Motif ID: Clock
Z-value: 0.463
Transcription factors associated with Clock:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Clock | ENSMUSG00000029238.8 | Clock |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Clock | mm10_v2_chr5_-_76304474_76304548 | 0.47 | 1.9e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.5 | GO:0048818 | positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005) |
| 0.6 | 3.0 | GO:0070460 | thyroid-stimulating hormone secretion(GO:0070460) |
| 0.5 | 1.5 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.4 | 1.7 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.3 | 0.9 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.3 | 1.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 0.8 | GO:0042373 | vitamin K metabolic process(GO:0042373) |
| 0.2 | 0.4 | GO:0097252 | oligodendrocyte apoptotic process(GO:0097252) |
| 0.2 | 1.0 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.2 | 1.0 | GO:0090273 | regulation of somatostatin secretion(GO:0090273) |
| 0.2 | 1.0 | GO:0033600 | negative regulation of mammary gland epithelial cell proliferation(GO:0033600) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 0.2 | 0.9 | GO:0031536 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) positive regulation of exit from mitosis(GO:0031536) |
| 0.2 | 0.7 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.2 | 0.8 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 0.2 | 4.5 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
| 0.1 | 0.7 | GO:0010668 | ectodermal cell differentiation(GO:0010668) |
| 0.1 | 1.1 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.1 | 0.6 | GO:0015819 | lysine transport(GO:0015819) |
| 0.1 | 0.8 | GO:0008616 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
| 0.1 | 1.3 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.1 | 0.4 | GO:0071051 | polyadenylation-dependent snoRNA 3'-end processing(GO:0071051) |
| 0.1 | 0.3 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.1 | 0.4 | GO:0046084 | adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084) |
| 0.1 | 0.8 | GO:0006983 | ER overload response(GO:0006983) |
| 0.1 | 0.4 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.1 | 0.9 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.1 | 0.3 | GO:0006547 | histidine metabolic process(GO:0006547) |
| 0.1 | 1.0 | GO:0033690 | positive regulation of osteoblast proliferation(GO:0033690) |
| 0.1 | 0.3 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.1 | 0.4 | GO:1900246 | positive regulation of RIG-I signaling pathway(GO:1900246) |
| 0.1 | 1.4 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
| 0.1 | 0.7 | GO:0033572 | transferrin transport(GO:0033572) |
| 0.1 | 0.3 | GO:0090209 | negative regulation of triglyceride metabolic process(GO:0090209) |
| 0.1 | 0.2 | GO:0002842 | T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) positive regulation of T cell mediated immune response to tumor cell(GO:0002842) |
| 0.1 | 0.4 | GO:0006265 | DNA topological change(GO:0006265) |
| 0.1 | 0.5 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.1 | 0.2 | GO:1902915 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.0 | 0.7 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.0 | 0.5 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.4 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.0 | 0.2 | GO:0051182 | coenzyme transport(GO:0051182) |
| 0.0 | 0.1 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.0 | 0.2 | GO:0048254 | snoRNA localization(GO:0048254) |
| 0.0 | 0.3 | GO:0034143 | regulation of toll-like receptor 4 signaling pathway(GO:0034143) |
| 0.0 | 1.3 | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200) |
| 0.0 | 1.3 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.0 | 0.2 | GO:0032310 | drug transmembrane transport(GO:0006855) prostaglandin secretion(GO:0032310) |
| 0.0 | 0.1 | GO:0050912 | detection of chemical stimulus involved in sensory perception(GO:0050907) detection of chemical stimulus involved in sensory perception of taste(GO:0050912) |
| 0.0 | 3.0 | GO:0008643 | carbohydrate transport(GO:0008643) |
| 0.0 | 0.4 | GO:0016082 | synaptic vesicle priming(GO:0016082) |
| 0.0 | 0.6 | GO:0014037 | Schwann cell differentiation(GO:0014037) |
| 0.0 | 0.2 | GO:0002072 | optic cup morphogenesis involved in camera-type eye development(GO:0002072) |
| 0.0 | 0.4 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.0 | 0.3 | GO:0060074 | synapse maturation(GO:0060074) |
| 0.0 | 0.0 | GO:0006545 | glycine biosynthetic process(GO:0006545) |
| 0.0 | 0.5 | GO:0042267 | natural killer cell mediated immunity(GO:0002228) natural killer cell mediated cytotoxicity(GO:0042267) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.0 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.3 | 1.2 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) |
| 0.2 | 0.7 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.2 | 0.7 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.2 | 0.7 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.2 | 0.5 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.1 | 0.8 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 0.5 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.1 | 0.3 | GO:0097433 | dense body(GO:0097433) |
| 0.1 | 0.6 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 0.4 | GO:0001651 | dense fibrillar component(GO:0001651) |
| 0.1 | 1.7 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 0.7 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.1 | 0.2 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.0 | 0.9 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 1.2 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 0.4 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 0.2 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 2.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 1.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.7 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 4.3 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.3 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 0.8 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 3.5 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.5 | 3.0 | GO:0043426 | MRF binding(GO:0043426) |
| 0.3 | 1.3 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.3 | 1.5 | GO:0009374 | biotin binding(GO:0009374) |
| 0.2 | 0.7 | GO:0004998 | transferrin receptor activity(GO:0004998) |
| 0.2 | 5.0 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
| 0.2 | 1.9 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.2 | 0.7 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.1 | 1.2 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.1 | 0.8 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.1 | 0.3 | GO:0048045 | 4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623) |
| 0.1 | 0.3 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) |
| 0.1 | 1.0 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 0.4 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.1 | 0.6 | GO:0015189 | L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189) |
| 0.1 | 1.0 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.1 | 1.3 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.1 | 0.5 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.1 | 0.7 | GO:0016624 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624) |
| 0.1 | 0.2 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.1 | 1.8 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 2.1 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.5 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 1.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.5 | GO:0048038 | quinone binding(GO:0048038) |
| 0.0 | 1.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.1 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.0 | 0.4 | GO:0008758 | thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606) |
| 0.0 | 1.0 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.0 | 0.7 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.3 | GO:0050308 | sugar-phosphatase activity(GO:0050308) |
| 0.0 | 0.2 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
| 0.0 | 0.2 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
| 0.0 | 0.3 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 0.4 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.2 | GO:0043559 | insulin binding(GO:0043559) |
| 0.0 | 0.3 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 0.9 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 0.2 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.0 | 0.1 | GO:0016421 | CoA carboxylase activity(GO:0016421) |
| 0.0 | 0.4 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.5 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.3 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 0.0 | GO:0008732 | threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.0 | 0.4 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896) |
| 0.0 | 0.2 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 0.4 | GO:0050681 | androgen receptor binding(GO:0050681) |
