Motif ID: Brca1

Z-value: 0.777


Transcription factors associated with Brca1:

Gene SymbolEntrez IDGene Name
Brca1 ENSMUSG00000017146.6 Brca1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Brca1mm10_v2_chr11_-_101551837_1015518930.038.0e-01Click!


Activity profile for motif Brca1.

activity profile for motif Brca1


Sorted Z-values histogram for motif Brca1

Sorted Z-values for motif Brca1



Network of associatons between targets according to the STRING database.



First level regulatory network of Brca1

PNG image of the network

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Top targets:


Showing 1 to 20 of 196 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 17.833 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr15_-_97020322 5.172 ENSMUST00000166223.1
 Slc38a4
solute carrier family 38, member 4
chr7_-_102100227 4.278 ENSMUST00000106937.1
 Art5
ADP-ribosyltransferase 5
chr7_-_144939823 4.017 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr17_-_70853482 3.788 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr11_+_44617310 3.460 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chrX_+_150594420 3.154 ENSMUST00000112713.2
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr7_-_102099932 2.915 ENSMUST00000106934.1
 Art5
ADP-ribosyltransferase 5
chr19_+_55741810 2.759 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr3_+_87906321 2.725 ENSMUST00000005017.8
 Hdgf
hepatoma-derived growth factor
chr12_-_10900296 2.707 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr11_+_59306920 2.584 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr2_-_28916668 2.537 ENSMUST00000113847.1
 Barhl1
BarH-like 1 (Drosophila)
chr11_-_98625661 2.496 ENSMUST00000104933.1
 Gm12355
predicted gene 12355
chr11_-_11890368 2.476 ENSMUST00000155690.1
 Ddc
dopa decarboxylase
chr11_-_106998483 2.278 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr13_-_107890059 2.245 ENSMUST00000105097.2
 Zswim6
zinc finger SWIM-type containing 6
chr3_+_5218516 2.224 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr19_-_24225015 2.195 ENSMUST00000099558.4
 Tjp2
tight junction protein 2
chrX_+_71663665 2.176 ENSMUST00000070449.5
 Gpr50
G-protein-coupled receptor 50

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 17.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 7.2 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.2 5.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.6 5.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.6 4.0 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 3.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 3.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 3.2 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 3.1 GO:0042254 ribosome biogenesis(GO:0042254)
0.3 3.0 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 3.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.3 2.8 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 2.8 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 2.8 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.4 2.7 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 2.6 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.4 2.5 GO:0098700 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 2.5 GO:0030901 midbrain development(GO:0030901)
0.1 2.4 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.3 2.3 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 5.0 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 4.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 4.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.3 GO:0005643 nuclear pore(GO:0005643)
0.0 3.2 GO:0008021 synaptic vesicle(GO:0008021)
0.3 3.0 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.3 2.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 2.8 GO:0001739 sex chromatin(GO:0001739)
0.4 2.7 GO:1990635 proximal dendrite(GO:1990635)
0.1 2.4 GO:0031512 motile primary cilium(GO:0031512)
0.4 2.3 GO:0000125 PCAF complex(GO:0000125)
0.1 2.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 2.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 2.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 2.2 GO:0005921 gap junction(GO:0005921)
0.1 2.0 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 1.9 GO:0005911 cell-cell junction(GO:0005911)
0.0 1.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.8 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
2.4 7.2 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 6.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 6.1 GO:0008432 JUN kinase binding(GO:0008432)
0.4 5.8 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 5.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 5.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.7 5.0 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.2 4.0 GO:0070064 proline-rich region binding(GO:0070064)
0.1 4.0 GO:0005109 frizzled binding(GO:0005109)
0.2 3.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 3.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.5 3.0 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.0 2.9 GO:0003682 chromatin binding(GO:0003682)
0.1 2.8 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 2.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.6 2.5 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.0 2.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 2.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 2.3 GO:0008174 mRNA methyltransferase activity(GO:0008174)