Motif ID: Atf4

Z-value: 1.222


Transcription factors associated with Atf4:

Gene SymbolEntrez IDGene Name
Atf4 ENSMUSG00000042406.7 Atf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_802552630.462.1e-04Click!


Activity profile for motif Atf4.

activity profile for motif Atf4


Sorted Z-values histogram for motif Atf4

Sorted Z-values for motif Atf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 102 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 23.921 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_+_144896523 17.155 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr1_-_71653162 11.888 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr13_-_53473074 9.752 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr11_-_75422586 9.049 ENSMUST00000138661.1
ENSMUST00000000769.7
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr4_+_46450892 8.920 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chrX_+_103422010 7.799 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr11_-_75422524 7.500 ENSMUST00000125982.1
ENSMUST00000137103.1
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr13_+_49682191 7.015 ENSMUST00000172254.1
 Iars
isoleucine-tRNA synthetase
chr8_+_75093591 6.491 ENSMUST00000005548.6
 Hmox1
heme oxygenase (decycling) 1
chr1_-_191183244 6.200 ENSMUST00000027941.8
 Atf3
activating transcription factor 3
chr19_-_12501996 6.034 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr4_-_129189600 5.911 ENSMUST00000117497.1
ENSMUST00000117350.1
 S100pbp

S100P binding protein

chr19_+_53140430 5.857 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr13_+_49682100 5.598 ENSMUST00000165316.1
ENSMUST00000047363.7
 Iars

isoleucine-tRNA synthetase

chr4_+_43957678 5.412 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chr12_-_104865076 5.358 ENSMUST00000109937.1
ENSMUST00000109936.1
 Clmn

calmin

chrX_+_106187100 5.271 ENSMUST00000081593.6
 Pgk1
phosphoglycerate kinase 1
chr4_-_129189512 4.616 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
 S100pbp


S100P binding protein


chr4_-_129189646 4.610 ENSMUST00000106059.1
 S100pbp
S100P binding protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 23.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
4.3 17.2 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
2.1 16.5 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
4.2 12.6 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
4.0 11.9 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161)
3.3 9.8 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.2 8.9 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.3 8.7 GO:0010960 magnesium ion homeostasis(GO:0010960)
2.5 7.4 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.0 6.7 GO:0006412 translation(GO:0006412)
2.2 6.5 GO:1904706 response to cisplatin(GO:0072718) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
1.5 6.2 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.2 5.8 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.2 5.6 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.1 5.4 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 5.3 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 4.3 GO:0007219 Notch signaling pathway(GO:0007219)
0.7 4.0 GO:1903352 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.1 3.9 GO:0006094 gluconeogenesis(GO:0006094)
0.4 3.7 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 60.7 GO:0005634 nucleus(GO:0005634)
1.2 16.5 GO:0043203 axon hillock(GO:0043203)
4.0 11.9 GO:0005577 fibrinogen complex(GO:0005577)
0.0 10.7 GO:0005730 nucleolus(GO:0005730)
0.0 9.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 6.5 GO:0005901 caveola(GO:0005901)
0.1 5.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 5.5 GO:0000139 Golgi membrane(GO:0000139)
0.7 5.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 5.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 4.6 GO:0016459 myosin complex(GO:0016459)
0.0 4.1 GO:0005840 ribosome(GO:0005840)
0.2 3.0 GO:0031528 microvillus membrane(GO:0031528)
0.0 2.7 GO:0005643 nuclear pore(GO:0005643)
0.0 2.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.5 GO:0000793 condensed chromosome(GO:0000793)
0.3 2.0 GO:0042825 TAP complex(GO:0042825)
0.2 1.9 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.4 1.7 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 1.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 48.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.8 17.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.4 16.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 15.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
3.2 12.7 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
4.2 12.6 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
2.0 11.9 GO:0045340 mercury ion binding(GO:0045340)
0.3 11.4 GO:0000049 tRNA binding(GO:0000049)
0.0 11.2 GO:0003779 actin binding(GO:0003779)
0.3 9.8 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812)
1.6 6.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 6.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 6.0 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.0 4.6 GO:0003774 motor activity(GO:0003774)
0.6 4.0 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
1.2 3.7 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 3.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.6 3.6 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.8 3.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
1.0 3.0 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)