Motif ID: Ascl2

Z-value: 0.951


Transcription factors associated with Ascl2:

Gene SymbolEntrez IDGene Name
Ascl2 ENSMUSG00000009248.5 Ascl2



Activity profile for motif Ascl2.

activity profile for motif Ascl2


Sorted Z-values histogram for motif Ascl2

Sorted Z-values for motif Ascl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ascl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_33923582 9.035 ENSMUST00000168727.1
 Gdf10
growth differentiation factor 10
chr2_-_122611238 7.607 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr2_-_170406501 7.167 ENSMUST00000154650.1
 Bcas1
breast carcinoma amplified sequence 1
chr16_+_91269759 5.280 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr12_-_40038025 5.036 ENSMUST00000101472.3
 Arl4a
ADP-ribosylation factor-like 4A
chr16_+_65815508 5.035 ENSMUST00000168064.1
 Vgll3
vestigial like 3 (Drosophila)
chr12_-_40037387 4.970 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr8_+_105518736 4.917 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr2_-_92370999 4.852 ENSMUST00000176810.1
ENSMUST00000090582.4
 Gyltl1b

glycosyltransferase-like 1B

chr9_-_43239816 4.698 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr7_+_45216671 4.541 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr7_+_142471838 4.506 ENSMUST00000038946.2
 Lsp1
lymphocyte specific 1
chrX_-_106485214 4.489 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1
chr8_-_105471481 4.278 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr10_+_94514825 4.255 ENSMUST00000065060.5
 Tmcc3
transmembrane and coiled coil domains 3
chr7_+_142472080 4.098 ENSMUST00000105966.1
 Lsp1
lymphocyte specific 1
chr4_-_43523388 3.985 ENSMUST00000107913.3
ENSMUST00000030184.5
 Tpm2

tropomyosin 2, beta

chrX_-_106485367 3.849 ENSMUST00000140707.1
 Fndc3c1
fibronectin type III domain containing 3C1
chr13_+_37826225 3.820 ENSMUST00000128570.1
 Rreb1
ras responsive element binding protein 1
chr4_+_45184815 3.691 ENSMUST00000134280.1
ENSMUST00000044773.5
 Frmpd1

FERM and PDZ domain containing 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 205 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.9 GO:0050873 brown fat cell differentiation(GO:0050873)
2.5 7.6 GO:0006601 creatine biosynthetic process(GO:0006601)
0.5 7.2 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.2 7.2 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.1 5.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.7 4.9 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.4 4.9 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.5 4.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 4.5 GO:0048368 lateral mesoderm development(GO:0048368)
0.1 4.3 GO:0001578 microtubule bundle formation(GO:0001578)
1.0 4.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.3 4.1 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 4.1 GO:0048663 neuron fate commitment(GO:0048663)
0.1 4.0 GO:0006270 DNA replication initiation(GO:0006270)
0.3 3.9 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 3.9 GO:0001890 placenta development(GO:0001890)
1.0 3.8 GO:0006842 tricarboxylic acid transport(GO:0006842) succinate transport(GO:0015744) citrate transport(GO:0015746)
0.5 3.8 GO:1903689 regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.9 3.7 GO:0010957 negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.3 3.6 GO:0090205 positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 38.4 GO:0044421 extracellular region part(GO:0044421)
0.0 15.9 GO:0005667 transcription factor complex(GO:0005667)
1.5 13.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 8.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 7.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 4.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 4.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 4.5 GO:0005581 collagen trimer(GO:0005581)
0.2 3.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 3.6 GO:0022626 cytosolic ribosome(GO:0022626)
0.5 3.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 3.5 GO:0005819 spindle(GO:0005819)
0.0 3.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 3.4 GO:0009897 external side of plasma membrane(GO:0009897)
1.1 3.3 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.9 2.8 GO:0005588 collagen type V trimer(GO:0005588)
0.1 2.8 GO:0000791 euchromatin(GO:0000791)
0.1 2.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 2.5 GO:0030478 actin cap(GO:0030478)
0.0 2.5 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 13.5 GO:0003924 GTPase activity(GO:0003924)
0.4 9.0 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.2 7.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
1.4 6.9 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.2 6.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 6.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 5.9 GO:0005198 structural molecule activity(GO:0005198)
0.0 5.8 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.3 5.6 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.1 5.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.4 4.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 4.9 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 4.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.4 4.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 4.0 GO:0015631 tubulin binding(GO:0015631)
1.3 3.8 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.0 3.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 3.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 3.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)