Motif ID: Bcl6

Z-value: 0.978


Transcription factors associated with Bcl6:

Gene SymbolEntrez IDGene Name
Bcl6 ENSMUSG00000022508.5 Bcl6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl6mm10_v2_chr16_-_23988852_239888520.644.2e-08Click!


Activity profile for motif Bcl6.

activity profile for motif Bcl6


Sorted Z-values histogram for motif Bcl6

Sorted Z-values for motif Bcl6



Network of associatons between targets according to the STRING database.



First level regulatory network of Bcl6

PNG image of the network

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Top targets:


Showing 1 to 20 of 194 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_64046925 12.535 ENSMUST00000107377.3
 Tnc
tenascin C
chr1_-_169747634 10.566 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr3_-_152982240 8.045 ENSMUST00000044278.5
 St6galnac5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr6_+_115134899 7.155 ENSMUST00000009538.5
ENSMUST00000169345.1
 Syn2

synapsin II

chr15_-_54919961 6.498 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
 Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr3_-_80802789 6.206 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr11_+_101245996 5.980 ENSMUST00000129680.1
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr4_+_144892813 5.597 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chrX_-_61185558 5.328 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr18_+_37484955 5.004 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr9_+_107296843 4.963 ENSMUST00000167072.1
 Cish
cytokine inducible SH2-containing protein
chr15_-_54920115 4.793 ENSMUST00000171545.1
 Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr12_+_88953399 4.687 ENSMUST00000057634.7
 Nrxn3
neurexin III
chr10_+_58813359 4.556 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr9_+_50752758 4.426 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr1_-_133753681 4.305 ENSMUST00000125659.1
ENSMUST00000165602.2
ENSMUST00000048953.7
 Atp2b4


ATPase, Ca++ transporting, plasma membrane 4


chr4_+_144893077 4.131 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr19_+_34217588 4.107 ENSMUST00000119603.1
 Stambpl1
STAM binding protein like 1
chr10_+_100015817 4.034 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr15_-_8710409 4.020 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 13.3 GO:0042572 retinol metabolic process(GO:0042572)
3.1 12.5 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
1.6 11.3 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.2 10.6 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.3 8.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.6 8.0 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
2.0 7.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 7.2 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
1.7 6.8 GO:0042938 dipeptide transport(GO:0042938)
0.3 6.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.6 6.0 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 5.5 GO:0060612 adipose tissue development(GO:0060612)
0.7 5.4 GO:0032264 IMP salvage(GO:0032264)
1.0 4.9 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.2 4.7 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 4.6 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.7 4.4 GO:0007021 tubulin complex assembly(GO:0007021)
1.4 4.3 GO:0010751 regulation of arginine metabolic process(GO:0000821) negative regulation of nitric oxide mediated signal transduction(GO:0010751) negative regulation of cellular amino acid metabolic process(GO:0045763)
0.9 4.3 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.4 4.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.7 GO:0005887 integral component of plasma membrane(GO:0005887)
0.8 13.3 GO:0005614 interstitial matrix(GO:0005614)
0.3 8.4 GO:0060077 inhibitory synapse(GO:0060077)
0.5 7.9 GO:0043205 fibril(GO:0043205)
0.1 6.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 6.2 GO:0032279 asymmetric synapse(GO:0032279)
0.2 4.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 4.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 4.6 GO:0043235 receptor complex(GO:0043235)
1.5 4.4 GO:0097512 cardiac myofibril(GO:0097512)
0.2 4.3 GO:0097228 sperm principal piece(GO:0097228)
0.1 3.9 GO:0031672 A band(GO:0031672)
0.7 3.5 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 3.4 GO:0005776 autophagosome(GO:0005776)
0.0 3.4 GO:0072562 blood microparticle(GO:0072562)
0.0 3.4 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 3.1 GO:0005811 lipid particle(GO:0005811)
0.0 3.1 GO:0005604 basement membrane(GO:0005604)
0.2 2.9 GO:0044292 dendrite terminus(GO:0044292)
0.2 2.5 GO:0005915 zonula adherens(GO:0005915)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 13.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
2.1 12.5 GO:0045545 syndecan binding(GO:0045545)
2.8 11.3 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.2 10.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
1.1 8.0 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
1.6 7.9 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
1.4 6.8 GO:0042895 antibiotic transporter activity(GO:0042895)
0.1 6.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
1.0 6.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 5.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.8 5.4 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 5.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 5.2 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.7 4.9 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 4.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.7 4.6 GO:0097322 7SK snRNA binding(GO:0097322)
0.5 4.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.3 4.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.3 4.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 4.2 GO:0015026 coreceptor activity(GO:0015026)