Motif ID: Bhlhe40

Z-value: 0.531


Transcription factors associated with Bhlhe40:

Gene SymbolEntrez IDGene Name
Bhlhe40 ENSMUSG00000030103.5 Bhlhe40

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe40mm10_v2_chr6_+_108660616_108660682-0.506.3e-05Click!


Activity profile for motif Bhlhe40.

activity profile for motif Bhlhe40


Sorted Z-values histogram for motif Bhlhe40

Sorted Z-values for motif Bhlhe40



Network of associatons between targets according to the STRING database.



First level regulatory network of Bhlhe40

PNG image of the network

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Top targets:


Showing 1 to 20 of 105 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_148039097 5.070 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr4_+_148039035 3.906 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr2_+_30286406 1.802 ENSMUST00000138666.1
ENSMUST00000113634.2
 Nup188

nucleoporin 188

chr4_-_137048695 1.780 ENSMUST00000049583.7
 Zbtb40
zinc finger and BTB domain containing 40
chr19_-_4201591 1.756 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr2_+_30286383 1.576 ENSMUST00000064447.5
 Nup188
nucleoporin 188
chr17_-_12769605 1.364 ENSMUST00000024599.7
 Igf2r
insulin-like growth factor 2 receptor
chrX_-_7188713 1.351 ENSMUST00000004428.7
 Clcn5
chloride channel 5
chrX_+_136270253 1.179 ENSMUST00000178632.1
ENSMUST00000053540.4
 Ngfrap1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr8_+_111033890 1.151 ENSMUST00000034441.7
 Aars
alanyl-tRNA synthetase
chr11_-_75348261 1.127 ENSMUST00000000767.5
ENSMUST00000092907.5
 Rpa1

replication protein A1

chr12_-_3426700 1.125 ENSMUST00000180149.1
 1110002L01Rik
RIKEN cDNA 1110002L01 gene
chr8_+_85037151 1.096 ENSMUST00000166592.1
 Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr3_-_95106907 1.082 ENSMUST00000107233.2
 Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
chr7_+_121707189 1.075 ENSMUST00000065310.2
 1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr8_+_85036906 1.019 ENSMUST00000093360.4
 Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr3_+_85574109 1.012 ENSMUST00000127348.1
ENSMUST00000107672.1
ENSMUST00000107674.1
 Pet112


PET112 homolog (S. cerevisiae)


chr3_-_96727453 0.996 ENSMUST00000141377.1
ENSMUST00000125183.1
 Polr3c

polymerase (RNA) III (DNA directed) polypeptide C

chr1_-_75219245 0.957 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chrX_+_153832225 0.957 ENSMUST00000148708.1
ENSMUST00000123264.1
ENSMUST00000049999.8
 Spin2c


spindlin family, member 2C



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 9.0 GO:0070829 heterochromatin maintenance(GO:0070829)
0.0 3.4 GO:0006405 RNA export from nucleus(GO:0006405)
0.1 2.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 2.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 2.0 GO:0097178 ruffle assembly(GO:0097178)
0.0 2.0 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 1.9 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.2 1.8 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 1.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 1.4 GO:0001889 liver development(GO:0001889)
0.4 1.2 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.2 1.2 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 1.1 GO:0097352 autophagosome maturation(GO:0097352)
0.0 1.1 GO:0006298 mismatch repair(GO:0006298)
0.3 0.9 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.1 0.9 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 0.9 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.1 0.8 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.7 GO:0080111 DNA demethylation(GO:0080111)
0.2 0.6 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) myotome development(GO:0061055)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.7 3.4 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 2.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 2.1 GO:0034399 nuclear periphery(GO:0034399)
0.1 2.0 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 1.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.3 1.8 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 1.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 1.1 GO:0000800 lateral element(GO:0000800)
0.1 1.0 GO:0033263 CORVET complex(GO:0033263)
0.1 0.9 GO:0033503 HULC complex(GO:0033503)
0.0 0.9 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.8 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.6 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.5 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.5 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.1 0.4 GO:1990037 Lewy body core(GO:1990037)
0.1 0.4 GO:0043202 lysosomal lumen(GO:0043202)
0.1 0.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 9.0 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.2 3.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.8 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 2.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.3 2.0 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 2.0 GO:0005123 death receptor binding(GO:0005123)
0.1 1.9 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.4 1.8 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.2 1.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.4 1.2 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 1.1 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.0 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.2 0.9 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.8 GO:0016936 galactoside binding(GO:0016936)
0.2 0.7 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.0 0.7 GO:0019187 beta-1,4-mannosyltransferase activity(GO:0019187)
0.2 0.6 GO:0015173 hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173)