Motif ID: Bhlhe40
Z-value: 0.531
Transcription factors associated with Bhlhe40:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Bhlhe40 | ENSMUSG00000030103.5 | Bhlhe40 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Bhlhe40 | mm10_v2_chr6_+_108660616_108660682 | -0.50 | 6.3e-05 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 9.0 | GO:0070829 | heterochromatin maintenance(GO:0070829) |
| 0.4 | 1.2 | GO:0006419 | alanyl-tRNA aminoacylation(GO:0006419) |
| 0.3 | 0.9 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
| 0.2 | 2.1 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.2 | 1.8 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.2 | 0.5 | GO:2000508 | regulation of dendritic cell chemotaxis(GO:2000508) positive regulation of dendritic cell chemotaxis(GO:2000510) |
| 0.2 | 1.2 | GO:0046477 | glycosylceramide catabolic process(GO:0046477) |
| 0.2 | 0.6 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) myotome development(GO:0061055) |
| 0.1 | 0.9 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.1 | 0.4 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 0.1 | 0.3 | GO:0002940 | tRNA N2-guanine methylation(GO:0002940) |
| 0.1 | 0.4 | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049) |
| 0.1 | 0.3 | GO:0072429 | response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) response to intra-S DNA damage checkpoint signaling(GO:0072429) |
| 0.1 | 0.4 | GO:0006407 | rRNA export from nucleus(GO:0006407) |
| 0.1 | 0.6 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.1 | 2.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.8 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.1 | 0.3 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.1 | 0.2 | GO:1902219 | regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
| 0.1 | 1.9 | GO:0015991 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662) |
| 0.1 | 0.2 | GO:2000574 | regulation of microtubule motor activity(GO:2000574) |
| 0.1 | 1.1 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.1 | 0.3 | GO:0002922 | positive regulation of humoral immune response(GO:0002922) progesterone receptor signaling pathway(GO:0050847) |
| 0.1 | 2.0 | GO:0097178 | ruffle assembly(GO:0097178) |
| 0.1 | 0.2 | GO:0046032 | ADP catabolic process(GO:0046032) |
| 0.1 | 0.9 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.0 | 1.1 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.0 | 3.4 | GO:0006405 | RNA export from nucleus(GO:0006405) |
| 0.0 | 0.7 | GO:0080111 | DNA demethylation(GO:0080111) |
| 0.0 | 0.4 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.0 | 1.4 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.0 | 0.4 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.0 | 0.4 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.4 | GO:0033363 | secretory granule organization(GO:0033363) |
| 0.0 | 0.5 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 0.4 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.0 | 0.5 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 2.0 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) |
| 0.0 | 0.1 | GO:0035542 | endosomal vesicle fusion(GO:0034058) regulation of SNARE complex assembly(GO:0035542) |
| 0.0 | 0.3 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.0 | 0.5 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.0 | 0.4 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.0 | 0.4 | GO:0034724 | DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724) |
| 0.0 | 1.4 | GO:0001889 | liver development(GO:0001889) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.4 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.3 | 1.8 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.2 | 1.9 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 1.0 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.1 | 2.8 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.1 | 0.5 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.1 | 0.9 | GO:0033503 | HULC complex(GO:0033503) |
| 0.1 | 0.4 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.1 | 2.0 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.1 | 1.4 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 1.1 | GO:0000800 | lateral element(GO:0000800) |
| 0.1 | 0.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 0.6 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.1 | 0.5 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 0.1 | 0.4 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.1 | 0.3 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
| 0.0 | 0.8 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 0.3 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.0 | 0.8 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 3.7 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 2.1 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.0 | 0.9 | GO:0031519 | PcG protein complex(GO:0031519) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 9.0 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.4 | 1.8 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.4 | 1.2 | GO:0004813 | alanine-tRNA ligase activity(GO:0004813) |
| 0.3 | 2.0 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
| 0.2 | 0.7 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
| 0.2 | 0.6 | GO:0015173 | hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.2 | 1.4 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.2 | 3.4 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.2 | 0.9 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.1 | 0.4 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.1 | 0.8 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.1 | 0.4 | GO:0004348 | glucosylceramidase activity(GO:0004348) |
| 0.1 | 2.8 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.1 | 0.3 | GO:0001851 | complement component C3b binding(GO:0001851) proteinase activated receptor binding(GO:0031871) |
| 0.1 | 2.0 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.1 | 0.4 | GO:0000832 | inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) |
| 0.1 | 0.4 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.1 | 1.4 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 0.2 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
| 0.1 | 2.1 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.2 | GO:0005128 | erythropoietin receptor binding(GO:0005128) |
| 0.1 | 1.9 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.1 | 0.5 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.1 | 0.2 | GO:0034597 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
| 0.1 | 0.3 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.0 | 0.5 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.4 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 0.1 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.0 | 0.2 | GO:0047631 | adenosine-diphosphatase activity(GO:0043262) ADP-ribose diphosphatase activity(GO:0047631) |
| 0.0 | 0.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 1.1 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 0.6 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 0.5 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 0.5 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.0 | 0.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 1.0 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.0 | 0.7 | GO:0019187 | beta-1,4-mannosyltransferase activity(GO:0019187) |
| 0.0 | 0.4 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
