Motif ID: Creb3

Z-value: 0.742


Transcription factors associated with Creb3:

Gene SymbolEntrez IDGene Name
Creb3 ENSMUSG00000028466.9 Creb3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb3mm10_v2_chr4_+_43562672_43562947-0.581.1e-06Click!


Activity profile for motif Creb3.

activity profile for motif Creb3


Sorted Z-values histogram for motif Creb3

Sorted Z-values for motif Creb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_144939823 6.271 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr11_-_94653964 4.927 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr7_+_128523576 4.572 ENSMUST00000033136.7
 Bag3
BCL2-associated athanogene 3
chr9_-_20976762 4.379 ENSMUST00000054197.5
 S1pr2
sphingosine-1-phosphate receptor 2
chr7_-_45092130 4.240 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr17_+_35439155 4.025 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr2_-_105399286 3.932 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr4_+_3938888 3.923 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr4_-_134012381 3.503 ENSMUST00000176113.1
 Lin28a
lin-28 homolog A (C. elegans)
chr7_-_45091713 3.486 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr3_-_36571952 3.485 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr13_-_38528412 3.314 ENSMUST00000035988.8
 Txndc5
thioredoxin domain containing 5
chr18_+_84720019 3.163 ENSMUST00000161429.1
ENSMUST00000052501.1
 Fam69c

family with sequence similarity 69, member C

chr2_+_119112793 3.120 ENSMUST00000140939.1
ENSMUST00000028795.3
 Rad51

RAD51 homolog

chr4_-_117182623 3.067 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr3_+_116878227 2.938 ENSMUST00000040260.6
 Frrs1
ferric-chelate reductase 1
chr9_-_32541589 2.893 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1
chr5_+_120431770 2.819 ENSMUST00000031591.7
 Lhx5
LIM homeobox protein 5
chr15_+_79516396 2.815 ENSMUST00000010974.7
 Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr2_-_23155864 2.689 ENSMUST00000028119.6
 Mastl
microtubule associated serine/threonine kinase-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.1 GO:0032526 response to retinoic acid(GO:0032526)
0.9 6.3 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 6.0 GO:0010664 negative regulation of striated muscle cell apoptotic process(GO:0010664)
1.0 4.9 GO:0072429 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.3 4.7 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.6 4.5 GO:0006621 protein retention in ER lumen(GO:0006621)
1.5 4.4 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 4.0 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.4 3.7 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.3 3.7 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.4 3.5 GO:1901724 positive regulation of cell proliferation involved in kidney development(GO:1901724)
0.0 3.5 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.5 3.3 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.1 3.3 GO:0043277 apoptotic cell clearance(GO:0043277)
0.0 3.3 GO:0043010 camera-type eye development(GO:0043010)
0.8 3.1 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.6 3.1 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.6 3.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 2.9 GO:0035855 megakaryocyte development(GO:0035855)
0.4 2.8 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 5.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
1.0 4.9 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 4.7 GO:0005811 lipid particle(GO:0005811)
0.0 4.6 GO:0030018 Z disc(GO:0030018)
0.1 4.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 4.0 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 3.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.5 3.5 GO:0001940 male pronucleus(GO:0001940)
0.5 3.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.5 3.1 GO:0030870 Mre11 complex(GO:0030870)
0.4 3.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.3 3.1 GO:0000800 lateral element(GO:0000800)
0.1 3.1 GO:0035371 microtubule plus-end(GO:0035371)
0.0 2.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 2.7 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.9 2.6 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.1 2.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.5 2.5 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 2.4 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.2 GO:0005509 calcium ion binding(GO:0005509)
0.3 6.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 5.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 5.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 4.9 GO:0004519 endonuclease activity(GO:0004519)
0.8 4.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
1.1 4.5 GO:0046923 ER retention sequence binding(GO:0046923)
0.5 4.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 4.2 GO:0019789 SUMO transferase activity(GO:0019789)
0.3 4.0 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.2 3.6 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.2 3.5 GO:0035198 miRNA binding(GO:0035198)
0.1 3.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.5 3.1 GO:0008312 7S RNA binding(GO:0008312)
0.4 3.1 GO:0000150 recombinase activity(GO:0000150)
0.3 3.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 3.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.6 2.9 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 2.9 GO:0005109 frizzled binding(GO:0005109)
0.3 2.7 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)