Motif ID: Cxxc1

Z-value: 0.346


Transcription factors associated with Cxxc1:

Gene SymbolEntrez IDGene Name
Cxxc1 ENSMUSG00000024560.6 Cxxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cxxc1mm10_v2_chr18_+_74216118_74216145-0.264.5e-02Click!


Activity profile for motif Cxxc1.

activity profile for motif Cxxc1


Sorted Z-values histogram for motif Cxxc1

Sorted Z-values for motif Cxxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Cxxc1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_49636847 1.938 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr12_+_110279228 1.802 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr11_-_89302545 1.494 ENSMUST00000061728.3
 Nog
noggin
chr8_+_92357787 1.476 ENSMUST00000034184.10
 Irx5
Iroquois related homeobox 5 (Drosophila)
chr11_-_68386974 1.100 ENSMUST00000135141.1
 Ntn1
netrin 1
chr11_-_69921057 1.095 ENSMUST00000108609.1
ENSMUST00000108608.1
ENSMUST00000164359.1
 Eif5a


eukaryotic translation initiation factor 5A


chr10_+_50895651 0.962 ENSMUST00000020071.3
 Sim1
single-minded homolog 1 (Drosophila)
chr11_-_69920892 0.809 ENSMUST00000152589.1
ENSMUST00000108612.1
ENSMUST00000108611.1
 Eif5a


eukaryotic translation initiation factor 5A


chr3_-_101307079 0.644 ENSMUST00000097146.2
 Gm10355
predicted gene 10355
chr17_-_14203695 0.632 ENSMUST00000053218.5
 Dact2
dapper homolog 2, antagonist of beta-catenin (xenopus)
chr8_+_70594466 0.616 ENSMUST00000019283.9
 Isyna1
myo-inositol 1-phosphate synthase A1
chr8_-_111393810 0.611 ENSMUST00000038475.8
 Fa2h
fatty acid 2-hydroxylase
chr3_-_8964037 0.590 ENSMUST00000091354.5
ENSMUST00000094381.4
 Tpd52

tumor protein D52

chr5_-_4758216 0.564 ENSMUST00000054294.4
 Fzd1
frizzled homolog 1 (Drosophila)
chr19_-_4439388 0.555 ENSMUST00000117462.1
ENSMUST00000048197.3
 Rhod

ras homolog gene family, member D

chr11_+_32205483 0.552 ENSMUST00000121182.1
 Snrnp25
small nuclear ribonucleoprotein 25 (U11/U12)
chr11_-_69920581 0.545 ENSMUST00000108610.1
 Eif5a
eukaryotic translation initiation factor 5A
chr5_-_125389177 0.517 ENSMUST00000108707.2
 Ubc
ubiquitin C
chr10_+_128058974 0.484 ENSMUST00000084771.2
 Ptges3
prostaglandin E synthase 3 (cytosolic)
chr11_+_32205411 0.481 ENSMUST00000039601.3
ENSMUST00000149043.1
 Snrnp25

small nuclear ribonucleoprotein 25 (U11/U12)

chr5_-_65391408 0.467 ENSMUST00000057885.6
 Rpl9
ribosomal protein L9
chr5_-_65391380 0.462 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
 Rpl9


ribosomal protein L9


chr10_+_128058947 0.428 ENSMUST00000052798.7
 Ptges3
prostaglandin E synthase 3 (cytosolic)
chr11_+_80383279 0.351 ENSMUST00000165565.1
ENSMUST00000017567.7
 Zfp207

zinc finger protein 207

chr1_-_180813534 0.316 ENSMUST00000159789.1
ENSMUST00000081026.4
 H3f3a

H3 histone, family 3A

chr10_-_79766872 0.286 ENSMUST00000047203.8
 Rnf126
ring finger protein 126
chr5_+_125389284 0.276 ENSMUST00000100700.2
 Gm10382
predicted gene 10382
chr11_+_88068242 0.275 ENSMUST00000018521.4
 Vezf1
vascular endothelial zinc finger 1
chr10_+_80249441 0.238 ENSMUST00000020361.6
 Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr1_-_124045523 0.234 ENSMUST00000112606.1
 Dpp10
dipeptidylpeptidase 10
chr2_+_112239468 0.227 ENSMUST00000028554.3
 Lpcat4
lysophosphatidylcholine acyltransferase 4
chr5_-_125389915 0.210 ENSMUST00000136312.1
 Ubc
ubiquitin C
chr15_+_74516196 0.203 ENSMUST00000042035.9
 Bai1
brain-specific angiogenesis inhibitor 1
chr1_-_124045247 0.185 ENSMUST00000112603.2
 Dpp10
dipeptidylpeptidase 10
chr18_-_43477764 0.183 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr5_+_65391497 0.183 ENSMUST00000031101.3
ENSMUST00000122026.1
 Lias

lipoic acid synthetase

chr19_+_38931008 0.179 ENSMUST00000145051.1
 Hells
helicase, lymphoid specific
chr17_+_86963279 0.150 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr12_-_54656496 0.143 ENSMUST00000056228.6
 Sptssa
serine palmitoyltransferase, small subunit A
chr10_+_126978690 0.139 ENSMUST00000105256.2
 Ctdsp2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr5_+_143403819 0.127 ENSMUST00000110731.2
 Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chrX_+_48623737 0.121 ENSMUST00000114936.1
 Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr10_-_7681118 0.098 ENSMUST00000159977.1
ENSMUST00000162682.1
 Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chr11_+_60537978 0.066 ENSMUST00000044250.3
 Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chrX_+_53607918 0.065 ENSMUST00000114827.1
 Cxx1c
CAAX box 1C
chr8_-_122443404 0.059 ENSMUST00000006692.4
 Mvd
mevalonate (diphospho) decarboxylase
chr10_+_85928491 0.052 ENSMUST00000170396.1
 Ascl4
achaete-scute complex homolog 4 (Drosophila)
chr7_+_128744870 0.049 ENSMUST00000042942.8
 Sec23ip
Sec23 interacting protein
chr7_-_4501636 0.046 ENSMUST00000013886.8
 Ppp1r12c
protein phosphatase 1, regulatory (inhibitor) subunit 12C
chrX_+_53607987 0.028 ENSMUST00000063384.3
ENSMUST00000169626.1
 Cxx1c

CAAX box 1C


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.4 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.4 1.5 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.3 1.8 GO:0019336 phenol-containing compound catabolic process(GO:0019336)
0.2 1.5 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.2 0.6 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.2 1.1 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.2 0.6 GO:0072061 inner medullary collecting duct development(GO:0072061)
0.1 1.9 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 0.9 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 0.3 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.1 0.6 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.7 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.1 0.6 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.2 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 0.2 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.3 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.0 0.1 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 1.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.6 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 0.1 GO:0019287 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.0 0.2 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.4 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.4 GO:1990047 spindle matrix(GO:1990047)
0.0 0.3 GO:0001740 Barr body(GO:0001740)
0.0 0.9 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.0 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.1 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 2.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.2 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 0.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.6 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 1.5 GO:0019955 cytokine binding(GO:0019955)
0.0 0.2 GO:0048038 quinone binding(GO:0048038)
0.0 0.2 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.6 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.0 0.9 GO:0019843 rRNA binding(GO:0019843)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)