Motif ID: Dlx1

Z-value: 1.136


Transcription factors associated with Dlx1:

Gene SymbolEntrez IDGene Name
Dlx1 ENSMUSG00000041911.3 Dlx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx1mm10_v2_chr2_+_71528657_715286830.401.8e-03Click!


Activity profile for motif Dlx1.

activity profile for motif Dlx1


Sorted Z-values histogram for motif Dlx1

Sorted Z-values for motif Dlx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_84069325 9.094 ENSMUST00000046422.4
ENSMUST00000072505.4
 Acot5

acyl-CoA thioesterase 5

chr15_-_8710734 8.470 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 8.451 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_70842617 7.464 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr15_-_37458523 7.395 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr18_+_23415400 6.486 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr4_+_102570065 6.348 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr5_-_92278155 6.346 ENSMUST00000159345.1
ENSMUST00000113102.3
 Naaa

N-acylethanolamine acid amidase

chr18_-_10706688 6.314 ENSMUST00000002549.7
ENSMUST00000117726.1
ENSMUST00000117828.1
 Abhd3


abhydrolase domain containing 3


chr6_+_145934113 6.160 ENSMUST00000032383.7
 Sspn
sarcospan
chr19_-_19001099 6.132 ENSMUST00000040153.8
ENSMUST00000112828.1
 Rorb

RAR-related orphan receptor beta

chr5_-_62765618 6.019 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_102589687 6.015 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chrX_+_99042581 5.841 ENSMUST00000036606.7
 Stard8
START domain containing 8
chr14_+_118787894 5.837 ENSMUST00000047761.6
ENSMUST00000071546.7
 Cldn10

claudin 10

chr9_+_94669876 5.771 ENSMUST00000033463.9
 Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr15_-_37459327 5.029 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr5_-_62766153 4.964 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_-_45103747 4.736 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr14_+_118854695 4.535 ENSMUST00000100314.3
 Cldn10
claudin 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.2 16.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.0 12.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 11.9 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.4 9.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 9.4 GO:0030032 lamellipodium assembly(GO:0030032)
2.3 9.1 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.2 6.3 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
1.0 6.1 GO:0046549 retinal cone cell development(GO:0046549)
0.8 5.8 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.6 4.6 GO:2000809 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809)
0.4 4.4 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
1.4 4.3 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
1.4 4.2 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.1 4.2 GO:0019882 antigen processing and presentation(GO:0019882)
1.4 4.1 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.2 4.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
1.3 4.0 GO:0097212 lysosomal membrane organization(GO:0097212)
0.2 4.0 GO:0003417 growth plate cartilage development(GO:0003417)
1.2 3.7 GO:0008228 opsonization(GO:0008228) modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.9 3.7 GO:0038128 ERBB2 signaling pathway(GO:0038128)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 16.9 GO:0043205 fibril(GO:0043205)
0.7 12.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.5 12.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 11.0 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.5 9.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 8.9 GO:0031594 neuromuscular junction(GO:0031594)
0.1 8.9 GO:0005923 bicellular tight junction(GO:0005923)
0.0 6.0 GO:0030027 lamellipodium(GO:0030027)
0.0 5.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 5.3 GO:0008021 synaptic vesicle(GO:0008021)
0.0 4.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.9 4.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
1.0 4.0 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 3.7 GO:0043198 dendritic shaft(GO:0043198)
0.1 3.6 GO:0005811 lipid particle(GO:0005811)
0.0 3.5 GO:0005802 trans-Golgi network(GO:0005802)
0.1 3.4 GO:0030673 axolemma(GO:0030673)
0.8 3.2 GO:0019815 B cell receptor complex(GO:0019815)
0.1 3.2 GO:0031901 early endosome membrane(GO:0031901)
0.1 2.7 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 20.3 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.3 13.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 12.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.4 11.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.5 9.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 9.0 GO:0005096 GTPase activator activity(GO:0005096)
0.1 8.3 GO:0030165 PDZ domain binding(GO:0030165)
0.5 7.5 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
2.1 6.3 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.3 6.3 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
2.0 6.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.7 5.8 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 5.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 5.0 GO:0008168 methyltransferase activity(GO:0008168)
1.6 4.7 GO:0019770 IgG receptor activity(GO:0019770)
0.8 4.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 4.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 4.3 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
1.4 4.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.2 3.9 GO:0005242 inward rectifier potassium channel activity(GO:0005242)