape(GO:0008360) |
0.0 | 0.3 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
0.0 | 2.6 | GO:0015992 | proton transport(GO:0015992) |
0.0 | 1.4 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
0.0 | 2.3 | GO:0098792 | xenophagy(GO:0098792) |
0.0 | 0.9 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
0.0 | 0.2 | GO:1902414 | protein localization to cell junction(GO:1902414) |
0.0 | 1.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
0.0 | 1.7 | GO:0016579 | protein deubiquitination(GO:0016579) |
0.0 | 0.3 | GO:0045475 | locomotor rhythm(GO:0045475) |
0.0 | 0.2 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
0.0 | 2.0 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
0.0 | 0.8 | GO:0035567 | non-canonical Wnt signaling pathway(GO:0035567) |
0.0 | 0.0 | GO:0046950 | cellular ketone body metabolic process(GO:0046950) |
0.0 | 1.9 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.2 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
0.3 | 0.9 | GO:0070469 | respiratory chain(GO:0070469) |
0.3 | 2.1 | GO:0045275 | respiratory chain complex III(GO:0045275) |
0.2 | 2.2 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
0.2 | 1.0 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
0.2 | 2.3 | GO:0017119 | Golgi transport complex(GO:0017119) |
0.1 | 1.3 | GO:0001527 | microfibril(GO:0001527) |
0.1 | 7.8 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
0.1 | 4.4 | GO:0005801 | cis-Golgi network(GO:0005801) |
0.1 | 1.5 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
0.1 | 1.8 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
0.1 | 1.0 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
0.1 | 11.1 | GO:0008021 | synaptic vesicle(GO:0008021) |
0.1 | 5.6 | GO:0030315 | T-tubule(GO:0030315) |
0.1 | 2.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.0 | 7.1 | GO:0043197 | dendritic spine(GO:0043197) |
0.0 | 2.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.0 | 0.9 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
0.0 | 0.4 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.0 | 0.5 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
0.0 | 1.7 | GO:0000786 | nucleosome(GO:0000786) |
0.0 | 4.1 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
0.0 | 3.9 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
0.0 | 1.1 | GO:0005643 | nuclear pore(GO:0005643) |
0.0 | 0.6 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 5.6 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
1.0 | 7.8 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
0.8 | 4.9 | GO:0016453 | acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453) |
0.5 | 11.1 | GO:0031489 | myosin V binding(GO:0031489) |
0.4 | 4.6 | GO:0048038 | quinone binding(GO:0048038) |
0.3 | 1.0 | GO:0003692 | left-handed Z-DNA binding(GO:0003692) |
0.3 | 1.4 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
0.3 | 0.8 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
0.3 | 2.1 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.3 | 5.3 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
0.2 | 0.7 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
0.2 | 1.5 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
0.2 | 2.2 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
0.2 | 1.8 | GO:0016920 | pyroglutamyl-peptidase activity(GO:0016920) |
0.2 | 0.5 | GO:0019770 | IgG receptor activity(GO:0019770) |
0.2 | 0.9 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
0.2 | 0.5 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
0.1 | 2.3 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
0.1 | 2.0 | GO:0015215 | nucleotide transmembrane transporter activity(GO:0015215) |
0.1 | 0.3 | GO:0004980 | melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980) |
0.1 | 1.5 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
0.1 | 1.4 | GO:0035380 | C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677) |
0.1 | 1.8 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
0.1 | 1.5 | GO:0001968 | fibronectin binding(GO:0001968) |
0.1 | 0.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.1 | 1.4 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
0.0 | 1.1 | GO:0019789 | SUMO transferase activity(GO:0019789) |
0.0 | 1.4 | GO:0050699 | WW domain binding(GO:0050699) |
0.0 | 0.8 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 0.2 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) |
0.0 | 1.7 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
0.0 | 0.6 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 2.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
0.0 | 6.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.0 | 1.7 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
0.0 | 0.5 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
0.0 | 1.6 | GO:0008234 | cysteine-type peptidase activity(GO:0008234) |
0.0 | 2.6 | GO:0030246 | carbohydrate binding(GO:0030246) |
0.0 | 0.0 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
0.0 | 0.5 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |