Motif ID: Clock

Z-value: 0.463


Transcription factors associated with Clock:

Gene SymbolEntrez IDGene Name
Clock ENSMUSG00000029238.8 Clock

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Clockmm10_v2_chr5_-_76304474_763045480.471.9e-04Click!


Activity profile for motif Clock.

activity profile for motif Clock


Sorted Z-values histogram for motif Clock

Sorted Z-values for motif Clock



Network of associatons between targets according to the STRING database.



First level regulatory network of Clock

PNG image of the network

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Top targets:


Showing 1 to 20 of 144 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_186705980 3.470 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chr12_-_90738438 2.986 ENSMUST00000082432.3
 Dio2
deiodinase, iodothyronine, type II
chrX_+_36328353 1.930 ENSMUST00000016383.3
 Lonrf3
LON peptidase N-terminal domain and ring finger 3
chr15_+_81811414 1.879 ENSMUST00000023024.7
 Tef
thyrotroph embryonic factor
chr4_-_82705735 1.668 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr6_+_108660616 1.604 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr19_+_4510472 1.532 ENSMUST00000068004.6
 Pcx
pyruvate carboxylase
chr4_-_97778042 1.512 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr11_-_55033398 1.438 ENSMUST00000108883.3
ENSMUST00000102727.2
 Anxa6

annexin A6

chr6_+_108660772 1.384 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40
chr4_+_97777780 1.359 ENSMUST00000107062.2
ENSMUST00000052018.5
ENSMUST00000107057.1
 Nfia


nuclear factor I/A


chr12_+_16653470 1.281 ENSMUST00000111064.1
 Ntsr2
neurotensin receptor 2
chr5_-_74702891 1.256 ENSMUST00000117388.1
 Lnx1
ligand of numb-protein X 1
chr16_-_45158453 1.213 ENSMUST00000181750.1
 Slc35a5
solute carrier family 35, member A5
chr1_-_153332724 1.200 ENSMUST00000027752.8
 Lamc1
laminin, gamma 1
chr15_+_72913357 1.178 ENSMUST00000166418.2
 Gm3150
predicted gene 3150
chr16_-_45158566 1.132 ENSMUST00000181177.1
 Slc35a5
solute carrier family 35, member A5
chr4_-_97584612 1.107 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr9_+_44066993 1.105 ENSMUST00000034508.7
 Usp2
ubiquitin specific peptidase 2
chr12_+_102129019 1.095 ENSMUST00000079020.4
 Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
1.2 3.5 GO:0048818 positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.6 3.0 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.0 3.0 GO:0008643 carbohydrate transport(GO:0008643)
0.4 1.7 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.5 1.5 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.1 1.4 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.1 1.3 GO:0097186 amelogenesis(GO:0097186)
0.0 1.3 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 1.3 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.3 1.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.1 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.2 1.0 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.2 1.0 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.2 1.0 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1 1.0 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.3 0.9 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 0.9 GO:0031536 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) positive regulation of exit from mitosis(GO:0031536)
0.1 0.9 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.2 0.8 GO:0042373 vitamin K metabolic process(GO:0042373)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.5 GO:0005604 basement membrane(GO:0005604)
0.1 1.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 1.2 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.0 1.2 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.1 GO:0042734 presynaptic membrane(GO:0042734)
0.3 1.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 1.0 GO:0005581 collagen trimer(GO:0005581)
0.0 0.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 0.7 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.2 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 0.7 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 0.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.2 0.5 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 0.5 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 0.4 GO:0001651 dense fibrillar component(GO:0001651)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.0 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.9 3.5 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.5 3.0 GO:0043426 MRF binding(GO:0043426)
0.1 2.1 GO:0030332 cyclin binding(GO:0030332)
0.2 1.9 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 1.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 1.5 GO:0009374 biotin binding(GO:0009374)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 1.3 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 1.3 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 1.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.2 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 1.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 1.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 1.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 0.8 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.2 0.7 GO:0004998 transferrin receptor activity(GO:0004998)
0.2 0.7 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.7 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)